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A2VEC9 (SSPO_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 67. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
SCO-spondin
Gene names
Name:SSPO
Synonyms:KIAA2036
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length5147 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Involved in the modulation of neuronal aggregation. May be involved in developmental events during the formation of the central nervous system By similarity.

Subcellular location

Secretedextracellular space By similarity.

Sequence similarities

Belongs to the thrombospondin family.

Contains 1 CTCK (C-terminal cystine knot-like) domain.

Contains 2 EGF-like domains.

Contains 1 EMI domain.

Contains 1 F5/8 type C domain.

Contains 10 LDL-receptor class A domains.

Contains 6 TIL (trypsin inhibitory-like) domains.

Contains 24 TSP type-1 domains.

Contains 3 VWFC domains.

Contains 3 VWFD domains.

Sequence caution

The sequence BAC98376.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
   Biological processCell adhesion
   Cellular componentSecreted
   Coding sequence diversityAlternative splicing
Polymorphism
   DomainEGF-like domain
Repeat
Signal
   LigandCalcium
   PTMDisulfide bond
Glycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processcell adhesion

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentextracellular space

Traceable author statement PubMed 22261194. Source: BHF-UCL

   Molecular_functionpeptidase inhibitor activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: A2VEC9-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: A2VEC9-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-1122: Missing.
     1123-1126: LWDG → MLPP
     1639-1639: A → ACVEAPAPPA...DCPQGEDELD
     1671-1671: L → LVRVGVGGGGGSAMLPPSTRALTPLPPQ
     2179-2314: LFPRNWDDLD...ETEHWPPGQE → VSPAQGRWGQ...RSGRNQSVLC
     2315-5147: Missing.
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1717 Potential
Chain18 – 51475130SCO-spondin
PRO_5000223757

Regions

Domain18 – 10285EMI
Domain194 – 408215VWFD 1
Domain469 – 52456TIL 1
Domain563 – 773211VWFD 2
Domain827 – 87953TIL 2
Domain880 – 93960VWFC 1
Domain1013 – 1219207VWFD 3
Domain1275 – 133157TIL 3
Domain1375 – 141238LDL-receptor class A 1
Domain1415 – 145036LDL-receptor class A 2
Domain1451 – 148737LDL-receptor class A 3
Domain1491 – 152939LDL-receptor class A 4
Domain1564 – 160037LDL-receptor class A 5
Domain1602 – 164140LDL-receptor class A 6
Domain1655 – 169339LDL-receptor class A 7
Domain1694 – 174855TSP type-1 1
Domain1750 – 180859TSP type-1 2
Domain1824 – 186340EGF-like 1
Domain1864 – 190138EGF-like 2
Domain1909 – 196557TSP type-1 3
Domain1965 – 202561VWFC 2
Domain2065 – 2224160F5/8 type C
Domain2233 – 226937LDL-receptor class A 8
Domain2390 – 242637LDL-receptor class A 9
Domain2463 – 249937LDL-receptor class A 10
Domain2500 – 255354TSP type-1 4
Domain2555 – 261056TSP type-1 5
Domain2633 – 267543TIL 4
Domain2715 – 276955TSP type-1 6
Domain2772 – 282857TSP type-1 7
Domain2830 – 288354TSP type-1 8
Domain2985 – 304056TSP type-1 9
Domain3041 – 308343TSP type-1 10
Domain3183 – 325068TSP type-1 11
Domain3252 – 330756TSP type-1 12
Domain3311 – 336555TIL 5
Domain3408 – 347063TSP type-1 13
Domain3472 – 352756TSP type-1 14
Domain3645 – 369349TSP type-1 15
Domain3811 – 3932122TSP type-1 16
Domain3946 – 400257TSP type-1 17
Domain4004 – 405956TSP type-1 18
Domain4159 – 421254TSP type-1 19
Domain4253 – 430553TSP type-1 20
Domain4307 – 436357TSP type-1 21
Domain4365 – 441955TSP type-1 22
Domain4615 – 466551TSP type-1 23
Domain4667 – 472357TIL 6
Domain4763 – 481654TSP type-1 24
Domain4984 – 504259VWFC 3
Domain5041 – 5140100CTCK

Amino acid modifications

Glycosylation881N-linked (GlcNAc...) Potential
Glycosylation1301N-linked (GlcNAc...) Potential
Glycosylation2611N-linked (GlcNAc...) Potential
Glycosylation5141N-linked (GlcNAc...) Potential
Glycosylation8191N-linked (GlcNAc...) Potential
Glycosylation9111N-linked (GlcNAc...) Potential
Glycosylation9441N-linked (GlcNAc...) Potential
Glycosylation9861N-linked (GlcNAc...) Potential
Glycosylation13521N-linked (GlcNAc...) Potential
Glycosylation16501N-linked (GlcNAc...) Potential
Glycosylation16631N-linked (GlcNAc...) Potential
Glycosylation18091N-linked (GlcNAc...) Potential
Glycosylation19931N-linked (GlcNAc...) Potential
Glycosylation20301N-linked (GlcNAc...) Potential
Glycosylation21331N-linked (GlcNAc...) Potential
Glycosylation26451N-linked (GlcNAc...) Potential
Glycosylation26941N-linked (GlcNAc...) Potential
Glycosylation29361N-linked (GlcNAc...) Potential
Glycosylation29671N-linked (GlcNAc...) Potential
Glycosylation30621N-linked (GlcNAc...) Potential
Glycosylation31161N-linked (GlcNAc...) Potential
Glycosylation31631N-linked (GlcNAc...) Potential
Glycosylation31731N-linked (GlcNAc...) Potential
Glycosylation33101N-linked (GlcNAc...) Potential
Glycosylation33991N-linked (GlcNAc...) Potential
Glycosylation35121N-linked (GlcNAc...) Potential
Glycosylation35221N-linked (GlcNAc...) Potential
Glycosylation35991N-linked (GlcNAc...) Potential
Glycosylation36261N-linked (GlcNAc...) Potential
Glycosylation37921N-linked (GlcNAc...) Potential
Glycosylation39141N-linked (GlcNAc...) Potential
Glycosylation39461N-linked (GlcNAc...) Potential
Glycosylation41391N-linked (GlcNAc...) Potential
Glycosylation43461N-linked (GlcNAc...) Potential
Glycosylation44171N-linked (GlcNAc...) Potential
Glycosylation47311N-linked (GlcNAc...) Potential
Glycosylation47481N-linked (GlcNAc...) Potential
Glycosylation47531N-linked (GlcNAc...) Potential
Glycosylation48631N-linked (GlcNAc...) Potential
Glycosylation49031N-linked (GlcNAc...) Potential
Glycosylation49481N-linked (GlcNAc...) Potential
Glycosylation49551N-linked (GlcNAc...) Potential
Glycosylation50611N-linked (GlcNAc...) Potential
Disulfide bond1376 ↔ 1389 By similarity
Disulfide bond1383 ↔ 1402 By similarity
Disulfide bond1396 ↔ 1411 By similarity
Disulfide bond1416 ↔ 1428 By similarity
Disulfide bond1423 ↔ 1441 By similarity
Disulfide bond1452 ↔ 1464 By similarity
Disulfide bond1459 ↔ 1477 By similarity
Disulfide bond1471 ↔ 1486 By similarity
Disulfide bond1492 ↔ 1504 By similarity
Disulfide bond1499 ↔ 1517 By similarity
Disulfide bond1511 ↔ 1528 By similarity
Disulfide bond1565 ↔ 1577 By similarity
Disulfide bond1572 ↔ 1590 By similarity
Disulfide bond1584 ↔ 1599 By similarity
Disulfide bond1603 ↔ 1616 By similarity
Disulfide bond1610 ↔ 1629 By similarity
Disulfide bond1623 ↔ 1640 By similarity
Disulfide bond1656 ↔ 1666 By similarity
Disulfide bond1661 ↔ 1679 By similarity
Disulfide bond1673 ↔ 1694 By similarity
Disulfide bond1706 ↔ 1742 By similarity
Disulfide bond1710 ↔ 1747 By similarity
Disulfide bond1721 ↔ 1732 By similarity
Disulfide bond1762 ↔ 1802 By similarity
Disulfide bond1766 ↔ 1807 By similarity
Disulfide bond1776 ↔ 1786 By similarity
Disulfide bond1828 ↔ 1843 By similarity
Disulfide bond1837 ↔ 1848 By similarity
Disulfide bond1850 ↔ 1862 By similarity
Disulfide bond1868 ↔ 1887 By similarity
Disulfide bond1870 ↔ 1890 By similarity
Disulfide bond1892 ↔ 1900 By similarity
Disulfide bond1910 ↔ 1949 By similarity
Disulfide bond1921 ↔ 1925 By similarity
Disulfide bond1959 ↔ 1964 By similarity
Disulfide bond2065 ↔ 2224 By similarity
Disulfide bond2234 ↔ 2246 By similarity
Disulfide bond2241 ↔ 2259 By similarity
Disulfide bond2253 ↔ 2268 By similarity
Disulfide bond2391 ↔ 2403 By similarity
Disulfide bond2398 ↔ 2416 By similarity
Disulfide bond2410 ↔ 2425 By similarity
Disulfide bond2464 ↔ 2476 By similarity
Disulfide bond2471 ↔ 2489 By similarity
Disulfide bond2483 ↔ 2498 By similarity
Disulfide bond2501 ↔ 2537 By similarity
Disulfide bond2512 ↔ 2516 By similarity
Disulfide bond2547 ↔ 2552 By similarity
Disulfide bond2567 ↔ 2604 By similarity
Disulfide bond2571 ↔ 2609 By similarity
Disulfide bond2582 ↔ 2594 By similarity
Disulfide bond2716 ↔ 2754 By similarity
Disulfide bond2727 ↔ 2731 By similarity
Disulfide bond2764 ↔ 2768 By similarity
Disulfide bond2784 ↔ 2822 By similarity
Disulfide bond2788 ↔ 2827 By similarity
Disulfide bond2804 ↔ 2812 By similarity
Disulfide bond2842 ↔ 2877 By similarity
Disulfide bond2846 ↔ 2882 By similarity
Disulfide bond2857 ↔ 2867 By similarity
Disulfide bond2986 ↔ 3024 By similarity
Disulfide bond2997 ↔ 3001 By similarity
Disulfide bond3034 ↔ 3039 By similarity
Disulfide bond3195 ↔ 3244 By similarity
Disulfide bond3199 ↔ 3249 By similarity
Disulfide bond3210 ↔ 3234 By similarity
Disulfide bond3264 ↔ 3301 By similarity
Disulfide bond3268 ↔ 3306 By similarity
Disulfide bond3279 ↔ 3291 By similarity
Disulfide bond3420 ↔ 3463 By similarity
Disulfide bond3424 ↔ 3469 By similarity
Disulfide bond3435 ↔ 3447 By similarity
Disulfide bond3484 ↔ 3519 By similarity
Disulfide bond3487 ↔ 3526 By similarity
Disulfide bond3497 ↔ 3509 By similarity
Disulfide bond3657 ↔ 3687 By similarity
Disulfide bond3661 ↔ 3692 By similarity
Disulfide bond3672 ↔ 3677 By similarity
Disulfide bond3823 ↔ 3926 By similarity
Disulfide bond3827 ↔ 3931 By similarity
Disulfide bond3839 ↔ 3851 By similarity
Disulfide bond3947 ↔ 3983 By similarity
Disulfide bond3958 ↔ 3962 By similarity
Disulfide bond3996 ↔ 4001 By similarity
Disulfide bond4016 ↔ 4053 By similarity
Disulfide bond4020 ↔ 4058 By similarity
Disulfide bond4031 ↔ 4043 By similarity
Disulfide bond4160 ↔ 4196 By similarity
Disulfide bond4171 ↔ 4175 By similarity
Disulfide bond4206 ↔ 4211 By similarity
Disulfide bond4366 ↔ 4403 By similarity
Disulfide bond4377 ↔ 4379 By similarity
Disulfide bond4413 ↔ 4418 By similarity
Disulfide bond4775 ↔ 4810 By similarity
Disulfide bond4779 ↔ 4815 By similarity
Disulfide bond4790 ↔ 4799 By similarity
Disulfide bond5041 ↔ 5101 By similarity
Disulfide bond5067 ↔ 5118 By similarity
Disulfide bond5077 ↔ 5134 By similarity
Disulfide bond5081 ↔ 5136 By similarity
Disulfide bond? ↔ 5139 By similarity

Natural variations

Alternative sequence1 – 11221122Missing in isoform 2.
VSP_035258
Alternative sequence1123 – 11264LWDG → MLPP in isoform 2.
VSP_035259
Alternative sequence16391A → ACVEAPAPPAMRGPPGQAGG PTSSRAPSPPSPPEAQGEGR KGQERSRTHLTVPAGSTQLP LCPGLFPCGVAPGLCLTPEQ LCDGIPDCPQGEDELD in isoform 2.
VSP_035260
Alternative sequence16711L → LVRVGVGGGGGSAMLPPSTR ALTPLPPQ in isoform 2.
VSP_035261
Alternative sequence2179 – 2314136LFPRN…PPGQE → VSPAQGRWGQQPTMPFCGFH SLCPQGPSSVPEGHGLHSML VEYLVSSRDCALWSRGLGAT VTWMLETIQVAQTQGRYVKP ARERGWGDTKFTEGLREPRP THVFVESSLGTALPSGGLHP SRRQTARSGRNQSVLC in isoform 2.
VSP_035262
Alternative sequence2315 – 51472833Missing in isoform 2.
VSP_035263
Natural variant1461Q → R.
Corresponds to variant rs709061 [ dbSNP | Ensembl ].
VAR_052660
Natural variant2981V → M.
Corresponds to variant rs17754559 [ dbSNP | Ensembl ].
VAR_052661
Natural variant5391V → M.
Corresponds to variant rs855677 [ dbSNP | Ensembl ].
VAR_059863
Natural variant12721S → P.
Corresponds to variant rs709060 [ dbSNP | Ensembl ].
VAR_059864
Natural variant12731L → P.
Corresponds to variant rs709060 [ dbSNP | Ensembl ].
VAR_052662
Natural variant14241S → G.
Corresponds to variant rs855691 [ dbSNP | Ensembl ].
VAR_059865
Natural variant14481P → Q.
Corresponds to variant rs855692 [ dbSNP | Ensembl ].
VAR_059866
Natural variant14531P → R.
Corresponds to variant rs2074704 [ dbSNP | Ensembl ].
VAR_059867
Natural variant17781S → P.
Corresponds to variant rs893601 [ dbSNP | Ensembl ].
VAR_059868
Natural variant17931L → P.
Corresponds to variant rs1635802 [ dbSNP | Ensembl ].
VAR_059869
Natural variant18821R → C.
Corresponds to variant rs1076277 [ dbSNP | Ensembl ].
VAR_059870
Natural variant20171T → M.
Corresponds to variant rs4725314 [ dbSNP | Ensembl ].
VAR_059871
Natural variant24521M → T.
Corresponds to variant rs2074689 [ dbSNP | Ensembl ].
VAR_061915
Natural variant25411R → Q.
Corresponds to variant rs59522380 [ dbSNP | Ensembl ].
VAR_061916
Natural variant28911L → V.
Corresponds to variant rs10260959 [ dbSNP | Ensembl ].
VAR_059872
Natural variant32731R → W.
Corresponds to variant rs740109 [ dbSNP | Ensembl ].
VAR_059873
Natural variant35121N → S.
Corresponds to variant rs10952230 [ dbSNP | Ensembl ].
VAR_059874
Natural variant38921C → W.
Corresponds to variant rs1557955 [ dbSNP | Ensembl ].
VAR_059875
Natural variant39091R → C.
Corresponds to variant rs745044 [ dbSNP | Ensembl ].
VAR_059876
Natural variant40281S → I.
Corresponds to variant rs1005603 [ dbSNP | Ensembl ].
VAR_059877
Natural variant41071Q → H.
Corresponds to variant rs12536873 [ dbSNP | Ensembl ].
VAR_061917
Natural variant41641H → R.
Corresponds to variant rs10233245 [ dbSNP | Ensembl ].
VAR_059878
Natural variant43301R → C.
Corresponds to variant rs1008336 [ dbSNP | Ensembl ].
VAR_059879
Natural variant47871H → R.
Corresponds to variant rs1004200 [ dbSNP | Ensembl ].
VAR_059880
Natural variant49411E → K.
Corresponds to variant rs12534509 [ dbSNP | Ensembl ].
VAR_059881

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified March 20, 2007. Version 1.
Checksum: 9A8F5C3179F028A3

FASTA5,147547,504
        10         20         30         40         50         60 
MLLPALLFGM AWALADGRWC EWTETIRVEE EVAPRQEDLV PCASLDHYSR LGWRLDLPWS 

        70         80         90        100        110        120 
GRSGLTRSPA PGLCPIYKPP ETRPAKWNRT VRTCCPGWGG AHCTEALAKA SPEGHCFAMW 

       130        140        150        160        170        180 
QCQLQAGSAN ASAGSLEECC ARPWGQSWWD GSSQACRSCS SRHLPGSASS PALLQPLAGA 

       190        200        210        220        230        240 
VGQLWSQHQR PSATCASWSG FHYRTFDGRH YHFLGRCTYL LAGAADSTWA VHLTPGDRCP 

       250        260        270        280        290        300 
QPGHCQRVTM GPEEVLIQAG NVSVKGQLVP EGQSWLLHGL SLQWLGDWLV LSGGLGVVVR 

       310        320        330        340        350        360 
LDRTGSISIS VDHELWGQTQ GLCGLYNGWP EDDFMEPGGG LAMLAATFGN SWRLPGSESG 

       370        380        390        400        410        420 
CLDAVEVAQG CDPLGLIDAD VEPGHLRAEA QDVCHQLLEG PFGQCHAQVS PAEYHEACLF 

       430        440        450        460        470        480 
AYCAGAMAGS GQEGRQQAVC ATFASYVQAC ARRHIHIRWR KPGFCERLCP GGQLYSDCVS 

       490        500        510        520        530        540 
LCPPSCEAVG QGEEESCREE CVSGCECPRG LFWNGTLCVP AAHCPCYYCR QRYVPGDTVR 

       550        560        570        580        590        600 
QLCNPCVCRD GRWHCAQALC PAECAVGGDG HYLTFDGRSY SFWGGQGCRY SLVQDYVKGQ 

       610        620        630        640        650        660 
LLILLEHGAC DAGSCLHAIS VSLEDTHIQL RDSGAVLVNG QDVGLPWIGA EGLSVRRASS 

       670        680        690        700        710        720 
AFLLLRWPGA QVLWGLSDPV AYITLDPRHA HQVQGLCGTF TQNQQDDFLT PAGDVETSIA 

       730        740        750        760        770        780 
AFASKFQVAG KGRCPSEDSA LLSPCTTHSQ RHAFAEAACA ILHSSVFQEC HRLVDKEPFY 

       790        800        810        820        830        840 
LRCLAAVCGC DPGSDCLCPV LSAYARRCAQ EGASPPWRNQ TLCPVMCPGG QEYRECAPAC 

       850        860        870        880        890        900 
GQHCGKPEDC GELGSCVAGC NCPLGLLWDP EGQCVPPSLC PCQLGARRYA PGSATMKECN 

       910        920        930        940        950        960 
RCICQERGLW NCTARHCPSQ AFCPRELVYA PGACLLTCDS PSANHSCPAG STDGCVCPPG 

       970        980        990       1000       1010       1020 
TVLLDERCVP PDLCPCRHSG QWYLPNATIQ EDCNVCVCRG RQWHCTGQRR SGRCQASGAP 

      1030       1040       1050       1060       1070       1080 
HYVTFDGLAF TYPGACEYLL VREASGLFTV SAQNLPCGAS GLTCTKALAV RLEGTVVHML 

      1090       1100       1110       1120       1130       1140 
RGRAVTVNGV SVTPPKVYTG PGLSLRRAGL FLLLSTHLGL TLLWDGGTRV LVQLSPQFRG 

      1150       1160       1170       1180       1190       1200 
RVAGLCGDFD GDASNDLRSR QGVLEPTAEL AAHSWRLSPL CPEPGDLPHP CTMNTHRAGW 

      1210       1220       1230       1240       1250       1260 
ARARCGALLQ PLFTLCHAEV PPQQHYEWCL YDACGCDSGG DCECLCSAIA TYADECARHG 

      1270       1280       1290       1300       1310       1320 
HHVRWRSQEL CSLQCEGGQV YEACGPTCPP TCHEQHPEPG WHCQVVACVE GCFCPEGTLL 

      1330       1340       1350       1360       1370       1380 
HGGACLEPAS CPCEWGRNSF PPGSVLQKDC GNCTCQEGQW HCGGDGGHCE ELVPACAEGE 

      1390       1400       1410       1420       1430       1440 
ALCQENGHCV PHGWLCDNQD DCGDGSDEEG CAAPGCGEGQ MTCSSGHCLP LALLCDRQDD 

      1450       1460       1470       1480       1490       1500 
CGDGTDEPSY PCPQGLLACA DGRCLPPALL CDGHPDCLDA ADEESCLGQV TCVPGEVSCV 

      1510       1520       1530       1540       1550       1560 
DGTCLGAIQL CDGVWDCPDG ADEGPGHCPL PSLPTPPAST LPGPSPGSLD TASSPLASAS 

      1570       1580       1590       1600       1610       1620 
PAPPCGPFEF RCGSGECTPR GWRCDQEEDC ADGSDERGCG GPCAPHHAPC ARGPHCVSPE 

      1630       1640       1650       1660       1670       1680 
QLCDGVRQCP DGSDEGPDAC GGLPALGGPN RTGLPCPEYT CPNGTCIGFQ LVCDGQPDCG 

      1690       1700       1710       1720       1730       1740 
RPGQVGPSPE EQGCGAWGPW SPWGPCSRTC GPWGQGRSRR CSPLGLLVLQ NCPGPEHQSQ 

      1750       1760       1770       1780       1790       1800 
ACFTAACPVD GEWSTWSPWS VCSEPCRGTM TRQRQCHSPQ NGGRTCAALP GGLHSTRQTK 

      1810       1820       1830       1840       1850       1860 
PCPQDGCPNA TCSGELMFQP CAPCPLTCDD ISGQVTCPPD WPCGSPGCWC PEGQVLGSEG 

      1870       1880       1890       1900       1910       1920 
WCVWPRQCPC LVDGARYWPG QRIKADCQLC ICQDGRPRRC RLNPDCAVDC GWSSWSPWAK 

      1930       1940       1950       1960       1970       1980 
CLGPCGSQSI QWSFRSSNNP RPSGRGRQCR GIHRKARRCQ TEPCEGCEHQ GQVHRVGERW 

      1990       2000       2010       2020       2030       2040 
HGGPCRVCQC LHNLTAHCSP YCPLGSCPQG WVLVEGTGES CCHCALPGEN QTVQPMATPA 

      2050       2060       2070       2080       2090       2100 
AAPAPSPQIR FPLATYILPP SGDPCYSPLG LAGLAEGSLH ASSQQLEHPT QAALLGAPTQ 

      2110       2120       2130       2140       2150       2160 
GPSPQGWHAG GDAYAKWHTR PHYLQLDLLQ PRNLTGILVP ETGSSNAYAS SFSLQFSSNG 

      2170       2180       2190       2200       2210       2220 
LHWHDYRDLL PGILPLPKLF PRNWDDLDPA VWTFGRMVQA RFVRVWPHDV HHSDVPLQVE 

      2230       2240       2250       2260       2270       2280 
LLGCEPGSPP APLCPGVGLR CASGECVLRG GPCDGVLDCE DGSDEEGCVL LPEGTGRFHS 

      2290       2300       2310       2320       2330       2340 
TAKTLALSSA QPGQLLHWPR EGLAETEHWP PGQESPTSPT ETRPVSPGPA SGVPHHGESV 

      2350       2360       2370       2380       2390       2400 
QMVTTTPIPQ MEARTLPPGM AAVTVVPPHP VTPATPAGQS VAPGPFPPVQ CGPGQTPCEV 

      2410       2420       2430       2440       2450       2460 
LGCVEQAQVC DGREDCLDGS DERHCARNLL MWLPSLPALW AASTVPFMMP TMALPGLPAS 

      2470       2480       2490       2500       2510       2520 
RALCSPSQLS CGSGECLSAE RRCDLRPDCQ DGSDEDGCVD CVLAPWSVWS SCSRSCGLGL 

      2530       2540       2550       2560       2570       2580 
TFQRQELLRP PLPGGSCPRD RFRSQSCFVQ ACPVAGAWAM WEAWGPCSVS CGGGHQSRQR 

      2590       2600       2610       2620       2630       2640 
SCVDPPPKNG GAPCPGASQE RAPCGLQPCS GGTDCELGRV YVSADLCQKG LVPPCPPSCL 

      2650       2660       2670       2680       2690       2700 
DPKANRSCSG HCVEGCRCPP GLLLHDTRCL PLSECPCLVG EELKWPGVSF LLGNCSQCVC 

      2710       2720       2730       2740       2750       2760 
EKGELLCQPG GCPLPCGWSA WSSWAPCDRS CGSGVRARFR SPSNPPAAWG GAPCEGDRQE 

      2770       2780       2790       2800       2810       2820 
LQGCHTVCGT EVFGWTPWTS WSSCSQSCLA PGGGPGWRSR SRLCPSPGDS SCPGDATQEE 

      2830       2840       2850       2860       2870       2880 
PCSPPVCPVP SIWGLWAPWS TCSAPCDGGI QTRGRSCSSL APGDTTCPGP HSQTRDCNTQ 

      2890       2900       2910       2920       2930       2940 
PCTAQCPENM LFRSAEQCHQ EGGPCPRLCL TQGPGIECTG FCAPGCTCPP GLFLHNASCL 

      2950       2960       2970       2980       2990       3000 
PRSQCPCQLH GQLYASGAMA RLDSCNNCTC VSGKMACTSE RCPVACGWSP WTLWSLCSCS 

      3010       3020       3030       3040       3050       3060 
CNVGIRRRFR AGTAPPAAFG GAECQGPTME AEFCSLRPCP GPGGEWGPWS PCSVPCGGGY 

      3070       3080       3090       3100       3110       3120 
RNRTRGSSRS LMEFSTCGLQ PCAGPVPGMC PRDKQWLDCA QGPASCAELS APRGTNQTCH 

      3130       3140       3150       3160       3170       3180 
PGCHCPSGML LLNNVCVPTQ DCPCAHEGHL YPPGSTVVRP CENCSCVSGL IANCSSWPCA 

      3190       3200       3210       3220       3230       3240 
EGEPTWSPWT PWSQCSASCG PARCHRHRFC ARSPSAVPST VAPLPLPATP TPLCSGPEAE 

      3250       3260       3270       3280       3290       3300 
EEPCLLQGCD RAGGWGPWGP WSHCSRSCGG GLRSRTRACD QPPPQGLGDY CEGPRAQGEV 

      3310       3320       3330       3340       3350       3360 
CQALPCPVTN CTAIEGAEYS PCGPPCPRSC DDLVHCVWRC QPGCYCPPGQ VLSSNGAICV 

      3370       3380       3390       3400       3410       3420 
QPGHCSCLDL LTGQRHHPGA RLARPDGCNH CTCLEGRLNC TDLPCPVPGG WCPWSEWTMC 

      3430       3440       3450       3460       3470       3480 
SQPCRGQTRS RSRACACPTP QHGGAPCTGE AGEAGAQHQR EACPSYATCP VDGAWGPWGP 

      3490       3500       3510       3520       3530       3540 
WSPCDMCLGQ SHRSRACSRP PTPEGGRPCP GNHTQSRPCQ ENSTQCTDCG GGQSLHPCGQ 

      3550       3560       3570       3580       3590       3600 
PCPRSCQDLS PGSVCQPGSV GCQPTCGCPL GQLSQDGLCV PPAHCRCQYQ PGAMGIPENQ 

      3610       3620       3630       3640       3650       3660 
SRSAGSRFSS WESLEPGEVV TGPCDNCTCV AGILQCQEVP DCPDPGVWSS WGPWEDCSVS 

      3670       3680       3690       3700       3710       3720 
CGGGEQLRSR RCARPPCPGP ARQSRTCSTQ VCREAGCPAG RLYRECQPGE GCPFSCAHVT 

      3730       3740       3750       3760       3770       3780 
QQVGCFSEGC EEGCHCPEGT FQHRLACVQE CPCVLTAWLL QELGATIGDP GQPLGPGDEL 

      3790       3800       3810       3820       3830       3840 
DSGQTLRTSC GNCSCAHGKL SCSLDDCFEA DGGFGPWSPW GPCSRSCGGL GTRTRSRQCV 

      3850       3860       3870       3880       3890       3900 
LTMPTLSGQG CRGPRQDLEC PSPDCPGAEG STVEPVTGLP GGWGPWSSWS PCSRSCTDPA 

      3910       3920       3930       3940       3950       3960 
RPAWRSRTRL CLANCTMGDP LQERPCNLPS CTELPVCPGP GCGAGNCSWT SWAPWEPCSR 

      3970       3980       3990       4000       4010       4020 
SCGVGQQRRL RAYRPPGPGG HWCPNILTAY QERRFCNLRA CPVPGGWSRW SPWSWCDRSC 

      4030       4040       4050       4060       4070       4080 
GGGQSLRSRS CSSPPSKNGG APCAGERHQA RLCNPMPCEA GCPAGMEVVT CANRCPRRCS 

      4090       4100       4110       4120       4130       4140 
DLQEGIVCQD DQVCQKGCRC PKGSLEQDGG CVPIGHCDCT DAQGHSWAPG SQHQDACNNC 

      4150       4160       4170       4180       4190       4200 
SCQAGQLSCT AQPCPPPTHC AWSHWSAWSP CSHSCGPRGQ QSRFRSSTSG SWAPECREEQ 

      4210       4220       4230       4240       4250       4260 
SQSQPCPQPS CPPLCLQGTR SRTLGDSWLQ GECQRCSCTP EGVICEDTEC AVPEAWTLWS 

      4270       4280       4290       4300       4310       4320 
SWSDCPVSCG GGNQVRTRAC RAAAPHHRSP PCLGPDTQTR QQPCPGLLEA CSWGPWGPCS 

      4330       4340       4350       4360       4370       4380 
RSCGPGLASR SGSCPCLMAK ADPTCNSTFL HLDTQGCYSG PCPEECVWSS WSSWTRCSCR 

      4390       4400       4410       4420       4430       4440 
VLVQQRYRHQ GPASRGARAG APCTRLDGHF RPCLISNCSE DSCTPPFEFH ACGSPCAGLC 

      4450       4460       4470       4480       4490       4500 
ATHLSHQLCQ DLPPCQPGCY CPKGLLEQAG GCIPPEECNC WHTSAAGAGM TLAPGDRLQL 

      4510       4520       4530       4540       4550       4560 
GCKECECRRG ELHCTSQGCQ GLLPLSEWSE WSPCGPCLPP SALAPASRTA LEEHWLRDPT 

      4570       4580       4590       4600       4610       4620 
GLSPTLAPLL ASEQHRHRLC LDPATGRPWT GAPHLCTAPL SQQRLCPDPG ACPDSCQWSL 

      4630       4640       4650       4660       4670       4680 
WGPWSPCQVP CSGGFRLRWR EAEALCGGGC REPWAQESCN GGPCPECEAQ DTVFTLDCAN 

      4690       4700       4710       4720       4730       4740 
QCPHSCADLW DRVQCLQGPC RPGCRCPPGQ LVQDGRCVPI SSCRCGLPSA NASWELAPAQ 

      4750       4760       4770       4780       4790       4800 
AVQLDCQNCT CVNESLVCPH QECPVLGPWS AWSSCSAPCG GGTMERHRTC EGGPGVAPCQ 

      4810       4820       4830       4840       4850       4860 
AQDTEQRQEC NLQPCPECPP GQVLSACATS CPCLCWHLQP GAICVQEPCQ PGCGCPGGQL 

      4870       4880       4890       4900       4910       4920 
LHNGTCVPPT ACPCTQHSLP WGLTLTLEEQ AQELPPGTVL TRNCTRCVCH GGAFSCSLVD 

      4930       4940       4950       4960       4970       4980 
CQVPPGETWQ QVAPGELGLC EQTCLEMNAT KTQSNCSSAR ASGCVCQPGH FRSQAGPCVP 

      4990       5000       5010       5020       5030       5040 
EDHCECWHLG RPHLPGSEWQ EACESCLCLS GRPVCTQHCS PLTCAQGEEM VLEPGSCCPS 

      5050       5060       5070       5080       5090       5100 
CRREAPEEQS PSCQLLTELR NFTKGTCYLD QVEVSYCSGY CPSSTHVMPE EPYLQSQCDC 

      5110       5120       5130       5140 
CSYRLDPESP VRILNLRCLG GHTEPVVLPV IHSCQCSSCQ GGDFSKR 

« Hide

Isoform 2 [UniParc].

Checksum: 2876F7F1383080E8
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FASTA1,314138,775

References

« Hide 'large scale' references
[1]"The nucleotide sequence of a long cDNA clone isolated from human."
Nagase T., Kikuno R., Ohara O.
Submitted (NOV-2002) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
Tissue: Brain.
[2]"The DNA sequence of human chromosome 7."
Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L. expand/collapse author list , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]"The complex multidomain organization of SCO-spondin protein is highly conserved in mammals."
Meiniel O., Meiniel A.
Brain Res. Brain Res. Rev. 53:321-327(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION (ISOFORM 1).

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB111888 mRNA. Translation: BAC98376.1. Different initiation.
AC004877 Genomic DNA. No translation available.
BN000852 mRNA. Translation: CAJ43920.1.
RefSeqNP_940857.2. NM_198455.2. [A2VEC9-1]
UniGeneHs.632022.

3D structure databases

ProteinModelPortalA2VEC9.
SMRA2VEC9. Positions 1350-1643, 2064-2225, 2387-2505, 2510-2609, 2717-2828, 2987-3065, 3186-3309, 3400-3521, 3811-3911, 4003-4059, 4255-4334, 5052-5138.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid116762. 3 interactions.
STRING9606.ENSP00000367255.

PTM databases

PhosphoSiteA2VEC9.

Proteomic databases

MaxQBA2VEC9.
PaxDbA2VEC9.
PRIDEA2VEC9.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID23145.
KEGGhsa:23145.
UCSCuc010lpk.3. human. [A2VEC9-1]

Organism-specific databases

CTD23145.
GeneCardsGC07P149473.
H-InvDBHIX0007194.
HGNCHGNC:21998. SSPO.
neXtProtNX_A2VEC9.
PharmGKBPA142670865.
HUGESearch...
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG12793.
HOGENOMHOG000154433.
HOVERGENHBG080794.
PhylomeDBA2VEC9.

Enzyme and pathway databases

ReactomeREACT_17015. Metabolism of proteins.

Gene expression databases

CleanExHS_SSPO.
GenevestigatorA2VEC9.

Family and domain databases

Gene3D2.60.120.260. 1 hit.
4.10.400.10. 10 hits.
InterProIPR000421. Coagulation_fac_5/8-C_type_dom.
IPR006207. Cys_knot_C.
IPR008979. Galactose-bd-like.
IPR023415. LDLR_class-A_CS.
IPR002172. LDrepeatLR_classA_rpt.
IPR008037. Prot_inh_PMP.
IPR000884. Thrombospondin_1_rpt.
IPR002919. TIL_dom.
IPR014853. Unchr_dom_Cys-rich.
IPR006552. VWC_out.
IPR001007. VWF_C.
IPR001846. VWF_type-D.
[Graphical view]
PfamPF08742. C8. 3 hits.
PF00754. F5_F8_type_C. 1 hit.
PF00057. Ldl_recept_a. 8 hits.
PF01826. TIL. 14 hits.
PF00090. TSP_1. 22 hits.
PF00094. VWD. 3 hits.
[Graphical view]
PRINTSPR00261. LDLRECEPTOR.
SMARTSM00832. C8. 3 hits.
SM00231. FA58C. 1 hit.
SM00192. LDLa. 10 hits.
SM00209. TSP1. 25 hits.
SM00214. VWC. 4 hits.
SM00215. VWC_out. 1 hit.
SM00216. VWD. 3 hits.
[Graphical view]
SUPFAMSSF49785. SSF49785. 1 hit.
SSF57283. SSF57283. 1 hit.
SSF57424. SSF57424. 10 hits.
SSF57567. SSF57567. 14 hits.
SSF82895. SSF82895. 23 hits.
PROSITEPS01225. CTCK_2. 1 hit.
PS00022. EGF_1. 1 hit.
PS50022. FA58C_3. 1 hit.
PS01209. LDLRA_1. 8 hits.
PS50068. LDLRA_2. 10 hits.
PS50092. TSP1. 24 hits.
PS01208. VWFC_1. 1 hit.
PS50184. VWFC_2. 2 hits.
PS51233. VWFD. 3 hits.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiSSPO.
GenomeRNAi23145.
NextBio44438.
PROA2VEC9.

Entry information

Entry nameSSPO_HUMAN
AccessionPrimary (citable) accession number: A2VEC9
Secondary accession number(s): Q76B61
Entry history
Integrated into UniProtKB/Swiss-Prot: June 12, 2007
Last sequence update: March 20, 2007
Last modified: June 11, 2014
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 7

Human chromosome 7: entries, gene names and cross-references to MIM