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Reviewed, UniProtKB/Swiss-Prot A2VE47 (ADPGK_BOVIN)

Last modified January 19, 2010. Version 21. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    ADP-dependent glucokinase
      Short name=ADP-GK
      Short name=ADPGK
    EC=2.7.1.147
Gene names
Name: ADPGK
OrganismBos taurus (Bovine)
Taxonomic identifier9913 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos

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Protein attributes

Sequence length497 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level.

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General annotation (Comments)

Function

Catalyzes the phosphorylation of D-glucose to D-glucose 6-phosphate using ADP as the phosphate donor. GDP and CDP can replace ADP, but with reduced efficiency By similarity.

Catalytic activity

ADP + D-glucose = AMP + D-glucose 6-phosphate.

Cofactor

Binds 1 magnesium ion per subunit By similarity.

Pathway

Carbohydrate degradation; glycolysis.

Subunit structure

Monomer By similarity.

Subcellular location

Secreted Potential.

Sequence similarities

Belongs to the ADP-dependent glucokinase family.

Contains 1 ADPK (ADP-dependent kinase) domain.

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Ontologies

Keywords
   Biological processGlycolysis
   Cellular componentSecreted
   DomainSignal
   LigandMagnesium
Metal-binding
   Molecular functionKinase
Transferase
Gene Ontology (GO)
   Biological processglycolysis

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentextracellular region

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionADP-specific glucokinase activity

Inferred from electronic annotation. Source: EC

magnesium ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2222 Potential
Chain23 – 497475ADP-dependent glucokinase
PRO_0000346789

Regions

Domain52 – 497446ADPK

Sites

Active site4811Proton acceptor By similarity
Metal binding2971Magnesium By similarity
Metal binding3281Magnesium By similarity
Metal binding4811Magnesium By similarity

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Sequences

Sequence LengthMass (Da)Tools
A2VE47-1 [UniParc].

Last modified March 20, 2007. Version 1.
Checksum: AFFC94E7DEB10179

FASTA49754,086
        10         20         30         40         50         60 
MALWRGSAYA GFLALAVGCV FLLEPQLPGS ALRSLWSSLQ LGPAPAPPGV GSPEGRLAAA 

        70         80         90        100        110        120 
WDALIVRPAR RWRRVAVGVN ACVDVVLSGV KLLQALGLSP GNGKDHSELH SRNDLEEAFV 

       130        140        150        160        170        180 
HFMGKGAAAE RFFSDKETFH DIAQVASEFP EAQHYVGGNA ALIGQKFAAN SDLKVLLCGP 

       190        200        210        220        230        240 
VGPKLHELLD DNVFVPPESL QEVDEFHLIL EYQAGEEWDQ LKAPHANRFI FSHDLSNGAM 

       250        260        270        280        290        300 
NMLEVFVSSL EEFQPDLVVL SGLHMMEGQS KEFQRKRLLE VVTSISDIPT GVPVHLELAS 

       310        320        330        340        350        360 
MTNKELMSTI VHQQVFPAVT SLGLNEQELL FLSQSASGPH SSLSSWNGVP DVGVVSDILF 

       370        380        390        400        410        420 
WILKEHGKSE SRASDLSRIH FHTLAYHILA TVDGHWANQL AAVAAGARVA ATQACATETI 

       430        440        450        460        470        480 
DTRRVSLKAP HEFMTSRLEA GSRVVLNPNE PVVEWHREGV SFHFTPVLVC KDPVRTVGLG 

       490 
DAISAEGLFY SEVHPHL

« Hide

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References

[1]NIH - Mammalian Gene Collection (MGC) project
Submitted (FEB-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: Hereford.
Tissue: Thymus.

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Cross-references

Sequence databases

EMBL
GenBank
DDBJ		BC133568 mRNA. Translation: AAI33569.1.
IPIIPI00699925.
RefSeqNP_001075907.1.
UniGeneBt.77006

3D structure databases

ModBaseSearch...

Genome annotation databases

EnsemblENSBTAT00000002065; ENSBTAP00000002065; ENSBTAG00000001578; Bos taurus. [Genome view]
GeneID518158.
KEGGbta:518158.

Organism-specific databases

CTD518158.

Phylogenomic databases

eggNOGmaNOG11315.
HOVERGENA2VE47.
InParanoidA2VE47.
OMAHYVGGNA.
OrthoDBEOG9QFZZZ.

Family and domain databases

InterProIPR007666. ADP_PFK/GK.
[Graphical view]
PANTHERPTHR21208. ADP_PFK/GK. 1 hit.
PfamPF04587. ADP_PFK_GK. 1 hit.
[Graphical view]
PROSITEPS51255. ADPK. 1 hit.
[Graphical view]
ProtoNetSearch...

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Entry information

Entry nameADPGK_BOVIN
AccessionPrimary (citable) accession number: A2VE47
Entry history
Integrated into UniProtKB/Swiss-Prot: September 2, 2008
Last sequence update: March 20, 2007
Last modified: January 19, 2010
This is version 21 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

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Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents