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A2X2G3

- PP2A3_ORYSI

UniProt

A2X2G3 - PP2A3_ORYSI

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Protein

Serine/threonine-protein phosphatase PP2A-3 catalytic subunit

Gene

PP2A3

Organism
Oryza sativa subsp. indica (Rice)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli

Functioni

Catalytic activityi

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Cofactori

Binds 2 manganese ions per subunit.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi55 – 551Manganese 1By similarity
Metal bindingi57 – 571Manganese 1By similarity
Metal bindingi83 – 831Manganese 1By similarity
Metal bindingi83 – 831Manganese 2By similarity
Metal bindingi115 – 1151Manganese 2By similarity
Active sitei116 – 1161Proton donorBy similarity
Metal bindingi165 – 1651Manganese 2By similarity
Metal bindingi239 – 2391Manganese 2By similarity

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. phosphoprotein phosphatase activity Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase

Keywords - Ligandi

Manganese, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein phosphatase PP2A-3 catalytic subunit (EC:3.1.3.16)
Gene namesi
Name:PP2A3
ORF Names:OsI_006256
OrganismiOryza sativa subsp. indica (Rice)
Taxonomic identifieri39946 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaeBEP cladeEhrhartoideaeOryzeaeOryza

Organism-specific databases

GrameneiA2X2G3.

Subcellular locationi

Cytoplasm By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 307307Serine/threonine-protein phosphatase PP2A-3 catalytic subunitPRO_0000301657Add
BLAST

Proteomic databases

PRIDEiA2X2G3.

Interactioni

Protein-protein interaction databases

STRINGi39947.LOC_Os02g12580.1.

Structurei

3D structure databases

ProteinModelPortaliA2X2G3.
SMRiA2X2G3. Positions 7-307.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the PPP phosphatase family. PP-2A subfamily.Curated

Phylogenomic databases

eggNOGiCOG0639.
HOGENOMiHOG000172696.

Family and domain databases

Gene3Di3.60.21.10. 1 hit.
InterProiIPR004843. Calcineurin-like_PHP_apaH.
IPR029052. Metallo-depent_PP-like.
IPR006186. Ser/Thr-sp_prot-phosphatase.
[Graphical view]
PfamiPF00149. Metallophos. 1 hit.
[Graphical view]
PRINTSiPR00114. STPHPHTASE.
SMARTiSM00156. PP2Ac. 1 hit.
[Graphical view]
SUPFAMiSSF56300. SSF56300. 1 hit.
PROSITEiPS00125. SER_THR_PHOSPHATASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A2X2G3-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MPSSHGDLDR QIAQLRECKH LAEGEVRALC EQAKAILMEE WNVQPVRCPV
60 70 80 90 100
TVCGDIHGQF YDLIELFRIG GEAPDTNYLF MGDYVDRGYY SVETVSLLVA
110 120 130 140 150
LKVRYRDRIT ILRGNHESRQ ITQVYGFYDE CLRKYGNANV WKYFTDLFDY
160 170 180 190 200
LPLTALIENQ VFCLHGGLSP SLDTLDNIRA LDRIQEVPHE GPMCDLLWSD
210 220 230 240 250
PDDRCGWGIS PRGAGYTFGQ DIAQQFNHTN GLSLISRAHQ LVMEGFNWCQ
260 270 280 290 300
DKNVVTVFSA PNYCYRCGNM AAILEIGENM DQNFLQFDPA PRQIEPDTTR

KTPDYFL
Length:307
Mass (Da):35,145
Last modified:September 11, 2007 - v2
Checksum:i97143563695D0DD6
GO

Sequence cautioni

The sequence CM000127 differs from that shown. Reason: Frameshift at positions 39 and 52.

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti60 – 601F → P in CM000127. (PubMed:15685292)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF159061 Genomic DNA. Translation: AAD41126.1.
CM000127 Genomic DNA. No translation available.
CT832108 mRNA. No translation available.
UniGeneiOs.10337.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF159061 Genomic DNA. Translation: AAD41126.1 .
CM000127 Genomic DNA. No translation available.
CT832108 mRNA. No translation available.
UniGenei Os.10337.

3D structure databases

ProteinModelPortali A2X2G3.
SMRi A2X2G3. Positions 7-307.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 39947.LOC_Os02g12580.1.

Proteomic databases

PRIDEi A2X2G3.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Organism-specific databases

Gramenei A2X2G3.

Phylogenomic databases

eggNOGi COG0639.
HOGENOMi HOG000172696.

Family and domain databases

Gene3Di 3.60.21.10. 1 hit.
InterProi IPR004843. Calcineurin-like_PHP_apaH.
IPR029052. Metallo-depent_PP-like.
IPR006186. Ser/Thr-sp_prot-phosphatase.
[Graphical view ]
Pfami PF00149. Metallophos. 1 hit.
[Graphical view ]
PRINTSi PR00114. STPHPHTASE.
SMARTi SM00156. PP2Ac. 1 hit.
[Graphical view ]
SUPFAMi SSF56300. SSF56300. 1 hit.
PROSITEi PS00125. SER_THR_PHOSPHATASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning and characterization of protein phosphatase 2A catalytic subunit genes from Oryza sativa."
    Yu R.M.K., Kong R.Y.C.
    Submitted (JUN-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: cv. IR36.
  2. "The genomes of Oryza sativa: a history of duplications."
    Yu J., Wang J., Lin W., Li S., Li H., Zhou J., Ni P., Dong W., Hu S., Zeng C., Zhang J., Zhang Y., Li R., Xu Z., Li S., Li X., Zheng H., Cong L.
    , Lin L., Yin J., Geng J., Li G., Shi J., Liu J., Lv H., Li J., Wang J., Deng Y., Ran L., Shi X., Wang X., Wu Q., Li C., Ren X., Wang J., Wang X., Li D., Liu D., Zhang X., Ji Z., Zhao W., Sun Y., Zhang Z., Bao J., Han Y., Dong L., Ji J., Chen P., Wu S., Liu J., Xiao Y., Bu D., Tan J., Yang L., Ye C., Zhang J., Xu J., Zhou Y., Yu Y., Zhang B., Zhuang S., Wei H., Liu B., Lei M., Yu H., Li Y., Xu H., Wei S., He X., Fang L., Zhang Z., Zhang Y., Huang X., Su Z., Tong W., Li J., Tong Z., Li S., Ye J., Wang L., Fang L., Lei T., Chen C.-S., Chen H.-C., Xu Z., Li H., Huang H., Zhang F., Xu H., Li N., Zhao C., Li S., Dong L., Huang Y., Li L., Xi Y., Qi Q., Li W., Zhang B., Hu W., Zhang Y., Tian X., Jiao Y., Liang X., Jin J., Gao L., Zheng W., Hao B., Liu S.-M., Wang W., Yuan L., Cao M., McDermott J., Samudrala R., Wang J., Wong G.K.-S., Yang H.
    PLoS Biol. 3:266-281(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. 93-11.
  3. "A collection of 10,096 indica rice full-length cDNAs reveals highly expressed sequence divergence between Oryza sativa indica and japonica subspecies."
    Liu X., Lu T., Yu S., Li Y., Huang Y., Huang T., Zhang L., Zhu J., Zhao Q., Fan D., Mu J., Shangguan Y., Feng Q., Guan J., Ying K., Zhang Y., Lin Z., Sun Z.
    , Qian Q., Lu Y., Han B.
    Plant Mol. Biol. 65:403-415(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: cv. Guang-Lu-Ai No.4.

Entry informationi

Entry nameiPP2A3_ORYSI
AccessioniPrimary (citable) accession number: A2X2G3
Secondary accession number(s): Q6Z6L8, Q6Z6L9, Q9XGT7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: September 11, 2007
Last modified: October 29, 2014
This is version 45 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3