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A2VE31 (S38A2_BOVIN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 45. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Sodium-coupled neutral amino acid transporter 2
Alternative name(s):
Amino acid transporter A2
Protein 40-9-1
Solute carrier family 38 member 2
System A amino acid transporter 2
System A transporter 1
System N amino acid transporter 2
Gene names
Name:SLC38A2
Synonyms:SNAT2
OrganismBos taurus (Bovine) [Reference proteome]
Taxonomic identifier9913 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos

Protein attributes

Sequence length506 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Functions as a sodium-dependent amino acid transporter. Mediates the saturable, pH-sensitive and electrogenic cotransport of neutral amino acids and sodium ions with a stoichiometry of 1:1. May function in the transport of amino acids at the blood-brain barrier and in the supply of maternal nutrients to the fetus through the placenta By similarity.

Enzyme regulation

Inhibited by N-methyl-D-glucamine and choline By similarity.

Subcellular location

Cell membrane; Multi-pass membrane protein By similarity. Note: Insulin promotes recruitment to the plasma membrane from a pool localized in the trans-Golgi network or endosomes By similarity. May localize to an endosomal compartment By similarity. Enriched in the somatodendritic compartment of neurons, it is also detected at the axonal shaft but excluded from the nerve terminal By similarity.

Post-translational modification

Polyubiquitination by NEDD4L regulates the degradation and the activity of SLC38A2 By similarity.

Sequence similarities

Belongs to the amino acid/polyamine transporter 2 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 506506Sodium-coupled neutral amino acid transporter 2
PRO_0000311368

Regions

Topological domain1 – 7676Cytoplasmic Potential
Transmembrane77 – 9721Helical; Potential
Topological domain98 – 1025Extracellular Potential
Transmembrane103 – 12321Helical; Potential
Topological domain124 – 15835Cytoplasmic Potential
Transmembrane159 – 17921Helical; Potential
Topological domain180 – 1889Extracellular Potential
Transmembrane189 – 20921Helical; Potential
Topological domain210 – 2178Cytoplasmic Potential
Transmembrane218 – 23821Helical; Potential
Topological domain239 – 29254Extracellular Potential
Transmembrane293 – 31321Helical; Potential
Topological domain314 – 32916Cytoplasmic Potential
Transmembrane330 – 35021Helical; Potential
Topological domain351 – 37121Extracellular Potential
Transmembrane372 – 39221Helical; Potential
Topological domain393 – 41321Cytoplasmic Potential
Transmembrane414 – 43421Helical; Potential
Topological domain435 – 4362Extracellular Potential
Transmembrane437 – 45721Helical; Potential
Topological domain458 – 47417Cytoplasmic Potential
Transmembrane475 – 49521Helical; Potential
Topological domain496 – 50611Extracellular Potential
Region1 – 9696Regulates protein turnover upon amino acid deprivation By similarity

Amino acid modifications

Modified residue121Phosphoserine By similarity
Modified residue221Phosphoserine By similarity
Modified residue551Phosphoserine By similarity
Glycosylation2581N-linked (GlcNAc...) Potential
Glycosylation2741N-linked (GlcNAc...) Potential

Experimental info

Sequence conflict4091S → N in CAC51429. Ref.2

Sequences

Sequence LengthMass (Da)Tools
A2VE31 [UniParc].

Last modified March 20, 2007. Version 1.
Checksum: 952C9D7F55E1659F

FASTA50656,214
        10         20         30         40         50         60 
MKKAEMGRFN ISPDEDSSSY SSNSDFNYSY PTKQAALKSH YADVDPENQN FLLESNLGKK 

        70         80         90        100        110        120 
KYETDFHPGT TSFGMSVFNL SNAIVGSGIL GLSYAMANTG IALFIILLTF VSIFSLYSVH 

       130        140        150        160        170        180 
LLLKTANEGG SLLYEQLGHK AFGMVGKLTA SGSITMQNIG AMSSYLFIVK YELPLVIQAL 

       190        200        210        220        230        240 
MNIEDTNGLW YLNGDYLVLL VSLVLILPLS LLRNLGYLGY TSGLSLLCMM FFLIVVIFKK 

       250        260        270        280        290        300 
FQISCPAEIA FLVNETVNSS LTQPATFLPD MGFNRTESDS CQPRYFIFNS QTVYAVPILT 

       310        320        330        340        350        360 
FSFVCHPAIL PIYEELKGRS RRRMMNVSKI SFFAMFLMYL LAALFGYLTF YGHVESELLH 

       370        380        390        400        410        420 
TYSSVMETDI LLLIVRLAVL VAVTLTVPVV IFPIRSSITH LLCASKEFSW WRHSVITVSI 

       430        440        450        460        470        480 
LVFTNLLVIF VPNIRDIFGF IGASAAAMLI FILPSAFYIK LVKKEPMKSV QKIGAMFFLL 

       490        500 
SGIVVMTGSM ALIVLDWVHN APGGGH 

« Hide

References

« Hide 'large scale' references
[1]NIH - Mammalian Gene Collection (MGC) project
Submitted (FEB-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: Hereford.
Tissue: Fetal skin.
[2]Schmidt T.
Thesis (2001), University of Goettingen, Germany
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 223-506.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BC133547 mRNA. Translation: AAI33548.1.
AJ344100 mRNA. Translation: CAC51429.1.
RefSeqNP_001075893.1. NM_001082424.1.
UniGeneBt.9238.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Proteomic databases

PRIDEA2VE31.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSBTAT00000014749; ENSBTAP00000014749; ENSBTAG00000011105.
GeneID338044.
KEGGbta:338044.

Organism-specific databases

CTD54407.

Phylogenomic databases

eggNOGNOG236441.
GeneTreeENSGT00650000093166.
HOGENOMHOG000013088.
HOVERGENHBG059571.
InParanoidA2VE31.
KOK14207.
OMAYEHVESE.
OrthoDBEOG7WHH9J.
TreeFamTF328787.

Family and domain databases

InterProIPR013057. AA_transpt_TM.
[Graphical view]
PfamPF01490. Aa_trans. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio20812495.

Entry information

Entry nameS38A2_BOVIN
AccessionPrimary (citable) accession number: A2VE31
Secondary accession number(s): Q95M41
Entry history
Integrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: March 20, 2007
Last modified: April 16, 2014
This is version 45 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families