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A2VE31

- S38A2_BOVIN

UniProt

A2VE31 - S38A2_BOVIN

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Protein
Sodium-coupled neutral amino acid transporter 2
Gene
SLC38A2, SNAT2
Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Functions as a sodium-dependent amino acid transporter. Mediates the saturable, pH-sensitive and electrogenic cotransport of neutral amino acids and sodium ions with a stoichiometry of 1:1. May function in the transport of amino acids at the blood-brain barrier and in the supply of maternal nutrients to the fetus through the placenta By similarity.

Enzyme regulationi

Inhibited by N-methyl-D-glucamine and choline By similarity.

GO - Molecular functioni

  1. amino acid transmembrane transporter activity Source: Ensembl
  2. symporter activity Source: UniProtKB-KW

GO - Biological processi

  1. sodium ion transport Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Amino-acid transport, Ion transport, Sodium transport, Symport, Transport

Keywords - Ligandi

Sodium

Enzyme and pathway databases

ReactomeiREACT_202360. Amino acid transport across the plasma membrane.
REACT_212967. Glutamate Neurotransmitter Release Cycle.

Names & Taxonomyi

Protein namesi
Recommended name:
Sodium-coupled neutral amino acid transporter 2
Alternative name(s):
Amino acid transporter A2
Protein 40-9-1
Solute carrier family 38 member 2
System A amino acid transporter 2
System A transporter 1
System N amino acid transporter 2
Gene namesi
Name:SLC38A2
Synonyms:SNAT2
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
ProteomesiUP000009136: Chromosome 5

Subcellular locationi

Cell membrane; Multi-pass membrane protein By similarity
Note: Insulin promotes recruitment to the plasma membrane from a pool localized in the trans-Golgi network or endosomes By similarity. May localize to an endosomal compartment By similarity. Enriched in the somatodendritic compartment of neurons, it is also detected at the axonal shaft but excluded from the nerve terminal By similarity.

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 7676Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei77 – 9721Helical; Reviewed prediction
Add
BLAST
Topological domaini98 – 1025Extracellular Reviewed prediction
Transmembranei103 – 12321Helical; Reviewed prediction
Add
BLAST
Topological domaini124 – 15835Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei159 – 17921Helical; Reviewed prediction
Add
BLAST
Topological domaini180 – 1889Extracellular Reviewed prediction
Transmembranei189 – 20921Helical; Reviewed prediction
Add
BLAST
Topological domaini210 – 2178Cytoplasmic Reviewed prediction
Transmembranei218 – 23821Helical; Reviewed prediction
Add
BLAST
Topological domaini239 – 29254Extracellular Reviewed prediction
Add
BLAST
Transmembranei293 – 31321Helical; Reviewed prediction
Add
BLAST
Topological domaini314 – 32916Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei330 – 35021Helical; Reviewed prediction
Add
BLAST
Topological domaini351 – 37121Extracellular Reviewed prediction
Add
BLAST
Transmembranei372 – 39221Helical; Reviewed prediction
Add
BLAST
Topological domaini393 – 41321Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei414 – 43421Helical; Reviewed prediction
Add
BLAST
Topological domaini435 – 4362Extracellular Reviewed prediction
Transmembranei437 – 45721Helical; Reviewed prediction
Add
BLAST
Topological domaini458 – 47417Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei475 – 49521Helical; Reviewed prediction
Add
BLAST
Topological domaini496 – 50611Extracellular Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 506506Sodium-coupled neutral amino acid transporter 2
PRO_0000311368Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei12 – 121Phosphoserine By similarity
Modified residuei22 – 221Phosphoserine By similarity
Modified residuei55 – 551Phosphoserine By similarity
Glycosylationi258 – 2581N-linked (GlcNAc...) Reviewed prediction
Glycosylationi274 – 2741N-linked (GlcNAc...) Reviewed prediction

Post-translational modificationi

Polyubiquitination by NEDD4L regulates the degradation and the activity of SLC38A2 By similarity.

Keywords - PTMi

Glycoprotein, Phosphoprotein, Ubl conjugation

Proteomic databases

PRIDEiA2VE31.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 9696Regulates protein turnover upon amino acid deprivation By similarity
Add
BLAST

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG236441.
GeneTreeiENSGT00650000093166.
HOGENOMiHOG000013088.
HOVERGENiHBG059571.
InParanoidiA2VE31.
KOiK14207.
OMAiYEHVESE.
OrthoDBiEOG7WHH9J.
TreeFamiTF328787.

Family and domain databases

InterProiIPR013057. AA_transpt_TM.
[Graphical view]
PfamiPF01490. Aa_trans. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A2VE31-1 [UniParc]FASTAAdd to Basket

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MKKAEMGRFN ISPDEDSSSY SSNSDFNYSY PTKQAALKSH YADVDPENQN    50
FLLESNLGKK KYETDFHPGT TSFGMSVFNL SNAIVGSGIL GLSYAMANTG 100
IALFIILLTF VSIFSLYSVH LLLKTANEGG SLLYEQLGHK AFGMVGKLTA 150
SGSITMQNIG AMSSYLFIVK YELPLVIQAL MNIEDTNGLW YLNGDYLVLL 200
VSLVLILPLS LLRNLGYLGY TSGLSLLCMM FFLIVVIFKK FQISCPAEIA 250
FLVNETVNSS LTQPATFLPD MGFNRTESDS CQPRYFIFNS QTVYAVPILT 300
FSFVCHPAIL PIYEELKGRS RRRMMNVSKI SFFAMFLMYL LAALFGYLTF 350
YGHVESELLH TYSSVMETDI LLLIVRLAVL VAVTLTVPVV IFPIRSSITH 400
LLCASKEFSW WRHSVITVSI LVFTNLLVIF VPNIRDIFGF IGASAAAMLI 450
FILPSAFYIK LVKKEPMKSV QKIGAMFFLL SGIVVMTGSM ALIVLDWVHN 500
APGGGH 506
Length:506
Mass (Da):56,214
Last modified:March 20, 2007 - v1
Checksum:i952C9D7F55E1659F
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti409 – 4091S → N in CAC51429. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC133547 mRNA. Translation: AAI33548.1.
AJ344100 mRNA. Translation: CAC51429.1.
RefSeqiNP_001075893.1. NM_001082424.1.
UniGeneiBt.9238.

Genome annotation databases

EnsembliENSBTAT00000014749; ENSBTAP00000014749; ENSBTAG00000011105.
GeneIDi338044.
KEGGibta:338044.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC133547 mRNA. Translation: AAI33548.1 .
AJ344100 mRNA. Translation: CAC51429.1 .
RefSeqi NP_001075893.1. NM_001082424.1.
UniGenei Bt.9238.

3D structure databases

ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi A2VE31.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSBTAT00000014749 ; ENSBTAP00000014749 ; ENSBTAG00000011105 .
GeneIDi 338044.
KEGGi bta:338044.

Organism-specific databases

CTDi 54407.

Phylogenomic databases

eggNOGi NOG236441.
GeneTreei ENSGT00650000093166.
HOGENOMi HOG000013088.
HOVERGENi HBG059571.
InParanoidi A2VE31.
KOi K14207.
OMAi YEHVESE.
OrthoDBi EOG7WHH9J.
TreeFami TF328787.

Enzyme and pathway databases

Reactomei REACT_202360. Amino acid transport across the plasma membrane.
REACT_212967. Glutamate Neurotransmitter Release Cycle.

Miscellaneous databases

NextBioi 20812495.

Family and domain databases

InterProi IPR013057. AA_transpt_TM.
[Graphical view ]
Pfami PF01490. Aa_trans. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. NIH - Mammalian Gene Collection (MGC) project
    Submitted (FEB-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Hereford.
    Tissue: Fetal skin.
  2. Schmidt T.
    Thesis (2001), University of Goettingen, Germany
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 223-506.

Entry informationi

Entry nameiS38A2_BOVIN
AccessioniPrimary (citable) accession number: A2VE31
Secondary accession number(s): Q95M41
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: March 20, 2007
Last modified: September 3, 2014
This is version 46 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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