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Protein

SCO-spondin

Gene

SSPO

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Involved in the modulation of neuronal aggregation. May be involved in developmental events during the formation of the central nervous system (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processCell adhesion
LigandCalcium

Enzyme and pathway databases

ReactomeiR-HSA-5083635. Defective B3GALTL causes Peters-plus syndrome (PpS).
R-HSA-5173214. O-glycosylation of TSR domain-containing proteins.

Names & Taxonomyi

Protein namesi
Recommended name:
SCO-spondinCurated
Gene namesi
Name:SSPOImported
Synonyms:KIAA2036
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componentsi: Chromosome 7, Unplaced

Organism-specific databases

EuPathDBiHostDB:ENSG00000197558.11.
HGNCiHGNC:21998. SSPO.
MIMi617356. gene.
neXtProtiNX_A2VEC9.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi23145.
OpenTargetsiENSG00000197558.
PharmGKBiPA142670865.

Polymorphism and mutation databases

BioMutaiSSPO.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 17Sequence analysisAdd BLAST17
ChainiPRO_500022375718 – 5150SCO-spondinAdd BLAST5133

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi? ↔ 5142By similarity
Glycosylationi88N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi130N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi261N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi515N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi820N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi912N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi945N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi987N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1353N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi1377 ↔ 1390By similarity
Disulfide bondi1384 ↔ 1403By similarity
Disulfide bondi1397 ↔ 1412By similarity
Disulfide bondi1417 ↔ 1429By similarity
Disulfide bondi1424 ↔ 1442By similarity
Disulfide bondi1453 ↔ 1465By similarity
Disulfide bondi1460 ↔ 1478By similarity
Disulfide bondi1472 ↔ 1487By similarity
Disulfide bondi1493 ↔ 1505By similarity
Disulfide bondi1500 ↔ 1518By similarity
Disulfide bondi1512 ↔ 1529By similarity
Disulfide bondi1566 ↔ 1578By similarity
Disulfide bondi1573 ↔ 1591By similarity
Disulfide bondi1585 ↔ 1600By similarity
Disulfide bondi1604 ↔ 1617By similarity
Disulfide bondi1611 ↔ 1630By similarity
Disulfide bondi1624 ↔ 1641By similarity
Glycosylationi1651N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi1657 ↔ 1667By similarity
Disulfide bondi1662 ↔ 1680By similarity
Glycosylationi1664N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi1674 ↔ 1695By similarity
Disulfide bondi1707 ↔ 1743By similarity
Disulfide bondi1711 ↔ 1748By similarity
Disulfide bondi1722 ↔ 1733By similarity
Disulfide bondi1763 ↔ 1803By similarity
Disulfide bondi1767 ↔ 1808By similarity
Disulfide bondi1777 ↔ 1787By similarity
Glycosylationi1810N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi1829 ↔ 1844By similarity
Disulfide bondi1838 ↔ 1849By similarity
Disulfide bondi1851 ↔ 1863By similarity
Disulfide bondi1869 ↔ 1888By similarity
Disulfide bondi1871 ↔ 1891By similarity
Disulfide bondi1893 ↔ 1901By similarity
Disulfide bondi1911 ↔ 1950By similarity
Disulfide bondi1922 ↔ 1926By similarity
Disulfide bondi1960 ↔ 1965By similarity
Glycosylationi1994N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2031N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi2066 ↔ 2225By similarity
Glycosylationi2134N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi2235 ↔ 2247By similarity
Disulfide bondi2242 ↔ 2260By similarity
Disulfide bondi2254 ↔ 2269By similarity
Disulfide bondi2392 ↔ 2404By similarity
Disulfide bondi2399 ↔ 2417By similarity
Disulfide bondi2411 ↔ 2426By similarity
Disulfide bondi2465 ↔ 2477By similarity
Disulfide bondi2472 ↔ 2490By similarity
Disulfide bondi2484 ↔ 2499By similarity
Disulfide bondi2502 ↔ 2538By similarity
Disulfide bondi2513 ↔ 2517By similarity
Disulfide bondi2548 ↔ 2553By similarity
Disulfide bondi2568 ↔ 2605By similarity
Disulfide bondi2572 ↔ 2610By similarity
Disulfide bondi2583 ↔ 2595By similarity
Glycosylationi2646N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2695N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi2717 ↔ 2755By similarity
Disulfide bondi2728 ↔ 2732By similarity
Disulfide bondi2765 ↔ 2769By similarity
Disulfide bondi2785 ↔ 2823By similarity
Disulfide bondi2789 ↔ 2828By similarity
Disulfide bondi2805 ↔ 2813By similarity
Disulfide bondi2843 ↔ 2878By similarity
Disulfide bondi2847 ↔ 2883By similarity
Disulfide bondi2858 ↔ 2868By similarity
Glycosylationi2937N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2968N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi2987 ↔ 3025By similarity
Disulfide bondi2998 ↔ 3002By similarity
Disulfide bondi3035 ↔ 3040By similarity
Glycosylationi3063N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi3117N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi3164N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi3174N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi3196 ↔ 3245By similarity
Disulfide bondi3200 ↔ 3250By similarity
Disulfide bondi3211 ↔ 3235By similarity
Disulfide bondi3265 ↔ 3302By similarity
Disulfide bondi3269 ↔ 3307By similarity
Disulfide bondi3280 ↔ 3292By similarity
Glycosylationi3311N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi3400N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi3421 ↔ 3464By similarity
Disulfide bondi3425 ↔ 3470By similarity
Disulfide bondi3436 ↔ 3448By similarity
Disulfide bondi3485 ↔ 3520By similarity
Disulfide bondi3488 ↔ 3527By similarity
Disulfide bondi3498 ↔ 3510By similarity
Glycosylationi3513N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi3523N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi3600N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi3627N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi3658 ↔ 3688By similarity
Disulfide bondi3662 ↔ 3693By similarity
Disulfide bondi3673 ↔ 3678By similarity
Glycosylationi3793N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi3824 ↔ 3928By similarity
Disulfide bondi3828 ↔ 3933By similarity
Disulfide bondi3840 ↔ 3852By similarity
Glycosylationi3916N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi3948N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi3949 ↔ 3985By similarity
Disulfide bondi3960 ↔ 3964By similarity
Disulfide bondi3998 ↔ 4003By similarity
Disulfide bondi4018 ↔ 4055By similarity
Disulfide bondi4022 ↔ 4060By similarity
Disulfide bondi4033 ↔ 4045By similarity
Glycosylationi4141N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi4162 ↔ 4198By similarity
Disulfide bondi4173 ↔ 4177By similarity
Disulfide bondi4208 ↔ 4213By similarity
Glycosylationi4348N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi4368 ↔ 4405By similarity
Disulfide bondi4379 ↔ 4381By similarity
Disulfide bondi4415 ↔ 4420By similarity
Glycosylationi4419N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi4734N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi4751N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi4756N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi4778 ↔ 4813By similarity
Disulfide bondi4782 ↔ 4818By similarity
Disulfide bondi4793 ↔ 4802By similarity
Glycosylationi4866N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi4906N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi4951N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi4958N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi5044 ↔ 5104By similarity
Glycosylationi5064N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi5070 ↔ 5121By similarity
Disulfide bondi5080 ↔ 5137By similarity
Disulfide bondi5084 ↔ 5139By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PeptideAtlasiA0A096LNW2.
PRIDEiA2VEC9.

PTM databases

iPTMnetiA2VEC9.
PhosphoSitePlusiA2VEC9.

Expressioni

Gene expression databases

BgeeiENSG00000197558.
CleanExiHS_SSPO.

Interactioni

Protein-protein interaction databases

BioGridi116762. 3 interactors.

Structurei

3D structure databases

ProteinModelPortaliA2VEC9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini18 – 102EMIAdd BLAST85
Domaini194 – 409VWFD 1PROSITE-ProRule annotationAdd BLAST216
Domaini470 – 525TIL 1Add BLAST56
Domaini564 – 774VWFD 2PROSITE-ProRule annotationAdd BLAST211
Domaini828 – 880TIL 2Add BLAST53
Domaini881 – 940VWFC 1PROSITE-ProRule annotationAdd BLAST60
Domaini1014 – 1220VWFD 3PROSITE-ProRule annotationAdd BLAST207
Domaini1276 – 1332TIL 3Add BLAST57
Domaini1376 – 1413LDL-receptor class A 1PROSITE-ProRule annotationAdd BLAST38
Domaini1416 – 1451LDL-receptor class A 2PROSITE-ProRule annotationAdd BLAST36
Domaini1452 – 1488LDL-receptor class A 3PROSITE-ProRule annotationAdd BLAST37
Domaini1492 – 1530LDL-receptor class A 4PROSITE-ProRule annotationAdd BLAST39
Domaini1565 – 1601LDL-receptor class A 5PROSITE-ProRule annotationAdd BLAST37
Domaini1603 – 1642LDL-receptor class A 6PROSITE-ProRule annotationAdd BLAST40
Domaini1656 – 1694LDL-receptor class A 7PROSITE-ProRule annotationAdd BLAST39
Domaini1695 – 1749TSP type-1 1PROSITE-ProRule annotationAdd BLAST55
Domaini1751 – 1809TSP type-1 2PROSITE-ProRule annotationAdd BLAST59
Domaini1825 – 1864EGF-like 1Add BLAST40
Domaini1865 – 1902EGF-like 2Add BLAST38
Domaini1910 – 1966TSP type-1 3PROSITE-ProRule annotationAdd BLAST57
Domaini1966 – 2026VWFC 2PROSITE-ProRule annotationAdd BLAST61
Domaini2066 – 2225F5/8 type CPROSITE-ProRule annotationAdd BLAST160
Domaini2234 – 2270LDL-receptor class A 8PROSITE-ProRule annotationAdd BLAST37
Domaini2391 – 2427LDL-receptor class A 9PROSITE-ProRule annotationAdd BLAST37
Domaini2464 – 2500LDL-receptor class A 10PROSITE-ProRule annotationAdd BLAST37
Domaini2501 – 2554TSP type-1 4PROSITE-ProRule annotationAdd BLAST54
Domaini2556 – 2611TSP type-1 5PROSITE-ProRule annotationAdd BLAST56
Domaini2634 – 2676TIL 4Add BLAST43
Domaini2716 – 2770TSP type-1 6PROSITE-ProRule annotationAdd BLAST55
Domaini2773 – 2829TSP type-1 7PROSITE-ProRule annotationAdd BLAST57
Domaini2831 – 2884TSP type-1 8PROSITE-ProRule annotationAdd BLAST54
Domaini2986 – 3041TSP type-1 9PROSITE-ProRule annotationAdd BLAST56
Domaini3042 – 3084TSP type-1 10PROSITE-ProRule annotationAdd BLAST43
Domaini3184 – 3251TSP type-1 11PROSITE-ProRule annotationAdd BLAST68
Domaini3253 – 3308TSP type-1 12PROSITE-ProRule annotationAdd BLAST56
Domaini3312 – 3366TIL 5Add BLAST55
Domaini3409 – 3471TSP type-1 13PROSITE-ProRule annotationAdd BLAST63
Domaini3473 – 3528TSP type-1 14PROSITE-ProRule annotationAdd BLAST56
Domaini3646 – 3694TSP type-1 15PROSITE-ProRule annotationAdd BLAST49
Domaini3812 – 3934TSP type-1 16PROSITE-ProRule annotationAdd BLAST123
Domaini3948 – 4004TSP type-1 17PROSITE-ProRule annotationAdd BLAST57
Domaini4006 – 4061TSP type-1 18PROSITE-ProRule annotationAdd BLAST56
Domaini4161 – 4214TSP type-1 19PROSITE-ProRule annotationAdd BLAST54
Domaini4255 – 4307TSP type-1 20PROSITE-ProRule annotationAdd BLAST53
Domaini4309 – 4365TSP type-1 21PROSITE-ProRule annotationAdd BLAST57
Domaini4367 – 4421TSP type-1 22PROSITE-ProRule annotationAdd BLAST55
Domaini4617 – 4667TSP type-1 23PROSITE-ProRule annotationAdd BLAST51
Domaini4670 – 4726TIL 6Add BLAST57
Domaini4766 – 4819TSP type-1 24PROSITE-ProRule annotationAdd BLAST54
Domaini4987 – 5045VWFC 3PROSITE-ProRule annotationAdd BLAST59
Domaini5044 – 5143CTCKPROSITE-ProRule annotationAdd BLAST100

Sequence similaritiesi

Belongs to the thrombospondin family.Curated

Keywords - Domaini

EGF-like domain, Repeat, Signal

Phylogenomic databases

GeneTreeiENSGT00760000118896.
HOGENOMiHOG000154433.
HOVERGENiHBG080794.
InParanoidiA2VEC9.
OMAiMQTKNEL.
OrthoDBiEOG091G0006.
PhylomeDBiA2VEC9.

Family and domain databases

CDDicd00112. LDLa. 9 hits.
Gene3Di2.20.100.10. 21 hits.
2.60.120.260. 1 hit.
InterProiView protein in InterPro
IPR006207. Cys_knot_C.
IPR000421. FA58C.
IPR008979. Galactose-bd-like_sf.
IPR036055. LDL_receptor-like_sf.
IPR023415. LDLR_class-A_CS.
IPR002172. LDrepeatLR_classA_rpt.
IPR036201. Pacifastin_dom_sf.
IPR030119. SCO-spondin.
IPR036084. Ser_inhib-like_sf.
IPR002919. TIL_dom.
IPR000884. TSP1_rpt.
IPR036383. TSP1_rpt_sf.
IPR014853. Unchr_dom_Cys-rich.
IPR001007. VWF_dom.
IPR001846. VWF_type-D.
PANTHERiPTHR11339:SF358. PTHR11339:SF358. 28 hits.
PfamiView protein in Pfam
PF08742. C8. 3 hits.
PF00754. F5_F8_type_C. 1 hit.
PF00057. Ldl_recept_a. 8 hits.
PF01826. TIL. 14 hits.
PF00090. TSP_1. 21 hits.
PF00094. VWD. 3 hits.
PRINTSiPR00261. LDLRECEPTOR.
SMARTiView protein in SMART
SM00832. C8. 3 hits.
SM00231. FA58C. 1 hit.
SM00192. LDLa. 10 hits.
SM00209. TSP1. 25 hits.
SM00214. VWC. 6 hits.
SM00215. VWC_out. 9 hits.
SM00216. VWD. 3 hits.
SUPFAMiSSF49785. SSF49785. 1 hit.
SSF57283. SSF57283. 1 hit.
SSF57424. SSF57424. 10 hits.
SSF57567. SSF57567. 14 hits.
SSF82895. SSF82895. 23 hits.
PROSITEiView protein in PROSITE
PS01225. CTCK_2. 1 hit.
PS00022. EGF_1. 1 hit.
PS50022. FA58C_3. 1 hit.
PS01209. LDLRA_1. 8 hits.
PS50068. LDLRA_2. 10 hits.
PS50092. TSP1. 24 hits.
PS01208. VWFC_1. 1 hit.
PS50184. VWFC_2. 2 hits.
PS51233. VWFD. 3 hits.

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: A2VEC9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

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        10         20         30         40         50
MLLPALLFGM AWALADGRWC EWTETIRVEE EVAPRQEDLV PCASLDHYSR
60 70 80 90 100
LGWRLDLPWS GRSGLTRSPA PGLCPIYKPP ETRPAKWNRT VRTCCPGWGG
110 120 130 140 150
AHCTEALAKA SPEGHCFAMW QCQLQAGSAN ASAGSLEECC ARPWGQSWWD
160 170 180 190 200
GSSQACRSCS SRHLPGSASS PALLQPLAGA VGQLWSQHQR PSATCASWSG
210 220 230 240 250
FHYRTFDGRH YHFLGRCTYL LAGAADSTWA VHLTPGDRCP QPGHCQRVTM
260 270 280 290 300
GPEEVLIQAG NVSVKGQLVP EGQSWLLHGL SLQWLGDWLV LSGGLGVVVR
310 320 330 340 350
LDRTGSISIS VDHELWGQTQ GLCGLYNGWP EDDFMEPGGG LAMLAATFGN
360 370 380 390 400
SWRLPGSESG CLDAVEVAQG CDSPLGLIDA DVEPGHLRAE AQDVCHQLLE
410 420 430 440 450
GPFGQCHAQV SPAEYHEACL FAYCAGAMAG SGQEGRQQAV CATFASYVQA
460 470 480 490 500
CARRHIHIRW RKPGFCERLC PGGQLYSDCV SLCPPSCEAV GQGEEESCRE
510 520 530 540 550
ECVSGCECPR GLFWNGTLCV PAAHCPCYYC RQRYVPGDTV RQLCNPCVCR
560 570 580 590 600
DGRWHCAQAL CPAECAVGGD GHYLTFDGRS YSFWGGQGCR YSLVQDYVKG
610 620 630 640 650
QLLILLEHGA CDAGSCLHAI SVSLEDTHIQ LRDSGAVLVN GQDVGLPWIG
660 670 680 690 700
AEGLSVRRAS SAFLLLRWPG AQVLWGLSDP VAYITLDPRH AHQVQGLCGT
710 720 730 740 750
FTQNQQDDFL TPAGDVETSI AAFASKFQVA GKGRCPSEDS ALLSPCTTHS
760 770 780 790 800
QRHAFAEAAC AILHSSVFQE CHRLVDKEPF YLRCLAAVCG CDPGSDCLCP
810 820 830 840 850
VLSAYARRCA QEGASPPWRN QTLCPVMCPG GQEYRECAPA CGQHCGKPED
860 870 880 890 900
CGELGSCVAG CNCPLGLLWD PEGQCVPPSL CPCQLGARRY APGSATMKEC
910 920 930 940 950
NRCICQERGL WNCTARHCPS QAFCPRELVY APGACLLTCD SPSANHSCPA
960 970 980 990 1000
GSTDGCVCPP GTVLLDERCV PPDLCPCRHS GQWYLPNATI QEDCNVCVCR
1010 1020 1030 1040 1050
GRQWHCTGQR RSGRCQASGA PHYVTFDGLA FTYPGACEYL LVREASGLFT
1060 1070 1080 1090 1100
VSAQNLPCGA SGLTCTKALA VRLEGTVVHM LRGRAVTVNG VSVTPPKVYT
1110 1120 1130 1140 1150
GPGLSLRRAG LFLLLSTHLG LTLLWDGGTR VLVQLSPQFR GRVAGLCGDF
1160 1170 1180 1190 1200
DGDASNDLRS RQGVLEPTAE LAAHSWRLSP LCPEPGDLPH PCTMNTHRAG
1210 1220 1230 1240 1250
WARARCGALL QPLFTLCHAE VPPQQHYEWC LYDACGCDSG GDCECLCSAI
1260 1270 1280 1290 1300
ATYADECARH GHHVRWRSQE LCSLQCEGGQ VYEACGPTCP PTCHEQHPEP
1310 1320 1330 1340 1350
GWHCQVVACV EGCFCPEGTL LHGGACLEPA SCPCEWGRNS FPPGSVLQKD
1360 1370 1380 1390 1400
CGNCTCQEGQ WHCGGDGGHC EELVPACAEG EALCQENGHC VPHGWLCDNQ
1410 1420 1430 1440 1450
DDCGDGSDEE GCAAPGCGEG QMTCSSGHCL PLALLCDRQD DCGDGTDEPS
1460 1470 1480 1490 1500
YPCPQGLLAC ADGRCLPPAL LCDGHPDCLD AADEESCLGQ VTCVPGEVSC
1510 1520 1530 1540 1550
VDGTCLGAIQ LCDGVWDCPD GADEGPGHCP LPSLPTPPAS TLPGPSPGSL
1560 1570 1580 1590 1600
DTASSPLASA SPAPPCGPFE FRCGSGECTP RGWRCDQEED CADGSDERGC
1610 1620 1630 1640 1650
GGPCAPHHAP CARGPHCVSP EQLCDGVRQC PDGSDEGPDA CGGLPALGGP
1660 1670 1680 1690 1700
NRTGLPCPEY TCPNGTCIGF QLVCDGQPDC GRPGQVGPSP EEQGCGAWGP
1710 1720 1730 1740 1750
WSPWGPCSRT CGPWGQGRSR RCSPLGLLVL QNCPGPEHQS QACFTAACPV
1760 1770 1780 1790 1800
DGEWSTWSPW SVCSEPCRGT MTRQRQCHSP QNGGRTCAAL PGGLHSTRQT
1810 1820 1830 1840 1850
KPCPQDGCPN ATCSGELMFQ PCAPCPLTCD DISGQVTCPP DWPCGSPGCW
1860 1870 1880 1890 1900
CPEGQVLGSE GWCVWPRQCP CLVDGARYWP GQRIKADCQL CICQDGRPRR
1910 1920 1930 1940 1950
CRLNPDCAVD CGWSSWSPWA KCLGPCGSQS IQWSFRSSNN PRPSGRGRQC
1960 1970 1980 1990 2000
RGIHRKARRC QTEPCEGCEH QGQVHRVGER WHGGPCRVCQ CLHNLTAHCS
2010 2020 2030 2040 2050
PYCPLGSCPQ GWVLVEGTGE SCCHCALPGE NQTVQPMATP AAAPAPSPQI
2060 2070 2080 2090 2100
RFPLATYILP PSGDPCYSPL GLAGLAEGSL HASSQQLEHP TQAALLGAPT
2110 2120 2130 2140 2150
QGPSPQGWHA GGDAYAKWHT RPHYLQLDLL QPRNLTGILV PETGSSNAYA
2160 2170 2180 2190 2200
SSFSLQFSSN GLHWHDYRDL LPGILPLPKL FPRNWDDLDP AVWTFGRMVQ
2210 2220 2230 2240 2250
ARFVRVWPHD VHHSDVPLQV ELLGCEPGSP PAPLCPGVGL RCASGECVLR
2260 2270 2280 2290 2300
GGPCDGVLDC EDGSDEEGCV LLPEGTGRFH STAKTLALSS AQPGQLLHWP
2310 2320 2330 2340 2350
REGLAETEHW PPGQESPTSP TETRPVSPGP ASGVPHHGES VQMVTTTPIP
2360 2370 2380 2390 2400
QMEARTLPPG MAAVTVVPPH PVTPATPAGQ SVAPGPFPPV QCGPGQTPCE
2410 2420 2430 2440 2450
VLGCVEQAQV CDGREDCLDG SDERHCARNL LMWLPSLPAL WAASTVPFMM
2460 2470 2480 2490 2500
PTMALPGLPA SRALCSPSQL SCGSGECLSA ERRCDLRPDC QDGSDEDGCV
2510 2520 2530 2540 2550
DCVLAPWSVW SSCSRSCGLG LTFQRQELLR PPLPGGSCPR DRFRSQSCFV
2560 2570 2580 2590 2600
QACPVAGAWA MWEAWGPCSV SCGGGHQSRQ RSCVDPPPKN GGAPCPGASQ
2610 2620 2630 2640 2650
ERAPCGLQPC SGGTDCELGR VYVSADLCQK GLVPPCPPSC LDPKANRSCS
2660 2670 2680 2690 2700
GHCVEGCRCP PGLLLHDTRC LPLSECPCLV GEELKWPGVS FLLGNCSQCV
2710 2720 2730 2740 2750
CEKGELLCQP GGCPLPCGWS AWSSWAPCDR SCGSGVRARF RSPSNPPAAW
2760 2770 2780 2790 2800
GGAPCEGDRQ ELQGCHTVCG TEVFGWTPWT SWSSCSQSCL APGGGPGWRS
2810 2820 2830 2840 2850
RSRLCPSPGD SSCPGDATQE EPCSPPVCPV PSIWGLWAPW STCSAPCDGG
2860 2870 2880 2890 2900
IQTRGRSCSS LAPGDTTCPG PHSQTRDCNT QPCTAQCPEN MLFRSAEQCH
2910 2920 2930 2940 2950
QEGGPCPRLC LTQGPGIECT GFCAPGCTCP PGLFLHNASC LPRSQCPCQL
2960 2970 2980 2990 3000
HGQLYASGAM ARLDSCNNCT CVSGKMACTS ERCPVACGWS PWTLWSLCSC
3010 3020 3030 3040 3050
SCNVGIRRRF RAGTAPPAAF GGAECQGPTM EAEFCSLRPC PGPGGEWGPW
3060 3070 3080 3090 3100
SPCSVPCGGG YRNRTRGSSR SLMEFSTCGL QPCAGPVPGM CPRDKQWLDC
3110 3120 3130 3140 3150
AQGPASCAEL SAPRGTNQTC HPGCHCPSGM LLLNNVCVPT QDCPCAHEGH
3160 3170 3180 3190 3200
LYPPGSTVVR PCENCSCVSG LIANCSSWPC AEGEPTWSPW TPWSQCSASC
3210 3220 3230 3240 3250
GPARCHRHRF CARSPSAVPS TVAPLPLPAT PTPLCSGPEA EEEPCLLQGC
3260 3270 3280 3290 3300
DRAGGWGPWG PWSHCSRSCG GGLRSRTRAC DQPPPQGLGD YCEGPRAQGE
3310 3320 3330 3340 3350
VCQALPCPVT NCTAIEGAEY SPCGPPCPRS CDDLVHCVWR CQPGCYCPPG
3360 3370 3380 3390 3400
QVLSSNGAIC VQPGHCSCLD LLTGQRHHPG ARLARPDGCN HCTCLEGRLN
3410 3420 3430 3440 3450
CTDLPCPVPG GWCPWSEWTM CSQPCRGQTR SRSRACACPT PQHGGAPCTG
3460 3470 3480 3490 3500
EAGEAGAQHQ REACPSYATC PVDGAWGPWG PWSPCDMCLG QSHRSRACSR
3510 3520 3530 3540 3550
PPTPEGGRPC PGNHTQSRPC QENSTQCTDC GGGQSLHPCG QPCPRSCQDL
3560 3570 3580 3590 3600
SPGSVCQPGS VGCQPTCGCP LGQLSQDGLC VPPAHCRCQY QPGAMGIPEN
3610 3620 3630 3640 3650
QSRSAGSRFS SWESLEPGEV VTGPCDNCTC VAGILQCQEV PDCPDPGVWS
3660 3670 3680 3690 3700
SWGPWEDCSV SCGGGEQLRS RRCARPPCPG PARQSRTCST QVCREAGCPA
3710 3720 3730 3740 3750
GRLYRECQPG EGCPFSCAHV TQQVGCFSEG CEEGCHCPEG TFQHRLACVQ
3760 3770 3780 3790 3800
ECPCVLTAWL LQELGATIGD PGQPLGPGDE LDSGQTLRTS CGNCSCAHGK
3810 3820 3830 3840 3850
LSCSLDDCFE ADGGFGPWSP WGPCSRSCGG LGTRTRSRQC VLTMPTLSGQ
3860 3870 3880 3890 3900
GCRGPRQDLE YCPSPDCPGA EGSTVEPVTG LPGGWGPWSS WSPCSRSCTD
3910 3920 3930 3940 3950
PARPAWRSRT RLCLANCTMG DPLQERPCNL PSCTELPVCP GPGCGAGNCS
3960 3970 3980 3990 4000
WTSWAPWEPC SRSCGVGQQR RLRAYRPPGP GGHWCPNILT AYQERRFCNL
4010 4020 4030 4040 4050
RACPVPGGWS RWSPWSWCDR SCGGGQSLRS RSCSSPPSKN GGAPCAGERH
4060 4070 4080 4090 4100
QARLCNPMPC EAGCPAGMEV VTCANRCPRR CSDLQEGIVC QDDQVCQKGC
4110 4120 4130 4140 4150
RCPKGSLEQD GGCVPIGHCD CTDAQGHSWA PGSQHQDACN NCSCQAGQLS
4160 4170 4180 4190 4200
CTAQPCPPPT HCAWSHWSAW SPCSHSCGPR GQQSRFRSST SGSWAPECRE
4210 4220 4230 4240 4250
EQSQSQPCPQ PSCPPLCLQG TRSRTLGDSW LQGECQRCSC TPEGVICEDT
4260 4270 4280 4290 4300
ECAVPEAWTL WSSWSDCPVS CGGGNQVRTR ACRAAAPHHR SPPCLGPDTQ
4310 4320 4330 4340 4350
TRQQPCPGLL EACSWGPWGP CSRSCGPGLA SRSGSCPCLM AKADPTCNST
4360 4370 4380 4390 4400
FLHLDTQGCY SGPCPEECVW SSWSSWTRCS CRVLVQQRYR HQGPASRGAR
4410 4420 4430 4440 4450
AGAPCTRLDG HFRPCLISNC SEDSCTPPFE FHACGSPCAG LCATHLSHQL
4460 4470 4480 4490 4500
CQDLPPCQPG CYCPKGLLEQ AGGCIPPEEC NCWHTSAAGA GMTLAPGDRL
4510 4520 4530 4540 4550
QLGCKECECR RGELHCTSQG CQGLLPLSEW SEWSPCGPCL PPSALAPASR
4560 4570 4580 4590 4600
TALEEHWLRD PTGLSPTLAP LLASEQHRHR LCLDPATGRP WTGAPHLCTA
4610 4620 4630 4640 4650
PLSQQRLCPD PGACPDSCQW SLWGPWSPCQ VPCSGGFRLR WREAEALCGG
4660 4670 4680 4690 4700
GCREPWAQES CNGGPCPESC EAQDTVFTLD CANQCPHSCA DLWDRVQCLQ
4710 4720 4730 4740 4750
GPCRPGCRCP PGQLVQDGRC VPISSCRCGL PSANASWELA PAQAVQLDCQ
4760 4770 4780 4790 4800
NCTCVNESLV CPHQECPVLG PWSAWSSCSA PCGGGTMERH RTCEGGPGVA
4810 4820 4830 4840 4850
PCQAQDTEQR QECNLQPCPE CPPGQVLSAC ATSCPCLCWH LQPGAICVQE
4860 4870 4880 4890 4900
PCQPGCGCPG GQLLHNGTCV PPTACPCTQH SLPWGLTLTL EEQAQELPPG
4910 4920 4930 4940 4950
TVLTRNCTRC VCHGGAFSCS LVDCQVPPGE TWQQVAPGEL GLCEQTCLEM
4960 4970 4980 4990 5000
NATKTQSNCS SARASGCVCQ PGHFRSQAGP CVPEDHCECW HLGRPHLPGS
5010 5020 5030 5040 5050
EWQEACESCL CLSGRPVCTQ HCSPLTCAQG EEMVLEPGSC CPSCRREAPE
5060 5070 5080 5090 5100
EQSPSCQLLT ELRNFTKGTC YLDQVEVSYC SGYCPSSTHV MPEEPYLQSQ
5110 5120 5130 5140 5150
CDCCSYRLDP ESPVRILNLR CLGGHTEPVV LPVIHSCQCS SCQGGDFSKR
Length:5,150
Mass (Da):547,841
Last modified:March 28, 2018 - v2
Checksum:i14C531CC9A29423E
GO
Isoform 2 (identifier: A2VEC9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1123: Missing.
     1124-1127: LWDG → MLPP
     1640-1640: A → ACVEAPAPPA...DCPQGEDELD
     1672-1672: L → LVRVGVGGGGGSAMLPPSTRALTPLPPQ
     2180-2315: LFPRNWDDLD...ETEHWPPGQE → VSPAQGRWGQ...RSGRNQSVLC
     2316-5147: Missing.

Note: No experimental confirmation available.
Show »
Length:1,317
Mass (Da):139,146
Checksum:i59DBAA7876F7F138
GO

Sequence cautioni

The sequence BAC98376 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_052660146Q → R. Corresponds to variant dbSNP:rs709061Ensembl.1
Natural variantiVAR_052661298V → M. Corresponds to variant dbSNP:rs17754559Ensembl.1
Natural variantiVAR_059863540V → M. Corresponds to variant dbSNP:rs855677Ensembl.1
Natural variantiVAR_0757091002R → W Found in patient with Joubert syndrome; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs199648588Ensembl.1
Natural variantiVAR_0598641273S → P. Corresponds to variant dbSNP:rs709060Ensembl.1
Natural variantiVAR_0526621274L → P. Corresponds to variant dbSNP:rs709060Ensembl.1
Natural variantiVAR_0598651425S → G. Corresponds to variant dbSNP:rs855691Ensembl.1
Natural variantiVAR_0598661449P → Q. Corresponds to variant dbSNP:rs855692Ensembl.1
Natural variantiVAR_0598671454P → R. Corresponds to variant dbSNP:rs2074704Ensembl.1
Natural variantiVAR_0598681779S → P. Corresponds to variant dbSNP:rs893601Ensembl.1
Natural variantiVAR_0598691794L → P. Corresponds to variant dbSNP:rs1635802Ensembl.1
Natural variantiVAR_0598701883R → C. Corresponds to variant dbSNP:rs1076277Ensembl.1
Natural variantiVAR_0598712018T → M. Corresponds to variant dbSNP:rs4725314Ensembl.1
Natural variantiVAR_0619152453M → T. Corresponds to variant dbSNP:rs2074689Ensembl.1
Natural variantiVAR_0619162542R → Q. Corresponds to variant dbSNP:rs59522380Ensembl.1
Natural variantiVAR_0757102799R → C Found in patient with Joubert syndrome; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs181269877Ensembl.1
Natural variantiVAR_0598722892L → V. Corresponds to variant dbSNP:rs10260959Ensembl.1
Natural variantiVAR_0598733274R → W. Corresponds to variant dbSNP:rs740109Ensembl.1
Natural variantiVAR_0598743513N → S. Corresponds to variant dbSNP:rs10952230Ensembl.1
Natural variantiVAR_0598753894C → W. Corresponds to variant dbSNP:rs1557955Ensembl.1
Natural variantiVAR_0598763911R → C. Corresponds to variant dbSNP:rs745044Ensembl.1
Natural variantiVAR_0598774030S → I. Corresponds to variant dbSNP:rs1005603Ensembl.1
Natural variantiVAR_0619174109Q → H. Corresponds to variant dbSNP:rs12536873Ensembl.1
Natural variantiVAR_0598784166H → R. Corresponds to variant dbSNP:rs10233245Ensembl.1
Natural variantiVAR_0598794332R → C. Corresponds to variant dbSNP:rs1008336Ensembl.1
Natural variantiVAR_0598804790H → R. Corresponds to variant dbSNP:rs1004200Ensembl.1
Natural variantiVAR_0598814944E → K. Corresponds to variant dbSNP:rs12534509Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0352581 – 1123Missing in isoform 2. 1 PublicationAdd BLAST1123
Alternative sequenceiVSP_0352591124 – 1127LWDG → MLPP in isoform 2. 1 Publication4
Alternative sequenceiVSP_0352601640A → ACVEAPAPPAMRGPPGQAGG PTSSRAPSPPSPPEAQGEGR KGQERSRTHLTVPAGSTQLP LCPGLFPCGVAPGLCLTPEQ LCDGIPDCPQGEDELD in isoform 2. 1 Publication1
Alternative sequenceiVSP_0352611672L → LVRVGVGGGGGSAMLPPSTR ALTPLPPQ in isoform 2. 1 Publication1
Alternative sequenceiVSP_0352622180 – 2315LFPRN…PPGQE → VSPAQGRWGQQPTMPFCGFH SLCPQGPSSVPEGHGLHSML VEYLVSSRDCALWSRGLGAT VTWMLETIQVAQTQGRYVKP ARERGWGDTKFTEGLREPRP THVFVESSLGTALPSGGLHP SRRQTARSGRNQSVLC in isoform 2. 1 PublicationAdd BLAST136
Alternative sequenceiVSP_0352632316 – 5147Missing in isoform 2. 1 PublicationAdd BLAST2832

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB111888 mRNA. Translation: BAC98376.1. Different initiation.
AC004877 Genomic DNA. No translation available.
KF459635 Genomic DNA. No translation available.
KF495712 Genomic DNA. No translation available.
KF459640 Genomic DNA. No translation available.
BN000852 mRNA. Translation: CAJ43920.1.
RefSeqiNP_940857.2. NM_198455.2. [A2VEC9-1]
UniGeneiHs.632022.

Genome annotation databases

GeneIDi23145.
KEGGihsa:23145.
UCSCiuc064jau.1. human.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiSSPO_HUMAN
AccessioniPrimary (citable) accession number: A2VEC9
Secondary accession number(s): A0A096LNW2, Q76B61
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 12, 2007
Last sequence update: March 28, 2018
Last modified: March 28, 2018
This is version 99 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome