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Protein

Serine/threonine-protein phosphatase PP2A-3 catalytic subunit

Gene

PP2A3

Organism
Oryza sativa subsp. indica (Rice)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Cofactori

Mn2+By similarityNote: Binds 2 manganese ions per subunit.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi55 – 551Manganese 1By similarity
Metal bindingi57 – 571Manganese 1By similarity
Metal bindingi83 – 831Manganese 1By similarity
Metal bindingi83 – 831Manganese 2By similarity
Metal bindingi115 – 1151Manganese 2By similarity
Active sitei116 – 1161Proton donorBy similarity
Metal bindingi165 – 1651Manganese 2By similarity
Metal bindingi239 – 2391Manganese 2By similarity

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. phosphoprotein phosphatase activity Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase

Keywords - Ligandi

Manganese, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein phosphatase PP2A-3 catalytic subunit (EC:3.1.3.16)
Gene namesi
Name:PP2A3
ORF Names:OsI_006256
OrganismiOryza sativa subsp. indica (Rice)
Taxonomic identifieri39946 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaeBEP cladeEhrhartoideaeOryzeaeOryza
ProteomesiUP000007015 Componenti: Chromosome 2

Organism-specific databases

GrameneiA2X2G3.

Subcellular locationi

Cytoplasm By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 307307Serine/threonine-protein phosphatase PP2A-3 catalytic subunitPRO_0000301657Add
BLAST

Proteomic databases

PRIDEiA2X2G3.

Interactioni

Protein-protein interaction databases

STRINGi39947.LOC_Os02g12580.1.

Structurei

3D structure databases

ProteinModelPortaliA2X2G3.
SMRiA2X2G3. Positions 7-307.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the PPP phosphatase family. PP-2A subfamily.Curated

Phylogenomic databases

eggNOGiCOG0639.
HOGENOMiHOG000172696.

Family and domain databases

Gene3Di3.60.21.10. 1 hit.
InterProiIPR004843. Calcineurin-like_PHP_apaH.
IPR029052. Metallo-depent_PP-like.
IPR006186. Ser/Thr-sp_prot-phosphatase.
[Graphical view]
PfamiPF00149. Metallophos. 1 hit.
[Graphical view]
PRINTSiPR00114. STPHPHTASE.
SMARTiSM00156. PP2Ac. 1 hit.
[Graphical view]
SUPFAMiSSF56300. SSF56300. 1 hit.
PROSITEiPS00125. SER_THR_PHOSPHATASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A2X2G3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPSSHGDLDR QIAQLRECKH LAEGEVRALC EQAKAILMEE WNVQPVRCPV
60 70 80 90 100
TVCGDIHGQF YDLIELFRIG GEAPDTNYLF MGDYVDRGYY SVETVSLLVA
110 120 130 140 150
LKVRYRDRIT ILRGNHESRQ ITQVYGFYDE CLRKYGNANV WKYFTDLFDY
160 170 180 190 200
LPLTALIENQ VFCLHGGLSP SLDTLDNIRA LDRIQEVPHE GPMCDLLWSD
210 220 230 240 250
PDDRCGWGIS PRGAGYTFGQ DIAQQFNHTN GLSLISRAHQ LVMEGFNWCQ
260 270 280 290 300
DKNVVTVFSA PNYCYRCGNM AAILEIGENM DQNFLQFDPA PRQIEPDTTR

KTPDYFL
Length:307
Mass (Da):35,145
Last modified:September 11, 2007 - v2
Checksum:i97143563695D0DD6
GO

Sequence cautioni

The sequence CM000127 differs from that shown. Reason: Frameshift at positions 39 and 52. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti60 – 601F → P in CM000127 (PubMed:15685292).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF159061 Genomic DNA. Translation: AAD41126.1.
CM000127 Genomic DNA. No translation available.
CT832108 mRNA. No translation available.
UniGeneiOs.10337.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF159061 Genomic DNA. Translation: AAD41126.1.
CM000127 Genomic DNA. No translation available.
CT832108 mRNA. No translation available.
UniGeneiOs.10337.

3D structure databases

ProteinModelPortaliA2X2G3.
SMRiA2X2G3. Positions 7-307.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi39947.LOC_Os02g12580.1.

Proteomic databases

PRIDEiA2X2G3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

GrameneiA2X2G3.

Phylogenomic databases

eggNOGiCOG0639.
HOGENOMiHOG000172696.

Family and domain databases

Gene3Di3.60.21.10. 1 hit.
InterProiIPR004843. Calcineurin-like_PHP_apaH.
IPR029052. Metallo-depent_PP-like.
IPR006186. Ser/Thr-sp_prot-phosphatase.
[Graphical view]
PfamiPF00149. Metallophos. 1 hit.
[Graphical view]
PRINTSiPR00114. STPHPHTASE.
SMARTiSM00156. PP2Ac. 1 hit.
[Graphical view]
SUPFAMiSSF56300. SSF56300. 1 hit.
PROSITEiPS00125. SER_THR_PHOSPHATASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning and characterization of protein phosphatase 2A catalytic subunit genes from Oryza sativa."
    Yu R.M.K., Kong R.Y.C.
    Submitted (MAY-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: cv. IR36.
  2. "The genomes of Oryza sativa: a history of duplications."
    Yu J., Wang J., Lin W., Li S., Li H., Zhou J., Ni P., Dong W., Hu S., Zeng C., Zhang J., Zhang Y., Li R., Xu Z., Li S., Li X., Zheng H., Cong L.
    , Lin L., Yin J., Geng J., Li G., Shi J., Liu J., Lv H., Li J., Wang J., Deng Y., Ran L., Shi X., Wang X., Wu Q., Li C., Ren X., Wang J., Wang X., Li D., Liu D., Zhang X., Ji Z., Zhao W., Sun Y., Zhang Z., Bao J., Han Y., Dong L., Ji J., Chen P., Wu S., Liu J., Xiao Y., Bu D., Tan J., Yang L., Ye C., Zhang J., Xu J., Zhou Y., Yu Y., Zhang B., Zhuang S., Wei H., Liu B., Lei M., Yu H., Li Y., Xu H., Wei S., He X., Fang L., Zhang Z., Zhang Y., Huang X., Su Z., Tong W., Li J., Tong Z., Li S., Ye J., Wang L., Fang L., Lei T., Chen C.-S., Chen H.-C., Xu Z., Li H., Huang H., Zhang F., Xu H., Li N., Zhao C., Li S., Dong L., Huang Y., Li L., Xi Y., Qi Q., Li W., Zhang B., Hu W., Zhang Y., Tian X., Jiao Y., Liang X., Jin J., Gao L., Zheng W., Hao B., Liu S.-M., Wang W., Yuan L., Cao M., McDermott J., Samudrala R., Wang J., Wong G.K.-S., Yang H.
    PLoS Biol. 3:266-281(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. 93-11.
  3. "A collection of 10,096 indica rice full-length cDNAs reveals highly expressed sequence divergence between Oryza sativa indica and japonica subspecies."
    Liu X., Lu T., Yu S., Li Y., Huang Y., Huang T., Zhang L., Zhu J., Zhao Q., Fan D., Mu J., Shangguan Y., Feng Q., Guan J., Ying K., Zhang Y., Lin Z., Sun Z.
    , Qian Q., Lu Y., Han B.
    Plant Mol. Biol. 65:403-415(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: cv. Guang-Lu-Ai No.4.

Entry informationi

Entry nameiPP2A3_ORYSI
AccessioniPrimary (citable) accession number: A2X2G3
Secondary accession number(s): Q6Z6L8, Q6Z6L9, Q9XGT7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: September 11, 2007
Last modified: March 4, 2015
This is version 48 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.