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A2VE78

- FBXL5_BOVIN

UniProt

A2VE78 - FBXL5_BOVIN

Protein

F-box/LRR-repeat protein 5

Gene

FBXL5

Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 51 (01 Oct 2014)
      Sequence version 1 (20 Mar 2007)
      Previous versions | rss
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    Functioni

    Component of some SCF (SKP1-cullin-F-box) protein ligase complex that plays a central role in iron homeostasis by promoting the ubiquitination and subsequent degradation of IREB2/IRP2. Upon high iron and oxygen level, it specifically recognizes and binds IREB2/IRP2, promoting its ubiquitination and degradation by the proteasome. Promotes ubiquitination and subsequent degradation of DCTN1/p150-glued By similarity.By similarity

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi15 – 151Iron 1By similarity
    Metal bindingi57 – 571Iron 1By similarity
    Metal bindingi58 – 581Iron 1By similarity
    Metal bindingi61 – 611Iron 1By similarity
    Metal bindingi61 – 611Iron 2By similarity
    Metal bindingi80 – 801Iron 2By similarity
    Metal bindingi126 – 1261Iron 2By similarity
    Metal bindingi130 – 1301Iron 1By similarity
    Metal bindingi130 – 1301Iron 2By similarity

    GO - Molecular functioni

    1. iron ion binding Source: UniProtKB

    GO - Biological processi

    1. iron ion homeostasis Source: UniProtKB
    2. protein ubiquitination Source: UniProtKB
    3. SCF-dependent proteasomal ubiquitin-dependent protein catabolic process Source: UniProtKB

    Keywords - Biological processi

    Ubl conjugation pathway

    Keywords - Ligandi

    Iron, Metal-binding

    Enzyme and pathway databases

    UniPathwayiUPA00143.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    F-box/LRR-repeat protein 5
    Alternative name(s):
    F-box and leucine-rich repeat protein 5
    Gene namesi
    Name:FBXL5
    OrganismiBos taurus (Bovine)
    Taxonomic identifieri9913 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
    ProteomesiUP000009136: Unplaced

    Subcellular locationi

    Cytoplasmperinuclear region By similarity

    GO - Cellular componenti

    1. perinuclear region of cytoplasm Source: UniProtKB
    2. SCF ubiquitin ligase complex Source: UniProtKB

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 691691F-box/LRR-repeat protein 5PRO_0000390464Add
    BLAST

    Post-translational modificationi

    Ubiquitinated upon iron and oxygen depletion, leading to its degradation by the proteasome. Ubiquitination is regulated by the hemerythrin-like region that acts as an oxygen and iron sensor By similarity.By similarity

    Keywords - PTMi

    Ubl conjugation

    Proteomic databases

    PRIDEiA2VE78.

    Interactioni

    Subunit structurei

    Part of a SCF (SKP1-cullin-F-box) protein ligase complex. Interacts with ACO1, IREB2/IRP2; the interaction depends on the 4Fe-4S cluster. Interacts with DCTN1/p150-glued By similarity.By similarity

    Protein-protein interaction databases

    STRINGi9913.ENSBTAP00000028266.

    Structurei

    3D structure databases

    ProteinModelPortaliA2VE78.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini202 – 24847F-boxPROSITE-ProRule annotationAdd
    BLAST
    Repeati340 – 36425LRR 1Add
    BLAST
    Repeati365 – 39228LRR 2Add
    BLAST
    Repeati393 – 41826LRR 3Add
    BLAST
    Repeati479 – 50830LRR 4Add
    BLAST
    Repeati576 – 60732LRR 5Add
    BLAST
    Repeati608 – 63528LRR 6Add
    BLAST
    Repeati636 – 66126LRR 7Add
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni1 – 159159Hemerythrin-likeBy similarityAdd
    BLAST

    Domaini

    The hemerythrin-like region acts as an oxygen and iron sensor by binding oxygen through a diiron metal-center. In absence of oxygen and iron, the protein is ubiquitinated and degraded By similarity.By similarity

    Sequence similaritiesi

    Contains 1 F-box domain.PROSITE-ProRule annotation
    Contains 7 LRR (leucine-rich) repeats.Curated

    Keywords - Domaini

    Leucine-rich repeat, Repeat

    Phylogenomic databases

    eggNOGiNOG29620.
    HOGENOMiHOG000006899.
    HOVERGENiHBG051589.
    InParanoidiA2VE78.
    KOiK10271.

    Family and domain databases

    InterProiIPR001810. F-box_dom.
    IPR012312. Haemerythrin/HHE_cat-bd_motif.
    IPR006553. Leu-rich_rpt_Cys-con_subtyp.
    [Graphical view]
    PfamiPF12937. F-box-like. 1 hit.
    PF01814. Hemerythrin. 1 hit.
    [Graphical view]
    SMARTiSM00256. FBOX. 1 hit.
    SM00367. LRR_CC. 1 hit.
    [Graphical view]
    SUPFAMiSSF81383. SSF81383. 1 hit.
    PROSITEiPS50181. FBOX. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A2VE78-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAPFPEEVDV FTAPHWRMKQ LVGLYCDKLS KTNFSNNNDF RALLQSLYAT    50
    FKEFKMHEQI ENEYIIGLLQ QRSQTIYNVH SDNKLSEMLS LFEKGLKNVK 100
    NEYEQLNYAK QLKERLEAFT KDFLPHMKEE EEVFQPMLME YFTYEELKDI 150
    KKKVIAQHCS QKDTAELLRG LSLWNQAEER QKFFKYSVDE KSDKEAEVSE 200
    QSTGITHLPP EVMVSIFSYL NPQELCRCSQ VSTKWSQLAK TGSLWKHLYP 250
    VHWARGDWYS GPAAELDTEP DEEWVKSRRD ESRAFQEWDE DADIDESEES 300
    GEESIAISIA QMEKRLLHGL IHNVLPYVGT SVKTLVLAYS SAVSSKMVRQ 350
    ILELCPNLEH LDLTQTDISD SAFDSWSWLG CCQSLRHLDL SGCEKITDVA 400
    LEKISRALGI LTTHESGLLK TSTSKVTSTT WKNKDITMQS FKQSACLHDV 450
    TNKDIGEEVD NEHPWTKPIS SDDFTSPYVW MLDAEDLADI EDAVEWRHRN 500
    VESLCVMETA SNFSCPSSAC YSKDIVGLRT SVCWQQHCAS PAFAYCGHSY 550
    CCTGTALRTM SALPESSALC RKAPRTRLLR EKDLIYSGSE KSDQETGRVL 600
    LFLSLSGCYQ ITDHGLRVLT LGGGLPYLEH LNLSGCLTVT GAGLQDLVSA 650
    CPSLNDEYFY YCDNINGPHA DTASGCQNLQ CGFRACCRSG E 691
    Length:691
    Mass (Da):78,412
    Last modified:March 20, 2007 - v1
    Checksum:i15A5BA66BDE12331
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC133613 mRNA. Translation: AAI33614.1.
    RefSeqiNP_001075909.1. NM_001082440.1.
    UniGeneiBt.17790.

    Genome annotation databases

    GeneIDi519695.
    KEGGibta:519695.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC133613 mRNA. Translation: AAI33614.1 .
    RefSeqi NP_001075909.1. NM_001082440.1.
    UniGenei Bt.17790.

    3D structure databases

    ProteinModelPortali A2VE78.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9913.ENSBTAP00000028266.

    Proteomic databases

    PRIDEi A2VE78.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 519695.
    KEGGi bta:519695.

    Organism-specific databases

    CTDi 26234.

    Phylogenomic databases

    eggNOGi NOG29620.
    HOGENOMi HOG000006899.
    HOVERGENi HBG051589.
    InParanoidi A2VE78.
    KOi K10271.

    Enzyme and pathway databases

    UniPathwayi UPA00143 .

    Miscellaneous databases

    NextBioi 20872928.

    Family and domain databases

    InterProi IPR001810. F-box_dom.
    IPR012312. Haemerythrin/HHE_cat-bd_motif.
    IPR006553. Leu-rich_rpt_Cys-con_subtyp.
    [Graphical view ]
    Pfami PF12937. F-box-like. 1 hit.
    PF01814. Hemerythrin. 1 hit.
    [Graphical view ]
    SMARTi SM00256. FBOX. 1 hit.
    SM00367. LRR_CC. 1 hit.
    [Graphical view ]
    SUPFAMi SSF81383. SSF81383. 1 hit.
    PROSITEi PS50181. FBOX. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. NIH - Mammalian Gene Collection (MGC) project
      Submitted (FEB-2007) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: Hereford.
      Tissue: Fetal lung.

    Entry informationi

    Entry nameiFBXL5_BOVIN
    AccessioniPrimary (citable) accession number: A2VE78
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 15, 2009
    Last sequence update: March 20, 2007
    Last modified: October 1, 2014
    This is version 51 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3