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A2X0M1

- MPK13_ORYSI

UniProt

A2X0M1 - MPK13_ORYSI

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Protein
Mitogen-activated protein kinase 13
Gene
MPK13, BIMK2, BWMK2, MAPK2, MPK17-2, OsI_005614
Organism
Oryza sativa subsp. indica (Rice)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Enzyme regulationi

Activated by threonine and tyrosine phosphorylation By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei42 – 421ATP By similarity
Active sitei139 – 1391Proton acceptor By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi19 – 279ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. MAP kinase activity Source: UniProtKB-EC

GO - Biological processi

  1. abscisic acid-activated signaling pathway Source: EnsemblPlants/Gramene
  2. response to hydrogen peroxide Source: EnsemblPlants/Gramene
  3. response to jasmonic acid Source: EnsemblPlants/Gramene
  4. response to wounding Source: EnsemblPlants/Gramene
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Mitogen-activated protein kinase 13 (EC:2.7.11.24)
Short name:
MAP kinase 13
Alternative name(s):
Benzothiadiazole-induced MAP kinase 2
MAP kinase 2
OsBIMK2
OsBWMK2
OsMAPK2
OsMPK17-2
Wound- and blast-induced MAPK 2
Gene namesi
Name:MPK13
Synonyms:BIMK2, BWMK2, MAPK2, MPK17-2
ORF Names:OsI_005614
OrganismiOryza sativa subsp. indica (Rice)
Taxonomic identifieri39946 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaeBEP cladeEhrhartoideaeOryzeaeOryza

Organism-specific databases

GrameneiA2X0M1.

Subcellular locationi

GO - Cellular componenti

  1. cytosol Source: EnsemblPlants/Gramene
  2. mitochondrion Source: EnsemblPlants/Gramene
  3. nucleus Source: EnsemblPlants/Gramene
  4. plasma membrane Source: EnsemblPlants/Gramene
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 506506Mitogen-activated protein kinase 13
PRO_0000300871Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei175 – 1751Phosphothreonine By similarity
Modified residuei177 – 1771Phosphotyrosine By similarity

Post-translational modificationi

Dually phosphorylated on Thr-175 and Tyr-177, which activates the enzyme By similarity.

Keywords - PTMi

Phosphoprotein

Proteomic databases

PRIDEiA2X0M1.

Expressioni

Inductioni

By salicylic acid (SA), ethylene and infection with rice blast fungus (M.grisea).

Structurei

3D structure databases

ProteinModelPortaliA2X0M1.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini13 – 304292Protein kinase
Add
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi175 – 1773TXY

Domaini

The TXY motif contains the threonine and tyrosine residues whose phosphorylation activates the MAP kinases.

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0515.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR003527. MAP_kinase_CS.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase_dom.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS01351. MAPK. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A2X0M1-1 [UniParc]FASTAAdd to Basket

« Hide

MEFFTEYGEA SQYQIQEVVG KGSYGVVAAA VDTHTGERVA IKKINDVFEH    50
VSDAIRILRE IKVLRLLRHP DIVVIKHIML PPTRREFRDI YVVFELMESD 100
LHQVIEANHD LSPEHHRFFL YQLLCALKYI HSANVFHRDL KPKNILANSD 150
CKLKICDFGL ARVAFNDSPS TIFWTDYVAT RWYRAPELCG SFFSKYTPAI 200
DIWSIGCIFA EILTGRPLFP GRNVVHQLDL ITDLLGTPSS ETLSRIRNEN 250
ARGYLTGMQR KHPIPFSHKF HNADPLALRL LERLLAFDPK DRPTAEEALA 300
DPYFRGISKL SREPSRLPVS KFEFEFERRK LTKDDVREMI YREILEYHPQ 350
MLQEYIRGGE QISFLYPSGV DRFKRQFAHL EENYSRGERS TPLRRQHASL 400
PRERVCSSVD SNNQDSDNEE RRAISSIART MISPPRSQEK GKNRASAYPN 450
GIINLNSNPK IYLKSASISA STCIIRGNKG PKENGISEDM EEVVYELSDN 500
VTRMLS 506
Length:506
Mass (Da):58,281
Last modified:September 11, 2007 - v2
Checksum:i7EBCBA768079F972
GO

Sequence cautioni

The sequence EAY84381.1 differs from that shown. Reason: Erroneous gene model prediction.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY524973 mRNA. Translation: AAS18417.1.
AY524974 Genomic DNA. Translation: AAS18418.1.
DQ826423 mRNA. Translation: ABH01190.2.
CM000127 Genomic DNA. Translation: EAY84381.1. Sequence problems.
UniGeneiOs.2356.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY524973 mRNA. Translation: AAS18417.1 .
AY524974 Genomic DNA. Translation: AAS18418.1 .
DQ826423 mRNA. Translation: ABH01190.2 .
CM000127 Genomic DNA. Translation: EAY84381.1 . Sequence problems.
UniGenei Os.2356.

3D structure databases

ProteinModelPortali A2X0M1.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi A2X0M1.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Organism-specific databases

Gramenei A2X0M1.

Phylogenomic databases

eggNOGi COG0515.

Family and domain databases

InterProi IPR011009. Kinase-like_dom.
IPR003527. MAP_kinase_CS.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase_dom.
[Graphical view ]
Pfami PF00069. Pkinase. 1 hit.
[Graphical view ]
SMARTi SM00220. S_TKc. 1 hit.
[Graphical view ]
SUPFAMi SSF56112. SSF56112. 1 hit.
PROSITEi PS01351. MAPK. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "OsBIMK2, a gene encoding a map kinase, is involved in disease resistance responses in rice."
    Song D., Song F., Goodman R.M., Zheng Z.
    Submitted (JAN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
    Strain: cv. Yuanfengzao.
  2. "Oryza sativa (indica cultivar-group) mitogen activated protein kinase 17-2 (MPK17-2) mRNA."
    Rao K.P., Kumar K., Sharma P., Sinha A.K.
    Submitted (JUN-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: cv. Pusa Basmati.
  3. "The genomes of Oryza sativa: a history of duplications."
    Yu J., Wang J., Lin W., Li S., Li H., Zhou J., Ni P., Dong W., Hu S., Zeng C., Zhang J., Zhang Y., Li R., Xu Z., Li S., Li X., Zheng H., Cong L.
    , Lin L., Yin J., Geng J., Li G., Shi J., Liu J., Lv H., Li J., Wang J., Deng Y., Ran L., Shi X., Wang X., Wu Q., Li C., Ren X., Wang J., Wang X., Li D., Liu D., Zhang X., Ji Z., Zhao W., Sun Y., Zhang Z., Bao J., Han Y., Dong L., Ji J., Chen P., Wu S., Liu J., Xiao Y., Bu D., Tan J., Yang L., Ye C., Zhang J., Xu J., Zhou Y., Yu Y., Zhang B., Zhuang S., Wei H., Liu B., Lei M., Yu H., Li Y., Xu H., Wei S., He X., Fang L., Zhang Z., Zhang Y., Huang X., Su Z., Tong W., Li J., Tong Z., Li S., Ye J., Wang L., Fang L., Lei T., Chen C.-S., Chen H.-C., Xu Z., Li H., Huang H., Zhang F., Xu H., Li N., Zhao C., Li S., Dong L., Huang Y., Li L., Xi Y., Qi Q., Li W., Zhang B., Hu W., Zhang Y., Tian X., Jiao Y., Liang X., Jin J., Gao L., Zheng W., Hao B., Liu S.-M., Wang W., Yuan L., Cao M., McDermott J., Samudrala R., Wang J., Wong G.K.-S., Yang H.
    PLoS Biol. 3:266-281(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. 93-11.
  4. "Molecular analysis of the rice MAP kinase gene family in relation to Magnaporthe grisea infection."
    Reyna N.S., Yang Y.
    Mol. Plant Microbe Interact. 19:530-540(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NOMENCLATURE.

Entry informationi

Entry nameiMPK13_ORYSI
AccessioniPrimary (citable) accession number: A2X0M1
Secondary accession number(s): Q0PIU6
, Q6QUV9, Q6Z831, Q9SE22
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: September 11, 2007
Last modified: April 16, 2014
This is version 45 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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