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Protein

SCO-spondin

Gene

SSPO

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Involved in the modulation of neuronal aggregation. May be involved in developmental events during the formation of the central nervous system (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cell adhesion

Keywords - Ligandi

Calcium

Enzyme and pathway databases

BioCyciZFISH:G66-33365-MONOMER.
ReactomeiR-HSA-5083635. Defective B3GALTL causes Peters-plus syndrome (PpS).
R-HSA-5173214. O-glycosylation of TSR domain-containing proteins.

Names & Taxonomyi

Protein namesi
Recommended name:
SCO-spondin
Gene namesi
Name:SSPO
Synonyms:KIAA2036
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Unplaced

Organism-specific databases

HGNCiHGNC:21998. SSPO.

Subcellular locationi

GO - Cellular componenti

  • extracellular space Source: BHF-UCL
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi23145.
PharmGKBiPA142670865.

Polymorphism and mutation databases

BioMutaiSSPO.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 17Sequence analysisAdd BLAST17
ChainiPRO_500022375718 – 5147SCO-spondinAdd BLAST5130

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi? ↔ 5139By similarity
Glycosylationi88N-linked (GlcNAc...)Sequence analysis1
Glycosylationi130N-linked (GlcNAc...)Sequence analysis1
Glycosylationi261N-linked (GlcNAc...)Sequence analysis1
Glycosylationi514N-linked (GlcNAc...)Sequence analysis1
Glycosylationi819N-linked (GlcNAc...)Sequence analysis1
Glycosylationi911N-linked (GlcNAc...)Sequence analysis1
Glycosylationi944N-linked (GlcNAc...)Sequence analysis1
Glycosylationi986N-linked (GlcNAc...)Sequence analysis1
Glycosylationi1352N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi1376 ↔ 1389By similarity
Disulfide bondi1383 ↔ 1402By similarity
Disulfide bondi1396 ↔ 1411By similarity
Disulfide bondi1416 ↔ 1428By similarity
Disulfide bondi1423 ↔ 1441By similarity
Disulfide bondi1452 ↔ 1464By similarity
Disulfide bondi1459 ↔ 1477By similarity
Disulfide bondi1471 ↔ 1486By similarity
Disulfide bondi1492 ↔ 1504By similarity
Disulfide bondi1499 ↔ 1517By similarity
Disulfide bondi1511 ↔ 1528By similarity
Disulfide bondi1565 ↔ 1577By similarity
Disulfide bondi1572 ↔ 1590By similarity
Disulfide bondi1584 ↔ 1599By similarity
Disulfide bondi1603 ↔ 1616By similarity
Disulfide bondi1610 ↔ 1629By similarity
Disulfide bondi1623 ↔ 1640By similarity
Glycosylationi1650N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi1656 ↔ 1666By similarity
Disulfide bondi1661 ↔ 1679By similarity
Glycosylationi1663N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi1673 ↔ 1694By similarity
Disulfide bondi1706 ↔ 1742By similarity
Disulfide bondi1710 ↔ 1747By similarity
Disulfide bondi1721 ↔ 1732By similarity
Disulfide bondi1762 ↔ 1802By similarity
Disulfide bondi1766 ↔ 1807By similarity
Disulfide bondi1776 ↔ 1786By similarity
Glycosylationi1809N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi1828 ↔ 1843By similarity
Disulfide bondi1837 ↔ 1848By similarity
Disulfide bondi1850 ↔ 1862By similarity
Disulfide bondi1868 ↔ 1887By similarity
Disulfide bondi1870 ↔ 1890By similarity
Disulfide bondi1892 ↔ 1900By similarity
Disulfide bondi1910 ↔ 1949By similarity
Disulfide bondi1921 ↔ 1925By similarity
Disulfide bondi1959 ↔ 1964By similarity
Glycosylationi1993N-linked (GlcNAc...)Sequence analysis1
Glycosylationi2030N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi2065 ↔ 2224By similarity
Glycosylationi2133N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi2234 ↔ 2246By similarity
Disulfide bondi2241 ↔ 2259By similarity
Disulfide bondi2253 ↔ 2268By similarity
Disulfide bondi2391 ↔ 2403By similarity
Disulfide bondi2398 ↔ 2416By similarity
Disulfide bondi2410 ↔ 2425By similarity
Disulfide bondi2464 ↔ 2476By similarity
Disulfide bondi2471 ↔ 2489By similarity
Disulfide bondi2483 ↔ 2498By similarity
Disulfide bondi2501 ↔ 2537By similarity
Disulfide bondi2512 ↔ 2516By similarity
Disulfide bondi2547 ↔ 2552By similarity
Disulfide bondi2567 ↔ 2604By similarity
Disulfide bondi2571 ↔ 2609By similarity
Disulfide bondi2582 ↔ 2594By similarity
Glycosylationi2645N-linked (GlcNAc...)Sequence analysis1
Glycosylationi2694N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi2716 ↔ 2754By similarity
Disulfide bondi2727 ↔ 2731By similarity
Disulfide bondi2764 ↔ 2768By similarity
Disulfide bondi2784 ↔ 2822By similarity
Disulfide bondi2788 ↔ 2827By similarity
Disulfide bondi2804 ↔ 2812By similarity
Disulfide bondi2842 ↔ 2877By similarity
Disulfide bondi2846 ↔ 2882By similarity
Disulfide bondi2857 ↔ 2867By similarity
Glycosylationi2936N-linked (GlcNAc...)Sequence analysis1
Glycosylationi2967N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi2986 ↔ 3024By similarity
Disulfide bondi2997 ↔ 3001By similarity
Disulfide bondi3034 ↔ 3039By similarity
Glycosylationi3062N-linked (GlcNAc...)Sequence analysis1
Glycosylationi3116N-linked (GlcNAc...)Sequence analysis1
Glycosylationi3163N-linked (GlcNAc...)Sequence analysis1
Glycosylationi3173N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi3195 ↔ 3244By similarity
Disulfide bondi3199 ↔ 3249By similarity
Disulfide bondi3210 ↔ 3234By similarity
Disulfide bondi3264 ↔ 3301By similarity
Disulfide bondi3268 ↔ 3306By similarity
Disulfide bondi3279 ↔ 3291By similarity
Glycosylationi3310N-linked (GlcNAc...)Sequence analysis1
Glycosylationi3399N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi3420 ↔ 3463By similarity
Disulfide bondi3424 ↔ 3469By similarity
Disulfide bondi3435 ↔ 3447By similarity
Disulfide bondi3484 ↔ 3519By similarity
Disulfide bondi3487 ↔ 3526By similarity
Disulfide bondi3497 ↔ 3509By similarity
Glycosylationi3512N-linked (GlcNAc...)Sequence analysis1
Glycosylationi3522N-linked (GlcNAc...)Sequence analysis1
Glycosylationi3599N-linked (GlcNAc...)Sequence analysis1
Glycosylationi3626N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi3657 ↔ 3687By similarity
Disulfide bondi3661 ↔ 3692By similarity
Disulfide bondi3672 ↔ 3677By similarity
Glycosylationi3792N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi3823 ↔ 3926By similarity
Disulfide bondi3827 ↔ 3931By similarity
Disulfide bondi3839 ↔ 3851By similarity
Glycosylationi3914N-linked (GlcNAc...)Sequence analysis1
Glycosylationi3946N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi3947 ↔ 3983By similarity
Disulfide bondi3958 ↔ 3962By similarity
Disulfide bondi3996 ↔ 4001By similarity
Disulfide bondi4016 ↔ 4053By similarity
Disulfide bondi4020 ↔ 4058By similarity
Disulfide bondi4031 ↔ 4043By similarity
Glycosylationi4139N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi4160 ↔ 4196By similarity
Disulfide bondi4171 ↔ 4175By similarity
Disulfide bondi4206 ↔ 4211By similarity
Glycosylationi4346N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi4366 ↔ 4403By similarity
Disulfide bondi4377 ↔ 4379By similarity
Disulfide bondi4413 ↔ 4418By similarity
Glycosylationi4417N-linked (GlcNAc...)Sequence analysis1
Glycosylationi4731N-linked (GlcNAc...)Sequence analysis1
Glycosylationi4748N-linked (GlcNAc...)Sequence analysis1
Glycosylationi4753N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi4775 ↔ 4810By similarity
Disulfide bondi4779 ↔ 4815By similarity
Disulfide bondi4790 ↔ 4799By similarity
Glycosylationi4863N-linked (GlcNAc...)Sequence analysis1
Glycosylationi4903N-linked (GlcNAc...)Sequence analysis1
Glycosylationi4948N-linked (GlcNAc...)Sequence analysis1
Glycosylationi4955N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi5041 ↔ 5101By similarity
Glycosylationi5061N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi5067 ↔ 5118By similarity
Disulfide bondi5077 ↔ 5134By similarity
Disulfide bondi5081 ↔ 5136By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiA2VEC9.

PTM databases

iPTMnetiA2VEC9.
PhosphoSitePlusiA2VEC9.

Expressioni

Gene expression databases

CleanExiHS_SSPO.

Interactioni

Protein-protein interaction databases

BioGridi116762. 3 interactors.

Structurei

3D structure databases

ProteinModelPortaliA2VEC9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini18 – 102EMIAdd BLAST85
Domaini194 – 408VWFD 1PROSITE-ProRule annotationAdd BLAST215
Domaini469 – 524TIL 1Add BLAST56
Domaini563 – 773VWFD 2PROSITE-ProRule annotationAdd BLAST211
Domaini827 – 879TIL 2Add BLAST53
Domaini880 – 939VWFC 1PROSITE-ProRule annotationAdd BLAST60
Domaini1013 – 1219VWFD 3PROSITE-ProRule annotationAdd BLAST207
Domaini1275 – 1331TIL 3Add BLAST57
Domaini1375 – 1412LDL-receptor class A 1PROSITE-ProRule annotationAdd BLAST38
Domaini1415 – 1450LDL-receptor class A 2PROSITE-ProRule annotationAdd BLAST36
Domaini1451 – 1487LDL-receptor class A 3PROSITE-ProRule annotationAdd BLAST37
Domaini1491 – 1529LDL-receptor class A 4PROSITE-ProRule annotationAdd BLAST39
Domaini1564 – 1600LDL-receptor class A 5PROSITE-ProRule annotationAdd BLAST37
Domaini1602 – 1641LDL-receptor class A 6PROSITE-ProRule annotationAdd BLAST40
Domaini1655 – 1693LDL-receptor class A 7PROSITE-ProRule annotationAdd BLAST39
Domaini1694 – 1748TSP type-1 1PROSITE-ProRule annotationAdd BLAST55
Domaini1750 – 1808TSP type-1 2PROSITE-ProRule annotationAdd BLAST59
Domaini1824 – 1863EGF-like 1Add BLAST40
Domaini1864 – 1901EGF-like 2Add BLAST38
Domaini1909 – 1965TSP type-1 3PROSITE-ProRule annotationAdd BLAST57
Domaini1965 – 2025VWFC 2PROSITE-ProRule annotationAdd BLAST61
Domaini2065 – 2224F5/8 type CPROSITE-ProRule annotationAdd BLAST160
Domaini2233 – 2269LDL-receptor class A 8PROSITE-ProRule annotationAdd BLAST37
Domaini2390 – 2426LDL-receptor class A 9PROSITE-ProRule annotationAdd BLAST37
Domaini2463 – 2499LDL-receptor class A 10PROSITE-ProRule annotationAdd BLAST37
Domaini2500 – 2553TSP type-1 4PROSITE-ProRule annotationAdd BLAST54
Domaini2555 – 2610TSP type-1 5PROSITE-ProRule annotationAdd BLAST56
Domaini2633 – 2675TIL 4Add BLAST43
Domaini2715 – 2769TSP type-1 6PROSITE-ProRule annotationAdd BLAST55
Domaini2772 – 2828TSP type-1 7PROSITE-ProRule annotationAdd BLAST57
Domaini2830 – 2883TSP type-1 8PROSITE-ProRule annotationAdd BLAST54
Domaini2985 – 3040TSP type-1 9PROSITE-ProRule annotationAdd BLAST56
Domaini3041 – 3083TSP type-1 10PROSITE-ProRule annotationAdd BLAST43
Domaini3183 – 3250TSP type-1 11PROSITE-ProRule annotationAdd BLAST68
Domaini3252 – 3307TSP type-1 12PROSITE-ProRule annotationAdd BLAST56
Domaini3311 – 3365TIL 5Add BLAST55
Domaini3408 – 3470TSP type-1 13PROSITE-ProRule annotationAdd BLAST63
Domaini3472 – 3527TSP type-1 14PROSITE-ProRule annotationAdd BLAST56
Domaini3645 – 3693TSP type-1 15PROSITE-ProRule annotationAdd BLAST49
Domaini3811 – 3932TSP type-1 16PROSITE-ProRule annotationAdd BLAST122
Domaini3946 – 4002TSP type-1 17PROSITE-ProRule annotationAdd BLAST57
Domaini4004 – 4059TSP type-1 18PROSITE-ProRule annotationAdd BLAST56
Domaini4159 – 4212TSP type-1 19PROSITE-ProRule annotationAdd BLAST54
Domaini4253 – 4305TSP type-1 20PROSITE-ProRule annotationAdd BLAST53
Domaini4307 – 4363TSP type-1 21PROSITE-ProRule annotationAdd BLAST57
Domaini4365 – 4419TSP type-1 22PROSITE-ProRule annotationAdd BLAST55
Domaini4615 – 4665TSP type-1 23PROSITE-ProRule annotationAdd BLAST51
Domaini4667 – 4723TIL 6Add BLAST57
Domaini4763 – 4816TSP type-1 24PROSITE-ProRule annotationAdd BLAST54
Domaini4984 – 5042VWFC 3PROSITE-ProRule annotationAdd BLAST59
Domaini5041 – 5140CTCKPROSITE-ProRule annotationAdd BLAST100

Sequence similaritiesi

Belongs to the thrombospondin family.Curated
Contains 1 CTCK (C-terminal cystine knot-like) domain.PROSITE-ProRule annotation
Contains 2 EGF-like domains.Curated
Contains 1 EMI domain.Curated
Contains 1 F5/8 type C domain.PROSITE-ProRule annotation
Contains 10 LDL-receptor class A domains.PROSITE-ProRule annotation
Contains 24 TSP type-1 domains.PROSITE-ProRule annotation
Contains 3 VWFC domains.PROSITE-ProRule annotation
Contains 3 VWFD domains.PROSITE-ProRule annotation

Keywords - Domaini

EGF-like domain, Repeat, Signal

Phylogenomic databases

HOGENOMiHOG000154433.
HOVERGENiHBG080794.
InParanoidiA2VEC9.
PhylomeDBiA2VEC9.

Family and domain databases

Gene3Di2.60.120.260. 1 hit.
4.10.400.10. 10 hits.
InterProiIPR006207. Cys_knot_C.
IPR000421. FA58C.
IPR008979. Galactose-bd-like.
IPR023415. LDLR_class-A_CS.
IPR002172. LDrepeatLR_classA_rpt.
IPR008037. Pacifastin_dom.
IPR002919. TIL_dom.
IPR000884. TSP1_rpt.
IPR014853. Unchr_dom_Cys-rich.
IPR001007. VWF_dom.
IPR001846. VWF_type-D.
[Graphical view]
PfamiPF08742. C8. 3 hits.
PF00754. F5_F8_type_C. 1 hit.
PF00057. Ldl_recept_a. 8 hits.
PF01826. TIL. 14 hits.
PF00090. TSP_1. 21 hits.
PF00094. VWD. 3 hits.
[Graphical view]
PRINTSiPR00261. LDLRECEPTOR.
SMARTiSM00832. C8. 3 hits.
SM00231. FA58C. 1 hit.
SM00192. LDLa. 10 hits.
SM00209. TSP1. 25 hits.
SM00214. VWC. 6 hits.
SM00215. VWC_out. 9 hits.
SM00216. VWD. 3 hits.
[Graphical view]
SUPFAMiSSF49785. SSF49785. 1 hit.
SSF57283. SSF57283. 1 hit.
SSF57424. SSF57424. 10 hits.
SSF57567. SSF57567. 14 hits.
SSF82895. SSF82895. 23 hits.
PROSITEiPS01225. CTCK_2. 1 hit.
PS00022. EGF_1. 1 hit.
PS50022. FA58C_3. 1 hit.
PS01209. LDLRA_1. 8 hits.
PS50068. LDLRA_2. 10 hits.
PS50092. TSP1. 24 hits.
PS01208. VWFC_1. 1 hit.
PS50184. VWFC_2. 2 hits.
PS51233. VWFD. 3 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: A2VEC9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MLLPALLFGM AWALADGRWC EWTETIRVEE EVAPRQEDLV PCASLDHYSR
60 70 80 90 100
LGWRLDLPWS GRSGLTRSPA PGLCPIYKPP ETRPAKWNRT VRTCCPGWGG
110 120 130 140 150
AHCTEALAKA SPEGHCFAMW QCQLQAGSAN ASAGSLEECC ARPWGQSWWD
160 170 180 190 200
GSSQACRSCS SRHLPGSASS PALLQPLAGA VGQLWSQHQR PSATCASWSG
210 220 230 240 250
FHYRTFDGRH YHFLGRCTYL LAGAADSTWA VHLTPGDRCP QPGHCQRVTM
260 270 280 290 300
GPEEVLIQAG NVSVKGQLVP EGQSWLLHGL SLQWLGDWLV LSGGLGVVVR
310 320 330 340 350
LDRTGSISIS VDHELWGQTQ GLCGLYNGWP EDDFMEPGGG LAMLAATFGN
360 370 380 390 400
SWRLPGSESG CLDAVEVAQG CDPLGLIDAD VEPGHLRAEA QDVCHQLLEG
410 420 430 440 450
PFGQCHAQVS PAEYHEACLF AYCAGAMAGS GQEGRQQAVC ATFASYVQAC
460 470 480 490 500
ARRHIHIRWR KPGFCERLCP GGQLYSDCVS LCPPSCEAVG QGEEESCREE
510 520 530 540 550
CVSGCECPRG LFWNGTLCVP AAHCPCYYCR QRYVPGDTVR QLCNPCVCRD
560 570 580 590 600
GRWHCAQALC PAECAVGGDG HYLTFDGRSY SFWGGQGCRY SLVQDYVKGQ
610 620 630 640 650
LLILLEHGAC DAGSCLHAIS VSLEDTHIQL RDSGAVLVNG QDVGLPWIGA
660 670 680 690 700
EGLSVRRASS AFLLLRWPGA QVLWGLSDPV AYITLDPRHA HQVQGLCGTF
710 720 730 740 750
TQNQQDDFLT PAGDVETSIA AFASKFQVAG KGRCPSEDSA LLSPCTTHSQ
760 770 780 790 800
RHAFAEAACA ILHSSVFQEC HRLVDKEPFY LRCLAAVCGC DPGSDCLCPV
810 820 830 840 850
LSAYARRCAQ EGASPPWRNQ TLCPVMCPGG QEYRECAPAC GQHCGKPEDC
860 870 880 890 900
GELGSCVAGC NCPLGLLWDP EGQCVPPSLC PCQLGARRYA PGSATMKECN
910 920 930 940 950
RCICQERGLW NCTARHCPSQ AFCPRELVYA PGACLLTCDS PSANHSCPAG
960 970 980 990 1000
STDGCVCPPG TVLLDERCVP PDLCPCRHSG QWYLPNATIQ EDCNVCVCRG
1010 1020 1030 1040 1050
RQWHCTGQRR SGRCQASGAP HYVTFDGLAF TYPGACEYLL VREASGLFTV
1060 1070 1080 1090 1100
SAQNLPCGAS GLTCTKALAV RLEGTVVHML RGRAVTVNGV SVTPPKVYTG
1110 1120 1130 1140 1150
PGLSLRRAGL FLLLSTHLGL TLLWDGGTRV LVQLSPQFRG RVAGLCGDFD
1160 1170 1180 1190 1200
GDASNDLRSR QGVLEPTAEL AAHSWRLSPL CPEPGDLPHP CTMNTHRAGW
1210 1220 1230 1240 1250
ARARCGALLQ PLFTLCHAEV PPQQHYEWCL YDACGCDSGG DCECLCSAIA
1260 1270 1280 1290 1300
TYADECARHG HHVRWRSQEL CSLQCEGGQV YEACGPTCPP TCHEQHPEPG
1310 1320 1330 1340 1350
WHCQVVACVE GCFCPEGTLL HGGACLEPAS CPCEWGRNSF PPGSVLQKDC
1360 1370 1380 1390 1400
GNCTCQEGQW HCGGDGGHCE ELVPACAEGE ALCQENGHCV PHGWLCDNQD
1410 1420 1430 1440 1450
DCGDGSDEEG CAAPGCGEGQ MTCSSGHCLP LALLCDRQDD CGDGTDEPSY
1460 1470 1480 1490 1500
PCPQGLLACA DGRCLPPALL CDGHPDCLDA ADEESCLGQV TCVPGEVSCV
1510 1520 1530 1540 1550
DGTCLGAIQL CDGVWDCPDG ADEGPGHCPL PSLPTPPAST LPGPSPGSLD
1560 1570 1580 1590 1600
TASSPLASAS PAPPCGPFEF RCGSGECTPR GWRCDQEEDC ADGSDERGCG
1610 1620 1630 1640 1650
GPCAPHHAPC ARGPHCVSPE QLCDGVRQCP DGSDEGPDAC GGLPALGGPN
1660 1670 1680 1690 1700
RTGLPCPEYT CPNGTCIGFQ LVCDGQPDCG RPGQVGPSPE EQGCGAWGPW
1710 1720 1730 1740 1750
SPWGPCSRTC GPWGQGRSRR CSPLGLLVLQ NCPGPEHQSQ ACFTAACPVD
1760 1770 1780 1790 1800
GEWSTWSPWS VCSEPCRGTM TRQRQCHSPQ NGGRTCAALP GGLHSTRQTK
1810 1820 1830 1840 1850
PCPQDGCPNA TCSGELMFQP CAPCPLTCDD ISGQVTCPPD WPCGSPGCWC
1860 1870 1880 1890 1900
PEGQVLGSEG WCVWPRQCPC LVDGARYWPG QRIKADCQLC ICQDGRPRRC
1910 1920 1930 1940 1950
RLNPDCAVDC GWSSWSPWAK CLGPCGSQSI QWSFRSSNNP RPSGRGRQCR
1960 1970 1980 1990 2000
GIHRKARRCQ TEPCEGCEHQ GQVHRVGERW HGGPCRVCQC LHNLTAHCSP
2010 2020 2030 2040 2050
YCPLGSCPQG WVLVEGTGES CCHCALPGEN QTVQPMATPA AAPAPSPQIR
2060 2070 2080 2090 2100
FPLATYILPP SGDPCYSPLG LAGLAEGSLH ASSQQLEHPT QAALLGAPTQ
2110 2120 2130 2140 2150
GPSPQGWHAG GDAYAKWHTR PHYLQLDLLQ PRNLTGILVP ETGSSNAYAS
2160 2170 2180 2190 2200
SFSLQFSSNG LHWHDYRDLL PGILPLPKLF PRNWDDLDPA VWTFGRMVQA
2210 2220 2230 2240 2250
RFVRVWPHDV HHSDVPLQVE LLGCEPGSPP APLCPGVGLR CASGECVLRG
2260 2270 2280 2290 2300
GPCDGVLDCE DGSDEEGCVL LPEGTGRFHS TAKTLALSSA QPGQLLHWPR
2310 2320 2330 2340 2350
EGLAETEHWP PGQESPTSPT ETRPVSPGPA SGVPHHGESV QMVTTTPIPQ
2360 2370 2380 2390 2400
MEARTLPPGM AAVTVVPPHP VTPATPAGQS VAPGPFPPVQ CGPGQTPCEV
2410 2420 2430 2440 2450
LGCVEQAQVC DGREDCLDGS DERHCARNLL MWLPSLPALW AASTVPFMMP
2460 2470 2480 2490 2500
TMALPGLPAS RALCSPSQLS CGSGECLSAE RRCDLRPDCQ DGSDEDGCVD
2510 2520 2530 2540 2550
CVLAPWSVWS SCSRSCGLGL TFQRQELLRP PLPGGSCPRD RFRSQSCFVQ
2560 2570 2580 2590 2600
ACPVAGAWAM WEAWGPCSVS CGGGHQSRQR SCVDPPPKNG GAPCPGASQE
2610 2620 2630 2640 2650
RAPCGLQPCS GGTDCELGRV YVSADLCQKG LVPPCPPSCL DPKANRSCSG
2660 2670 2680 2690 2700
HCVEGCRCPP GLLLHDTRCL PLSECPCLVG EELKWPGVSF LLGNCSQCVC
2710 2720 2730 2740 2750
EKGELLCQPG GCPLPCGWSA WSSWAPCDRS CGSGVRARFR SPSNPPAAWG
2760 2770 2780 2790 2800
GAPCEGDRQE LQGCHTVCGT EVFGWTPWTS WSSCSQSCLA PGGGPGWRSR
2810 2820 2830 2840 2850
SRLCPSPGDS SCPGDATQEE PCSPPVCPVP SIWGLWAPWS TCSAPCDGGI
2860 2870 2880 2890 2900
QTRGRSCSSL APGDTTCPGP HSQTRDCNTQ PCTAQCPENM LFRSAEQCHQ
2910 2920 2930 2940 2950
EGGPCPRLCL TQGPGIECTG FCAPGCTCPP GLFLHNASCL PRSQCPCQLH
2960 2970 2980 2990 3000
GQLYASGAMA RLDSCNNCTC VSGKMACTSE RCPVACGWSP WTLWSLCSCS
3010 3020 3030 3040 3050
CNVGIRRRFR AGTAPPAAFG GAECQGPTME AEFCSLRPCP GPGGEWGPWS
3060 3070 3080 3090 3100
PCSVPCGGGY RNRTRGSSRS LMEFSTCGLQ PCAGPVPGMC PRDKQWLDCA
3110 3120 3130 3140 3150
QGPASCAELS APRGTNQTCH PGCHCPSGML LLNNVCVPTQ DCPCAHEGHL
3160 3170 3180 3190 3200
YPPGSTVVRP CENCSCVSGL IANCSSWPCA EGEPTWSPWT PWSQCSASCG
3210 3220 3230 3240 3250
PARCHRHRFC ARSPSAVPST VAPLPLPATP TPLCSGPEAE EEPCLLQGCD
3260 3270 3280 3290 3300
RAGGWGPWGP WSHCSRSCGG GLRSRTRACD QPPPQGLGDY CEGPRAQGEV
3310 3320 3330 3340 3350
CQALPCPVTN CTAIEGAEYS PCGPPCPRSC DDLVHCVWRC QPGCYCPPGQ
3360 3370 3380 3390 3400
VLSSNGAICV QPGHCSCLDL LTGQRHHPGA RLARPDGCNH CTCLEGRLNC
3410 3420 3430 3440 3450
TDLPCPVPGG WCPWSEWTMC SQPCRGQTRS RSRACACPTP QHGGAPCTGE
3460 3470 3480 3490 3500
AGEAGAQHQR EACPSYATCP VDGAWGPWGP WSPCDMCLGQ SHRSRACSRP
3510 3520 3530 3540 3550
PTPEGGRPCP GNHTQSRPCQ ENSTQCTDCG GGQSLHPCGQ PCPRSCQDLS
3560 3570 3580 3590 3600
PGSVCQPGSV GCQPTCGCPL GQLSQDGLCV PPAHCRCQYQ PGAMGIPENQ
3610 3620 3630 3640 3650
SRSAGSRFSS WESLEPGEVV TGPCDNCTCV AGILQCQEVP DCPDPGVWSS
3660 3670 3680 3690 3700
WGPWEDCSVS CGGGEQLRSR RCARPPCPGP ARQSRTCSTQ VCREAGCPAG
3710 3720 3730 3740 3750
RLYRECQPGE GCPFSCAHVT QQVGCFSEGC EEGCHCPEGT FQHRLACVQE
3760 3770 3780 3790 3800
CPCVLTAWLL QELGATIGDP GQPLGPGDEL DSGQTLRTSC GNCSCAHGKL
3810 3820 3830 3840 3850
SCSLDDCFEA DGGFGPWSPW GPCSRSCGGL GTRTRSRQCV LTMPTLSGQG
3860 3870 3880 3890 3900
CRGPRQDLEC PSPDCPGAEG STVEPVTGLP GGWGPWSSWS PCSRSCTDPA
3910 3920 3930 3940 3950
RPAWRSRTRL CLANCTMGDP LQERPCNLPS CTELPVCPGP GCGAGNCSWT
3960 3970 3980 3990 4000
SWAPWEPCSR SCGVGQQRRL RAYRPPGPGG HWCPNILTAY QERRFCNLRA
4010 4020 4030 4040 4050
CPVPGGWSRW SPWSWCDRSC GGGQSLRSRS CSSPPSKNGG APCAGERHQA
4060 4070 4080 4090 4100
RLCNPMPCEA GCPAGMEVVT CANRCPRRCS DLQEGIVCQD DQVCQKGCRC
4110 4120 4130 4140 4150
PKGSLEQDGG CVPIGHCDCT DAQGHSWAPG SQHQDACNNC SCQAGQLSCT
4160 4170 4180 4190 4200
AQPCPPPTHC AWSHWSAWSP CSHSCGPRGQ QSRFRSSTSG SWAPECREEQ
4210 4220 4230 4240 4250
SQSQPCPQPS CPPLCLQGTR SRTLGDSWLQ GECQRCSCTP EGVICEDTEC
4260 4270 4280 4290 4300
AVPEAWTLWS SWSDCPVSCG GGNQVRTRAC RAAAPHHRSP PCLGPDTQTR
4310 4320 4330 4340 4350
QQPCPGLLEA CSWGPWGPCS RSCGPGLASR SGSCPCLMAK ADPTCNSTFL
4360 4370 4380 4390 4400
HLDTQGCYSG PCPEECVWSS WSSWTRCSCR VLVQQRYRHQ GPASRGARAG
4410 4420 4430 4440 4450
APCTRLDGHF RPCLISNCSE DSCTPPFEFH ACGSPCAGLC ATHLSHQLCQ
4460 4470 4480 4490 4500
DLPPCQPGCY CPKGLLEQAG GCIPPEECNC WHTSAAGAGM TLAPGDRLQL
4510 4520 4530 4540 4550
GCKECECRRG ELHCTSQGCQ GLLPLSEWSE WSPCGPCLPP SALAPASRTA
4560 4570 4580 4590 4600
LEEHWLRDPT GLSPTLAPLL ASEQHRHRLC LDPATGRPWT GAPHLCTAPL
4610 4620 4630 4640 4650
SQQRLCPDPG ACPDSCQWSL WGPWSPCQVP CSGGFRLRWR EAEALCGGGC
4660 4670 4680 4690 4700
REPWAQESCN GGPCPECEAQ DTVFTLDCAN QCPHSCADLW DRVQCLQGPC
4710 4720 4730 4740 4750
RPGCRCPPGQ LVQDGRCVPI SSCRCGLPSA NASWELAPAQ AVQLDCQNCT
4760 4770 4780 4790 4800
CVNESLVCPH QECPVLGPWS AWSSCSAPCG GGTMERHRTC EGGPGVAPCQ
4810 4820 4830 4840 4850
AQDTEQRQEC NLQPCPECPP GQVLSACATS CPCLCWHLQP GAICVQEPCQ
4860 4870 4880 4890 4900
PGCGCPGGQL LHNGTCVPPT ACPCTQHSLP WGLTLTLEEQ AQELPPGTVL
4910 4920 4930 4940 4950
TRNCTRCVCH GGAFSCSLVD CQVPPGETWQ QVAPGELGLC EQTCLEMNAT
4960 4970 4980 4990 5000
KTQSNCSSAR ASGCVCQPGH FRSQAGPCVP EDHCECWHLG RPHLPGSEWQ
5010 5020 5030 5040 5050
EACESCLCLS GRPVCTQHCS PLTCAQGEEM VLEPGSCCPS CRREAPEEQS
5060 5070 5080 5090 5100
PSCQLLTELR NFTKGTCYLD QVEVSYCSGY CPSSTHVMPE EPYLQSQCDC
5110 5120 5130 5140
CSYRLDPESP VRILNLRCLG GHTEPVVLPV IHSCQCSSCQ GGDFSKR
Length:5,147
Mass (Da):547,504
Last modified:March 20, 2007 - v1
Checksum:i9A8F5C3179F028A3
GO
Isoform 2 (identifier: A2VEC9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1122: Missing.
     1123-1126: LWDG → MLPP
     1639-1639: A → ACVEAPAPPA...DCPQGEDELD
     1671-1671: L → LVRVGVGGGGGSAMLPPSTRALTPLPPQ
     2179-2314: LFPRNWDDLD...ETEHWPPGQE → VSPAQGRWGQ...RSGRNQSVLC
     2315-5147: Missing.

Note: No experimental confirmation available.
Show »
Length:1,314
Mass (Da):138,775
Checksum:i2876F7F1383080E8
GO

Sequence cautioni

The sequence BAC98376 differs from that shown. Reason: Erroneous initiation.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_052660146Q → R.Corresponds to variant rs709061dbSNPEnsembl.1
Natural variantiVAR_052661298V → M.Corresponds to variant rs17754559dbSNPEnsembl.1
Natural variantiVAR_059863539V → M.Corresponds to variant rs855677dbSNPEnsembl.1
Natural variantiVAR_0757091001R → W Found in patient with Joubert syndrome; unknown pathological significance. 1 PublicationCorresponds to variant rs199648588dbSNPEnsembl.1
Natural variantiVAR_0598641272S → P.Corresponds to variant rs709060dbSNPEnsembl.1
Natural variantiVAR_0526621273L → P.Corresponds to variant rs709060dbSNPEnsembl.1
Natural variantiVAR_0598651424S → G.Corresponds to variant rs855691dbSNPEnsembl.1
Natural variantiVAR_0598661448P → Q.Corresponds to variant rs855692dbSNPEnsembl.1
Natural variantiVAR_0598671453P → R.Corresponds to variant rs2074704dbSNPEnsembl.1
Natural variantiVAR_0598681778S → P.Corresponds to variant rs893601dbSNPEnsembl.1
Natural variantiVAR_0598691793L → P.Corresponds to variant rs1635802dbSNPEnsembl.1
Natural variantiVAR_0598701882R → C.Corresponds to variant rs1076277dbSNPEnsembl.1
Natural variantiVAR_0598712017T → M.Corresponds to variant rs4725314dbSNPEnsembl.1
Natural variantiVAR_0619152452M → T.Corresponds to variant rs2074689dbSNPEnsembl.1
Natural variantiVAR_0619162541R → Q.Corresponds to variant rs59522380dbSNPEnsembl.1
Natural variantiVAR_0757102798R → C Found in patient with Joubert syndrome; unknown pathological significance. 1 PublicationCorresponds to variant rs181269877dbSNPEnsembl.1
Natural variantiVAR_0598722891L → V.Corresponds to variant rs10260959dbSNPEnsembl.1
Natural variantiVAR_0598733273R → W.Corresponds to variant rs740109dbSNPEnsembl.1
Natural variantiVAR_0598743512N → S.Corresponds to variant rs10952230dbSNPEnsembl.1
Natural variantiVAR_0598753892C → W.Corresponds to variant rs1557955dbSNPEnsembl.1
Natural variantiVAR_0598763909R → C.Corresponds to variant rs745044dbSNPEnsembl.1
Natural variantiVAR_0598774028S → I.Corresponds to variant rs1005603dbSNPEnsembl.1
Natural variantiVAR_0619174107Q → H.Corresponds to variant rs12536873dbSNPEnsembl.1
Natural variantiVAR_0598784164H → R.Corresponds to variant rs10233245dbSNPEnsembl.1
Natural variantiVAR_0598794330R → C.Corresponds to variant rs1008336dbSNPEnsembl.1
Natural variantiVAR_0598804787H → R.Corresponds to variant rs1004200dbSNPEnsembl.1
Natural variantiVAR_0598814941E → K.Corresponds to variant rs12534509dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0352581 – 1122Missing in isoform 2. 1 PublicationAdd BLAST1122
Alternative sequenceiVSP_0352591123 – 1126LWDG → MLPP in isoform 2. 1 Publication4
Alternative sequenceiVSP_0352601639A → ACVEAPAPPAMRGPPGQAGG PTSSRAPSPPSPPEAQGEGR KGQERSRTHLTVPAGSTQLP LCPGLFPCGVAPGLCLTPEQ LCDGIPDCPQGEDELD in isoform 2. 1 Publication1
Alternative sequenceiVSP_0352611671L → LVRVGVGGGGGSAMLPPSTR ALTPLPPQ in isoform 2. 1 Publication1
Alternative sequenceiVSP_0352622179 – 2314LFPRN…PPGQE → VSPAQGRWGQQPTMPFCGFH SLCPQGPSSVPEGHGLHSML VEYLVSSRDCALWSRGLGAT VTWMLETIQVAQTQGRYVKP ARERGWGDTKFTEGLREPRP THVFVESSLGTALPSGGLHP SRRQTARSGRNQSVLC in isoform 2. 1 PublicationAdd BLAST136
Alternative sequenceiVSP_0352632315 – 5147Missing in isoform 2. 1 PublicationAdd BLAST2833

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB111888 mRNA. Translation: BAC98376.1. Different initiation.
AC004877 Genomic DNA. No translation available.
BN000852 mRNA. Translation: CAJ43920.1.
RefSeqiNP_940857.2. NM_198455.2. [A2VEC9-1]
UniGeneiHs.632022.

Genome annotation databases

GeneIDi23145.
KEGGihsa:23145.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB111888 mRNA. Translation: BAC98376.1. Different initiation.
AC004877 Genomic DNA. No translation available.
BN000852 mRNA. Translation: CAJ43920.1.
RefSeqiNP_940857.2. NM_198455.2. [A2VEC9-1]
UniGeneiHs.632022.

3D structure databases

ProteinModelPortaliA2VEC9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116762. 3 interactors.

PTM databases

iPTMnetiA2VEC9.
PhosphoSitePlusiA2VEC9.

Polymorphism and mutation databases

BioMutaiSSPO.

Proteomic databases

PRIDEiA2VEC9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi23145.
KEGGihsa:23145.

Organism-specific databases

CTDi23145.
DisGeNETi23145.
GeneCardsiSSPO.
H-InvDBHIX0007194.
HGNCiHGNC:21998. SSPO.
neXtProtiNX_A2VEC9.
PharmGKBiPA142670865.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

HOGENOMiHOG000154433.
HOVERGENiHBG080794.
InParanoidiA2VEC9.
PhylomeDBiA2VEC9.

Enzyme and pathway databases

BioCyciZFISH:G66-33365-MONOMER.
ReactomeiR-HSA-5083635. Defective B3GALTL causes Peters-plus syndrome (PpS).
R-HSA-5173214. O-glycosylation of TSR domain-containing proteins.

Miscellaneous databases

ChiTaRSiSSPO. human.
GeneWikiiSSPO.
GenomeRNAii23145.
PROiA2VEC9.

Gene expression databases

CleanExiHS_SSPO.

Family and domain databases

Gene3Di2.60.120.260. 1 hit.
4.10.400.10. 10 hits.
InterProiIPR006207. Cys_knot_C.
IPR000421. FA58C.
IPR008979. Galactose-bd-like.
IPR023415. LDLR_class-A_CS.
IPR002172. LDrepeatLR_classA_rpt.
IPR008037. Pacifastin_dom.
IPR002919. TIL_dom.
IPR000884. TSP1_rpt.
IPR014853. Unchr_dom_Cys-rich.
IPR001007. VWF_dom.
IPR001846. VWF_type-D.
[Graphical view]
PfamiPF08742. C8. 3 hits.
PF00754. F5_F8_type_C. 1 hit.
PF00057. Ldl_recept_a. 8 hits.
PF01826. TIL. 14 hits.
PF00090. TSP_1. 21 hits.
PF00094. VWD. 3 hits.
[Graphical view]
PRINTSiPR00261. LDLRECEPTOR.
SMARTiSM00832. C8. 3 hits.
SM00231. FA58C. 1 hit.
SM00192. LDLa. 10 hits.
SM00209. TSP1. 25 hits.
SM00214. VWC. 6 hits.
SM00215. VWC_out. 9 hits.
SM00216. VWD. 3 hits.
[Graphical view]
SUPFAMiSSF49785. SSF49785. 1 hit.
SSF57283. SSF57283. 1 hit.
SSF57424. SSF57424. 10 hits.
SSF57567. SSF57567. 14 hits.
SSF82895. SSF82895. 23 hits.
PROSITEiPS01225. CTCK_2. 1 hit.
PS00022. EGF_1. 1 hit.
PS50022. FA58C_3. 1 hit.
PS01209. LDLRA_1. 8 hits.
PS50068. LDLRA_2. 10 hits.
PS50092. TSP1. 24 hits.
PS01208. VWFC_1. 1 hit.
PS50184. VWFC_2. 2 hits.
PS51233. VWFD. 3 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSSPO_HUMAN
AccessioniPrimary (citable) accession number: A2VEC9
Secondary accession number(s): Q76B61
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 12, 2007
Last sequence update: March 20, 2007
Last modified: November 2, 2016
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.