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A2VE78

- FBXL5_BOVIN

UniProt

A2VE78 - FBXL5_BOVIN

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Protein

F-box/LRR-repeat protein 5

Gene

FBXL5

Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Component of some SCF (SKP1-cullin-F-box) protein ligase complex that plays a central role in iron homeostasis by promoting the ubiquitination and subsequent degradation of IREB2/IRP2. Upon high iron and oxygen level, it specifically recognizes and binds IREB2/IRP2, promoting its ubiquitination and degradation by the proteasome. Promotes ubiquitination and subsequent degradation of DCTN1/p150-glued (By similarity).By similarity

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi15 – 151Iron 1By similarity
Metal bindingi57 – 571Iron 1By similarity
Metal bindingi58 – 581Iron 1By similarity
Metal bindingi61 – 611Iron 1By similarity
Metal bindingi61 – 611Iron 2By similarity
Metal bindingi80 – 801Iron 2By similarity
Metal bindingi126 – 1261Iron 2By similarity
Metal bindingi130 – 1301Iron 1By similarity
Metal bindingi130 – 1301Iron 2By similarity

GO - Molecular functioni

  1. iron ion binding Source: UniProtKB

GO - Biological processi

  1. iron ion homeostasis Source: UniProtKB
  2. protein ubiquitination Source: UniProtKB
  3. SCF-dependent proteasomal ubiquitin-dependent protein catabolic process Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Ubl conjugation pathway

Keywords - Ligandi

Iron, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00143.

Names & Taxonomyi

Protein namesi
Recommended name:
F-box/LRR-repeat protein 5
Alternative name(s):
F-box and leucine-rich repeat protein 5
Gene namesi
Name:FBXL5
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
ProteomesiUP000009136: Unplaced

Subcellular locationi

Cytoplasmperinuclear region By similarity

GO - Cellular componenti

  1. perinuclear region of cytoplasm Source: UniProtKB
  2. SCF ubiquitin ligase complex Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 691691F-box/LRR-repeat protein 5PRO_0000390464Add
BLAST

Post-translational modificationi

Ubiquitinated upon iron and oxygen depletion, leading to its degradation by the proteasome. Ubiquitination is regulated by the hemerythrin-like region that acts as an oxygen and iron sensor (By similarity).By similarity

Keywords - PTMi

Ubl conjugation

Proteomic databases

PRIDEiA2VE78.

Interactioni

Subunit structurei

Part of a SCF (SKP1-cullin-F-box) protein ligase complex. Interacts with ACO1, IREB2/IRP2; the interaction depends on the 4Fe-4S cluster. Interacts with DCTN1/p150-glued (By similarity).By similarity

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000028266.

Structurei

3D structure databases

ProteinModelPortaliA2VE78.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini202 – 24847F-boxPROSITE-ProRule annotationAdd
BLAST
Repeati340 – 36425LRR 1Add
BLAST
Repeati365 – 39228LRR 2Add
BLAST
Repeati393 – 41826LRR 3Add
BLAST
Repeati479 – 50830LRR 4Add
BLAST
Repeati576 – 60732LRR 5Add
BLAST
Repeati608 – 63528LRR 6Add
BLAST
Repeati636 – 66126LRR 7Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 159159Hemerythrin-likeBy similarityAdd
BLAST

Domaini

The hemerythrin-like region acts as an oxygen and iron sensor by binding oxygen through a diiron metal-center. In absence of oxygen and iron, the protein is ubiquitinated and degraded (By similarity).By similarity

Sequence similaritiesi

Contains 1 F-box domain.PROSITE-ProRule annotation
Contains 7 LRR (leucine-rich) repeats.Curated

Keywords - Domaini

Leucine-rich repeat, Repeat

Phylogenomic databases

eggNOGiNOG29620.
HOGENOMiHOG000006899.
HOVERGENiHBG051589.
InParanoidiA2VE78.
KOiK10271.

Family and domain databases

InterProiIPR001810. F-box_dom.
IPR012312. Haemerythrin/HHE_cat-bd_motif.
IPR006553. Leu-rich_rpt_Cys-con_subtyp.
[Graphical view]
PfamiPF12937. F-box-like. 1 hit.
PF01814. Hemerythrin. 1 hit.
[Graphical view]
SMARTiSM00256. FBOX. 1 hit.
SM00367. LRR_CC. 1 hit.
[Graphical view]
SUPFAMiSSF81383. SSF81383. 1 hit.
PROSITEiPS50181. FBOX. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A2VE78-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAPFPEEVDV FTAPHWRMKQ LVGLYCDKLS KTNFSNNNDF RALLQSLYAT
60 70 80 90 100
FKEFKMHEQI ENEYIIGLLQ QRSQTIYNVH SDNKLSEMLS LFEKGLKNVK
110 120 130 140 150
NEYEQLNYAK QLKERLEAFT KDFLPHMKEE EEVFQPMLME YFTYEELKDI
160 170 180 190 200
KKKVIAQHCS QKDTAELLRG LSLWNQAEER QKFFKYSVDE KSDKEAEVSE
210 220 230 240 250
QSTGITHLPP EVMVSIFSYL NPQELCRCSQ VSTKWSQLAK TGSLWKHLYP
260 270 280 290 300
VHWARGDWYS GPAAELDTEP DEEWVKSRRD ESRAFQEWDE DADIDESEES
310 320 330 340 350
GEESIAISIA QMEKRLLHGL IHNVLPYVGT SVKTLVLAYS SAVSSKMVRQ
360 370 380 390 400
ILELCPNLEH LDLTQTDISD SAFDSWSWLG CCQSLRHLDL SGCEKITDVA
410 420 430 440 450
LEKISRALGI LTTHESGLLK TSTSKVTSTT WKNKDITMQS FKQSACLHDV
460 470 480 490 500
TNKDIGEEVD NEHPWTKPIS SDDFTSPYVW MLDAEDLADI EDAVEWRHRN
510 520 530 540 550
VESLCVMETA SNFSCPSSAC YSKDIVGLRT SVCWQQHCAS PAFAYCGHSY
560 570 580 590 600
CCTGTALRTM SALPESSALC RKAPRTRLLR EKDLIYSGSE KSDQETGRVL
610 620 630 640 650
LFLSLSGCYQ ITDHGLRVLT LGGGLPYLEH LNLSGCLTVT GAGLQDLVSA
660 670 680 690
CPSLNDEYFY YCDNINGPHA DTASGCQNLQ CGFRACCRSG E
Length:691
Mass (Da):78,412
Last modified:March 20, 2007 - v1
Checksum:i15A5BA66BDE12331
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC133613 mRNA. Translation: AAI33614.1.
RefSeqiNP_001075909.1. NM_001082440.1.
UniGeneiBt.17790.

Genome annotation databases

GeneIDi519695.
KEGGibta:519695.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC133613 mRNA. Translation: AAI33614.1 .
RefSeqi NP_001075909.1. NM_001082440.1.
UniGenei Bt.17790.

3D structure databases

ProteinModelPortali A2VE78.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9913.ENSBTAP00000028266.

Proteomic databases

PRIDEi A2VE78.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 519695.
KEGGi bta:519695.

Organism-specific databases

CTDi 26234.

Phylogenomic databases

eggNOGi NOG29620.
HOGENOMi HOG000006899.
HOVERGENi HBG051589.
InParanoidi A2VE78.
KOi K10271.

Enzyme and pathway databases

UniPathwayi UPA00143 .

Miscellaneous databases

NextBioi 20872928.

Family and domain databases

InterProi IPR001810. F-box_dom.
IPR012312. Haemerythrin/HHE_cat-bd_motif.
IPR006553. Leu-rich_rpt_Cys-con_subtyp.
[Graphical view ]
Pfami PF12937. F-box-like. 1 hit.
PF01814. Hemerythrin. 1 hit.
[Graphical view ]
SMARTi SM00256. FBOX. 1 hit.
SM00367. LRR_CC. 1 hit.
[Graphical view ]
SUPFAMi SSF81383. SSF81383. 1 hit.
PROSITEi PS50181. FBOX. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. NIH - Mammalian Gene Collection (MGC) project
    Submitted (FEB-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Hereford.
    Tissue: Fetal lung.

Entry informationi

Entry nameiFBXL5_BOVIN
AccessioniPrimary (citable) accession number: A2VE78
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 2009
Last sequence update: March 20, 2007
Last modified: October 1, 2014
This is version 51 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3