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A2WQG7 (H2A5_ORYSI) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 36. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Probable histone H2A.5
Gene names
ORF Names:OsI_002060
AND
ORF Names:OsI_010711
OrganismOryza sativa subsp. indica (Rice)
Taxonomic identifier39946 [NCBI]
Taxonomic lineageEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaeBEP cladeEhrhartoideaeOryzeaeOryza

Protein attributes

Sequence length159 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.

Subunit structure

The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

Subcellular location

Nucleus By similarity. Chromosome By similarity.

Domain

Contains 2 SPKK motifs which may interact with the minor groove of A/T-rich DNA sites. Phosphorylation of this motif may regulate DNA binding. This motif is reiterated in both termini of histone H1 and in the N-terminus of sea urchin histones H2B, but its presence in the C-terminus seems to be unique to plant H2A.

Sequence similarities

Belongs to the histone H2A family.

Ontologies

Keywords
   Cellular componentChromosome
Nucleosome core
Nucleus
   LigandDNA-binding
Gene Ontology (GO)
   Biological_processnucleosome assembly

Inferred from electronic annotation. Source: InterPro

   Cellular_componentnucleosome

Inferred from electronic annotation. Source: UniProtKB-KW

nucleus

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionDNA binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 159159Probable histone H2A.5
PRO_0000296123

Regions

Motif147 – 1504SPKK motif 1
Motif155 – 1584SPKK motif 2

Sequences

Sequence LengthMass (Da)Tools
A2WQG7 [UniParc].

Last modified March 20, 2007. Version 1.
Checksum: DF8301D4C45A7697

FASTA15916,401
        10         20         30         40         50         60 
MDAAGAGAGG KLKKGAAGRK AGGPRKKAVS RSVKAGLQFP VGRIGRYLKK GRYAQRIGTG 

        70         80         90        100        110        120 
APVYLAAVLE YLAAEVLELA GNAARDNKKN RIIPRHVLLA IRNDEELGKL LAGVTIAHGG 

       130        140        150 
VLPNINPVLL PKKTAEKAAA AGKEAKSPKK AAGKSPKKA 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CM000126 Genomic DNA. Translation: EAY74213.1.
CM000128 Genomic DNA. Translation: EAY89478.1.

3D structure databases

ProteinModelPortalA2WQG7.
SMRA2WQG7. Positions 28-134.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING39947.LOC_Os03g17100.1.

Proteomic databases

PRIDEA2WQG7.
ProMEXA2WQG7.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Organism-specific databases

GrameneA2WQG7.

Phylogenomic databases

eggNOGCOG5262.
HOGENOMHOG000234652.

Family and domain databases

Gene3D1.10.20.10. 1 hit.
InterProIPR009072. Histone-fold.
IPR007125. Histone_core_D.
IPR002119. Histone_H2A.
[Graphical view]
PfamPF00125. Histone. 1 hit.
[Graphical view]
PRINTSPR00620. HISTONEH2A.
SMARTSM00414. H2A. 1 hit.
[Graphical view]
SUPFAMSSF47113. SSF47113. 1 hit.
PROSITEPS00046. HISTONE_H2A. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameH2A5_ORYSI
AccessionPrimary (citable) accession number: A2WQG7
Entry history
Integrated into UniProtKB/Swiss-Prot: July 24, 2007
Last sequence update: March 20, 2007
Last modified: April 16, 2014
This is version 36 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families