Reviewed, UniProtKB/Swiss-Prot A2X0Q3 (ANM5_ORYSI)

Names and origin

Protein names

Recommended name:
    Protein arginine N-methyltransferase 5
    EC=2.1.1.125
    EC=2.1.1.-
Alternative name(s):
    Shk1 kinase-binding protein 1 homolog

Gene names

Name:	PRMT5
Synonyms:	SKB1
ORF Names:	OsI_005646

Organism

Oryza sativa subsp. indica (Rice)

Taxonomic identifier

39946 [NCBI]

Taxonomic lineage

Eukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliophyta › Liliopsida › Poales › Poaceae › BEP clade › Ehrhartoideae › Oryzeae › Oryza

Protein attributes

Sequence length	649 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Methylates arginine residues in proteins such as histone H4 By similarity.
Catalytic activity	S-adenosyl-L-methionine + histone-arginine = S-adenosyl-L-homocysteine + histone-N(omega)-methyl-arginine.
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the protein arginine N-methyltransferase family.

Ontologies

Keywords
Cellular component	Cytoplasm
Ligand	S-adenosyl-L-methionine
Molecular function	Methyltransferase Transferase
Gene Ontology (GO)
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	histone-arginine N-methyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 649	649	Protein arginine N-methyltransferase 5		PRO_0000293994

Sequences

	Sequence		Length	Mass (Da)
	A2X0Q3-1 [UniParc]. Last modified July 10, 2007. Version 2. Checksum: FBBFEFA015642816	FASTA	649	72,700
	10 20 30 40 50 60 MPLGQRAGDK SESRYCGVEV LDFPAGEELP AVLSHSLSSS FDFLLAPLVD PDYRPTPGSV 70 80 90 100 110 120 LPVAASDLVL GPAQWSSHIV GKINEWIDLD AEDEQLRLDS EITLKQEIAW ASHLSLQACV 130 140 150 160 170 180 LPPPKRSSCA NYARVVNHIL QGLTNLQLWL RIPLEKSEPM DEDHDGAKDN SDMSDTVDSW 190 200 210 220 230 240 EWWNSFRLLC EHSSQLCVAL DVLSTLPSMN SLGRWFGEPV RAAILQTNAF LTNARGYPCL 250 260 270 280 290 300 SKRHQKLLTG FFNHSVQVII SGRSNHNVSQ GGVLSGDENH TEDTAVRHAL SPYLDYIAYI 310 320 330 340 350 360 YQRMDPLPEQ ERFEINYRDF LQSPLQPLMD NLEAQTYETF EKDTVKYTQY QRAIAKALVD 370 380 390 400 410 420 RVSDDDVSTT KTVLMVVGAG RGPLVRASLQ AAEETGRKLK VYAVEKNPNA VITLHSLIKL 430 440 450 460 470 480 EGWESLVTII SSDMRCWEAP EKADILVSEL LGSFGDNELS PECLDGAQRF LKPDGISIPS 490 500 510 520 530 540 SYTSFIEPIT ASKLHNDIKA HKDIAHFETA YVVKLHRIAR LAPTQSVFTF DHPNPSPNAS 550 560 570 580 590 600 NQRYTKLKFE IPQETGSCLV HGFAGYFDAV LYKDVHLGIE PNTATPNMFS WFPIFFPLRK 610 620 630 640 PIYVPSKTPI EVHFWRCCGA TKVWYEWAVT APSPSPIHNS NGRSYWVGL

References

[1]

"The genomes of Oryza sativa: a history of duplications." Yu J., Wang J., Lin W., Li S., Li H., Zhou J., Ni P., Dong W., Hu S., Zeng C., Zhang J., Zhang Y., Li R., Xu Z., Li S., Li X., Zheng H., Cong L. , Lin L., Yin J., Geng J., Li G., Shi J., Liu J., Lv H., Li J., Wang J., Deng Y., Ran L., Shi X., Wang X., Wu Q., Li C., Ren X., Wang J., Wang X., Li D., Liu D., Zhang X., Ji Z., Zhao W., Sun Y., Zhang Z., Bao J., Han Y., Dong L., Ji J., Chen P., Wu S., Liu J., Xiao Y., Bu D., Tan J., Yang L., Ye C., Zhang J., Xu J., Zhou Y., Yu Y., Zhang B., Zhuang S., Wei H., Liu B., Lei M., Yu H., Li Y., Xu H., Wei S., He X., Fang L., Zhang Z., Zhang Y., Huang X., Su Z., Tong W., Li J., Tong Z., Li S., Ye J., Wang L., Fang L., Lei T., Chen C.-S., Chen H.-C., Xu Z., Li H., Huang H., Zhang F., Xu H., Li N., Zhao C., Li S., Dong L., Huang Y., Li L., Xi Y., Qi Q., Li W., Zhang B., Hu W., Zhang Y., Tian X., Jiao Y., Liang X., Jin J., Gao L., Zheng W., Hao B., Liu S.-M., Wang W., Yuan L., Cao M., McDermott J., Samudrala R., Wang J., Wong G.K.-S., Yang H. PLoS Biol. 3:266-281(2005) [PubMed: 15685292] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: cv. 93-11.

Cross-references

Sequence databases
EMBLGenBankDDBJ	CM000127 Genomic DNA. No translation available.
3D structure databases
ModBase	Search...
Family and domain databases
InterPro	IPR007857. Skb1_MeTrfase. [Graphical view]
Pfam	PF05185. PRMT5. 1 hit. [Graphical view]
PIRSF	PIRSF015894. Skb1_MeTrfase. 1 hit.
ProtoNet	Search...

Entry information

Entry name

ANM5_ORYSI

Accession

Primary (citable) accession number: A2X0Q3

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 10, 2007
Last sequence update:	July 10, 2007
Last modified:	June 16, 2009
This is version 14 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

PPAP (Plant Proteome Annotation Project)