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Protein

Ferric-chelate reductase 1

Gene

FRRS1

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Ferric-chelate reductases reduce Fe3+ to Fe2+ before its transport from the endosome to the cytoplasm.By similarity

Cofactori

hemeBy similarityNote: Binds 2 heme groups non-covalently.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi373Iron (heme axial ligand)PROSITE-ProRule annotation1
Metal bindingi413Iron (heme axial ligand)PROSITE-ProRule annotation1
Metal bindingi441Iron (heme axial ligand)PROSITE-ProRule annotation1
Metal bindingi470Iron (heme axial ligand)PROSITE-ProRule annotation1

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Electron transport, Transport

Keywords - Ligandi

Heme, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Ferric-chelate reductase 1 (EC:1.-.-.-)
Gene namesi
Name:FRRS1
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Unplaced

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei6 – 26Helical; Name=1Sequence analysisAdd BLAST21
Transmembranei372 – 392Helical; Name=2Sequence analysisAdd BLAST21
Transmembranei416 – 436Helical; Name=3Sequence analysisAdd BLAST21
Transmembranei445 – 465Helical; Name=4Sequence analysisAdd BLAST21
Transmembranei490 – 510Helical; Name=5Sequence analysisAdd BLAST21
Transmembranei514 – 534Helical; Name=6Sequence analysisAdd BLAST21
Transmembranei568 – 588Helical; Name=7Sequence analysisAdd BLAST21

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003148421 – 591Ferric-chelate reductase 1Add BLAST591

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi50N-linked (GlcNAc...)Sequence analysis1
Glycosylationi85N-linked (GlcNAc...)Sequence analysis1
Glycosylationi308N-linked (GlcNAc...)Sequence analysis1
Glycosylationi321N-linked (GlcNAc...)Sequence analysis1
Glycosylationi353N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiA2VE04.
PRIDEiA2VE04.

Expressioni

Gene expression databases

BgeeiENSBTAG00000003440.

Interactioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000004475.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini13 – 179ReelinPROSITE-ProRule annotationAdd BLAST167
Domaini216 – 331DOMONPROSITE-ProRule annotationAdd BLAST116
Domaini335 – 533Cytochrome b561PROSITE-ProRule annotationAdd BLAST199

Sequence similaritiesi

Belongs to the FRRS1 family.Curated
Contains 1 cytochrome b561 domain.PROSITE-ProRule annotation
Contains 1 DOMON domain.PROSITE-ProRule annotation
Contains 1 reelin domain.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4293. Eukaryota.
ENOG410XR70. LUCA.
HOGENOMiHOG000112648.
HOVERGENiHBG107929.
InParanoidiA2VE04.

Family and domain databases

CDDicd08544. Reeler. 1 hit.
InterProiIPR006593. Cyt_b561/ferric_Rdtase_TM.
IPR005018. DOMON_domain.
IPR002861. Reeler_dom.
[Graphical view]
PfamiPF03351. DOMON. 1 hit.
PF02014. Reeler. 1 hit.
[Graphical view]
SMARTiSM00665. B561. 1 hit.
SM00664. DoH. 1 hit.
[Graphical view]
PROSITEiPS50939. CYTOCHROME_B561. 1 hit.
PS50836. DOMON. 1 hit.
PS51019. REELIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A2VE04-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTAPGFTVSA FILLLHVSFV ANYPSGKVTK SCGGMIPEHG HTPQSHPAHN
60 70 80 90 100
ISVSQKTFRP GDQIKVTLSG PPFKGFLLEA RDAENLSGPP VGSFTLIDSH
110 120 130 140 150
VSQLLTCEDV QGSAVSHRSP SKKTEIKVFW DAPSGAPNHI TFLATVVEKY
160 170 180 190 200
KIYWVKIPGP VISQPNVPPF TTPEATIAPM PTVPSVSHLT RSFNASDCGN
210 220 230 240 250
KKFCIRSPLN CDPEKERACV LLSFTRDDQS VMVEMSGPSK GYLSVAFSHD
260 270 280 290 300
RWMGDDDAYV CILEDQIVHI QPSHLTGRSH PIMDFGDPLE DMAWRLVDGV
310 320 330 340 350
MQCSFRRNIT LPGVKNRFDL NASYYIFVAD GAAVDGRIHK HSQQPLITYE
360 370 380 390 400
KYNVTGDPKN IGGSHSLLLL KVHGALMFVA WMTTVSVGVL IARFFKPVWS
410 420 430 440 450
KALFGDAAWF QVHRTLMLTT SALTFIAFLL PFIYRGGWNW HAGYHPYLGF
460 470 480 490 500
IVMVLAVLQL LLAAFRPPLH DPRRQMFNWT HWSMGTAARI IAVAAMFLGM
510 520 530 540 550
DLPGLNLPGP WKTYAMIGFV AWHVGTEIIL EIHAYRLSRK VEILDDDRIQ
560 570 580 590
ILQSFTAAEA EGYVFKKVVL AIYVCGNLTF LTMFLSAINR L
Length:591
Mass (Da):65,660
Last modified:March 20, 2007 - v1
Checksum:i80ED278CA93D3351
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC133504 mRNA. Translation: AAI33505.1.
RefSeqiNP_001077164.1. NM_001083695.1.
UniGeneiBt.76681.

Genome annotation databases

GeneIDi516522.
KEGGibta:516522.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC133504 mRNA. Translation: AAI33505.1.
RefSeqiNP_001077164.1. NM_001083695.1.
UniGeneiBt.76681.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000004475.

Proteomic databases

PaxDbiA2VE04.
PRIDEiA2VE04.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi516522.
KEGGibta:516522.

Organism-specific databases

CTDi391059.

Phylogenomic databases

eggNOGiKOG4293. Eukaryota.
ENOG410XR70. LUCA.
HOGENOMiHOG000112648.
HOVERGENiHBG107929.
InParanoidiA2VE04.

Gene expression databases

BgeeiENSBTAG00000003440.

Family and domain databases

CDDicd08544. Reeler. 1 hit.
InterProiIPR006593. Cyt_b561/ferric_Rdtase_TM.
IPR005018. DOMON_domain.
IPR002861. Reeler_dom.
[Graphical view]
PfamiPF03351. DOMON. 1 hit.
PF02014. Reeler. 1 hit.
[Graphical view]
SMARTiSM00665. B561. 1 hit.
SM00664. DoH. 1 hit.
[Graphical view]
PROSITEiPS50939. CYTOCHROME_B561. 1 hit.
PS50836. DOMON. 1 hit.
PS51019. REELIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiFRRS1_BOVIN
AccessioniPrimary (citable) accession number: A2VE04
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: March 20, 2007
Last modified: September 7, 2016
This is version 55 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.