ID   A2VED2_HUMAN            Unreviewed;       870 AA.
AC   A2VED2;
DT   20-MAR-2007, integrated into UniProtKB/TrEMBL.
DT   20-MAR-2007, sequence version 1.
DT   27-MAR-2024, entry version 86.
DE   SubName: Full=Augmented in rheumatoid arthritis 17 {ECO:0000313|EMBL:FAA00322.1};
GN   Name=AURA17 {ECO:0000313|EMBL:FAA00322.1};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|EMBL:FAA00322.1};
RN   [1] {ECO:0000313|EMBL:FAA00322.1}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=17082220; DOI=10.1093/dnares/dsl006;
RA   Nakamura N., Shimaoka Y., Tougan T., Onda H., Okuzaki D., Zhao H.,
RA   Fujimori A., Yabuta N., Nagamori I., Tanigawa A., Sato J., Oda T.,
RA   Hayashida K., Suzuki R., Yukioka M., Nojima H., Ochi T.;
RT   "Isolation and expression profiling of genes upregulated in bone marrow-
RT   derived mononuclear cells of rheumatoid arthritis patients.";
RL   DNA Res. 13:169-183(2006).
RN   [2] {ECO:0000313|EMBL:FAA00322.1}
RP   NUCLEOTIDE SEQUENCE.
RA   Nojima H., Tougan T.;
RL   Submitted (FEB-2007) to the EMBL/GenBank/DDBJ databases.
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DR   EMBL; BR000408; FAA00322.1; -; mRNA.
DR   AlphaFoldDB; A2VED2; -.
DR   SMR; A2VED2; -.
DR   PeptideAtlas; A2VED2; -.
DR   ChiTaRS; LRRK2; human.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR   Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 1.
DR   Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR   Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 2.
DR   InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR   InterPro; IPR011989; ARM-like.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR001611; Leu-rich_rpt.
DR   InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR   InterPro; IPR032675; LRR_dom_sf.
DR   PANTHER; PTHR24373; SLIT RELATED LEUCINE-RICH REPEAT NEURONAL PROTEIN; 1.
DR   PANTHER; PTHR24373:SF275; VASORIN; 1.
DR   Pfam; PF13516; LRR_6; 1.
DR   Pfam; PF13855; LRR_8; 1.
DR   SMART; SM00364; LRR_BAC; 7.
DR   SMART; SM00369; LRR_TYP; 6.
DR   SUPFAM; SSF48371; ARM repeat; 1.
DR   SUPFAM; SSF52058; L domain-like; 1.
DR   PROSITE; PS51450; LRR; 5.
PE   2: Evidence at transcript level;
KW   GTP-binding {ECO:0000256|ARBA:ARBA00023134};
KW   Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00023134};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737}.
SQ   SEQUENCE   870 AA;  97591 MW;  3F8387DBABE294A5 CRC64;
     MLSMLMHSSS KEVFQASANA LSTLLEQNVN FRKILLSKGI HLNVLELMQK HIHSPEVAES
     GCKMLNHLFE GSNTSLDIMA AVVPKILTVM KRHETSLPVQ LEALRAILHF IVPGMPEESR
     EDTEFHHKLN MVKKQCFKND IHKLVLAALN RFIGNPGIQK CGLKVISSIV HFPDALEMLS
     LEGAMDSVLH TLQMYPDDQE IQCLGLSLIG YLITKKNVFI GTGHLLAKIL VSSLYRFKDV
     AEIQTKGFQT ILAILKLSAS FSKLLVHHSF DLVIFHQMSS NIMEQKDQQF LNLCCKCFAK
     VAMDDYLKNV MLERACDQNN SIMVECLLLL GADANQAKEG SSLICQVCEK ESSPKLVELL
     LNSGSREQDV RKALTISIGK GDSQIISLLL RRLALDVANN SICLGGFCIG KVEPSWLGPL
     FPDKTSNLRK QTNIASTLAR MVIRYQMKSA VEEGTASGSD GNFSEDVLSK FDEWTFIPDS
     SMDSVFAQSD DLDSEGSEGS FLVKKKSNSI SVGEFYRDAV LQRCSPNLQR HSNSLGPIFD
     HEDLLKRKRK ILSSDDSLRS SKLQSHMRHS DSISSLASER EYITSLDLSA NELRDIDALS
     QKCCISVHLE HLEKLELHQN ALTSFPQQLC ETLKSLTHLD LHSNKFTSFP SYLLKMSCIA
     NLDVSRNDIG PSVVLDPTVK CPTLKQFNLS YNQLSFVPEN LTDVVEKLEQ LILEGNKISG
     ICSPLRLKEL KILNLSKNHI SSLSENFLEA CPKVESFSAR MNFLAAMPFL PPSMTILKLS
     QNKFSCIPEA ILNLPHLRSL DMSSNDIQYL PGPAHWKSLN LRELLFSHNQ ISILDLSEKA
     YLWSRVEKLH LSHNKLKEVR RLLPLKKYTL
//