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A2VEC9

- SSPO_HUMAN

UniProt

A2VEC9 - SSPO_HUMAN

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Protein

SCO-spondin

Gene
SSPO, KIAA2036
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

Involved in the modulation of neuronal aggregation. May be involved in developmental events during the formation of the central nervous system By similarity.

GO - Molecular functioni

  1. peptidase inhibitor activity Source: InterPro

GO - Biological processi

  1. cell adhesion Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Cell adhesion

Keywords - Ligandi

Calcium

Enzyme and pathway databases

ReactomeiREACT_200626. O-glycosylation of TSR domain-containing proteins.

Names & Taxonomyi

Protein namesi
Recommended name:
SCO-spondin
Gene namesi
Name:SSPO
Synonyms:KIAA2036
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Unplaced

Organism-specific databases

HGNCiHGNC:21998. SSPO.

Subcellular locationi

Secretedextracellular space By similarity

GO - Cellular componenti

  1. extracellular space Source: BHF-UCL
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142670865.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1717 Reviewed predictionAdd
BLAST
Chaini18 – 51475130SCO-spondinPRO_5000223757Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi? ↔ 5139 By similarity
Glycosylationi88 – 881N-linked (GlcNAc...) Reviewed prediction
Glycosylationi130 – 1301N-linked (GlcNAc...) Reviewed prediction
Glycosylationi261 – 2611N-linked (GlcNAc...) Reviewed prediction
Glycosylationi514 – 5141N-linked (GlcNAc...) Reviewed prediction
Glycosylationi819 – 8191N-linked (GlcNAc...) Reviewed prediction
Glycosylationi911 – 9111N-linked (GlcNAc...) Reviewed prediction
Glycosylationi944 – 9441N-linked (GlcNAc...) Reviewed prediction
Glycosylationi986 – 9861N-linked (GlcNAc...) Reviewed prediction
Glycosylationi1352 – 13521N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi1376 ↔ 1389 By similarity
Disulfide bondi1383 ↔ 1402 By similarity
Disulfide bondi1396 ↔ 1411 By similarity
Disulfide bondi1416 ↔ 1428 By similarity
Disulfide bondi1423 ↔ 1441 By similarity
Disulfide bondi1452 ↔ 1464 By similarity
Disulfide bondi1459 ↔ 1477 By similarity
Disulfide bondi1471 ↔ 1486 By similarity
Disulfide bondi1492 ↔ 1504 By similarity
Disulfide bondi1499 ↔ 1517 By similarity
Disulfide bondi1511 ↔ 1528 By similarity
Disulfide bondi1565 ↔ 1577 By similarity
Disulfide bondi1572 ↔ 1590 By similarity
Disulfide bondi1584 ↔ 1599 By similarity
Disulfide bondi1603 ↔ 1616 By similarity
Disulfide bondi1610 ↔ 1629 By similarity
Disulfide bondi1623 ↔ 1640 By similarity
Glycosylationi1650 – 16501N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi1656 ↔ 1666 By similarity
Disulfide bondi1661 ↔ 1679 By similarity
Glycosylationi1663 – 16631N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi1673 ↔ 1694 By similarity
Disulfide bondi1706 ↔ 1742 By similarity
Disulfide bondi1710 ↔ 1747 By similarity
Disulfide bondi1721 ↔ 1732 By similarity
Disulfide bondi1762 ↔ 1802 By similarity
Disulfide bondi1766 ↔ 1807 By similarity
Disulfide bondi1776 ↔ 1786 By similarity
Glycosylationi1809 – 18091N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi1828 ↔ 1843 By similarity
Disulfide bondi1837 ↔ 1848 By similarity
Disulfide bondi1850 ↔ 1862 By similarity
Disulfide bondi1868 ↔ 1887 By similarity
Disulfide bondi1870 ↔ 1890 By similarity
Disulfide bondi1892 ↔ 1900 By similarity
Disulfide bondi1910 ↔ 1949 By similarity
Disulfide bondi1921 ↔ 1925 By similarity
Disulfide bondi1959 ↔ 1964 By similarity
Glycosylationi1993 – 19931N-linked (GlcNAc...) Reviewed prediction
Glycosylationi2030 – 20301N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi2065 ↔ 2224 By similarity
Glycosylationi2133 – 21331N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi2234 ↔ 2246 By similarity
Disulfide bondi2241 ↔ 2259 By similarity
Disulfide bondi2253 ↔ 2268 By similarity
Disulfide bondi2391 ↔ 2403 By similarity
Disulfide bondi2398 ↔ 2416 By similarity
Disulfide bondi2410 ↔ 2425 By similarity
Disulfide bondi2464 ↔ 2476 By similarity
Disulfide bondi2471 ↔ 2489 By similarity
Disulfide bondi2483 ↔ 2498 By similarity
Disulfide bondi2501 ↔ 2537 By similarity
Disulfide bondi2512 ↔ 2516 By similarity
Disulfide bondi2547 ↔ 2552 By similarity
Disulfide bondi2567 ↔ 2604 By similarity
Disulfide bondi2571 ↔ 2609 By similarity
Disulfide bondi2582 ↔ 2594 By similarity
Glycosylationi2645 – 26451N-linked (GlcNAc...) Reviewed prediction
Glycosylationi2694 – 26941N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi2716 ↔ 2754 By similarity
Disulfide bondi2727 ↔ 2731 By similarity
Disulfide bondi2764 ↔ 2768 By similarity
Disulfide bondi2784 ↔ 2822 By similarity
Disulfide bondi2788 ↔ 2827 By similarity
Disulfide bondi2804 ↔ 2812 By similarity
Disulfide bondi2842 ↔ 2877 By similarity
Disulfide bondi2846 ↔ 2882 By similarity
Disulfide bondi2857 ↔ 2867 By similarity
Glycosylationi2936 – 29361N-linked (GlcNAc...) Reviewed prediction
Glycosylationi2967 – 29671N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi2986 ↔ 3024 By similarity
Disulfide bondi2997 ↔ 3001 By similarity
Disulfide bondi3034 ↔ 3039 By similarity
Glycosylationi3062 – 30621N-linked (GlcNAc...) Reviewed prediction
Glycosylationi3116 – 31161N-linked (GlcNAc...) Reviewed prediction
Glycosylationi3163 – 31631N-linked (GlcNAc...) Reviewed prediction
Glycosylationi3173 – 31731N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi3195 ↔ 3244 By similarity
Disulfide bondi3199 ↔ 3249 By similarity
Disulfide bondi3210 ↔ 3234 By similarity
Disulfide bondi3264 ↔ 3301 By similarity
Disulfide bondi3268 ↔ 3306 By similarity
Disulfide bondi3279 ↔ 3291 By similarity
Glycosylationi3310 – 33101N-linked (GlcNAc...) Reviewed prediction
Glycosylationi3399 – 33991N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi3420 ↔ 3463 By similarity
Disulfide bondi3424 ↔ 3469 By similarity
Disulfide bondi3435 ↔ 3447 By similarity
Disulfide bondi3484 ↔ 3519 By similarity
Disulfide bondi3487 ↔ 3526 By similarity
Disulfide bondi3497 ↔ 3509 By similarity
Glycosylationi3512 – 35121N-linked (GlcNAc...) Reviewed prediction
Glycosylationi3522 – 35221N-linked (GlcNAc...) Reviewed prediction
Glycosylationi3599 – 35991N-linked (GlcNAc...) Reviewed prediction
Glycosylationi3626 – 36261N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi3657 ↔ 3687 By similarity
Disulfide bondi3661 ↔ 3692 By similarity
Disulfide bondi3672 ↔ 3677 By similarity
Glycosylationi3792 – 37921N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi3823 ↔ 3926 By similarity
Disulfide bondi3827 ↔ 3931 By similarity
Disulfide bondi3839 ↔ 3851 By similarity
Glycosylationi3914 – 39141N-linked (GlcNAc...) Reviewed prediction
Glycosylationi3946 – 39461N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi3947 ↔ 3983 By similarity
Disulfide bondi3958 ↔ 3962 By similarity
Disulfide bondi3996 ↔ 4001 By similarity
Disulfide bondi4016 ↔ 4053 By similarity
Disulfide bondi4020 ↔ 4058 By similarity
Disulfide bondi4031 ↔ 4043 By similarity
Glycosylationi4139 – 41391N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi4160 ↔ 4196 By similarity
Disulfide bondi4171 ↔ 4175 By similarity
Disulfide bondi4206 ↔ 4211 By similarity
Glycosylationi4346 – 43461N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi4366 ↔ 4403 By similarity
Disulfide bondi4377 ↔ 4379 By similarity
Disulfide bondi4413 ↔ 4418 By similarity
Glycosylationi4417 – 44171N-linked (GlcNAc...) Reviewed prediction
Glycosylationi4731 – 47311N-linked (GlcNAc...) Reviewed prediction
Glycosylationi4748 – 47481N-linked (GlcNAc...) Reviewed prediction
Glycosylationi4753 – 47531N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi4775 ↔ 4810 By similarity
Disulfide bondi4779 ↔ 4815 By similarity
Disulfide bondi4790 ↔ 4799 By similarity
Glycosylationi4863 – 48631N-linked (GlcNAc...) Reviewed prediction
Glycosylationi4903 – 49031N-linked (GlcNAc...) Reviewed prediction
Glycosylationi4948 – 49481N-linked (GlcNAc...) Reviewed prediction
Glycosylationi4955 – 49551N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi5041 ↔ 5101 By similarity
Glycosylationi5061 – 50611N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi5067 ↔ 5118 By similarity
Disulfide bondi5077 ↔ 5134 By similarity
Disulfide bondi5081 ↔ 5136 By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiA2VEC9.
PaxDbiA2VEC9.
PRIDEiA2VEC9.

PTM databases

PhosphoSiteiA2VEC9.

Expressioni

Gene expression databases

CleanExiHS_SSPO.
GenevestigatoriA2VEC9.

Interactioni

Protein-protein interaction databases

BioGridi116762. 3 interactions.
STRINGi9606.ENSP00000367255.

Structurei

3D structure databases

ProteinModelPortaliA2VEC9.
SMRiA2VEC9. Positions 1350-1643, 2064-2225, 2387-2505, 2510-2609, 2717-2828, 2987-3065, 3186-3309, 3400-3521, 3811-3911, 4003-4059, 4255-4334, 5052-5138.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini18 – 10285EMIAdd
BLAST
Domaini194 – 408215VWFD 1Add
BLAST
Domaini469 – 52456TIL 1Add
BLAST
Domaini563 – 773211VWFD 2Add
BLAST
Domaini827 – 87953TIL 2Add
BLAST
Domaini880 – 93960VWFC 1Add
BLAST
Domaini1013 – 1219207VWFD 3Add
BLAST
Domaini1275 – 133157TIL 3Add
BLAST
Domaini1375 – 141238LDL-receptor class A 1Add
BLAST
Domaini1415 – 145036LDL-receptor class A 2Add
BLAST
Domaini1451 – 148737LDL-receptor class A 3Add
BLAST
Domaini1491 – 152939LDL-receptor class A 4Add
BLAST
Domaini1564 – 160037LDL-receptor class A 5Add
BLAST
Domaini1602 – 164140LDL-receptor class A 6Add
BLAST
Domaini1655 – 169339LDL-receptor class A 7Add
BLAST
Domaini1694 – 174855TSP type-1 1Add
BLAST
Domaini1750 – 180859TSP type-1 2Add
BLAST
Domaini1824 – 186340EGF-like 1Add
BLAST
Domaini1864 – 190138EGF-like 2Add
BLAST
Domaini1909 – 196557TSP type-1 3Add
BLAST
Domaini1965 – 202561VWFC 2Add
BLAST
Domaini2065 – 2224160F5/8 type CAdd
BLAST
Domaini2233 – 226937LDL-receptor class A 8Add
BLAST
Domaini2390 – 242637LDL-receptor class A 9Add
BLAST
Domaini2463 – 249937LDL-receptor class A 10Add
BLAST
Domaini2500 – 255354TSP type-1 4Add
BLAST
Domaini2555 – 261056TSP type-1 5Add
BLAST
Domaini2633 – 267543TIL 4Add
BLAST
Domaini2715 – 276955TSP type-1 6Add
BLAST
Domaini2772 – 282857TSP type-1 7Add
BLAST
Domaini2830 – 288354TSP type-1 8Add
BLAST
Domaini2985 – 304056TSP type-1 9Add
BLAST
Domaini3041 – 308343TSP type-1 10Add
BLAST
Domaini3183 – 325068TSP type-1 11Add
BLAST
Domaini3252 – 330756TSP type-1 12Add
BLAST
Domaini3311 – 336555TIL 5Add
BLAST
Domaini3408 – 347063TSP type-1 13Add
BLAST
Domaini3472 – 352756TSP type-1 14Add
BLAST
Domaini3645 – 369349TSP type-1 15Add
BLAST
Domaini3811 – 3932122TSP type-1 16Add
BLAST
Domaini3946 – 400257TSP type-1 17Add
BLAST
Domaini4004 – 405956TSP type-1 18Add
BLAST
Domaini4159 – 421254TSP type-1 19Add
BLAST
Domaini4253 – 430553TSP type-1 20Add
BLAST
Domaini4307 – 436357TSP type-1 21Add
BLAST
Domaini4365 – 441955TSP type-1 22Add
BLAST
Domaini4615 – 466551TSP type-1 23Add
BLAST
Domaini4667 – 472357TIL 6Add
BLAST
Domaini4763 – 481654TSP type-1 24Add
BLAST
Domaini4984 – 504259VWFC 3Add
BLAST
Domaini5041 – 5140100CTCKAdd
BLAST

Sequence similaritiesi

Belongs to the thrombospondin family.
Contains 2 EGF-like domains.
Contains 1 EMI domain.
Contains 1 F5/8 type C domain.
Contains 24 TSP type-1 domains.
Contains 3 VWFC domains.
Contains 3 VWFD domains.

Keywords - Domaini

EGF-like domain, Repeat, Signal

Phylogenomic databases

eggNOGiNOG12793.
HOGENOMiHOG000154433.
HOVERGENiHBG080794.
PhylomeDBiA2VEC9.

Family and domain databases

Gene3Di2.60.120.260. 1 hit.
4.10.400.10. 10 hits.
InterProiIPR000421. Coagulation_fac_5/8-C_type_dom.
IPR006207. Cys_knot_C.
IPR008979. Galactose-bd-like.
IPR023415. LDLR_class-A_CS.
IPR002172. LDrepeatLR_classA_rpt.
IPR008037. Prot_inh_PMP.
IPR000884. Thrombospondin_1_rpt.
IPR002919. TIL_dom.
IPR014853. Unchr_dom_Cys-rich.
IPR006552. VWC_out.
IPR001007. VWF_C.
IPR001846. VWF_type-D.
[Graphical view]
PfamiPF08742. C8. 3 hits.
PF00754. F5_F8_type_C. 1 hit.
PF00057. Ldl_recept_a. 8 hits.
PF01826. TIL. 14 hits.
PF00090. TSP_1. 22 hits.
PF00094. VWD. 3 hits.
[Graphical view]
PRINTSiPR00261. LDLRECEPTOR.
SMARTiSM00832. C8. 3 hits.
SM00231. FA58C. 1 hit.
SM00192. LDLa. 10 hits.
SM00209. TSP1. 25 hits.
SM00214. VWC. 4 hits.
SM00215. VWC_out. 1 hit.
SM00216. VWD. 3 hits.
[Graphical view]
SUPFAMiSSF49785. SSF49785. 1 hit.
SSF57283. SSF57283. 1 hit.
SSF57424. SSF57424. 10 hits.
SSF57567. SSF57567. 14 hits.
SSF82895. SSF82895. 23 hits.
PROSITEiPS01225. CTCK_2. 1 hit.
PS00022. EGF_1. 1 hit.
PS50022. FA58C_3. 1 hit.
PS01209. LDLRA_1. 8 hits.
PS50068. LDLRA_2. 10 hits.
PS50092. TSP1. 24 hits.
PS01208. VWFC_1. 1 hit.
PS50184. VWFC_2. 2 hits.
PS51233. VWFD. 3 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: A2VEC9-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

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MLLPALLFGM AWALADGRWC EWTETIRVEE EVAPRQEDLV PCASLDHYSR     50
LGWRLDLPWS GRSGLTRSPA PGLCPIYKPP ETRPAKWNRT VRTCCPGWGG 100
AHCTEALAKA SPEGHCFAMW QCQLQAGSAN ASAGSLEECC ARPWGQSWWD 150
GSSQACRSCS SRHLPGSASS PALLQPLAGA VGQLWSQHQR PSATCASWSG 200
FHYRTFDGRH YHFLGRCTYL LAGAADSTWA VHLTPGDRCP QPGHCQRVTM 250
GPEEVLIQAG NVSVKGQLVP EGQSWLLHGL SLQWLGDWLV LSGGLGVVVR 300
LDRTGSISIS VDHELWGQTQ GLCGLYNGWP EDDFMEPGGG LAMLAATFGN 350
SWRLPGSESG CLDAVEVAQG CDPLGLIDAD VEPGHLRAEA QDVCHQLLEG 400
PFGQCHAQVS PAEYHEACLF AYCAGAMAGS GQEGRQQAVC ATFASYVQAC 450
ARRHIHIRWR KPGFCERLCP GGQLYSDCVS LCPPSCEAVG QGEEESCREE 500
CVSGCECPRG LFWNGTLCVP AAHCPCYYCR QRYVPGDTVR QLCNPCVCRD 550
GRWHCAQALC PAECAVGGDG HYLTFDGRSY SFWGGQGCRY SLVQDYVKGQ 600
LLILLEHGAC DAGSCLHAIS VSLEDTHIQL RDSGAVLVNG QDVGLPWIGA 650
EGLSVRRASS AFLLLRWPGA QVLWGLSDPV AYITLDPRHA HQVQGLCGTF 700
TQNQQDDFLT PAGDVETSIA AFASKFQVAG KGRCPSEDSA LLSPCTTHSQ 750
RHAFAEAACA ILHSSVFQEC HRLVDKEPFY LRCLAAVCGC DPGSDCLCPV 800
LSAYARRCAQ EGASPPWRNQ TLCPVMCPGG QEYRECAPAC GQHCGKPEDC 850
GELGSCVAGC NCPLGLLWDP EGQCVPPSLC PCQLGARRYA PGSATMKECN 900
RCICQERGLW NCTARHCPSQ AFCPRELVYA PGACLLTCDS PSANHSCPAG 950
STDGCVCPPG TVLLDERCVP PDLCPCRHSG QWYLPNATIQ EDCNVCVCRG 1000
RQWHCTGQRR SGRCQASGAP HYVTFDGLAF TYPGACEYLL VREASGLFTV 1050
SAQNLPCGAS GLTCTKALAV RLEGTVVHML RGRAVTVNGV SVTPPKVYTG 1100
PGLSLRRAGL FLLLSTHLGL TLLWDGGTRV LVQLSPQFRG RVAGLCGDFD 1150
GDASNDLRSR QGVLEPTAEL AAHSWRLSPL CPEPGDLPHP CTMNTHRAGW 1200
ARARCGALLQ PLFTLCHAEV PPQQHYEWCL YDACGCDSGG DCECLCSAIA 1250
TYADECARHG HHVRWRSQEL CSLQCEGGQV YEACGPTCPP TCHEQHPEPG 1300
WHCQVVACVE GCFCPEGTLL HGGACLEPAS CPCEWGRNSF PPGSVLQKDC 1350
GNCTCQEGQW HCGGDGGHCE ELVPACAEGE ALCQENGHCV PHGWLCDNQD 1400
DCGDGSDEEG CAAPGCGEGQ MTCSSGHCLP LALLCDRQDD CGDGTDEPSY 1450
PCPQGLLACA DGRCLPPALL CDGHPDCLDA ADEESCLGQV TCVPGEVSCV 1500
DGTCLGAIQL CDGVWDCPDG ADEGPGHCPL PSLPTPPAST LPGPSPGSLD 1550
TASSPLASAS PAPPCGPFEF RCGSGECTPR GWRCDQEEDC ADGSDERGCG 1600
GPCAPHHAPC ARGPHCVSPE QLCDGVRQCP DGSDEGPDAC GGLPALGGPN 1650
RTGLPCPEYT CPNGTCIGFQ LVCDGQPDCG RPGQVGPSPE EQGCGAWGPW 1700
SPWGPCSRTC GPWGQGRSRR CSPLGLLVLQ NCPGPEHQSQ ACFTAACPVD 1750
GEWSTWSPWS VCSEPCRGTM TRQRQCHSPQ NGGRTCAALP GGLHSTRQTK 1800
PCPQDGCPNA TCSGELMFQP CAPCPLTCDD ISGQVTCPPD WPCGSPGCWC 1850
PEGQVLGSEG WCVWPRQCPC LVDGARYWPG QRIKADCQLC ICQDGRPRRC 1900
RLNPDCAVDC GWSSWSPWAK CLGPCGSQSI QWSFRSSNNP RPSGRGRQCR 1950
GIHRKARRCQ TEPCEGCEHQ GQVHRVGERW HGGPCRVCQC LHNLTAHCSP 2000
YCPLGSCPQG WVLVEGTGES CCHCALPGEN QTVQPMATPA AAPAPSPQIR 2050
FPLATYILPP SGDPCYSPLG LAGLAEGSLH ASSQQLEHPT QAALLGAPTQ 2100
GPSPQGWHAG GDAYAKWHTR PHYLQLDLLQ PRNLTGILVP ETGSSNAYAS 2150
SFSLQFSSNG LHWHDYRDLL PGILPLPKLF PRNWDDLDPA VWTFGRMVQA 2200
RFVRVWPHDV HHSDVPLQVE LLGCEPGSPP APLCPGVGLR CASGECVLRG 2250
GPCDGVLDCE DGSDEEGCVL LPEGTGRFHS TAKTLALSSA QPGQLLHWPR 2300
EGLAETEHWP PGQESPTSPT ETRPVSPGPA SGVPHHGESV QMVTTTPIPQ 2350
MEARTLPPGM AAVTVVPPHP VTPATPAGQS VAPGPFPPVQ CGPGQTPCEV 2400
LGCVEQAQVC DGREDCLDGS DERHCARNLL MWLPSLPALW AASTVPFMMP 2450
TMALPGLPAS RALCSPSQLS CGSGECLSAE RRCDLRPDCQ DGSDEDGCVD 2500
CVLAPWSVWS SCSRSCGLGL TFQRQELLRP PLPGGSCPRD RFRSQSCFVQ 2550
ACPVAGAWAM WEAWGPCSVS CGGGHQSRQR SCVDPPPKNG GAPCPGASQE 2600
RAPCGLQPCS GGTDCELGRV YVSADLCQKG LVPPCPPSCL DPKANRSCSG 2650
HCVEGCRCPP GLLLHDTRCL PLSECPCLVG EELKWPGVSF LLGNCSQCVC 2700
EKGELLCQPG GCPLPCGWSA WSSWAPCDRS CGSGVRARFR SPSNPPAAWG 2750
GAPCEGDRQE LQGCHTVCGT EVFGWTPWTS WSSCSQSCLA PGGGPGWRSR 2800
SRLCPSPGDS SCPGDATQEE PCSPPVCPVP SIWGLWAPWS TCSAPCDGGI 2850
QTRGRSCSSL APGDTTCPGP HSQTRDCNTQ PCTAQCPENM LFRSAEQCHQ 2900
EGGPCPRLCL TQGPGIECTG FCAPGCTCPP GLFLHNASCL PRSQCPCQLH 2950
GQLYASGAMA RLDSCNNCTC VSGKMACTSE RCPVACGWSP WTLWSLCSCS 3000
CNVGIRRRFR AGTAPPAAFG GAECQGPTME AEFCSLRPCP GPGGEWGPWS 3050
PCSVPCGGGY RNRTRGSSRS LMEFSTCGLQ PCAGPVPGMC PRDKQWLDCA 3100
QGPASCAELS APRGTNQTCH PGCHCPSGML LLNNVCVPTQ DCPCAHEGHL 3150
YPPGSTVVRP CENCSCVSGL IANCSSWPCA EGEPTWSPWT PWSQCSASCG 3200
PARCHRHRFC ARSPSAVPST VAPLPLPATP TPLCSGPEAE EEPCLLQGCD 3250
RAGGWGPWGP WSHCSRSCGG GLRSRTRACD QPPPQGLGDY CEGPRAQGEV 3300
CQALPCPVTN CTAIEGAEYS PCGPPCPRSC DDLVHCVWRC QPGCYCPPGQ 3350
VLSSNGAICV QPGHCSCLDL LTGQRHHPGA RLARPDGCNH CTCLEGRLNC 3400
TDLPCPVPGG WCPWSEWTMC SQPCRGQTRS RSRACACPTP QHGGAPCTGE 3450
AGEAGAQHQR EACPSYATCP VDGAWGPWGP WSPCDMCLGQ SHRSRACSRP 3500
PTPEGGRPCP GNHTQSRPCQ ENSTQCTDCG GGQSLHPCGQ PCPRSCQDLS 3550
PGSVCQPGSV GCQPTCGCPL GQLSQDGLCV PPAHCRCQYQ PGAMGIPENQ 3600
SRSAGSRFSS WESLEPGEVV TGPCDNCTCV AGILQCQEVP DCPDPGVWSS 3650
WGPWEDCSVS CGGGEQLRSR RCARPPCPGP ARQSRTCSTQ VCREAGCPAG 3700
RLYRECQPGE GCPFSCAHVT QQVGCFSEGC EEGCHCPEGT FQHRLACVQE 3750
CPCVLTAWLL QELGATIGDP GQPLGPGDEL DSGQTLRTSC GNCSCAHGKL 3800
SCSLDDCFEA DGGFGPWSPW GPCSRSCGGL GTRTRSRQCV LTMPTLSGQG 3850
CRGPRQDLEC PSPDCPGAEG STVEPVTGLP GGWGPWSSWS PCSRSCTDPA 3900
RPAWRSRTRL CLANCTMGDP LQERPCNLPS CTELPVCPGP GCGAGNCSWT 3950
SWAPWEPCSR SCGVGQQRRL RAYRPPGPGG HWCPNILTAY QERRFCNLRA 4000
CPVPGGWSRW SPWSWCDRSC GGGQSLRSRS CSSPPSKNGG APCAGERHQA 4050
RLCNPMPCEA GCPAGMEVVT CANRCPRRCS DLQEGIVCQD DQVCQKGCRC 4100
PKGSLEQDGG CVPIGHCDCT DAQGHSWAPG SQHQDACNNC SCQAGQLSCT 4150
AQPCPPPTHC AWSHWSAWSP CSHSCGPRGQ QSRFRSSTSG SWAPECREEQ 4200
SQSQPCPQPS CPPLCLQGTR SRTLGDSWLQ GECQRCSCTP EGVICEDTEC 4250
AVPEAWTLWS SWSDCPVSCG GGNQVRTRAC RAAAPHHRSP PCLGPDTQTR 4300
QQPCPGLLEA CSWGPWGPCS RSCGPGLASR SGSCPCLMAK ADPTCNSTFL 4350
HLDTQGCYSG PCPEECVWSS WSSWTRCSCR VLVQQRYRHQ GPASRGARAG 4400
APCTRLDGHF RPCLISNCSE DSCTPPFEFH ACGSPCAGLC ATHLSHQLCQ 4450
DLPPCQPGCY CPKGLLEQAG GCIPPEECNC WHTSAAGAGM TLAPGDRLQL 4500
GCKECECRRG ELHCTSQGCQ GLLPLSEWSE WSPCGPCLPP SALAPASRTA 4550
LEEHWLRDPT GLSPTLAPLL ASEQHRHRLC LDPATGRPWT GAPHLCTAPL 4600
SQQRLCPDPG ACPDSCQWSL WGPWSPCQVP CSGGFRLRWR EAEALCGGGC 4650
REPWAQESCN GGPCPECEAQ DTVFTLDCAN QCPHSCADLW DRVQCLQGPC 4700
RPGCRCPPGQ LVQDGRCVPI SSCRCGLPSA NASWELAPAQ AVQLDCQNCT 4750
CVNESLVCPH QECPVLGPWS AWSSCSAPCG GGTMERHRTC EGGPGVAPCQ 4800
AQDTEQRQEC NLQPCPECPP GQVLSACATS CPCLCWHLQP GAICVQEPCQ 4850
PGCGCPGGQL LHNGTCVPPT ACPCTQHSLP WGLTLTLEEQ AQELPPGTVL 4900
TRNCTRCVCH GGAFSCSLVD CQVPPGETWQ QVAPGELGLC EQTCLEMNAT 4950
KTQSNCSSAR ASGCVCQPGH FRSQAGPCVP EDHCECWHLG RPHLPGSEWQ 5000
EACESCLCLS GRPVCTQHCS PLTCAQGEEM VLEPGSCCPS CRREAPEEQS 5050
PSCQLLTELR NFTKGTCYLD QVEVSYCSGY CPSSTHVMPE EPYLQSQCDC 5100
CSYRLDPESP VRILNLRCLG GHTEPVVLPV IHSCQCSSCQ GGDFSKR 5147
Length:5,147
Mass (Da):547,504
Last modified:March 20, 2007 - v1
Checksum:i9A8F5C3179F028A3
GO
Isoform 2 (identifier: A2VEC9-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1122: Missing.
     1123-1126: LWDG → MLPP
     1639-1639: A → ACVEAPAPPA...DCPQGEDELD
     1671-1671: L → LVRVGVGGGGGSAMLPPSTRALTPLPPQ
     2179-2314: LFPRNWDDLD...ETEHWPPGQE → VSPAQGRWGQ...RSGRNQSVLC
     2315-5147: Missing.

Note: No experimental confirmation available.

Show »
Length:1,314
Mass (Da):138,775
Checksum:i2876F7F1383080E8
GO

Sequence cautioni

The sequence BAC98376.1 differs from that shown. Reason: Erroneous initiation.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti146 – 1461Q → R.
Corresponds to variant rs709061 [ dbSNP | Ensembl ].
VAR_052660
Natural varianti298 – 2981V → M.
Corresponds to variant rs17754559 [ dbSNP | Ensembl ].
VAR_052661
Natural varianti539 – 5391V → M.
Corresponds to variant rs855677 [ dbSNP | Ensembl ].
VAR_059863
Natural varianti1272 – 12721S → P.
Corresponds to variant rs709060 [ dbSNP | Ensembl ].
VAR_059864
Natural varianti1273 – 12731L → P.
Corresponds to variant rs709060 [ dbSNP | Ensembl ].
VAR_052662
Natural varianti1424 – 14241S → G.
Corresponds to variant rs855691 [ dbSNP | Ensembl ].
VAR_059865
Natural varianti1448 – 14481P → Q.
Corresponds to variant rs855692 [ dbSNP | Ensembl ].
VAR_059866
Natural varianti1453 – 14531P → R.
Corresponds to variant rs2074704 [ dbSNP | Ensembl ].
VAR_059867
Natural varianti1778 – 17781S → P.
Corresponds to variant rs893601 [ dbSNP | Ensembl ].
VAR_059868
Natural varianti1793 – 17931L → P.
Corresponds to variant rs1635802 [ dbSNP | Ensembl ].
VAR_059869
Natural varianti1882 – 18821R → C.
Corresponds to variant rs1076277 [ dbSNP | Ensembl ].
VAR_059870
Natural varianti2017 – 20171T → M.
Corresponds to variant rs4725314 [ dbSNP | Ensembl ].
VAR_059871
Natural varianti2452 – 24521M → T.
Corresponds to variant rs2074689 [ dbSNP | Ensembl ].
VAR_061915
Natural varianti2541 – 25411R → Q.
Corresponds to variant rs59522380 [ dbSNP | Ensembl ].
VAR_061916
Natural varianti2891 – 28911L → V.
Corresponds to variant rs10260959 [ dbSNP | Ensembl ].
VAR_059872
Natural varianti3273 – 32731R → W.
Corresponds to variant rs740109 [ dbSNP | Ensembl ].
VAR_059873
Natural varianti3512 – 35121N → S.
Corresponds to variant rs10952230 [ dbSNP | Ensembl ].
VAR_059874
Natural varianti3892 – 38921C → W.
Corresponds to variant rs1557955 [ dbSNP | Ensembl ].
VAR_059875
Natural varianti3909 – 39091R → C.
Corresponds to variant rs745044 [ dbSNP | Ensembl ].
VAR_059876
Natural varianti4028 – 40281S → I.
Corresponds to variant rs1005603 [ dbSNP | Ensembl ].
VAR_059877
Natural varianti4107 – 41071Q → H.
Corresponds to variant rs12536873 [ dbSNP | Ensembl ].
VAR_061917
Natural varianti4164 – 41641H → R.
Corresponds to variant rs10233245 [ dbSNP | Ensembl ].
VAR_059878
Natural varianti4330 – 43301R → C.
Corresponds to variant rs1008336 [ dbSNP | Ensembl ].
VAR_059879
Natural varianti4787 – 47871H → R.
Corresponds to variant rs1004200 [ dbSNP | Ensembl ].
VAR_059880
Natural varianti4941 – 49411E → K.
Corresponds to variant rs12534509 [ dbSNP | Ensembl ].
VAR_059881

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 11221122Missing in isoform 2. VSP_035258Add
BLAST
Alternative sequencei1123 – 11264LWDG → MLPP in isoform 2. VSP_035259
Alternative sequencei1639 – 16391A → ACVEAPAPPAMRGPPGQAGG PTSSRAPSPPSPPEAQGEGR KGQERSRTHLTVPAGSTQLP LCPGLFPCGVAPGLCLTPEQ LCDGIPDCPQGEDELD in isoform 2. VSP_035260
Alternative sequencei1671 – 16711L → LVRVGVGGGGGSAMLPPSTR ALTPLPPQ in isoform 2. VSP_035261
Alternative sequencei2179 – 2314136LFPRN…PPGQE → VSPAQGRWGQQPTMPFCGFH SLCPQGPSSVPEGHGLHSML VEYLVSSRDCALWSRGLGAT VTWMLETIQVAQTQGRYVKP ARERGWGDTKFTEGLREPRP THVFVESSLGTALPSGGLHP SRRQTARSGRNQSVLC in isoform 2. VSP_035262Add
BLAST
Alternative sequencei2315 – 51472833Missing in isoform 2. VSP_035263Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB111888 mRNA. Translation: BAC98376.1. Different initiation.
AC004877 Genomic DNA. No translation available.
BN000852 mRNA. Translation: CAJ43920.1.
RefSeqiNP_940857.2. NM_198455.2. [A2VEC9-1]
UniGeneiHs.632022.

Genome annotation databases

GeneIDi23145.
KEGGihsa:23145.
UCSCiuc010lpk.3. human. [A2VEC9-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB111888 mRNA. Translation: BAC98376.1 . Different initiation.
AC004877 Genomic DNA. No translation available.
BN000852 mRNA. Translation: CAJ43920.1 .
RefSeqi NP_940857.2. NM_198455.2. [A2VEC9-1 ]
UniGenei Hs.632022.

3D structure databases

ProteinModelPortali A2VEC9.
SMRi A2VEC9. Positions 1350-1643, 2064-2225, 2387-2505, 2510-2609, 2717-2828, 2987-3065, 3186-3309, 3400-3521, 3811-3911, 4003-4059, 4255-4334, 5052-5138.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 116762. 3 interactions.
STRINGi 9606.ENSP00000367255.

PTM databases

PhosphoSitei A2VEC9.

Proteomic databases

MaxQBi A2VEC9.
PaxDbi A2VEC9.
PRIDEi A2VEC9.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 23145.
KEGGi hsa:23145.
UCSCi uc010lpk.3. human. [A2VEC9-1 ]

Organism-specific databases

CTDi 23145.
GeneCardsi GC07P149473.
H-InvDB HIX0007194.
HGNCi HGNC:21998. SSPO.
neXtProti NX_A2VEC9.
PharmGKBi PA142670865.
HUGEi Search...
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG12793.
HOGENOMi HOG000154433.
HOVERGENi HBG080794.
PhylomeDBi A2VEC9.

Enzyme and pathway databases

Reactomei REACT_200626. O-glycosylation of TSR domain-containing proteins.

Miscellaneous databases

GeneWikii SSPO.
GenomeRNAii 23145.
NextBioi 44438.
PROi A2VEC9.

Gene expression databases

CleanExi HS_SSPO.
Genevestigatori A2VEC9.

Family and domain databases

Gene3Di 2.60.120.260. 1 hit.
4.10.400.10. 10 hits.
InterProi IPR000421. Coagulation_fac_5/8-C_type_dom.
IPR006207. Cys_knot_C.
IPR008979. Galactose-bd-like.
IPR023415. LDLR_class-A_CS.
IPR002172. LDrepeatLR_classA_rpt.
IPR008037. Prot_inh_PMP.
IPR000884. Thrombospondin_1_rpt.
IPR002919. TIL_dom.
IPR014853. Unchr_dom_Cys-rich.
IPR006552. VWC_out.
IPR001007. VWF_C.
IPR001846. VWF_type-D.
[Graphical view ]
Pfami PF08742. C8. 3 hits.
PF00754. F5_F8_type_C. 1 hit.
PF00057. Ldl_recept_a. 8 hits.
PF01826. TIL. 14 hits.
PF00090. TSP_1. 22 hits.
PF00094. VWD. 3 hits.
[Graphical view ]
PRINTSi PR00261. LDLRECEPTOR.
SMARTi SM00832. C8. 3 hits.
SM00231. FA58C. 1 hit.
SM00192. LDLa. 10 hits.
SM00209. TSP1. 25 hits.
SM00214. VWC. 4 hits.
SM00215. VWC_out. 1 hit.
SM00216. VWD. 3 hits.
[Graphical view ]
SUPFAMi SSF49785. SSF49785. 1 hit.
SSF57283. SSF57283. 1 hit.
SSF57424. SSF57424. 10 hits.
SSF57567. SSF57567. 14 hits.
SSF82895. SSF82895. 23 hits.
PROSITEi PS01225. CTCK_2. 1 hit.
PS00022. EGF_1. 1 hit.
PS50022. FA58C_3. 1 hit.
PS01209. LDLRA_1. 8 hits.
PS50068. LDLRA_2. 10 hits.
PS50092. TSP1. 24 hits.
PS01208. VWFC_1. 1 hit.
PS50184. VWFC_2. 2 hits.
PS51233. VWFD. 3 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The nucleotide sequence of a long cDNA clone isolated from human."
    Nagase T., Kikuno R., Ohara O.
    Submitted (NOV-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Brain.
  2. "The DNA sequence of human chromosome 7."
    Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L.
    , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
    Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The complex multidomain organization of SCO-spondin protein is highly conserved in mammals."
    Meiniel O., Meiniel A.
    Brain Res. Brain Res. Rev. 53:321-327(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION (ISOFORM 1).

Entry informationi

Entry nameiSSPO_HUMAN
AccessioniPrimary (citable) accession number: A2VEC9
Secondary accession number(s): Q76B61
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 12, 2007
Last sequence update: March 20, 2007
Last modified: September 3, 2014
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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