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Protein

Probable histone H2A.5

Gene

OsI_002060

more
Organism
Oryza sativa subsp. indica (Rice)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.

GO - Molecular functioni

Keywordsi

Molecular functionDNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Probable histone H2A.5
Gene namesi
ORF Names:OsI_002060
AND
ORF Names:OsI_010711
OrganismiOryza sativa subsp. indica (Rice)
Taxonomic identifieri39946 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaeBOP cladeOryzoideaeOryzeaeOryzinaeOryzaOryza sativa
Proteomesi
  • UP000007015 Componentsi: Chromosome 1, Chromosome 3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Chromosome, Nucleosome core, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002961231 – 159Probable histone H2A.5Add BLAST159

Proteomic databases

PRIDEiA2WQG7

Expressioni

Gene expression databases

ExpressionAtlasiA2WQG7 baseline and differential

Interactioni

Subunit structurei

The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

GO - Molecular functioni

Protein-protein interaction databases

STRINGi39946.BGIOSGA010990-PA

Structurei

3D structure databases

ProteinModelPortaliA2WQG7
SMRiA2WQG7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi147 – 150SPKK motif 14
Motifi155 – 158SPKK motif 24

Domaini

Sequence similaritiesi

Belongs to the histone H2A family.Curated

Phylogenomic databases

eggNOGiKOG1756 Eukaryota
COG5262 LUCA
HOGENOMiHOG000234652
OMAiLEYLAXA
OrthoDBiEOG09360WU4

Family and domain databases

CDDicd00074 H2A, 1 hit
Gene3Di1.10.20.10, 1 hit
InterProiView protein in InterPro
IPR009072 Histone-fold
IPR002119 Histone_H2A
IPR007125 Histone_H2A/H2B/H3
IPR032454 Histone_H2A_C
IPR032458 Histone_H2A_CS
PfamiView protein in Pfam
PF00125 Histone, 1 hit
PF16211 Histone_H2A_C, 1 hit
PRINTSiPR00620 HISTONEH2A
SMARTiView protein in SMART
SM00414 H2A, 1 hit
SUPFAMiSSF47113 SSF47113, 1 hit
PROSITEiView protein in PROSITE
PS00046 HISTONE_H2A, 1 hit

Sequencei

Sequence statusi: Complete.

A2WQG7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDAAGAGAGG KLKKGAAGRK AGGPRKKAVS RSVKAGLQFP VGRIGRYLKK
60 70 80 90 100
GRYAQRIGTG APVYLAAVLE YLAAEVLELA GNAARDNKKN RIIPRHVLLA
110 120 130 140 150
IRNDEELGKL LAGVTIAHGG VLPNINPVLL PKKTAEKAAA AGKEAKSPKK

AAGKSPKKA
Length:159
Mass (Da):16,401
Last modified:March 20, 2007 - v1
Checksum:iDF8301D4C45A7697
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CM000126 Genomic DNA Translation: EAY74213.1
CM000128 Genomic DNA Translation: EAY89478.1

Genome annotation databases

EnsemblPlantsiBGIOSGA003601-TA; BGIOSGA003601-PA; BGIOSGA003601
BGIOSGA010990-TA; BGIOSGA010990-PA; BGIOSGA010990
GrameneiBGIOSGA003601-TA; BGIOSGA003601-PA; BGIOSGA003601
BGIOSGA010990-TA; BGIOSGA010990-PA; BGIOSGA010990

Similar proteinsi

Entry informationi

Entry nameiH2A5_ORYSI
AccessioniPrimary (citable) accession number: A2WQG7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 24, 2007
Last sequence update: March 20, 2007
Last modified: March 28, 2018
This is version 56 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health