A2VE47 (ADPGK_BOVIN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
ADP-dependent glucokinase
Short name=ADP-GK
Short name=ADPGK
EC=2.7.1.147

Gene names

Name:

ADPGK

Organism

Bos taurus (Bovine)

Taxonomic identifier

9913 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos

Protein attributes

Sequence length	497 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Catalyzes the phosphorylation of D-glucose to D-glucose 6-phosphate using ADP as the phosphate donor. GDP and CDP can replace ADP, but with reduced efficiency By similarity.
Catalytic activity	ADP + D-glucose = AMP + D-glucose 6-phosphate.
Cofactor	Binds 1 magnesium ion per subunit By similarity.
Pathway	Carbohydrate degradation; glycolysis.
Subunit structure	Monomer By similarity.
Subcellular location	Secreted Potential.
Sequence similarities	Belongs to the ADP-dependent glucokinase family. Contains 1 ADPK (ADP-dependent kinase) domain.

Ontologies

Keywords
Biological process	Glycolysis
Cellular component	Secreted
Domain	Signal
Ligand	Magnesium Metal-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	glycolysis Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ADP-specific glucokinase activity Inferred from electronic annotation. Source: EC metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 22	22	Potential
	Chain	23 – 497	475	ADP-dependent glucokinase		PRO_0000346789
Regions
	Domain	52 – 497	446	ADPK
Sites
	Active site	481	1	Proton acceptor By similarity
	Metal binding	297	1	Magnesium By similarity
	Metal binding	328	1	Magnesium By similarity
	Metal binding	481	1	Magnesium By similarity

Sequences

	Sequence		Length	Mass (Da)
	A2VE47 [UniParc]. Last modified March 20, 2007. Version 1. Checksum: AFFC94E7DEB10179	FASTA	497	54,086
	10 20 30 40 50 60 MALWRGSAYA GFLALAVGCV FLLEPQLPGS ALRSLWSSLQ LGPAPAPPGV GSPEGRLAAA 70 80 90 100 110 120 WDALIVRPAR RWRRVAVGVN ACVDVVLSGV KLLQALGLSP GNGKDHSELH SRNDLEEAFV 130 140 150 160 170 180 HFMGKGAAAE RFFSDKETFH DIAQVASEFP EAQHYVGGNA ALIGQKFAAN SDLKVLLCGP 190 200 210 220 230 240 VGPKLHELLD DNVFVPPESL QEVDEFHLIL EYQAGEEWDQ LKAPHANRFI FSHDLSNGAM 250 260 270 280 290 300 NMLEVFVSSL EEFQPDLVVL SGLHMMEGQS KEFQRKRLLE VVTSISDIPT GVPVHLELAS 310 320 330 340 350 360 MTNKELMSTI VHQQVFPAVT SLGLNEQELL FLSQSASGPH SSLSSWNGVP DVGVVSDILF 370 380 390 400 410 420 WILKEHGKSE SRASDLSRIH FHTLAYHILA TVDGHWANQL AAVAAGARVA ATQACATETI 430 440 450 460 470 480 DTRRVSLKAP HEFMTSRLEA GSRVVLNPNE PVVEWHREGV SFHFTPVLVC KDPVRTVGLG 490 DAISAEGLFY SEVHPHL

References

[1]	NIH - Mammalian Gene Collection (MGC) project Submitted (FEB-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: Hereford. Tissue: Thymus.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BC133568 mRNA. Translation: AAI33569.1.
IPI	IPI00699925.
RefSeq	NP_001075907.1. NM_001082438.1.
UniGene	Bt.77006.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	A2VE47.
Proteomic databases
PRIDE	A2VE47.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSBTAT00000002065; ENSBTAP00000002065; ENSBTAG00000001578.
GeneID	518158.
KEGG	bta:518158.
Organism-specific databases
CTD	83440.
Phylogenomic databases
eggNOG	maNOG11315.
GeneTree	ENSGT00390000017953.
HOVERGEN	HBG050461.
InParanoid	A2VE47.
OMA	NAALIGQ.
OrthoDB	EOG47WNNN.
Family and domain databases
InterPro	IPR007666. ADP_PFK/GK. [Graphical view]
KO	K08074.
PANTHER	PTHR21208. ADP_PFK/GK. 1 hit.
Pfam	PF04587. ADP_PFK_GK. 1 hit. [Graphical view]
PROSITE	PS51255. ADPK. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ADPGK_BOVIN

Accession

Primary (citable) accession number: A2VE47

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 2, 2008
Last sequence update:	March 20, 2007
Last modified:	November 16, 2011
This is version 31 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program