A2VEC9 (SSPO_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
SCO-spondin

Gene names

Name:	SSPO
Synonyms:	KIAA2036

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	5147 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Involved in the modulation of neuronal aggregation. May be involved in developmental events during the formation of the central nervous system By similarity.
Subcellular location	Secreted › extracellular space By similarity.
Sequence similarities	Belongs to the thrombospondin family. Contains 1 CTCK (C-terminal cystine knot-like) domain. Contains 2 EGF-like domains. Contains 1 EMI domain. Contains 1 F5/8 type C domain. Contains 10 LDL-receptor class A domains. Contains 6 TIL (trypsin inhibitory-like) domains. Contains 24 TSP type-1 domains. Contains 3 VWFC domains. Contains 3 VWFD domains.
Sequence caution	The sequence BAC98376.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Biological process	Cell adhesion
Cellular component	Secreted
Coding sequence diversity	Alternative splicing Polymorphism
Domain	EGF-like domain Repeat Signal
Ligand	Calcium
PTM	Disulfide bond Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	cell adhesion Inferred from electronic annotation. Source: UniProtKB-KW negative regulation of peptidase activity Inferred from electronic annotation. Source: GOC
Cellular_component	extracellular space Traceable author statement PubMed 22261194. Source: BHF-UCL
Molecular_function	peptidase inhibitor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: A2VEC9-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: A2VEC9-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-1122: Missing.
     1123-1126: LWDG → MLPP
     1639-1639: A → ACVEAPAPPA...DCPQGEDELD
     1671-1671: L → LVRVGVGGGGGSAMLPPSTRALTPLPPQ
     2179-2314: LFPRNWDDLD...ETEHWPPGQE → VSPAQGRWGQ...RSGRNQSVLC
     2315-5147: Missing.

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 17	17	Potential
	Chain	18 – 5147	5130	SCO-spondin		PRO_5000223757
Regions
	Domain	18 – 102	85	EMI
	Domain	194 – 408	215	VWFD 1
	Domain	469 – 524	56	TIL 1
	Domain	563 – 773	211	VWFD 2
	Domain	827 – 879	53	TIL 2
	Domain	880 – 939	60	VWFC 1
	Domain	1013 – 1219	207	VWFD 3
	Domain	1275 – 1331	57	TIL 3
	Domain	1375 – 1412	38	LDL-receptor class A 1
	Domain	1415 – 1450	36	LDL-receptor class A 2
	Domain	1451 – 1487	37	LDL-receptor class A 3
	Domain	1491 – 1529	39	LDL-receptor class A 4
	Domain	1564 – 1600	37	LDL-receptor class A 5
	Domain	1602 – 1641	40	LDL-receptor class A 6
	Domain	1655 – 1693	39	LDL-receptor class A 7
	Domain	1694 – 1748	55	TSP type-1 1
	Domain	1750 – 1808	59	TSP type-1 2
	Domain	1824 – 1863	40	EGF-like 1
	Domain	1864 – 1901	38	EGF-like 2
	Domain	1909 – 1965	57	TSP type-1 3
	Domain	1965 – 2025	61	VWFC 2
	Domain	2065 – 2224	160	F5/8 type C
	Domain	2233 – 2269	37	LDL-receptor class A 8
	Domain	2390 – 2426	37	LDL-receptor class A 9
	Domain	2463 – 2499	37	LDL-receptor class A 10
	Domain	2500 – 2553	54	TSP type-1 4
	Domain	2555 – 2610	56	TSP type-1 5
	Domain	2633 – 2675	43	TIL 4
	Domain	2715 – 2769	55	TSP type-1 6
	Domain	2772 – 2828	57	TSP type-1 7
	Domain	2830 – 2883	54	TSP type-1 8
	Domain	2985 – 3040	56	TSP type-1 9
	Domain	3041 – 3083	43	TSP type-1 10
	Domain	3183 – 3250	68	TSP type-1 11
	Domain	3252 – 3307	56	TSP type-1 12
	Domain	3311 – 3365	55	TIL 5
	Domain	3408 – 3470	63	TSP type-1 13
	Domain	3472 – 3527	56	TSP type-1 14
	Domain	3645 – 3693	49	TSP type-1 15
	Domain	3811 – 3932	122	TSP type-1 16
	Domain	3946 – 4002	57	TSP type-1 17
	Domain	4004 – 4059	56	TSP type-1 18
	Domain	4159 – 4212	54	TSP type-1 19
	Domain	4253 – 4305	53	TSP type-1 20
	Domain	4307 – 4363	57	TSP type-1 21
	Domain	4365 – 4419	55	TSP type-1 22
	Domain	4615 – 4665	51	TSP type-1 23
	Domain	4667 – 4723	57	TIL 6
	Domain	4763 – 4816	54	TSP type-1 24
	Domain	4984 – 5042	59	VWFC 3
	Domain	5041 – 5140	100	CTCK
Amino acid modifications
	Glycosylation	88	1	N-linked (GlcNAc...) Potential
	Glycosylation	130	1	N-linked (GlcNAc...) Potential
	Glycosylation	261	1	N-linked (GlcNAc...) Potential
	Glycosylation	514	1	N-linked (GlcNAc...) Potential
	Glycosylation	819	1	N-linked (GlcNAc...) Potential
	Glycosylation	911	1	N-linked (GlcNAc...) Potential
	Glycosylation	944	1	N-linked (GlcNAc...) Potential
	Glycosylation	986	1	N-linked (GlcNAc...) Potential
	Glycosylation	1352	1	N-linked (GlcNAc...) Potential
	Glycosylation	1650	1	N-linked (GlcNAc...) Potential
	Glycosylation	1663	1	N-linked (GlcNAc...) Potential
	Glycosylation	1809	1	N-linked (GlcNAc...) Potential
	Glycosylation	1993	1	N-linked (GlcNAc...) Potential
	Glycosylation	2030	1	N-linked (GlcNAc...) Potential
	Glycosylation	2133	1	N-linked (GlcNAc...) Potential
	Glycosylation	2645	1	N-linked (GlcNAc...) Potential
	Glycosylation	2694	1	N-linked (GlcNAc...) Potential
	Glycosylation	2936	1	N-linked (GlcNAc...) Potential
	Glycosylation	2967	1	N-linked (GlcNAc...) Potential
	Glycosylation	3062	1	N-linked (GlcNAc...) Potential
	Glycosylation	3116	1	N-linked (GlcNAc...) Potential
	Glycosylation	3163	1	N-linked (GlcNAc...) Potential
	Glycosylation	3173	1	N-linked (GlcNAc...) Potential
	Glycosylation	3310	1	N-linked (GlcNAc...) Potential
	Glycosylation	3399	1	N-linked (GlcNAc...) Potential
	Glycosylation	3512	1	N-linked (GlcNAc...) Potential
	Glycosylation	3522	1	N-linked (GlcNAc...) Potential
	Glycosylation	3599	1	N-linked (GlcNAc...) Potential
	Glycosylation	3626	1	N-linked (GlcNAc...) Potential
	Glycosylation	3792	1	N-linked (GlcNAc...) Potential
	Glycosylation	3914	1	N-linked (GlcNAc...) Potential
	Glycosylation	3946	1	N-linked (GlcNAc...) Potential
	Glycosylation	4139	1	N-linked (GlcNAc...) Potential
	Glycosylation	4346	1	N-linked (GlcNAc...) Potential
	Glycosylation	4417	1	N-linked (GlcNAc...) Potential
	Glycosylation	4731	1	N-linked (GlcNAc...) Potential
	Glycosylation	4748	1	N-linked (GlcNAc...) Potential
	Glycosylation	4753	1	N-linked (GlcNAc...) Potential
	Glycosylation	4863	1	N-linked (GlcNAc...) Potential
	Glycosylation	4903	1	N-linked (GlcNAc...) Potential
	Glycosylation	4948	1	N-linked (GlcNAc...) Potential
	Glycosylation	4955	1	N-linked (GlcNAc...) Potential
	Glycosylation	5061	1	N-linked (GlcNAc...) Potential
	Disulfide bond	1376 ↔ 1389		By similarity
	Disulfide bond	1383 ↔ 1402		By similarity
	Disulfide bond	1396 ↔ 1411		By similarity
	Disulfide bond	1416 ↔ 1428		By similarity
	Disulfide bond	1423 ↔ 1441		By similarity
	Disulfide bond	1452 ↔ 1464		By similarity
	Disulfide bond	1459 ↔ 1477		By similarity
	Disulfide bond	1471 ↔ 1486		By similarity
	Disulfide bond	1492 ↔ 1504		By similarity
	Disulfide bond	1499 ↔ 1517		By similarity
	Disulfide bond	1511 ↔ 1528		By similarity
	Disulfide bond	1565 ↔ 1577		By similarity
	Disulfide bond	1572 ↔ 1590		By similarity
	Disulfide bond	1584 ↔ 1599		By similarity
	Disulfide bond	1603 ↔ 1616		By similarity
	Disulfide bond	1610 ↔ 1629		By similarity
	Disulfide bond	1623 ↔ 1640		By similarity
	Disulfide bond	1656 ↔ 1666		By similarity
	Disulfide bond	1661 ↔ 1679		By similarity
	Disulfide bond	1673 ↔ 1694		By similarity
	Disulfide bond	1706 ↔ 1742		By similarity
	Disulfide bond	1710 ↔ 1747		By similarity
	Disulfide bond	1721 ↔ 1732		By similarity
	Disulfide bond	1762 ↔ 1802		By similarity
	Disulfide bond	1766 ↔ 1807		By similarity
	Disulfide bond	1776 ↔ 1786		By similarity
	Disulfide bond	1828 ↔ 1843		By similarity
	Disulfide bond	1837 ↔ 1848		By similarity
	Disulfide bond	1850 ↔ 1862		By similarity
	Disulfide bond	1868 ↔ 1887		By similarity
	Disulfide bond	1870 ↔ 1890		By similarity
	Disulfide bond	1892 ↔ 1900		By similarity
	Disulfide bond	1910 ↔ 1949		By similarity
	Disulfide bond	1921 ↔ 1925		By similarity
	Disulfide bond	1959 ↔ 1964		By similarity
	Disulfide bond	2065 ↔ 2224		By similarity
	Disulfide bond	2234 ↔ 2246		By similarity
	Disulfide bond	2241 ↔ 2259		By similarity
	Disulfide bond	2253 ↔ 2268		By similarity
	Disulfide bond	2391 ↔ 2403		By similarity
	Disulfide bond	2398 ↔ 2416		By similarity
	Disulfide bond	2410 ↔ 2425		By similarity
	Disulfide bond	2464 ↔ 2476		By similarity
	Disulfide bond	2471 ↔ 2489		By similarity
	Disulfide bond	2483 ↔ 2498		By similarity
	Disulfide bond	2501 ↔ 2537		By similarity
	Disulfide bond	2512 ↔ 2516		By similarity
	Disulfide bond	2547 ↔ 2552		By similarity
	Disulfide bond	2567 ↔ 2604		By similarity
	Disulfide bond	2571 ↔ 2609		By similarity
	Disulfide bond	2582 ↔ 2594		By similarity
	Disulfide bond	2716 ↔ 2754		By similarity
	Disulfide bond	2727 ↔ 2731		By similarity
	Disulfide bond	2764 ↔ 2768		By similarity
	Disulfide bond	2784 ↔ 2822		By similarity
	Disulfide bond	2788 ↔ 2827		By similarity
	Disulfide bond	2804 ↔ 2812		By similarity
	Disulfide bond	2842 ↔ 2877		By similarity
	Disulfide bond	2846 ↔ 2882		By similarity
	Disulfide bond	2857 ↔ 2867		By similarity
	Disulfide bond	2986 ↔ 3024		By similarity
	Disulfide bond	2997 ↔ 3001		By similarity
	Disulfide bond	3034 ↔ 3039		By similarity
	Disulfide bond	3195 ↔ 3244		By similarity
	Disulfide bond	3199 ↔ 3249		By similarity
	Disulfide bond	3210 ↔ 3234		By similarity
	Disulfide bond	3264 ↔ 3301		By similarity
	Disulfide bond	3268 ↔ 3306		By similarity
	Disulfide bond	3279 ↔ 3291		By similarity
	Disulfide bond	3420 ↔ 3463		By similarity
	Disulfide bond	3424 ↔ 3469		By similarity
	Disulfide bond	3435 ↔ 3447		By similarity
	Disulfide bond	3484 ↔ 3519		By similarity
	Disulfide bond	3487 ↔ 3526		By similarity
	Disulfide bond	3497 ↔ 3509		By similarity
	Disulfide bond	3657 ↔ 3687		By similarity
	Disulfide bond	3661 ↔ 3692		By similarity
	Disulfide bond	3672 ↔ 3677		By similarity
	Disulfide bond	3823 ↔ 3926		By similarity
	Disulfide bond	3827 ↔ 3931		By similarity
	Disulfide bond	3839 ↔ 3851		By similarity
	Disulfide bond	3947 ↔ 3983		By similarity
	Disulfide bond	3958 ↔ 3962		By similarity
	Disulfide bond	3996 ↔ 4001		By similarity
	Disulfide bond	4016 ↔ 4053		By similarity
	Disulfide bond	4020 ↔ 4058		By similarity
	Disulfide bond	4031 ↔ 4043		By similarity
	Disulfide bond	4160 ↔ 4196		By similarity
	Disulfide bond	4171 ↔ 4175		By similarity
	Disulfide bond	4206 ↔ 4211		By similarity
	Disulfide bond	4366 ↔ 4403		By similarity
	Disulfide bond	4377 ↔ 4379		By similarity
	Disulfide bond	4413 ↔ 4418		By similarity
	Disulfide bond	4775 ↔ 4810		By similarity
	Disulfide bond	4779 ↔ 4815		By similarity
	Disulfide bond	4790 ↔ 4799		By similarity
	Disulfide bond	5041 ↔ 5101		By similarity
	Disulfide bond	5067 ↔ 5118		By similarity
	Disulfide bond	5077 ↔ 5134		By similarity
	Disulfide bond	5081 ↔ 5136		By similarity
	Disulfide bond	? ↔ 5139		By similarity
Natural variations
	Alternative sequence	1 – 1122	1122	Missing in isoform 2.		VSP_035258
	Alternative sequence	1123 – 1126	4	LWDG → MLPP in isoform 2.		VSP_035259
	Alternative sequence	1639	1	A → ACVEAPAPPAMRGPPGQAGG PTSSRAPSPPSPPEAQGEGR KGQERSRTHLTVPAGSTQLP LCPGLFPCGVAPGLCLTPEQ LCDGIPDCPQGEDELD in isoform 2.		VSP_035260
	Alternative sequence	1671	1	L → LVRVGVGGGGGSAMLPPSTR ALTPLPPQ in isoform 2.		VSP_035261
	Alternative sequence	2179 – 2314	136	LFPRN…PPGQE → VSPAQGRWGQQPTMPFCGFH SLCPQGPSSVPEGHGLHSML VEYLVSSRDCALWSRGLGAT VTWMLETIQVAQTQGRYVKP ARERGWGDTKFTEGLREPRP THVFVESSLGTALPSGGLHP SRRQTARSGRNQSVLC in isoform 2.		VSP_035262
	Alternative sequence	2315 – 5147	2833	Missing in isoform 2.		VSP_035263
	Natural variant	146	1	Q → R. Corresponds to variant rs709061 [ dbSNP | Ensembl ].		VAR_052660
	Natural variant	298	1	V → M. Corresponds to variant rs17754559 [ dbSNP | Ensembl ].		VAR_052661
	Natural variant	539	1	V → M. Corresponds to variant rs855677 [ dbSNP | Ensembl ].		VAR_059863
	Natural variant	1272	1	S → P. Corresponds to variant rs709060 [ dbSNP | Ensembl ].		VAR_059864
	Natural variant	1273	1	L → P. Corresponds to variant rs709060 [ dbSNP | Ensembl ].		VAR_052662
	Natural variant	1424	1	S → G. Corresponds to variant rs855691 [ dbSNP | Ensembl ].		VAR_059865
	Natural variant	1448	1	P → Q. Corresponds to variant rs855692 [ dbSNP | Ensembl ].		VAR_059866
	Natural variant	1453	1	P → R. Corresponds to variant rs2074704 [ dbSNP | Ensembl ].		VAR_059867
	Natural variant	1778	1	S → P. Corresponds to variant rs893601 [ dbSNP | Ensembl ].		VAR_059868
	Natural variant	1793	1	L → P. Corresponds to variant rs1635802 [ dbSNP | Ensembl ].		VAR_059869
	Natural variant	1882	1	R → C. Corresponds to variant rs1076277 [ dbSNP | Ensembl ].		VAR_059870
	Natural variant	2017	1	T → M. Corresponds to variant rs4725314 [ dbSNP | Ensembl ].		VAR_059871
	Natural variant	2452	1	M → T. Corresponds to variant rs2074689 [ dbSNP | Ensembl ].		VAR_061915
	Natural variant	2541	1	R → Q. Corresponds to variant rs59522380 [ dbSNP | Ensembl ].		VAR_061916
	Natural variant	2891	1	L → V. Corresponds to variant rs10260959 [ dbSNP | Ensembl ].		VAR_059872
	Natural variant	3273	1	R → W. Corresponds to variant rs740109 [ dbSNP | Ensembl ].		VAR_059873
	Natural variant	3512	1	N → S. Corresponds to variant rs10952230 [ dbSNP | Ensembl ].		VAR_059874
	Natural variant	3892	1	C → W. Corresponds to variant rs1557955 [ dbSNP | Ensembl ].		VAR_059875
	Natural variant	3909	1	R → C. Corresponds to variant rs745044 [ dbSNP | Ensembl ].		VAR_059876
	Natural variant	4028	1	S → I. Corresponds to variant rs1005603 [ dbSNP | Ensembl ].		VAR_059877
	Natural variant	4107	1	Q → H. Corresponds to variant rs12536873 [ dbSNP | Ensembl ].		VAR_061917
	Natural variant	4164	1	H → R. Corresponds to variant rs10233245 [ dbSNP | Ensembl ].		VAR_059878
	Natural variant	4330	1	R → C. Corresponds to variant rs1008336 [ dbSNP | Ensembl ].		VAR_059879
	Natural variant	4787	1	H → R. Corresponds to variant rs1004200 [ dbSNP | Ensembl ].		VAR_059880
	Natural variant	4941	1	E → K. Corresponds to variant rs12534509 [ dbSNP | Ensembl ].		VAR_059881

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified March 20, 2007. Version 1. Checksum: 9A8F5C3179F028A3	FASTA	5,147	547,504
	10 20 30 40 50 60 MLLPALLFGM AWALADGRWC EWTETIRVEE EVAPRQEDLV PCASLDHYSR LGWRLDLPWS 70 80 90 100 110 120 GRSGLTRSPA PGLCPIYKPP ETRPAKWNRT VRTCCPGWGG AHCTEALAKA SPEGHCFAMW 130 140 150 160 170 180 QCQLQAGSAN ASAGSLEECC ARPWGQSWWD GSSQACRSCS SRHLPGSASS PALLQPLAGA 190 200 210 220 230 240 VGQLWSQHQR PSATCASWSG FHYRTFDGRH YHFLGRCTYL LAGAADSTWA VHLTPGDRCP 250 260 270 280 290 300 QPGHCQRVTM GPEEVLIQAG NVSVKGQLVP EGQSWLLHGL SLQWLGDWLV LSGGLGVVVR 310 320 330 340 350 360 LDRTGSISIS VDHELWGQTQ GLCGLYNGWP EDDFMEPGGG LAMLAATFGN SWRLPGSESG 370 380 390 400 410 420 CLDAVEVAQG CDPLGLIDAD VEPGHLRAEA QDVCHQLLEG PFGQCHAQVS PAEYHEACLF 430 440 450 460 470 480 AYCAGAMAGS GQEGRQQAVC ATFASYVQAC ARRHIHIRWR KPGFCERLCP GGQLYSDCVS 490 500 510 520 530 540 LCPPSCEAVG QGEEESCREE CVSGCECPRG LFWNGTLCVP AAHCPCYYCR QRYVPGDTVR 550 560 570 580 590 600 QLCNPCVCRD GRWHCAQALC PAECAVGGDG HYLTFDGRSY SFWGGQGCRY SLVQDYVKGQ 610 620 630 640 650 660 LLILLEHGAC DAGSCLHAIS VSLEDTHIQL RDSGAVLVNG QDVGLPWIGA EGLSVRRASS 670 680 690 700 710 720 AFLLLRWPGA QVLWGLSDPV AYITLDPRHA HQVQGLCGTF TQNQQDDFLT PAGDVETSIA 730 740 750 760 770 780 AFASKFQVAG KGRCPSEDSA LLSPCTTHSQ RHAFAEAACA ILHSSVFQEC HRLVDKEPFY 790 800 810 820 830 840 LRCLAAVCGC DPGSDCLCPV LSAYARRCAQ EGASPPWRNQ TLCPVMCPGG QEYRECAPAC 850 860 870 880 890 900 GQHCGKPEDC GELGSCVAGC NCPLGLLWDP EGQCVPPSLC PCQLGARRYA PGSATMKECN 910 920 930 940 950 960 RCICQERGLW NCTARHCPSQ AFCPRELVYA PGACLLTCDS PSANHSCPAG STDGCVCPPG 970 980 990 1000 1010 1020 TVLLDERCVP PDLCPCRHSG QWYLPNATIQ EDCNVCVCRG RQWHCTGQRR SGRCQASGAP 1030 1040 1050 1060 1070 1080 HYVTFDGLAF TYPGACEYLL VREASGLFTV SAQNLPCGAS GLTCTKALAV RLEGTVVHML 1090 1100 1110 1120 1130 1140 RGRAVTVNGV SVTPPKVYTG PGLSLRRAGL FLLLSTHLGL TLLWDGGTRV LVQLSPQFRG 1150 1160 1170 1180 1190 1200 RVAGLCGDFD GDASNDLRSR QGVLEPTAEL AAHSWRLSPL CPEPGDLPHP CTMNTHRAGW 1210 1220 1230 1240 1250 1260 ARARCGALLQ PLFTLCHAEV PPQQHYEWCL YDACGCDSGG DCECLCSAIA TYADECARHG 1270 1280 1290 1300 1310 1320 HHVRWRSQEL CSLQCEGGQV YEACGPTCPP TCHEQHPEPG WHCQVVACVE GCFCPEGTLL 1330 1340 1350 1360 1370 1380 HGGACLEPAS CPCEWGRNSF PPGSVLQKDC GNCTCQEGQW HCGGDGGHCE ELVPACAEGE 1390 1400 1410 1420 1430 1440 ALCQENGHCV PHGWLCDNQD DCGDGSDEEG CAAPGCGEGQ MTCSSGHCLP LALLCDRQDD 1450 1460 1470 1480 1490 1500 CGDGTDEPSY PCPQGLLACA DGRCLPPALL CDGHPDCLDA ADEESCLGQV TCVPGEVSCV 1510 1520 1530 1540 1550 1560 DGTCLGAIQL CDGVWDCPDG ADEGPGHCPL PSLPTPPAST LPGPSPGSLD TASSPLASAS 1570 1580 1590 1600 1610 1620 PAPPCGPFEF RCGSGECTPR GWRCDQEEDC ADGSDERGCG GPCAPHHAPC ARGPHCVSPE 1630 1640 1650 1660 1670 1680 QLCDGVRQCP DGSDEGPDAC GGLPALGGPN RTGLPCPEYT CPNGTCIGFQ LVCDGQPDCG 1690 1700 1710 1720 1730 1740 RPGQVGPSPE EQGCGAWGPW SPWGPCSRTC GPWGQGRSRR CSPLGLLVLQ NCPGPEHQSQ 1750 1760 1770 1780 1790 1800 ACFTAACPVD GEWSTWSPWS VCSEPCRGTM TRQRQCHSPQ NGGRTCAALP GGLHSTRQTK 1810 1820 1830 1840 1850 1860 PCPQDGCPNA TCSGELMFQP CAPCPLTCDD ISGQVTCPPD WPCGSPGCWC PEGQVLGSEG 1870 1880 1890 1900 1910 1920 WCVWPRQCPC LVDGARYWPG QRIKADCQLC ICQDGRPRRC RLNPDCAVDC GWSSWSPWAK 1930 1940 1950 1960 1970 1980 CLGPCGSQSI QWSFRSSNNP RPSGRGRQCR GIHRKARRCQ TEPCEGCEHQ GQVHRVGERW 1990 2000 2010 2020 2030 2040 HGGPCRVCQC LHNLTAHCSP YCPLGSCPQG WVLVEGTGES CCHCALPGEN QTVQPMATPA 2050 2060 2070 2080 2090 2100 AAPAPSPQIR FPLATYILPP SGDPCYSPLG LAGLAEGSLH ASSQQLEHPT QAALLGAPTQ 2110 2120 2130 2140 2150 2160 GPSPQGWHAG GDAYAKWHTR PHYLQLDLLQ PRNLTGILVP ETGSSNAYAS SFSLQFSSNG 2170 2180 2190 2200 2210 2220 LHWHDYRDLL PGILPLPKLF PRNWDDLDPA VWTFGRMVQA RFVRVWPHDV HHSDVPLQVE 2230 2240 2250 2260 2270 2280 LLGCEPGSPP APLCPGVGLR CASGECVLRG GPCDGVLDCE DGSDEEGCVL LPEGTGRFHS 2290 2300 2310 2320 2330 2340 TAKTLALSSA QPGQLLHWPR EGLAETEHWP PGQESPTSPT ETRPVSPGPA SGVPHHGESV 2350 2360 2370 2380 2390 2400 QMVTTTPIPQ MEARTLPPGM AAVTVVPPHP VTPATPAGQS VAPGPFPPVQ CGPGQTPCEV 2410 2420 2430 2440 2450 2460 LGCVEQAQVC DGREDCLDGS DERHCARNLL MWLPSLPALW AASTVPFMMP TMALPGLPAS 2470 2480 2490 2500 2510 2520 RALCSPSQLS CGSGECLSAE RRCDLRPDCQ DGSDEDGCVD CVLAPWSVWS SCSRSCGLGL 2530 2540 2550 2560 2570 2580 TFQRQELLRP PLPGGSCPRD RFRSQSCFVQ ACPVAGAWAM WEAWGPCSVS CGGGHQSRQR 2590 2600 2610 2620 2630 2640 SCVDPPPKNG GAPCPGASQE RAPCGLQPCS GGTDCELGRV YVSADLCQKG LVPPCPPSCL 2650 2660 2670 2680 2690 2700 DPKANRSCSG HCVEGCRCPP GLLLHDTRCL PLSECPCLVG EELKWPGVSF LLGNCSQCVC 2710 2720 2730 2740 2750 2760 EKGELLCQPG GCPLPCGWSA WSSWAPCDRS CGSGVRARFR SPSNPPAAWG GAPCEGDRQE 2770 2780 2790 2800 2810 2820 LQGCHTVCGT EVFGWTPWTS WSSCSQSCLA PGGGPGWRSR SRLCPSPGDS SCPGDATQEE 2830 2840 2850 2860 2870 2880 PCSPPVCPVP SIWGLWAPWS TCSAPCDGGI QTRGRSCSSL APGDTTCPGP HSQTRDCNTQ 2890 2900 2910 2920 2930 2940 PCTAQCPENM LFRSAEQCHQ EGGPCPRLCL TQGPGIECTG FCAPGCTCPP GLFLHNASCL 2950 2960 2970 2980 2990 3000 PRSQCPCQLH GQLYASGAMA RLDSCNNCTC VSGKMACTSE RCPVACGWSP WTLWSLCSCS 3010 3020 3030 3040 3050 3060 CNVGIRRRFR AGTAPPAAFG GAECQGPTME AEFCSLRPCP GPGGEWGPWS PCSVPCGGGY 3070 3080 3090 3100 3110 3120 RNRTRGSSRS LMEFSTCGLQ PCAGPVPGMC PRDKQWLDCA QGPASCAELS APRGTNQTCH 3130 3140 3150 3160 3170 3180 PGCHCPSGML LLNNVCVPTQ DCPCAHEGHL YPPGSTVVRP CENCSCVSGL IANCSSWPCA 3190 3200 3210 3220 3230 3240 EGEPTWSPWT PWSQCSASCG PARCHRHRFC ARSPSAVPST VAPLPLPATP TPLCSGPEAE 3250 3260 3270 3280 3290 3300 EEPCLLQGCD RAGGWGPWGP WSHCSRSCGG GLRSRTRACD QPPPQGLGDY CEGPRAQGEV 3310 3320 3330 3340 3350 3360 CQALPCPVTN CTAIEGAEYS PCGPPCPRSC DDLVHCVWRC QPGCYCPPGQ VLSSNGAICV 3370 3380 3390 3400 3410 3420 QPGHCSCLDL LTGQRHHPGA RLARPDGCNH CTCLEGRLNC TDLPCPVPGG WCPWSEWTMC 3430 3440 3450 3460 3470 3480 SQPCRGQTRS RSRACACPTP QHGGAPCTGE AGEAGAQHQR EACPSYATCP VDGAWGPWGP 3490 3500 3510 3520 3530 3540 WSPCDMCLGQ SHRSRACSRP PTPEGGRPCP GNHTQSRPCQ ENSTQCTDCG GGQSLHPCGQ 3550 3560 3570 3580 3590 3600 PCPRSCQDLS PGSVCQPGSV GCQPTCGCPL GQLSQDGLCV PPAHCRCQYQ PGAMGIPENQ 3610 3620 3630 3640 3650 3660 SRSAGSRFSS WESLEPGEVV TGPCDNCTCV AGILQCQEVP DCPDPGVWSS WGPWEDCSVS 3670 3680 3690 3700 3710 3720 CGGGEQLRSR RCARPPCPGP ARQSRTCSTQ VCREAGCPAG RLYRECQPGE GCPFSCAHVT 3730 3740 3750 3760 3770 3780 QQVGCFSEGC EEGCHCPEGT FQHRLACVQE CPCVLTAWLL QELGATIGDP GQPLGPGDEL 3790 3800 3810 3820 3830 3840 DSGQTLRTSC GNCSCAHGKL SCSLDDCFEA DGGFGPWSPW GPCSRSCGGL GTRTRSRQCV 3850 3860 3870 3880 3890 3900 LTMPTLSGQG CRGPRQDLEC PSPDCPGAEG STVEPVTGLP GGWGPWSSWS PCSRSCTDPA 3910 3920 3930 3940 3950 3960 RPAWRSRTRL CLANCTMGDP LQERPCNLPS CTELPVCPGP GCGAGNCSWT SWAPWEPCSR 3970 3980 3990 4000 4010 4020 SCGVGQQRRL RAYRPPGPGG HWCPNILTAY QERRFCNLRA CPVPGGWSRW SPWSWCDRSC 4030 4040 4050 4060 4070 4080 GGGQSLRSRS CSSPPSKNGG APCAGERHQA RLCNPMPCEA GCPAGMEVVT CANRCPRRCS 4090 4100 4110 4120 4130 4140 DLQEGIVCQD DQVCQKGCRC PKGSLEQDGG CVPIGHCDCT DAQGHSWAPG SQHQDACNNC 4150 4160 4170 4180 4190 4200 SCQAGQLSCT AQPCPPPTHC AWSHWSAWSP CSHSCGPRGQ QSRFRSSTSG SWAPECREEQ 4210 4220 4230 4240 4250 4260 SQSQPCPQPS CPPLCLQGTR SRTLGDSWLQ GECQRCSCTP EGVICEDTEC AVPEAWTLWS 4270 4280 4290 4300 4310 4320 SWSDCPVSCG GGNQVRTRAC RAAAPHHRSP PCLGPDTQTR QQPCPGLLEA CSWGPWGPCS 4330 4340 4350 4360 4370 4380 RSCGPGLASR SGSCPCLMAK ADPTCNSTFL HLDTQGCYSG PCPEECVWSS WSSWTRCSCR 4390 4400 4410 4420 4430 4440 VLVQQRYRHQ GPASRGARAG APCTRLDGHF RPCLISNCSE DSCTPPFEFH ACGSPCAGLC 4450 4460 4470 4480 4490 4500 ATHLSHQLCQ DLPPCQPGCY CPKGLLEQAG GCIPPEECNC WHTSAAGAGM TLAPGDRLQL 4510 4520 4530 4540 4550 4560 GCKECECRRG ELHCTSQGCQ GLLPLSEWSE WSPCGPCLPP SALAPASRTA LEEHWLRDPT 4570 4580 4590 4600 4610 4620 GLSPTLAPLL ASEQHRHRLC LDPATGRPWT GAPHLCTAPL SQQRLCPDPG ACPDSCQWSL 4630 4640 4650 4660 4670 4680 WGPWSPCQVP CSGGFRLRWR EAEALCGGGC REPWAQESCN GGPCPECEAQ DTVFTLDCAN 4690 4700 4710 4720 4730 4740 QCPHSCADLW DRVQCLQGPC RPGCRCPPGQ LVQDGRCVPI SSCRCGLPSA NASWELAPAQ 4750 4760 4770 4780 4790 4800 AVQLDCQNCT CVNESLVCPH QECPVLGPWS AWSSCSAPCG GGTMERHRTC EGGPGVAPCQ 4810 4820 4830 4840 4850 4860 AQDTEQRQEC NLQPCPECPP GQVLSACATS CPCLCWHLQP GAICVQEPCQ PGCGCPGGQL 4870 4880 4890 4900 4910 4920 LHNGTCVPPT ACPCTQHSLP WGLTLTLEEQ AQELPPGTVL TRNCTRCVCH GGAFSCSLVD 4930 4940 4950 4960 4970 4980 CQVPPGETWQ QVAPGELGLC EQTCLEMNAT KTQSNCSSAR ASGCVCQPGH FRSQAGPCVP 4990 5000 5010 5020 5030 5040 EDHCECWHLG RPHLPGSEWQ EACESCLCLS GRPVCTQHCS PLTCAQGEEM VLEPGSCCPS 5050 5060 5070 5080 5090 5100 CRREAPEEQS PSCQLLTELR NFTKGTCYLD QVEVSYCSGY CPSSTHVMPE EPYLQSQCDC 5110 5120 5130 5140 CSYRLDPESP VRILNLRCLG GHTEPVVLPV IHSCQCSSCQ GGDFSKR
	Isoform 2 [UniParc]. Checksum: 2876F7F1383080E8	FASTA	1,314	138,775
	10 20 30 40 50 60 MLPPGTRVLV QLSPQFRGRV AGLCGDFDGD ASNDLRSRQG VLEPTAELAA HSWRLSPLCP 70 80 90 100 110 120 EPGDLPHPCT MNTHRAGWAR ARCGALLQPL FTLCHAEVPP QQHYEWCLYD ACGCDSGGDC 130 140 150 160 170 180 ECLCSAIATY ADECARHGHH VRWRSQELCS LQCEGGQVYE ACGPTCPPTC HEQHPEPGWH 190 200 210 220 230 240 CQVVACVEGC FCPEGTLLHG GACLEPASCP CEWGRNSFPP GSVLQKDCGN CTCQEGQWHC 250 260 270 280 290 300 GGDGGHCEEL VPACAEGEAL CQENGHCVPH GWLCDNQDDC GDGSDEEGCA APGCGEGQMT 310 320 330 340 350 360 CSSGHCLPLA LLCDRQDDCG DGTDEPSYPC PQGLLACADG RCLPPALLCD GHPDCLDAAD 370 380 390 400 410 420 EESCLGQVTC VPGEVSCVDG TCLGAIQLCD GVWDCPDGAD EGPGHCPLPS LPTPPASTLP 430 440 450 460 470 480 GPSPGSLDTA SSPLASASPA PPCGPFEFRC GSGECTPRGW RCDQEEDCAD GSDERGCGGP 490 500 510 520 530 540 CAPHHAPCAR GPHCVSPEQL CDGVRQCPDG SDEGPDACVE APAPPAMRGP PGQAGGPTSS 550 560 570 580 590 600 RAPSPPSPPE AQGEGRKGQE RSRTHLTVPA GSTQLPLCPG LFPCGVAPGL CLTPEQLCDG 610 620 630 640 650 660 IPDCPQGEDE LDCGGLPALG GPNRTGLPCP EYTCPNGTCI GFQLVRVGVG GGGGSAMLPP 670 680 690 700 710 720 STRALTPLPP QVCDGQPDCG RPGQVGPSPE EQGCGAWGPW SPWGPCSRTC GPWGQGRSRR 730 740 750 760 770 780 CSPLGLLVLQ NCPGPEHQSQ ACFTAACPVD GEWSTWSPWS VCSEPCRGTM TRQRQCHSPQ 790 800 810 820 830 840 NGGRTCAALP GGLHSTRQTK PCPQDGCPNA TCSGELMFQP CAPCPLTCDD ISGQVTCPPD 850 860 870 880 890 900 WPCGSPGCWC PEGQVLGSEG WCVWPRQCPC LVDGARYWPG QRIKADCQLC ICQDGRPRRC 910 920 930 940 950 960 RLNPDCAVDC GWSSWSPWAK CLGPCGSQSI QWSFRSSNNP RPSGRGRQCR GIHRKARRCQ 970 980 990 1000 1010 1020 TEPCEGCEHQ GQVHRVGERW HGGPCRVCQC LHNLTAHCSP YCPLGSCPQG WVLVEGTGES 1030 1040 1050 1060 1070 1080 CCHCALPGEN QTVQPMATPA AAPAPSPQIR FPLATYILPP SGDPCYSPLG LAGLAEGSLH 1090 1100 1110 1120 1130 1140 ASSQQLEHPT QAALLGAPTQ GPSPQGWHAG GDAYAKWHTR PHYLQLDLLQ PRNLTGILVP 1150 1160 1170 1180 1190 1200 ETGSSNAYAS SFSLQFSSNG LHWHDYRDLL PGILPLPKVS PAQGRWGQQP TMPFCGFHSL 1210 1220 1230 1240 1250 1260 CPQGPSSVPE GHGLHSMLVE YLVSSRDCAL WSRGLGATVT WMLETIQVAQ TQGRYVKPAR 1270 1280 1290 1300 1310 ERGWGDTKFT EGLREPRPTH VFVESSLGTA LPSGGLHPSR RQTARSGRNQ SVLC

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The nucleotide sequence of a long cDNA clone isolated from human." Nagase T., Kikuno R., Ohara O. Submitted (NOV-2002) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). Tissue: Brain.
[2]	"The DNA sequence of human chromosome 7." Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L. , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K. Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"The complex multidomain organization of SCO-spondin protein is highly conserved in mammals." Meiniel O., Meiniel A. Brain Res. Brain Res. Rev. 53:321-327(2007) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION (ISOFORM 1).

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB111888 mRNA. Translation: BAC98376.1. Different initiation. AC004877 Genomic DNA. No translation available. BN000852 mRNA. Translation: CAJ43920.1.
IPI	IPI00446753. IPI00843797.
RefSeq	NP_940857.2. NM_198455.2.
UniGene	Hs.632022.
3D structure databases
ProteinModelPortal	A2VEC9.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000367255.
PTM databases
PhosphoSite	A2VEC9.
Proteomic databases
PaxDb	A2VEC9.
PRIDE	A2VEC9.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	23145.
KEGG	hsa:23145.
UCSC	uc010lpk.3. human.
Organism-specific databases
CTD	23145.
GeneCards	GC07P149473.
H-InvDB	HIX0007194.
HGNC	HGNC:21998. SSPO.
neXtProt	NX_A2VEC9.
PharmGKB	PA142670865.
HUGE	Search...
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG12793.
HOGENOM	HOG000154433.
HOVERGEN	HBG080794.
OrthoDB	EOG4BP1BV.
Gene expression databases
CleanEx	HS_SSPO.
Genevestigator	A2VEC9.
Family and domain databases
Gene3D	4.10.400.10. 10 hits.
InterPro	IPR000421. Coagulation_fac_5/8-C_type_dom. IPR006207. Cys_knot_C. IPR008979. Galactose-bd-like. IPR023415. LDLR_class-A_CS. IPR002172. LDrepeatLR_classA_rpt. IPR008037. Prot_inh_PMP. IPR000884. Thrombospondin_1_rpt. IPR002919. TIL_dom. IPR014853. Unchr_dom_Cys-rich. IPR006552. VWC_out. IPR001007. VWF_C. IPR001846. VWF_type-D. [Graphical view]
Pfam	PF08742. C8. 3 hits. PF00754. F5_F8_type_C. 1 hit. PF00057. Ldl_recept_a. 8 hits. PF01826. TIL. 13 hits. PF00090. TSP_1. 22 hits. PF00094. VWD. 3 hits. [Graphical view]
SMART	SM00832. C8. 3 hits. SM00231. FA58C. 1 hit. SM00192. LDLa. 10 hits. SM00209. TSP1. 25 hits. SM00214. VWC. 4 hits. SM00215. VWC_out. 1 hit. SM00216. VWD. 3 hits. [Graphical view]
SUPFAM	SSF57567. Cysrich_TIL. 16 hits. SSF49785. Gal_bind_like. 1 hit. SSF57424. LDL_rcpt_classA_cys-rich. 9 hits. SSF57283. PMP_SGCI. 1 hit. SSF82895. TSP1. 24 hits.
PROSITE	PS01185. CTCK_1. False negative. PS01225. CTCK_2. 1 hit. PS00022. EGF_1. 1 hit. PS01186. EGF_2. False negative. PS50026. EGF_3. False negative. PS51041. EMI. False negative. PS01285. FA58C_1. False negative. PS01286. FA58C_2. False negative. PS50022. FA58C_3. 1 hit. PS01209. LDLRA_1. 8 hits. PS50068. LDLRA_2. 10 hits. PS50092. TSP1. 24 hits. PS01208. VWFC_1. 1 hit. PS50184. VWFC_2. 2 hits. PS51233. VWFD. 3 hits. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	23145.
NextBio	44438.

Entry information

Entry name

SSPO_HUMAN

Accession

Primary (citable) accession number: A2VEC9
Secondary accession number(s): Q76B61

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 12, 2007
Last sequence update:	March 20, 2007
Last modified:	April 3, 2013
This is version 56 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.