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A2VE31

- S38A2_BOVIN

UniProt

A2VE31 - S38A2_BOVIN

Protein

Sodium-coupled neutral amino acid transporter 2

Gene

SLC38A2

Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 47 (01 Oct 2014)
      Sequence version 1 (20 Mar 2007)
      Previous versions | rss
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    Functioni

    Functions as a sodium-dependent amino acid transporter. Mediates the saturable, pH-sensitive and electrogenic cotransport of neutral amino acids and sodium ions with a stoichiometry of 1:1. May function in the transport of amino acids at the blood-brain barrier and in the supply of maternal nutrients to the fetus through the placenta By similarity.By similarity

    Enzyme regulationi

    Inhibited by N-methyl-D-glucamine and choline.By similarity

    GO - Molecular functioni

    1. amino acid transmembrane transporter activity Source: Ensembl
    2. symporter activity Source: UniProtKB-KW

    GO - Biological processi

    1. sodium ion transport Source: UniProtKB-KW

    Keywords - Biological processi

    Amino-acid transport, Ion transport, Sodium transport, Symport, Transport

    Keywords - Ligandi

    Sodium

    Enzyme and pathway databases

    ReactomeiREACT_202360. Amino acid transport across the plasma membrane.
    REACT_212967. Glutamate Neurotransmitter Release Cycle.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Sodium-coupled neutral amino acid transporter 2
    Alternative name(s):
    Amino acid transporter A2
    Protein 40-9-1
    Solute carrier family 38 member 2
    System A amino acid transporter 2
    System A transporter 1
    System N amino acid transporter 2
    Gene namesi
    Name:SLC38A2
    Synonyms:SNAT2
    OrganismiBos taurus (Bovine)
    Taxonomic identifieri9913 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
    ProteomesiUP000009136: Chromosome 5

    Subcellular locationi

    Cell membrane By similarity; Multi-pass membrane protein By similarity
    Note: Insulin promotes recruitment to the plasma membrane from a pool localized in the trans-Golgi network or endosomes. May localize to an endosomal compartment. Enriched in the somatodendritic compartment of neurons, it is also detected at the axonal shaft but excluded from the nerve terminal.By similarity

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 506506Sodium-coupled neutral amino acid transporter 2PRO_0000311368Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei12 – 121PhosphoserineBy similarity
    Modified residuei22 – 221PhosphoserineBy similarity
    Modified residuei55 – 551PhosphoserineBy similarity
    Glycosylationi258 – 2581N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi274 – 2741N-linked (GlcNAc...)Sequence Analysis

    Post-translational modificationi

    Polyubiquitination by NEDD4L regulates the degradation and the activity of SLC38A2.By similarity

    Keywords - PTMi

    Glycoprotein, Phosphoprotein, Ubl conjugation

    Proteomic databases

    PRIDEiA2VE31.

    Structurei

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 7676CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini98 – 1025ExtracellularSequence Analysis
    Topological domaini124 – 15835CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini180 – 1889ExtracellularSequence Analysis
    Topological domaini210 – 2178CytoplasmicSequence Analysis
    Topological domaini239 – 29254ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini314 – 32916CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini351 – 37121ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini393 – 41321CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini435 – 4362ExtracellularSequence Analysis
    Topological domaini458 – 47417CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini496 – 50611ExtracellularSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei77 – 9721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei103 – 12321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei159 – 17921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei189 – 20921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei218 – 23821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei293 – 31321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei330 – 35021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei372 – 39221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei414 – 43421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei437 – 45721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei475 – 49521HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni1 – 9696Regulates protein turnover upon amino acid deprivationBy similarityAdd
    BLAST

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG236441.
    GeneTreeiENSGT00650000093166.
    HOGENOMiHOG000013088.
    HOVERGENiHBG059571.
    InParanoidiA2VE31.
    KOiK14207.
    OMAiYEHVESE.
    OrthoDBiEOG7WHH9J.
    TreeFamiTF328787.

    Family and domain databases

    InterProiIPR013057. AA_transpt_TM.
    [Graphical view]
    PfamiPF01490. Aa_trans. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A2VE31-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKKAEMGRFN ISPDEDSSSY SSNSDFNYSY PTKQAALKSH YADVDPENQN    50
    FLLESNLGKK KYETDFHPGT TSFGMSVFNL SNAIVGSGIL GLSYAMANTG 100
    IALFIILLTF VSIFSLYSVH LLLKTANEGG SLLYEQLGHK AFGMVGKLTA 150
    SGSITMQNIG AMSSYLFIVK YELPLVIQAL MNIEDTNGLW YLNGDYLVLL 200
    VSLVLILPLS LLRNLGYLGY TSGLSLLCMM FFLIVVIFKK FQISCPAEIA 250
    FLVNETVNSS LTQPATFLPD MGFNRTESDS CQPRYFIFNS QTVYAVPILT 300
    FSFVCHPAIL PIYEELKGRS RRRMMNVSKI SFFAMFLMYL LAALFGYLTF 350
    YGHVESELLH TYSSVMETDI LLLIVRLAVL VAVTLTVPVV IFPIRSSITH 400
    LLCASKEFSW WRHSVITVSI LVFTNLLVIF VPNIRDIFGF IGASAAAMLI 450
    FILPSAFYIK LVKKEPMKSV QKIGAMFFLL SGIVVMTGSM ALIVLDWVHN 500
    APGGGH 506
    Length:506
    Mass (Da):56,214
    Last modified:March 20, 2007 - v1
    Checksum:i952C9D7F55E1659F
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti409 – 4091S → N in CAC51429. 1 PublicationCurated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC133547 mRNA. Translation: AAI33548.1.
    AJ344100 mRNA. Translation: CAC51429.1.
    RefSeqiNP_001075893.1. NM_001082424.1.
    UniGeneiBt.9238.

    Genome annotation databases

    EnsembliENSBTAT00000014749; ENSBTAP00000014749; ENSBTAG00000011105.
    GeneIDi338044.
    KEGGibta:338044.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC133547 mRNA. Translation: AAI33548.1 .
    AJ344100 mRNA. Translation: CAC51429.1 .
    RefSeqi NP_001075893.1. NM_001082424.1.
    UniGenei Bt.9238.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi A2VE31.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSBTAT00000014749 ; ENSBTAP00000014749 ; ENSBTAG00000011105 .
    GeneIDi 338044.
    KEGGi bta:338044.

    Organism-specific databases

    CTDi 54407.

    Phylogenomic databases

    eggNOGi NOG236441.
    GeneTreei ENSGT00650000093166.
    HOGENOMi HOG000013088.
    HOVERGENi HBG059571.
    InParanoidi A2VE31.
    KOi K14207.
    OMAi YEHVESE.
    OrthoDBi EOG7WHH9J.
    TreeFami TF328787.

    Enzyme and pathway databases

    Reactomei REACT_202360. Amino acid transport across the plasma membrane.
    REACT_212967. Glutamate Neurotransmitter Release Cycle.

    Miscellaneous databases

    NextBioi 20812495.

    Family and domain databases

    InterProi IPR013057. AA_transpt_TM.
    [Graphical view ]
    Pfami PF01490. Aa_trans. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. NIH - Mammalian Gene Collection (MGC) project
      Submitted (FEB-2007) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: Hereford.
      Tissue: Fetal skin.
    2. Schmidt T.
      Thesis (2001), University of Goettingen, Germany
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 223-506.

    Entry informationi

    Entry nameiS38A2_BOVIN
    AccessioniPrimary (citable) accession number: A2VE31
    Secondary accession number(s): Q95M41
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 13, 2007
    Last sequence update: March 20, 2007
    Last modified: October 1, 2014
    This is version 47 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3