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A2VDZ9 (VAPB_BOVIN) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 50. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Vesicle-associated membrane protein-associated protein B

Short name=VAMP-B
Short name=VAMP-associated protein B
Short name=VAP-B
Gene names
Name:VAPB
OrganismBos taurus (Bovine) [Reference proteome]
Taxonomic identifier9913 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos

Protein attributes

Sequence length243 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Participates in the endoplasmic reticulum unfolded protein response (UPR) by inducing ERN1/IRE1 activity By similarity. Involved in cellular calcium homeostasis regulation By similarity.

Subunit structure

Homodimer, and heterodimer with VAPA. Interacts with RMDN3, VAMP1 and VAMP2. Interacts (via MSP domain) with ZFYVE27 By similarity.

Subcellular location

Endoplasmic reticulum membrane; Single-pass type IV membrane protein By similarity.

Sequence similarities

Belongs to the VAMP-associated protein (VAP) (TC 9.B.17) family. [View classification]

Contains 1 MSP domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed By similarity
Chain2 – 243242Vesicle-associated membrane protein-associated protein B
PRO_0000308177

Regions

Topological domain2 – 218217Cytoplasmic Potential
Transmembrane219 – 23921Helical; Anchor for type IV membrane protein; Potential
Domain7 – 124118MSP
Coiled coil161 – 19636 Potential

Amino acid modifications

Modified residue21N-acetylalanine By similarity
Modified residue1501Phosphothreonine By similarity
Modified residue1601Phosphoserine By similarity

Sequences

Sequence LengthMass (Da)Tools
A2VDZ9 [UniParc].

Last modified March 20, 2007. Version 1.
Checksum: 1ECA446A771C28AA

FASTA24327,158
        10         20         30         40         50         60 
MAKVEQVLSL EPQHELKFRG PFTDVVTTNL KLGNPTDRNV CFKVKTTAPR RYCVRPNSGI 

        70         80         90        100        110        120 
IDAGASINVS VMLQPFDYDP NEKSKHKFMV QSMFAPTDTS DMEAVWKEAK PEDLMDSKLR 

       130        140        150        160        170        180 
CVFELPAEND KPHDVEINKI IPTTASKTET PTVSKALSSS LDDTEVKKVM EECKRLQSEV 

       190        200        210        220        230        240 
QRLREENKQF KEEDGLRMRK TAQSNSPAPA SAMAGKEEGL STRLLALVVL FFIVGVIIGK 


IAL 

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References

[1]NIH - Mammalian Gene Collection (MGC) project
Submitted (FEB-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: Hereford.
Tissue: Basal ganglia.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BC133497 mRNA. Translation: AAI33498.1.
RefSeqNP_001075892.1. NM_001082423.1.
UniGeneBt.15679.

3D structure databases

ProteinModelPortalA2VDZ9.
SMRA2VDZ9. Positions 1-134.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9913.ENSBTAP00000023164.

Proteomic databases

PaxDbA2VDZ9.
PRIDEA2VDZ9.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSBTAT00000023164; ENSBTAP00000023164; ENSBTAG00000017424.
GeneID326580.
KEGGbta:326580.

Organism-specific databases

CTD9217.

Phylogenomic databases

eggNOGCOG5066.
GeneTreeENSGT00390000006947.
HOGENOMHOG000293182.
HOVERGENHBG028551.
InParanoidA2VDZ9.
KOK10707.
OMAGLRMRKA.
OrthoDBEOG7CK389.
TreeFamTF317024.

Family and domain databases

Gene3D2.60.40.360. 1 hit.
InterProIPR000535. MSP_dom.
IPR008962. PapD-like.
IPR016763. Vesicle-associated_membrane.
[Graphical view]
PfamPF00635. Motile_Sperm. 1 hit.
[Graphical view]
PIRSFPIRSF019693. VAMP-associated. 1 hit.
SUPFAMSSF49354. SSF49354. 1 hit.
PROSITEPS50202. MSP. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio20809653.

Entry information

Entry nameVAPB_BOVIN
AccessionPrimary (citable) accession number: A2VDZ9
Entry history
Integrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: March 20, 2007
Last modified: February 19, 2014
This is version 50 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families