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A2X0M1

- MPK13_ORYSI

UniProt

A2X0M1 - MPK13_ORYSI

Protein

Mitogen-activated protein kinase 13

Gene

MPK13

Organism
Oryza sativa subsp. indica (Rice)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 46 (01 Oct 2014)
      Sequence version 2 (11 Sep 2007)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + a protein = ADP + a phosphoprotein.

    Enzyme regulationi

    Activated by threonine and tyrosine phosphorylation.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei42 – 421ATPPROSITE-ProRule annotation
    Active sitei139 – 1391Proton acceptorPROSITE-ProRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi19 – 279ATPPROSITE-ProRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. MAP kinase activity Source: UniProtKB-EC

    GO - Biological processi

    1. abscisic acid-activated signaling pathway Source: EnsemblPlants/Gramene
    2. response to hydrogen peroxide Source: EnsemblPlants/Gramene
    3. response to jasmonic acid Source: EnsemblPlants/Gramene
    4. response to wounding Source: EnsemblPlants/Gramene

    Keywords - Molecular functioni

    Kinase, Serine/threonine-protein kinase, Transferase

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Mitogen-activated protein kinase 13 (EC:2.7.11.24)
    Short name:
    MAP kinase 13
    Alternative name(s):
    Benzothiadiazole-induced MAP kinase 2
    MAP kinase 2
    OsBIMK2
    OsBWMK2
    OsMAPK2
    OsMPK17-2
    Wound- and blast-induced MAPK 2
    Gene namesi
    Name:MPK13
    Synonyms:BIMK2, BWMK2, MAPK2, MPK17-2
    ORF Names:OsI_005614
    OrganismiOryza sativa subsp. indica (Rice)
    Taxonomic identifieri39946 [NCBI]
    Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaeBEP cladeEhrhartoideaeOryzeaeOryza

    Organism-specific databases

    GrameneiA2X0M1.

    Subcellular locationi

    GO - Cellular componenti

    1. cytosol Source: EnsemblPlants/Gramene
    2. mitochondrion Source: EnsemblPlants/Gramene
    3. nucleus Source: EnsemblPlants/Gramene
    4. plasma membrane Source: EnsemblPlants/Gramene

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 506506Mitogen-activated protein kinase 13PRO_0000300871Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei175 – 1751PhosphothreonineBy similarity
    Modified residuei177 – 1771PhosphotyrosineBy similarity

    Post-translational modificationi

    Dually phosphorylated on Thr-175 and Tyr-177, which activates the enzyme.By similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    PRIDEiA2X0M1.

    Expressioni

    Inductioni

    By salicylic acid (SA), ethylene and infection with rice blast fungus (M.grisea).

    Structurei

    3D structure databases

    ProteinModelPortaliA2X0M1.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini13 – 304292Protein kinasePROSITE-ProRule annotationAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi175 – 1773TXY

    Domaini

    The TXY motif contains the threonine and tyrosine residues whose phosphorylation activates the MAP kinases.

    Sequence similaritiesi

    Contains 1 protein kinase domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG0515.

    Family and domain databases

    InterProiIPR011009. Kinase-like_dom.
    IPR003527. MAP_kinase_CS.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR002290. Ser/Thr_dual-sp_kinase_dom.
    [Graphical view]
    PfamiPF00069. Pkinase. 1 hit.
    [Graphical view]
    SMARTiSM00220. S_TKc. 1 hit.
    [Graphical view]
    SUPFAMiSSF56112. SSF56112. 1 hit.
    PROSITEiPS01351. MAPK. 1 hit.
    PS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A2X0M1-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEFFTEYGEA SQYQIQEVVG KGSYGVVAAA VDTHTGERVA IKKINDVFEH    50
    VSDAIRILRE IKVLRLLRHP DIVVIKHIML PPTRREFRDI YVVFELMESD 100
    LHQVIEANHD LSPEHHRFFL YQLLCALKYI HSANVFHRDL KPKNILANSD 150
    CKLKICDFGL ARVAFNDSPS TIFWTDYVAT RWYRAPELCG SFFSKYTPAI 200
    DIWSIGCIFA EILTGRPLFP GRNVVHQLDL ITDLLGTPSS ETLSRIRNEN 250
    ARGYLTGMQR KHPIPFSHKF HNADPLALRL LERLLAFDPK DRPTAEEALA 300
    DPYFRGISKL SREPSRLPVS KFEFEFERRK LTKDDVREMI YREILEYHPQ 350
    MLQEYIRGGE QISFLYPSGV DRFKRQFAHL EENYSRGERS TPLRRQHASL 400
    PRERVCSSVD SNNQDSDNEE RRAISSIART MISPPRSQEK GKNRASAYPN 450
    GIINLNSNPK IYLKSASISA STCIIRGNKG PKENGISEDM EEVVYELSDN 500
    VTRMLS 506
    Length:506
    Mass (Da):58,281
    Last modified:September 11, 2007 - v2
    Checksum:i7EBCBA768079F972
    GO

    Sequence cautioni

    The sequence EAY84381.1 differs from that shown. Reason: Erroneous gene model prediction.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY524973 mRNA. Translation: AAS18417.1.
    AY524974 Genomic DNA. Translation: AAS18418.1.
    DQ826423 mRNA. Translation: ABH01190.2.
    CM000127 Genomic DNA. Translation: EAY84381.1. Sequence problems.
    UniGeneiOs.2356.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY524973 mRNA. Translation: AAS18417.1 .
    AY524974 Genomic DNA. Translation: AAS18418.1 .
    DQ826423 mRNA. Translation: ABH01190.2 .
    CM000127 Genomic DNA. Translation: EAY84381.1 . Sequence problems.
    UniGenei Os.2356.

    3D structure databases

    ProteinModelPortali A2X0M1.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi A2X0M1.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Organism-specific databases

    Gramenei A2X0M1.

    Phylogenomic databases

    eggNOGi COG0515.

    Family and domain databases

    InterProi IPR011009. Kinase-like_dom.
    IPR003527. MAP_kinase_CS.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR002290. Ser/Thr_dual-sp_kinase_dom.
    [Graphical view ]
    Pfami PF00069. Pkinase. 1 hit.
    [Graphical view ]
    SMARTi SM00220. S_TKc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56112. SSF56112. 1 hit.
    PROSITEi PS01351. MAPK. 1 hit.
    PS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "OsBIMK2, a gene encoding a map kinase, is involved in disease resistance responses in rice."
      Song D., Song F., Goodman R.M., Zheng Z.
      Submitted (JAN-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
      Strain: cv. Yuanfengzao.
    2. "Oryza sativa (indica cultivar-group) mitogen activated protein kinase 17-2 (MPK17-2) mRNA."
      Rao K.P., Kumar K., Sharma P., Sinha A.K.
      Submitted (JUN-2006) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: cv. Pusa Basmati.
    3. "The genomes of Oryza sativa: a history of duplications."
      Yu J., Wang J., Lin W., Li S., Li H., Zhou J., Ni P., Dong W., Hu S., Zeng C., Zhang J., Zhang Y., Li R., Xu Z., Li S., Li X., Zheng H., Cong L.
      , Lin L., Yin J., Geng J., Li G., Shi J., Liu J., Lv H., Li J., Wang J., Deng Y., Ran L., Shi X., Wang X., Wu Q., Li C., Ren X., Wang J., Wang X., Li D., Liu D., Zhang X., Ji Z., Zhao W., Sun Y., Zhang Z., Bao J., Han Y., Dong L., Ji J., Chen P., Wu S., Liu J., Xiao Y., Bu D., Tan J., Yang L., Ye C., Zhang J., Xu J., Zhou Y., Yu Y., Zhang B., Zhuang S., Wei H., Liu B., Lei M., Yu H., Li Y., Xu H., Wei S., He X., Fang L., Zhang Z., Zhang Y., Huang X., Su Z., Tong W., Li J., Tong Z., Li S., Ye J., Wang L., Fang L., Lei T., Chen C.-S., Chen H.-C., Xu Z., Li H., Huang H., Zhang F., Xu H., Li N., Zhao C., Li S., Dong L., Huang Y., Li L., Xi Y., Qi Q., Li W., Zhang B., Hu W., Zhang Y., Tian X., Jiao Y., Liang X., Jin J., Gao L., Zheng W., Hao B., Liu S.-M., Wang W., Yuan L., Cao M., McDermott J., Samudrala R., Wang J., Wong G.K.-S., Yang H.
      PLoS Biol. 3:266-281(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: cv. 93-11.
    4. "Molecular analysis of the rice MAP kinase gene family in relation to Magnaporthe grisea infection."
      Reyna N.S., Yang Y.
      Mol. Plant Microbe Interact. 19:530-540(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NOMENCLATURE.

    Entry informationi

    Entry nameiMPK13_ORYSI
    AccessioniPrimary (citable) accession number: A2X0M1
    Secondary accession number(s): Q0PIU6
    , Q6QUV9, Q6Z831, Q9SE22
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 11, 2007
    Last sequence update: September 11, 2007
    Last modified: October 1, 2014
    This is version 46 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programPlant Protein Annotation Program

    Miscellaneousi

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3