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Protein

Sodium-coupled neutral amino acid transporter 2

Gene

SLC38A2

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Functions as a sodium-dependent amino acid transporter. Mediates the saturable, pH-sensitive and electrogenic cotransport of neutral amino acids and sodium ions with a stoichiometry of 1:1. May function in the transport of amino acids at the blood-brain barrier and in the supply of maternal nutrients to the fetus through the placenta (By similarity).By similarity

Enzyme regulationi

Inhibited by N-methyl-D-glucamine and choline.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Amino-acid transport, Ion transport, Sodium transport, Symport, Transport

Keywords - Ligandi

Sodium

Enzyme and pathway databases

ReactomeiR-BTA-210500. Glutamate Neurotransmitter Release Cycle.
R-BTA-352230. Amino acid transport across the plasma membrane.

Names & Taxonomyi

Protein namesi
Recommended name:
Sodium-coupled neutral amino acid transporter 2
Alternative name(s):
Amino acid transporter A2
Protein 40-9-1
Solute carrier family 38 member 2
System A amino acid transporter 2
System A transporter 1
System N amino acid transporter 2
Gene namesi
Name:SLC38A2
Synonyms:SNAT2
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 5

Subcellular locationi

  • Cell membrane By similarity; Multi-pass membrane protein By similarity

  • Note: Insulin promotes recruitment to the plasma membrane from a pool localized in the trans-Golgi network or endosomes. May localize to an endosomal compartment. Enriched in the somatodendritic compartment of neurons, it is also detected at the axonal shaft but excluded from the nerve terminal.By similarity

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 76CytoplasmicSequence analysisAdd BLAST76
Transmembranei77 – 97HelicalSequence analysisAdd BLAST21
Topological domaini98 – 102ExtracellularSequence analysis5
Transmembranei103 – 123HelicalSequence analysisAdd BLAST21
Topological domaini124 – 158CytoplasmicSequence analysisAdd BLAST35
Transmembranei159 – 179HelicalSequence analysisAdd BLAST21
Topological domaini180 – 188ExtracellularSequence analysis9
Transmembranei189 – 209HelicalSequence analysisAdd BLAST21
Topological domaini210 – 217CytoplasmicSequence analysis8
Transmembranei218 – 238HelicalSequence analysisAdd BLAST21
Topological domaini239 – 292ExtracellularSequence analysisAdd BLAST54
Transmembranei293 – 313HelicalSequence analysisAdd BLAST21
Topological domaini314 – 329CytoplasmicSequence analysisAdd BLAST16
Transmembranei330 – 350HelicalSequence analysisAdd BLAST21
Topological domaini351 – 371ExtracellularSequence analysisAdd BLAST21
Transmembranei372 – 392HelicalSequence analysisAdd BLAST21
Topological domaini393 – 413CytoplasmicSequence analysisAdd BLAST21
Transmembranei414 – 434HelicalSequence analysisAdd BLAST21
Topological domaini435 – 436ExtracellularSequence analysis2
Transmembranei437 – 457HelicalSequence analysisAdd BLAST21
Topological domaini458 – 474CytoplasmicSequence analysisAdd BLAST17
Transmembranei475 – 495HelicalSequence analysisAdd BLAST21
Topological domaini496 – 506ExtracellularSequence analysisAdd BLAST11

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003113681 – 506Sodium-coupled neutral amino acid transporter 2Add BLAST506

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei12PhosphoserineBy similarity1
Modified residuei21PhosphoserineBy similarity1
Modified residuei22PhosphoserineBy similarity1
Modified residuei55PhosphoserineBy similarity1
Glycosylationi258N-linked (GlcNAc...)Sequence analysis1
Glycosylationi274N-linked (GlcNAc...)Sequence analysis1

Post-translational modificationi

Polyubiquitination by NEDD4L regulates the degradation and the activity of SLC38A2.By similarity

Keywords - PTMi

Glycoprotein, Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDbiA2VE31.
PRIDEiA2VE31.

Expressioni

Gene expression databases

BgeeiENSBTAG00000011105.

Interactioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000014749.

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 96Regulates protein turnover upon amino acid deprivationBy similarityAdd BLAST96

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1305. Eukaryota.
COG0814. LUCA.
GeneTreeiENSGT00760000119147.
HOGENOMiHOG000013088.
HOVERGENiHBG059571.
InParanoidiA2VE31.
KOiK14207.
OMAiITHLLCA.
OrthoDBiEOG091G0GP8.
TreeFamiTF328787.

Family and domain databases

InterProiIPR013057. AA_transpt_TM.
[Graphical view]
PfamiPF01490. Aa_trans. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A2VE31-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKKAEMGRFN ISPDEDSSSY SSNSDFNYSY PTKQAALKSH YADVDPENQN
60 70 80 90 100
FLLESNLGKK KYETDFHPGT TSFGMSVFNL SNAIVGSGIL GLSYAMANTG
110 120 130 140 150
IALFIILLTF VSIFSLYSVH LLLKTANEGG SLLYEQLGHK AFGMVGKLTA
160 170 180 190 200
SGSITMQNIG AMSSYLFIVK YELPLVIQAL MNIEDTNGLW YLNGDYLVLL
210 220 230 240 250
VSLVLILPLS LLRNLGYLGY TSGLSLLCMM FFLIVVIFKK FQISCPAEIA
260 270 280 290 300
FLVNETVNSS LTQPATFLPD MGFNRTESDS CQPRYFIFNS QTVYAVPILT
310 320 330 340 350
FSFVCHPAIL PIYEELKGRS RRRMMNVSKI SFFAMFLMYL LAALFGYLTF
360 370 380 390 400
YGHVESELLH TYSSVMETDI LLLIVRLAVL VAVTLTVPVV IFPIRSSITH
410 420 430 440 450
LLCASKEFSW WRHSVITVSI LVFTNLLVIF VPNIRDIFGF IGASAAAMLI
460 470 480 490 500
FILPSAFYIK LVKKEPMKSV QKIGAMFFLL SGIVVMTGSM ALIVLDWVHN

APGGGH
Length:506
Mass (Da):56,214
Last modified:March 20, 2007 - v1
Checksum:i952C9D7F55E1659F
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti409S → N in CAC51429 (Ref. 2) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC133547 mRNA. Translation: AAI33548.1.
AJ344100 mRNA. Translation: CAC51429.1.
RefSeqiNP_001075893.1. NM_001082424.1.
UniGeneiBt.9238.

Genome annotation databases

EnsembliENSBTAT00000014749; ENSBTAP00000014749; ENSBTAG00000011105.
GeneIDi338044.
KEGGibta:338044.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC133547 mRNA. Translation: AAI33548.1.
AJ344100 mRNA. Translation: CAC51429.1.
RefSeqiNP_001075893.1. NM_001082424.1.
UniGeneiBt.9238.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000014749.

Proteomic databases

PaxDbiA2VE31.
PRIDEiA2VE31.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000014749; ENSBTAP00000014749; ENSBTAG00000011105.
GeneIDi338044.
KEGGibta:338044.

Organism-specific databases

CTDi54407.

Phylogenomic databases

eggNOGiKOG1305. Eukaryota.
COG0814. LUCA.
GeneTreeiENSGT00760000119147.
HOGENOMiHOG000013088.
HOVERGENiHBG059571.
InParanoidiA2VE31.
KOiK14207.
OMAiITHLLCA.
OrthoDBiEOG091G0GP8.
TreeFamiTF328787.

Enzyme and pathway databases

ReactomeiR-BTA-210500. Glutamate Neurotransmitter Release Cycle.
R-BTA-352230. Amino acid transport across the plasma membrane.

Gene expression databases

BgeeiENSBTAG00000011105.

Family and domain databases

InterProiIPR013057. AA_transpt_TM.
[Graphical view]
PfamiPF01490. Aa_trans. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiS38A2_BOVIN
AccessioniPrimary (citable) accession number: A2VE31
Secondary accession number(s): Q95M41
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: March 20, 2007
Last modified: November 2, 2016
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.