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Protein

UDP-N-acetylglucosamine/UDP-glucose/GDP-mannose transporter

Gene

SLC35D2

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Antiporter transporting nucleotide sugars such as UDP-N-acetylglucosamine (UDP-GlcNAc), UDP-glucose (UDP-Glc) and GDP-mannose (GDP-Man) pooled in the cytosol into the lumen of the Golgi in exchange for the corresponding nucleosides monophosphates (UMP for UDP-sugars and GMP for GDP-sugars). May take part in heparan sulfate synthesis by supplying UDP-GlcNAc, the donor substrate, and thus be involved in growth factor signaling (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Sugar transport, Transport

Enzyme and pathway databases

ReactomeiR-BTA-173599. Formation of the active cofactor, UDP-glucuronate.
R-BTA-727802. Transport of nucleotide sugars.

Names & Taxonomyi

Protein namesi
Recommended name:
UDP-N-acetylglucosamine/UDP-glucose/GDP-mannose transporter
Alternative name(s):
Solute carrier family 35 member D2
Gene namesi
Name:SLC35D2
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 3

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 38CytoplasmicSequence analysisAdd BLAST38
Transmembranei39 – 59HelicalSequence analysisAdd BLAST21
Topological domaini60 – 68ExtracellularSequence analysis9
Transmembranei69 – 89HelicalSequence analysisAdd BLAST21
Topological domaini90 – 156CytoplasmicSequence analysisAdd BLAST67
Transmembranei157 – 177HelicalSequence analysisAdd BLAST21
Topological domaini178 – 184ExtracellularSequence analysis7
Transmembranei185 – 205HelicalSequence analysisAdd BLAST21
Topological domaini206 – 216CytoplasmicSequence analysisAdd BLAST11
Transmembranei217 – 237HelicalSequence analysisAdd BLAST21
Topological domaini238 – 253ExtracellularSequence analysisAdd BLAST16
Transmembranei254 – 274HelicalSequence analysisAdd BLAST21
Topological domaini275 – 280CytoplasmicSequence analysis6
Transmembranei281 – 303HelicalSequence analysisAdd BLAST23
Topological domaini304 – 314ExtracellularSequence analysisAdd BLAST11
Transmembranei315 – 335HelicalSequence analysisAdd BLAST21
Topological domaini336 – 355CytoplasmicSequence analysisAdd BLAST20

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003130791 – 355UDP-N-acetylglucosamine/UDP-glucose/GDP-mannose transporterAdd BLAST355

Proteomic databases

PaxDbiA2VE55.
PRIDEiA2VE55.

Expressioni

Gene expression databases

BgeeiENSBTAG00000005445.

Interactioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000007164.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1444. Eukaryota.
COG5070. LUCA.
GeneTreeiENSGT00390000014204.
HOGENOMiHOG000038339.
HOVERGENiHBG054071.
InParanoidiA2VE55.
KOiK15281.
OMAiKFSRPVQ.
OrthoDBiEOG091G0KCU.
TreeFamiTF313307.

Family and domain databases

InterProiIPR004853. Sugar_P_trans_dom.
[Graphical view]
PfamiPF03151. TPT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A2VE55-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAEVHRRQHA RVKGEAPAKS STHRHEEELG MASAETLTVF LKLLAAGFYG
60 70 80 90 100
VSSFLIVVVN KSVLTNYRFP SSLCVGLGQM VATVAVLWVG KALRVVKFPD
110 120 130 140 150
FDRNVPRKTF PLPLLYFGNQ ITGLFSTKKL NLPMFTVLRR FSILFTMFAE
160 170 180 190 200
GVLLKKTFSW GIKMTVFAMI IGAFVAASSD LAFDLEGYVF ILINDVLTAA
210 220 230 240 250
NGAYVKQKLD SKELGKYGLL YYNALFMILP TLAIAYFTGD AQKALDFEGW
260 270 280 290 300
ADTLFLLQFT LSCVMGFILM YATVLCTQYN SALTTTIVGC IKNILITYIG
310 320 330 340 350
MVFGGDYIFT WTNFIGLNIS IAGSLVYSYI TFSEEQLSKQ SEASSKLDIK

GKGAV
Length:355
Mass (Da):39,280
Last modified:March 20, 2007 - v1
Checksum:i4F45D60684F90A30
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC133580 mRNA. Translation: AAI33581.1.
RefSeqiNP_001075928.1. NM_001082459.2.
UniGeneiBt.58895.

Genome annotation databases

EnsembliENSBTAT00000007164; ENSBTAP00000007164; ENSBTAG00000005445.
GeneIDi613734.
KEGGibta:613734.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC133580 mRNA. Translation: AAI33581.1.
RefSeqiNP_001075928.1. NM_001082459.2.
UniGeneiBt.58895.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000007164.

Proteomic databases

PaxDbiA2VE55.
PRIDEiA2VE55.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000007164; ENSBTAP00000007164; ENSBTAG00000005445.
GeneIDi613734.
KEGGibta:613734.

Organism-specific databases

CTDi23169.

Phylogenomic databases

eggNOGiKOG1444. Eukaryota.
COG5070. LUCA.
GeneTreeiENSGT00390000014204.
HOGENOMiHOG000038339.
HOVERGENiHBG054071.
InParanoidiA2VE55.
KOiK15281.
OMAiKFSRPVQ.
OrthoDBiEOG091G0KCU.
TreeFamiTF313307.

Enzyme and pathway databases

ReactomeiR-BTA-173599. Formation of the active cofactor, UDP-glucuronate.
R-BTA-727802. Transport of nucleotide sugars.

Gene expression databases

BgeeiENSBTAG00000005445.

Family and domain databases

InterProiIPR004853. Sugar_P_trans_dom.
[Graphical view]
PfamiPF03151. TPT. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiS35D2_BOVIN
AccessioniPrimary (citable) accession number: A2VE55
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: March 20, 2007
Last modified: November 30, 2016
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.