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A2VEC9

- SSPO_HUMAN

UniProt

A2VEC9 - SSPO_HUMAN

Protein

SCO-spondin

Gene

SSPO

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 69 (01 Oct 2014)
      Sequence version 1 (20 Mar 2007)
      Previous versions | rss
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    Functioni

    Involved in the modulation of neuronal aggregation. May be involved in developmental events during the formation of the central nervous system By similarity.By similarity

    GO - Molecular functioni

    1. peptidase inhibitor activity Source: InterPro

    GO - Biological processi

    1. cell adhesion Source: UniProtKB-KW

    Keywords - Biological processi

    Cell adhesion

    Keywords - Ligandi

    Calcium

    Enzyme and pathway databases

    ReactomeiREACT_200626. O-glycosylation of TSR domain-containing proteins.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    SCO-spondin
    Gene namesi
    Name:SSPO
    Synonyms:KIAA2036
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Unplaced

    Organism-specific databases

    HGNCiHGNC:21998. SSPO.

    Subcellular locationi

    Secretedextracellular space By similarity

    GO - Cellular componenti

    1. extracellular space Source: BHF-UCL

    Keywords - Cellular componenti

    Secreted

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA142670865.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1717Sequence AnalysisAdd
    BLAST
    Chaini18 – 51475130SCO-spondinPRO_5000223757Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi? ↔ 5139By similarity
    Glycosylationi88 – 881N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi130 – 1301N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi261 – 2611N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi514 – 5141N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi819 – 8191N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi911 – 9111N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi944 – 9441N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi986 – 9861N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi1352 – 13521N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi1376 ↔ 1389By similarity
    Disulfide bondi1383 ↔ 1402By similarity
    Disulfide bondi1396 ↔ 1411By similarity
    Disulfide bondi1416 ↔ 1428By similarity
    Disulfide bondi1423 ↔ 1441By similarity
    Disulfide bondi1452 ↔ 1464By similarity
    Disulfide bondi1459 ↔ 1477By similarity
    Disulfide bondi1471 ↔ 1486By similarity
    Disulfide bondi1492 ↔ 1504By similarity
    Disulfide bondi1499 ↔ 1517By similarity
    Disulfide bondi1511 ↔ 1528By similarity
    Disulfide bondi1565 ↔ 1577By similarity
    Disulfide bondi1572 ↔ 1590By similarity
    Disulfide bondi1584 ↔ 1599By similarity
    Disulfide bondi1603 ↔ 1616By similarity
    Disulfide bondi1610 ↔ 1629By similarity
    Disulfide bondi1623 ↔ 1640By similarity
    Glycosylationi1650 – 16501N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi1656 ↔ 1666By similarity
    Disulfide bondi1661 ↔ 1679By similarity
    Glycosylationi1663 – 16631N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi1673 ↔ 1694By similarity
    Disulfide bondi1706 ↔ 1742By similarity
    Disulfide bondi1710 ↔ 1747By similarity
    Disulfide bondi1721 ↔ 1732By similarity
    Disulfide bondi1762 ↔ 1802By similarity
    Disulfide bondi1766 ↔ 1807By similarity
    Disulfide bondi1776 ↔ 1786By similarity
    Glycosylationi1809 – 18091N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi1828 ↔ 1843By similarity
    Disulfide bondi1837 ↔ 1848By similarity
    Disulfide bondi1850 ↔ 1862By similarity
    Disulfide bondi1868 ↔ 1887By similarity
    Disulfide bondi1870 ↔ 1890By similarity
    Disulfide bondi1892 ↔ 1900By similarity
    Disulfide bondi1910 ↔ 1949By similarity
    Disulfide bondi1921 ↔ 1925By similarity
    Disulfide bondi1959 ↔ 1964By similarity
    Glycosylationi1993 – 19931N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi2030 – 20301N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi2065 ↔ 2224By similarity
    Glycosylationi2133 – 21331N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi2234 ↔ 2246By similarity
    Disulfide bondi2241 ↔ 2259By similarity
    Disulfide bondi2253 ↔ 2268By similarity
    Disulfide bondi2391 ↔ 2403By similarity
    Disulfide bondi2398 ↔ 2416By similarity
    Disulfide bondi2410 ↔ 2425By similarity
    Disulfide bondi2464 ↔ 2476By similarity
    Disulfide bondi2471 ↔ 2489By similarity
    Disulfide bondi2483 ↔ 2498By similarity
    Disulfide bondi2501 ↔ 2537By similarity
    Disulfide bondi2512 ↔ 2516By similarity
    Disulfide bondi2547 ↔ 2552By similarity
    Disulfide bondi2567 ↔ 2604By similarity
    Disulfide bondi2571 ↔ 2609By similarity
    Disulfide bondi2582 ↔ 2594By similarity
    Glycosylationi2645 – 26451N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi2694 – 26941N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi2716 ↔ 2754By similarity
    Disulfide bondi2727 ↔ 2731By similarity
    Disulfide bondi2764 ↔ 2768By similarity
    Disulfide bondi2784 ↔ 2822By similarity
    Disulfide bondi2788 ↔ 2827By similarity
    Disulfide bondi2804 ↔ 2812By similarity
    Disulfide bondi2842 ↔ 2877By similarity
    Disulfide bondi2846 ↔ 2882By similarity
    Disulfide bondi2857 ↔ 2867By similarity
    Glycosylationi2936 – 29361N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi2967 – 29671N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi2986 ↔ 3024By similarity
    Disulfide bondi2997 ↔ 3001By similarity
    Disulfide bondi3034 ↔ 3039By similarity
    Glycosylationi3062 – 30621N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi3116 – 31161N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi3163 – 31631N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi3173 – 31731N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi3195 ↔ 3244By similarity
    Disulfide bondi3199 ↔ 3249By similarity
    Disulfide bondi3210 ↔ 3234By similarity
    Disulfide bondi3264 ↔ 3301By similarity
    Disulfide bondi3268 ↔ 3306By similarity
    Disulfide bondi3279 ↔ 3291By similarity
    Glycosylationi3310 – 33101N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi3399 – 33991N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi3420 ↔ 3463By similarity
    Disulfide bondi3424 ↔ 3469By similarity
    Disulfide bondi3435 ↔ 3447By similarity
    Disulfide bondi3484 ↔ 3519By similarity
    Disulfide bondi3487 ↔ 3526By similarity
    Disulfide bondi3497 ↔ 3509By similarity
    Glycosylationi3512 – 35121N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi3522 – 35221N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi3599 – 35991N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi3626 – 36261N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi3657 ↔ 3687By similarity
    Disulfide bondi3661 ↔ 3692By similarity
    Disulfide bondi3672 ↔ 3677By similarity
    Glycosylationi3792 – 37921N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi3823 ↔ 3926By similarity
    Disulfide bondi3827 ↔ 3931By similarity
    Disulfide bondi3839 ↔ 3851By similarity
    Glycosylationi3914 – 39141N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi3946 – 39461N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi3947 ↔ 3983By similarity
    Disulfide bondi3958 ↔ 3962By similarity
    Disulfide bondi3996 ↔ 4001By similarity
    Disulfide bondi4016 ↔ 4053By similarity
    Disulfide bondi4020 ↔ 4058By similarity
    Disulfide bondi4031 ↔ 4043By similarity
    Glycosylationi4139 – 41391N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi4160 ↔ 4196By similarity
    Disulfide bondi4171 ↔ 4175By similarity
    Disulfide bondi4206 ↔ 4211By similarity
    Glycosylationi4346 – 43461N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi4366 ↔ 4403By similarity
    Disulfide bondi4377 ↔ 4379By similarity
    Disulfide bondi4413 ↔ 4418By similarity
    Glycosylationi4417 – 44171N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi4731 – 47311N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi4748 – 47481N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi4753 – 47531N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi4775 ↔ 4810By similarity
    Disulfide bondi4779 ↔ 4815By similarity
    Disulfide bondi4790 ↔ 4799By similarity
    Glycosylationi4863 – 48631N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi4903 – 49031N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi4948 – 49481N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi4955 – 49551N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi5041 ↔ 5101By similarity
    Glycosylationi5061 – 50611N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi5067 ↔ 5118By similarity
    Disulfide bondi5077 ↔ 5134By similarity
    Disulfide bondi5081 ↔ 5136By similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    MaxQBiA2VEC9.
    PaxDbiA2VEC9.
    PRIDEiA2VEC9.

    PTM databases

    PhosphoSiteiA2VEC9.

    Expressioni

    Gene expression databases

    CleanExiHS_SSPO.
    GenevestigatoriA2VEC9.

    Interactioni

    Protein-protein interaction databases

    BioGridi116762. 3 interactions.
    STRINGi9606.ENSP00000367255.

    Structurei

    3D structure databases

    ProteinModelPortaliA2VEC9.
    SMRiA2VEC9. Positions 1350-1643, 2064-2225, 2387-2505, 2510-2609, 2717-2828, 2987-3065, 3186-3309, 3400-3521, 3811-3911, 4003-4059, 4255-4334, 5052-5138.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini18 – 10285EMIAdd
    BLAST
    Domaini194 – 408215VWFD 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini469 – 52456TIL 1Add
    BLAST
    Domaini563 – 773211VWFD 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini827 – 87953TIL 2Add
    BLAST
    Domaini880 – 93960VWFC 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini1013 – 1219207VWFD 3PROSITE-ProRule annotationAdd
    BLAST
    Domaini1275 – 133157TIL 3Add
    BLAST
    Domaini1375 – 141238LDL-receptor class A 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini1415 – 145036LDL-receptor class A 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini1451 – 148737LDL-receptor class A 3PROSITE-ProRule annotationAdd
    BLAST
    Domaini1491 – 152939LDL-receptor class A 4PROSITE-ProRule annotationAdd
    BLAST
    Domaini1564 – 160037LDL-receptor class A 5PROSITE-ProRule annotationAdd
    BLAST
    Domaini1602 – 164140LDL-receptor class A 6PROSITE-ProRule annotationAdd
    BLAST
    Domaini1655 – 169339LDL-receptor class A 7PROSITE-ProRule annotationAdd
    BLAST
    Domaini1694 – 174855TSP type-1 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini1750 – 180859TSP type-1 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini1824 – 186340EGF-like 1Add
    BLAST
    Domaini1864 – 190138EGF-like 2Add
    BLAST
    Domaini1909 – 196557TSP type-1 3PROSITE-ProRule annotationAdd
    BLAST
    Domaini1965 – 202561VWFC 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini2065 – 2224160F5/8 type CPROSITE-ProRule annotationAdd
    BLAST
    Domaini2233 – 226937LDL-receptor class A 8PROSITE-ProRule annotationAdd
    BLAST
    Domaini2390 – 242637LDL-receptor class A 9PROSITE-ProRule annotationAdd
    BLAST
    Domaini2463 – 249937LDL-receptor class A 10PROSITE-ProRule annotationAdd
    BLAST
    Domaini2500 – 255354TSP type-1 4PROSITE-ProRule annotationAdd
    BLAST
    Domaini2555 – 261056TSP type-1 5PROSITE-ProRule annotationAdd
    BLAST
    Domaini2633 – 267543TIL 4Add
    BLAST
    Domaini2715 – 276955TSP type-1 6PROSITE-ProRule annotationAdd
    BLAST
    Domaini2772 – 282857TSP type-1 7PROSITE-ProRule annotationAdd
    BLAST
    Domaini2830 – 288354TSP type-1 8PROSITE-ProRule annotationAdd
    BLAST
    Domaini2985 – 304056TSP type-1 9PROSITE-ProRule annotationAdd
    BLAST
    Domaini3041 – 308343TSP type-1 10PROSITE-ProRule annotationAdd
    BLAST
    Domaini3183 – 325068TSP type-1 11PROSITE-ProRule annotationAdd
    BLAST
    Domaini3252 – 330756TSP type-1 12PROSITE-ProRule annotationAdd
    BLAST
    Domaini3311 – 336555TIL 5Add
    BLAST
    Domaini3408 – 347063TSP type-1 13PROSITE-ProRule annotationAdd
    BLAST
    Domaini3472 – 352756TSP type-1 14PROSITE-ProRule annotationAdd
    BLAST
    Domaini3645 – 369349TSP type-1 15PROSITE-ProRule annotationAdd
    BLAST
    Domaini3811 – 3932122TSP type-1 16PROSITE-ProRule annotationAdd
    BLAST
    Domaini3946 – 400257TSP type-1 17PROSITE-ProRule annotationAdd
    BLAST
    Domaini4004 – 405956TSP type-1 18PROSITE-ProRule annotationAdd
    BLAST
    Domaini4159 – 421254TSP type-1 19PROSITE-ProRule annotationAdd
    BLAST
    Domaini4253 – 430553TSP type-1 20PROSITE-ProRule annotationAdd
    BLAST
    Domaini4307 – 436357TSP type-1 21PROSITE-ProRule annotationAdd
    BLAST
    Domaini4365 – 441955TSP type-1 22PROSITE-ProRule annotationAdd
    BLAST
    Domaini4615 – 466551TSP type-1 23PROSITE-ProRule annotationAdd
    BLAST
    Domaini4667 – 472357TIL 6Add
    BLAST
    Domaini4763 – 481654TSP type-1 24PROSITE-ProRule annotationAdd
    BLAST
    Domaini4984 – 504259VWFC 3PROSITE-ProRule annotationAdd
    BLAST
    Domaini5041 – 5140100CTCKPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the thrombospondin family.Curated
    Contains 1 CTCK (C-terminal cystine knot-like) domain.PROSITE-ProRule annotation
    Contains 2 EGF-like domains.Curated
    Contains 1 EMI domain.Curated
    Contains 1 F5/8 type C domain.PROSITE-ProRule annotation
    Contains 10 LDL-receptor class A domains.PROSITE-ProRule annotation
    Contains 24 TSP type-1 domains.PROSITE-ProRule annotation
    Contains 3 VWFC domains.PROSITE-ProRule annotation
    Contains 3 VWFD domains.PROSITE-ProRule annotation

    Keywords - Domaini

    EGF-like domain, Repeat, Signal

    Phylogenomic databases

    eggNOGiNOG12793.
    HOGENOMiHOG000154433.
    HOVERGENiHBG080794.
    PhylomeDBiA2VEC9.

    Family and domain databases

    Gene3Di2.60.120.260. 1 hit.
    4.10.400.10. 10 hits.
    InterProiIPR000421. Coagulation_fac_5/8-C_type_dom.
    IPR006207. Cys_knot_C.
    IPR008979. Galactose-bd-like.
    IPR023415. LDLR_class-A_CS.
    IPR002172. LDrepeatLR_classA_rpt.
    IPR008037. Prot_inh_PMP.
    IPR000884. Thrombospondin_1_rpt.
    IPR002919. TIL_dom.
    IPR014853. Unchr_dom_Cys-rich.
    IPR006552. VWC_out.
    IPR001007. VWF_C.
    IPR001846. VWF_type-D.
    [Graphical view]
    PfamiPF08742. C8. 3 hits.
    PF00754. F5_F8_type_C. 1 hit.
    PF00057. Ldl_recept_a. 8 hits.
    PF01826. TIL. 14 hits.
    PF00090. TSP_1. 22 hits.
    PF00094. VWD. 3 hits.
    [Graphical view]
    PRINTSiPR00261. LDLRECEPTOR.
    SMARTiSM00832. C8. 3 hits.
    SM00231. FA58C. 1 hit.
    SM00192. LDLa. 10 hits.
    SM00209. TSP1. 25 hits.
    SM00214. VWC. 4 hits.
    SM00215. VWC_out. 1 hit.
    SM00216. VWD. 3 hits.
    [Graphical view]
    SUPFAMiSSF49785. SSF49785. 1 hit.
    SSF57283. SSF57283. 1 hit.
    SSF57424. SSF57424. 10 hits.
    SSF57567. SSF57567. 14 hits.
    SSF82895. SSF82895. 23 hits.
    PROSITEiPS01225. CTCK_2. 1 hit.
    PS00022. EGF_1. 1 hit.
    PS50022. FA58C_3. 1 hit.
    PS01209. LDLRA_1. 8 hits.
    PS50068. LDLRA_2. 10 hits.
    PS50092. TSP1. 24 hits.
    PS01208. VWFC_1. 1 hit.
    PS50184. VWFC_2. 2 hits.
    PS51233. VWFD. 3 hits.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: A2VEC9-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

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    MLLPALLFGM AWALADGRWC EWTETIRVEE EVAPRQEDLV PCASLDHYSR     50
    LGWRLDLPWS GRSGLTRSPA PGLCPIYKPP ETRPAKWNRT VRTCCPGWGG 100
    AHCTEALAKA SPEGHCFAMW QCQLQAGSAN ASAGSLEECC ARPWGQSWWD 150
    GSSQACRSCS SRHLPGSASS PALLQPLAGA VGQLWSQHQR PSATCASWSG 200
    FHYRTFDGRH YHFLGRCTYL LAGAADSTWA VHLTPGDRCP QPGHCQRVTM 250
    GPEEVLIQAG NVSVKGQLVP EGQSWLLHGL SLQWLGDWLV LSGGLGVVVR 300
    LDRTGSISIS VDHELWGQTQ GLCGLYNGWP EDDFMEPGGG LAMLAATFGN 350
    SWRLPGSESG CLDAVEVAQG CDPLGLIDAD VEPGHLRAEA QDVCHQLLEG 400
    PFGQCHAQVS PAEYHEACLF AYCAGAMAGS GQEGRQQAVC ATFASYVQAC 450
    ARRHIHIRWR KPGFCERLCP GGQLYSDCVS LCPPSCEAVG QGEEESCREE 500
    CVSGCECPRG LFWNGTLCVP AAHCPCYYCR QRYVPGDTVR QLCNPCVCRD 550
    GRWHCAQALC PAECAVGGDG HYLTFDGRSY SFWGGQGCRY SLVQDYVKGQ 600
    LLILLEHGAC DAGSCLHAIS VSLEDTHIQL RDSGAVLVNG QDVGLPWIGA 650
    EGLSVRRASS AFLLLRWPGA QVLWGLSDPV AYITLDPRHA HQVQGLCGTF 700
    TQNQQDDFLT PAGDVETSIA AFASKFQVAG KGRCPSEDSA LLSPCTTHSQ 750
    RHAFAEAACA ILHSSVFQEC HRLVDKEPFY LRCLAAVCGC DPGSDCLCPV 800
    LSAYARRCAQ EGASPPWRNQ TLCPVMCPGG QEYRECAPAC GQHCGKPEDC 850
    GELGSCVAGC NCPLGLLWDP EGQCVPPSLC PCQLGARRYA PGSATMKECN 900
    RCICQERGLW NCTARHCPSQ AFCPRELVYA PGACLLTCDS PSANHSCPAG 950
    STDGCVCPPG TVLLDERCVP PDLCPCRHSG QWYLPNATIQ EDCNVCVCRG 1000
    RQWHCTGQRR SGRCQASGAP HYVTFDGLAF TYPGACEYLL VREASGLFTV 1050
    SAQNLPCGAS GLTCTKALAV RLEGTVVHML RGRAVTVNGV SVTPPKVYTG 1100
    PGLSLRRAGL FLLLSTHLGL TLLWDGGTRV LVQLSPQFRG RVAGLCGDFD 1150
    GDASNDLRSR QGVLEPTAEL AAHSWRLSPL CPEPGDLPHP CTMNTHRAGW 1200
    ARARCGALLQ PLFTLCHAEV PPQQHYEWCL YDACGCDSGG DCECLCSAIA 1250
    TYADECARHG HHVRWRSQEL CSLQCEGGQV YEACGPTCPP TCHEQHPEPG 1300
    WHCQVVACVE GCFCPEGTLL HGGACLEPAS CPCEWGRNSF PPGSVLQKDC 1350
    GNCTCQEGQW HCGGDGGHCE ELVPACAEGE ALCQENGHCV PHGWLCDNQD 1400
    DCGDGSDEEG CAAPGCGEGQ MTCSSGHCLP LALLCDRQDD CGDGTDEPSY 1450
    PCPQGLLACA DGRCLPPALL CDGHPDCLDA ADEESCLGQV TCVPGEVSCV 1500
    DGTCLGAIQL CDGVWDCPDG ADEGPGHCPL PSLPTPPAST LPGPSPGSLD 1550
    TASSPLASAS PAPPCGPFEF RCGSGECTPR GWRCDQEEDC ADGSDERGCG 1600
    GPCAPHHAPC ARGPHCVSPE QLCDGVRQCP DGSDEGPDAC GGLPALGGPN 1650
    RTGLPCPEYT CPNGTCIGFQ LVCDGQPDCG RPGQVGPSPE EQGCGAWGPW 1700
    SPWGPCSRTC GPWGQGRSRR CSPLGLLVLQ NCPGPEHQSQ ACFTAACPVD 1750
    GEWSTWSPWS VCSEPCRGTM TRQRQCHSPQ NGGRTCAALP GGLHSTRQTK 1800
    PCPQDGCPNA TCSGELMFQP CAPCPLTCDD ISGQVTCPPD WPCGSPGCWC 1850
    PEGQVLGSEG WCVWPRQCPC LVDGARYWPG QRIKADCQLC ICQDGRPRRC 1900
    RLNPDCAVDC GWSSWSPWAK CLGPCGSQSI QWSFRSSNNP RPSGRGRQCR 1950
    GIHRKARRCQ TEPCEGCEHQ GQVHRVGERW HGGPCRVCQC LHNLTAHCSP 2000
    YCPLGSCPQG WVLVEGTGES CCHCALPGEN QTVQPMATPA AAPAPSPQIR 2050
    FPLATYILPP SGDPCYSPLG LAGLAEGSLH ASSQQLEHPT QAALLGAPTQ 2100
    GPSPQGWHAG GDAYAKWHTR PHYLQLDLLQ PRNLTGILVP ETGSSNAYAS 2150
    SFSLQFSSNG LHWHDYRDLL PGILPLPKLF PRNWDDLDPA VWTFGRMVQA 2200
    RFVRVWPHDV HHSDVPLQVE LLGCEPGSPP APLCPGVGLR CASGECVLRG 2250
    GPCDGVLDCE DGSDEEGCVL LPEGTGRFHS TAKTLALSSA QPGQLLHWPR 2300
    EGLAETEHWP PGQESPTSPT ETRPVSPGPA SGVPHHGESV QMVTTTPIPQ 2350
    MEARTLPPGM AAVTVVPPHP VTPATPAGQS VAPGPFPPVQ CGPGQTPCEV 2400
    LGCVEQAQVC DGREDCLDGS DERHCARNLL MWLPSLPALW AASTVPFMMP 2450
    TMALPGLPAS RALCSPSQLS CGSGECLSAE RRCDLRPDCQ DGSDEDGCVD 2500
    CVLAPWSVWS SCSRSCGLGL TFQRQELLRP PLPGGSCPRD RFRSQSCFVQ 2550
    ACPVAGAWAM WEAWGPCSVS CGGGHQSRQR SCVDPPPKNG GAPCPGASQE 2600
    RAPCGLQPCS GGTDCELGRV YVSADLCQKG LVPPCPPSCL DPKANRSCSG 2650
    HCVEGCRCPP GLLLHDTRCL PLSECPCLVG EELKWPGVSF LLGNCSQCVC 2700
    EKGELLCQPG GCPLPCGWSA WSSWAPCDRS CGSGVRARFR SPSNPPAAWG 2750
    GAPCEGDRQE LQGCHTVCGT EVFGWTPWTS WSSCSQSCLA PGGGPGWRSR 2800
    SRLCPSPGDS SCPGDATQEE PCSPPVCPVP SIWGLWAPWS TCSAPCDGGI 2850
    QTRGRSCSSL APGDTTCPGP HSQTRDCNTQ PCTAQCPENM LFRSAEQCHQ 2900
    EGGPCPRLCL TQGPGIECTG FCAPGCTCPP GLFLHNASCL PRSQCPCQLH 2950
    GQLYASGAMA RLDSCNNCTC VSGKMACTSE RCPVACGWSP WTLWSLCSCS 3000
    CNVGIRRRFR AGTAPPAAFG GAECQGPTME AEFCSLRPCP GPGGEWGPWS 3050
    PCSVPCGGGY RNRTRGSSRS LMEFSTCGLQ PCAGPVPGMC PRDKQWLDCA 3100
    QGPASCAELS APRGTNQTCH PGCHCPSGML LLNNVCVPTQ DCPCAHEGHL 3150
    YPPGSTVVRP CENCSCVSGL IANCSSWPCA EGEPTWSPWT PWSQCSASCG 3200
    PARCHRHRFC ARSPSAVPST VAPLPLPATP TPLCSGPEAE EEPCLLQGCD 3250
    RAGGWGPWGP WSHCSRSCGG GLRSRTRACD QPPPQGLGDY CEGPRAQGEV 3300
    CQALPCPVTN CTAIEGAEYS PCGPPCPRSC DDLVHCVWRC QPGCYCPPGQ 3350
    VLSSNGAICV QPGHCSCLDL LTGQRHHPGA RLARPDGCNH CTCLEGRLNC 3400
    TDLPCPVPGG WCPWSEWTMC SQPCRGQTRS RSRACACPTP QHGGAPCTGE 3450
    AGEAGAQHQR EACPSYATCP VDGAWGPWGP WSPCDMCLGQ SHRSRACSRP 3500
    PTPEGGRPCP GNHTQSRPCQ ENSTQCTDCG GGQSLHPCGQ PCPRSCQDLS 3550
    PGSVCQPGSV GCQPTCGCPL GQLSQDGLCV PPAHCRCQYQ PGAMGIPENQ 3600
    SRSAGSRFSS WESLEPGEVV TGPCDNCTCV AGILQCQEVP DCPDPGVWSS 3650
    WGPWEDCSVS CGGGEQLRSR RCARPPCPGP ARQSRTCSTQ VCREAGCPAG 3700
    RLYRECQPGE GCPFSCAHVT QQVGCFSEGC EEGCHCPEGT FQHRLACVQE 3750
    CPCVLTAWLL QELGATIGDP GQPLGPGDEL DSGQTLRTSC GNCSCAHGKL 3800
    SCSLDDCFEA DGGFGPWSPW GPCSRSCGGL GTRTRSRQCV LTMPTLSGQG 3850
    CRGPRQDLEC PSPDCPGAEG STVEPVTGLP GGWGPWSSWS PCSRSCTDPA 3900
    RPAWRSRTRL CLANCTMGDP LQERPCNLPS CTELPVCPGP GCGAGNCSWT 3950
    SWAPWEPCSR SCGVGQQRRL RAYRPPGPGG HWCPNILTAY QERRFCNLRA 4000
    CPVPGGWSRW SPWSWCDRSC GGGQSLRSRS CSSPPSKNGG APCAGERHQA 4050
    RLCNPMPCEA GCPAGMEVVT CANRCPRRCS DLQEGIVCQD DQVCQKGCRC 4100
    PKGSLEQDGG CVPIGHCDCT DAQGHSWAPG SQHQDACNNC SCQAGQLSCT 4150
    AQPCPPPTHC AWSHWSAWSP CSHSCGPRGQ QSRFRSSTSG SWAPECREEQ 4200
    SQSQPCPQPS CPPLCLQGTR SRTLGDSWLQ GECQRCSCTP EGVICEDTEC 4250
    AVPEAWTLWS SWSDCPVSCG GGNQVRTRAC RAAAPHHRSP PCLGPDTQTR 4300
    QQPCPGLLEA CSWGPWGPCS RSCGPGLASR SGSCPCLMAK ADPTCNSTFL 4350
    HLDTQGCYSG PCPEECVWSS WSSWTRCSCR VLVQQRYRHQ GPASRGARAG 4400
    APCTRLDGHF RPCLISNCSE DSCTPPFEFH ACGSPCAGLC ATHLSHQLCQ 4450
    DLPPCQPGCY CPKGLLEQAG GCIPPEECNC WHTSAAGAGM TLAPGDRLQL 4500
    GCKECECRRG ELHCTSQGCQ GLLPLSEWSE WSPCGPCLPP SALAPASRTA 4550
    LEEHWLRDPT GLSPTLAPLL ASEQHRHRLC LDPATGRPWT GAPHLCTAPL 4600
    SQQRLCPDPG ACPDSCQWSL WGPWSPCQVP CSGGFRLRWR EAEALCGGGC 4650
    REPWAQESCN GGPCPECEAQ DTVFTLDCAN QCPHSCADLW DRVQCLQGPC 4700
    RPGCRCPPGQ LVQDGRCVPI SSCRCGLPSA NASWELAPAQ AVQLDCQNCT 4750
    CVNESLVCPH QECPVLGPWS AWSSCSAPCG GGTMERHRTC EGGPGVAPCQ 4800
    AQDTEQRQEC NLQPCPECPP GQVLSACATS CPCLCWHLQP GAICVQEPCQ 4850
    PGCGCPGGQL LHNGTCVPPT ACPCTQHSLP WGLTLTLEEQ AQELPPGTVL 4900
    TRNCTRCVCH GGAFSCSLVD CQVPPGETWQ QVAPGELGLC EQTCLEMNAT 4950
    KTQSNCSSAR ASGCVCQPGH FRSQAGPCVP EDHCECWHLG RPHLPGSEWQ 5000
    EACESCLCLS GRPVCTQHCS PLTCAQGEEM VLEPGSCCPS CRREAPEEQS 5050
    PSCQLLTELR NFTKGTCYLD QVEVSYCSGY CPSSTHVMPE EPYLQSQCDC 5100
    CSYRLDPESP VRILNLRCLG GHTEPVVLPV IHSCQCSSCQ GGDFSKR 5147
    Length:5,147
    Mass (Da):547,504
    Last modified:March 20, 2007 - v1
    Checksum:i9A8F5C3179F028A3
    GO
    Isoform 2 (identifier: A2VEC9-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-1122: Missing.
         1123-1126: LWDG → MLPP
         1639-1639: A → ACVEAPAPPA...DCPQGEDELD
         1671-1671: L → LVRVGVGGGGGSAMLPPSTRALTPLPPQ
         2179-2314: LFPRNWDDLD...ETEHWPPGQE → VSPAQGRWGQ...RSGRNQSVLC
         2315-5147: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:1,314
    Mass (Da):138,775
    Checksum:i2876F7F1383080E8
    GO

    Sequence cautioni

    The sequence BAC98376.1 differs from that shown. Reason: Erroneous initiation.

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti146 – 1461Q → R.
    Corresponds to variant rs709061 [ dbSNP | Ensembl ].
    VAR_052660
    Natural varianti298 – 2981V → M.
    Corresponds to variant rs17754559 [ dbSNP | Ensembl ].
    VAR_052661
    Natural varianti539 – 5391V → M.
    Corresponds to variant rs855677 [ dbSNP | Ensembl ].
    VAR_059863
    Natural varianti1272 – 12721S → P.
    Corresponds to variant rs709060 [ dbSNP | Ensembl ].
    VAR_059864
    Natural varianti1273 – 12731L → P.
    Corresponds to variant rs709060 [ dbSNP | Ensembl ].
    VAR_052662
    Natural varianti1424 – 14241S → G.
    Corresponds to variant rs855691 [ dbSNP | Ensembl ].
    VAR_059865
    Natural varianti1448 – 14481P → Q.
    Corresponds to variant rs855692 [ dbSNP | Ensembl ].
    VAR_059866
    Natural varianti1453 – 14531P → R.
    Corresponds to variant rs2074704 [ dbSNP | Ensembl ].
    VAR_059867
    Natural varianti1778 – 17781S → P.
    Corresponds to variant rs893601 [ dbSNP | Ensembl ].
    VAR_059868
    Natural varianti1793 – 17931L → P.
    Corresponds to variant rs1635802 [ dbSNP | Ensembl ].
    VAR_059869
    Natural varianti1882 – 18821R → C.
    Corresponds to variant rs1076277 [ dbSNP | Ensembl ].
    VAR_059870
    Natural varianti2017 – 20171T → M.
    Corresponds to variant rs4725314 [ dbSNP | Ensembl ].
    VAR_059871
    Natural varianti2452 – 24521M → T.
    Corresponds to variant rs2074689 [ dbSNP | Ensembl ].
    VAR_061915
    Natural varianti2541 – 25411R → Q.
    Corresponds to variant rs59522380 [ dbSNP | Ensembl ].
    VAR_061916
    Natural varianti2891 – 28911L → V.
    Corresponds to variant rs10260959 [ dbSNP | Ensembl ].
    VAR_059872
    Natural varianti3273 – 32731R → W.
    Corresponds to variant rs740109 [ dbSNP | Ensembl ].
    VAR_059873
    Natural varianti3512 – 35121N → S.
    Corresponds to variant rs10952230 [ dbSNP | Ensembl ].
    VAR_059874
    Natural varianti3892 – 38921C → W.
    Corresponds to variant rs1557955 [ dbSNP | Ensembl ].
    VAR_059875
    Natural varianti3909 – 39091R → C.
    Corresponds to variant rs745044 [ dbSNP | Ensembl ].
    VAR_059876
    Natural varianti4028 – 40281S → I.
    Corresponds to variant rs1005603 [ dbSNP | Ensembl ].
    VAR_059877
    Natural varianti4107 – 41071Q → H.
    Corresponds to variant rs12536873 [ dbSNP | Ensembl ].
    VAR_061917
    Natural varianti4164 – 41641H → R.
    Corresponds to variant rs10233245 [ dbSNP | Ensembl ].
    VAR_059878
    Natural varianti4330 – 43301R → C.
    Corresponds to variant rs1008336 [ dbSNP | Ensembl ].
    VAR_059879
    Natural varianti4787 – 47871H → R.
    Corresponds to variant rs1004200 [ dbSNP | Ensembl ].
    VAR_059880
    Natural varianti4941 – 49411E → K.
    Corresponds to variant rs12534509 [ dbSNP | Ensembl ].
    VAR_059881

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 11221122Missing in isoform 2. 1 PublicationVSP_035258Add
    BLAST
    Alternative sequencei1123 – 11264LWDG → MLPP in isoform 2. 1 PublicationVSP_035259
    Alternative sequencei1639 – 16391A → ACVEAPAPPAMRGPPGQAGG PTSSRAPSPPSPPEAQGEGR KGQERSRTHLTVPAGSTQLP LCPGLFPCGVAPGLCLTPEQ LCDGIPDCPQGEDELD in isoform 2. 1 PublicationVSP_035260
    Alternative sequencei1671 – 16711L → LVRVGVGGGGGSAMLPPSTR ALTPLPPQ in isoform 2. 1 PublicationVSP_035261
    Alternative sequencei2179 – 2314136LFPRN…PPGQE → VSPAQGRWGQQPTMPFCGFH SLCPQGPSSVPEGHGLHSML VEYLVSSRDCALWSRGLGAT VTWMLETIQVAQTQGRYVKP ARERGWGDTKFTEGLREPRP THVFVESSLGTALPSGGLHP SRRQTARSGRNQSVLC in isoform 2. 1 PublicationVSP_035262Add
    BLAST
    Alternative sequencei2315 – 51472833Missing in isoform 2. 1 PublicationVSP_035263Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB111888 mRNA. Translation: BAC98376.1. Different initiation.
    AC004877 Genomic DNA. No translation available.
    BN000852 mRNA. Translation: CAJ43920.1.
    RefSeqiNP_940857.2. NM_198455.2. [A2VEC9-1]
    UniGeneiHs.632022.

    Genome annotation databases

    GeneIDi23145.
    KEGGihsa:23145.
    UCSCiuc010lpk.3. human. [A2VEC9-1]

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB111888 mRNA. Translation: BAC98376.1 . Different initiation.
    AC004877 Genomic DNA. No translation available.
    BN000852 mRNA. Translation: CAJ43920.1 .
    RefSeqi NP_940857.2. NM_198455.2. [A2VEC9-1 ]
    UniGenei Hs.632022.

    3D structure databases

    ProteinModelPortali A2VEC9.
    SMRi A2VEC9. Positions 1350-1643, 2064-2225, 2387-2505, 2510-2609, 2717-2828, 2987-3065, 3186-3309, 3400-3521, 3811-3911, 4003-4059, 4255-4334, 5052-5138.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 116762. 3 interactions.
    STRINGi 9606.ENSP00000367255.

    PTM databases

    PhosphoSitei A2VEC9.

    Proteomic databases

    MaxQBi A2VEC9.
    PaxDbi A2VEC9.
    PRIDEi A2VEC9.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 23145.
    KEGGi hsa:23145.
    UCSCi uc010lpk.3. human. [A2VEC9-1 ]

    Organism-specific databases

    CTDi 23145.
    GeneCardsi GC07P149473.
    H-InvDB HIX0007194.
    HGNCi HGNC:21998. SSPO.
    neXtProti NX_A2VEC9.
    PharmGKBi PA142670865.
    HUGEi Search...
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG12793.
    HOGENOMi HOG000154433.
    HOVERGENi HBG080794.
    PhylomeDBi A2VEC9.

    Enzyme and pathway databases

    Reactomei REACT_200626. O-glycosylation of TSR domain-containing proteins.

    Miscellaneous databases

    GeneWikii SSPO.
    GenomeRNAii 23145.
    NextBioi 44438.
    PROi A2VEC9.

    Gene expression databases

    CleanExi HS_SSPO.
    Genevestigatori A2VEC9.

    Family and domain databases

    Gene3Di 2.60.120.260. 1 hit.
    4.10.400.10. 10 hits.
    InterProi IPR000421. Coagulation_fac_5/8-C_type_dom.
    IPR006207. Cys_knot_C.
    IPR008979. Galactose-bd-like.
    IPR023415. LDLR_class-A_CS.
    IPR002172. LDrepeatLR_classA_rpt.
    IPR008037. Prot_inh_PMP.
    IPR000884. Thrombospondin_1_rpt.
    IPR002919. TIL_dom.
    IPR014853. Unchr_dom_Cys-rich.
    IPR006552. VWC_out.
    IPR001007. VWF_C.
    IPR001846. VWF_type-D.
    [Graphical view ]
    Pfami PF08742. C8. 3 hits.
    PF00754. F5_F8_type_C. 1 hit.
    PF00057. Ldl_recept_a. 8 hits.
    PF01826. TIL. 14 hits.
    PF00090. TSP_1. 22 hits.
    PF00094. VWD. 3 hits.
    [Graphical view ]
    PRINTSi PR00261. LDLRECEPTOR.
    SMARTi SM00832. C8. 3 hits.
    SM00231. FA58C. 1 hit.
    SM00192. LDLa. 10 hits.
    SM00209. TSP1. 25 hits.
    SM00214. VWC. 4 hits.
    SM00215. VWC_out. 1 hit.
    SM00216. VWD. 3 hits.
    [Graphical view ]
    SUPFAMi SSF49785. SSF49785. 1 hit.
    SSF57283. SSF57283. 1 hit.
    SSF57424. SSF57424. 10 hits.
    SSF57567. SSF57567. 14 hits.
    SSF82895. SSF82895. 23 hits.
    PROSITEi PS01225. CTCK_2. 1 hit.
    PS00022. EGF_1. 1 hit.
    PS50022. FA58C_3. 1 hit.
    PS01209. LDLRA_1. 8 hits.
    PS50068. LDLRA_2. 10 hits.
    PS50092. TSP1. 24 hits.
    PS01208. VWFC_1. 1 hit.
    PS50184. VWFC_2. 2 hits.
    PS51233. VWFD. 3 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The nucleotide sequence of a long cDNA clone isolated from human."
      Nagase T., Kikuno R., Ohara O.
      Submitted (NOV-2002) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Brain.
    2. "The DNA sequence of human chromosome 7."
      Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L.
      , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
      Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "The complex multidomain organization of SCO-spondin protein is highly conserved in mammals."
      Meiniel O., Meiniel A.
      Brain Res. Brain Res. Rev. 53:321-327(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION (ISOFORM 1).

    Entry informationi

    Entry nameiSSPO_HUMAN
    AccessioniPrimary (citable) accession number: A2VEC9
    Secondary accession number(s): Q76B61
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 12, 2007
    Last sequence update: March 20, 2007
    Last modified: October 1, 2014
    This is version 69 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 7
      Human chromosome 7: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3