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Protein

Sodium-coupled neutral amino acid transporter 2

Gene

SLC38A2

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Functions as a sodium-dependent amino acid transporter. Mediates the saturable, pH-sensitive and electrogenic cotransport of neutral amino acids and sodium ions with a stoichiometry of 1:1. May function in the transport of amino acids at the blood-brain barrier and in the supply of maternal nutrients to the fetus through the placenta (By similarity).By similarity

Enzyme regulationi

Inhibited by N-methyl-D-glucamine and choline.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processAmino-acid transport, Ion transport, Sodium transport, Symport, Transport
LigandSodium

Enzyme and pathway databases

ReactomeiR-BTA-210500 Glutamate Neurotransmitter Release Cycle
R-BTA-352230 Amino acid transport across the plasma membrane

Names & Taxonomyi

Protein namesi
Recommended name:
Sodium-coupled neutral amino acid transporter 2
Alternative name(s):
Amino acid transporter A2
Protein 40-9-1
Solute carrier family 38 member 2
System A amino acid transporter 2
System A transporter 1
System N amino acid transporter 2
Gene namesi
Name:SLC38A2
Synonyms:SNAT2
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 5

Organism-specific databases

VGNCiVGNC:34849 SLC38A2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 76CytoplasmicSequence analysisAdd BLAST76
Transmembranei77 – 97HelicalSequence analysisAdd BLAST21
Topological domaini98 – 102ExtracellularSequence analysis5
Transmembranei103 – 123HelicalSequence analysisAdd BLAST21
Topological domaini124 – 158CytoplasmicSequence analysisAdd BLAST35
Transmembranei159 – 179HelicalSequence analysisAdd BLAST21
Topological domaini180 – 188ExtracellularSequence analysis9
Transmembranei189 – 209HelicalSequence analysisAdd BLAST21
Topological domaini210 – 217CytoplasmicSequence analysis8
Transmembranei218 – 238HelicalSequence analysisAdd BLAST21
Topological domaini239 – 292ExtracellularSequence analysisAdd BLAST54
Transmembranei293 – 313HelicalSequence analysisAdd BLAST21
Topological domaini314 – 329CytoplasmicSequence analysisAdd BLAST16
Transmembranei330 – 350HelicalSequence analysisAdd BLAST21
Topological domaini351 – 371ExtracellularSequence analysisAdd BLAST21
Transmembranei372 – 392HelicalSequence analysisAdd BLAST21
Topological domaini393 – 413CytoplasmicSequence analysisAdd BLAST21
Transmembranei414 – 434HelicalSequence analysisAdd BLAST21
Topological domaini435 – 436ExtracellularSequence analysis2
Transmembranei437 – 457HelicalSequence analysisAdd BLAST21
Topological domaini458 – 474CytoplasmicSequence analysisAdd BLAST17
Transmembranei475 – 495HelicalSequence analysisAdd BLAST21
Topological domaini496 – 506ExtracellularSequence analysisAdd BLAST11

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003113681 – 506Sodium-coupled neutral amino acid transporter 2Add BLAST506

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei12PhosphoserineBy similarity1
Modified residuei21PhosphoserineBy similarity1
Modified residuei22PhosphoserineBy similarity1
Modified residuei55PhosphoserineBy similarity1
Disulfide bondi245 ↔ 281PROSITE-ProRule annotation
Glycosylationi258N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi274N-linked (GlcNAc...) asparagineSequence analysis1

Post-translational modificationi

Polyubiquitination by NEDD4L regulates the degradation and the activity of SLC38A2.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDbiA2VE31
PRIDEiA2VE31

Expressioni

Gene expression databases

BgeeiENSBTAG00000011105

Interactioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000014749

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 96Regulates protein turnover upon amino acid deprivationBy similarityAdd BLAST96

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1305 Eukaryota
COG0814 LUCA
GeneTreeiENSGT00760000119147
HOGENOMiHOG000013088
HOVERGENiHBG059571
InParanoidiA2VE31
KOiK14207
OMAiALMNIED
OrthoDBiEOG091G0GP8
TreeFamiTF328787

Family and domain databases

InterProiView protein in InterPro
IPR013057 AA_transpt_TM
PfamiView protein in Pfam
PF01490 Aa_trans, 1 hit

Sequencei

Sequence statusi: Complete.

A2VE31-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKKAEMGRFN ISPDEDSSSY SSNSDFNYSY PTKQAALKSH YADVDPENQN
60 70 80 90 100
FLLESNLGKK KYETDFHPGT TSFGMSVFNL SNAIVGSGIL GLSYAMANTG
110 120 130 140 150
IALFIILLTF VSIFSLYSVH LLLKTANEGG SLLYEQLGHK AFGMVGKLTA
160 170 180 190 200
SGSITMQNIG AMSSYLFIVK YELPLVIQAL MNIEDTNGLW YLNGDYLVLL
210 220 230 240 250
VSLVLILPLS LLRNLGYLGY TSGLSLLCMM FFLIVVIFKK FQISCPAEIA
260 270 280 290 300
FLVNETVNSS LTQPATFLPD MGFNRTESDS CQPRYFIFNS QTVYAVPILT
310 320 330 340 350
FSFVCHPAIL PIYEELKGRS RRRMMNVSKI SFFAMFLMYL LAALFGYLTF
360 370 380 390 400
YGHVESELLH TYSSVMETDI LLLIVRLAVL VAVTLTVPVV IFPIRSSITH
410 420 430 440 450
LLCASKEFSW WRHSVITVSI LVFTNLLVIF VPNIRDIFGF IGASAAAMLI
460 470 480 490 500
FILPSAFYIK LVKKEPMKSV QKIGAMFFLL SGIVVMTGSM ALIVLDWVHN

APGGGH
Length:506
Mass (Da):56,214
Last modified:March 20, 2007 - v1
Checksum:i952C9D7F55E1659F
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti409S → N in CAC51429 (Ref. 2) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC133547 mRNA Translation: AAI33548.1
AJ344100 mRNA Translation: CAC51429.1
RefSeqiNP_001075893.1, NM_001082424.1
UniGeneiBt.9238

Genome annotation databases

EnsembliENSBTAT00000014749; ENSBTAP00000014749; ENSBTAG00000011105
GeneIDi338044
KEGGibta:338044

Similar proteinsi

Entry informationi

Entry nameiS38A2_BOVIN
AccessioniPrimary (citable) accession number: A2VE31
Secondary accession number(s): Q95M41
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: March 20, 2007
Last modified: March 28, 2018
This is version 69 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health