ID TP4A3_BOVIN Reviewed; 173 AA. AC A2VDT1; DT 08-APR-2008, integrated into UniProtKB/Swiss-Prot. DT 20-MAR-2007, sequence version 1. DT 27-MAR-2024, entry version 94. DE RecName: Full=Protein tyrosine phosphatase type IVA 3; DE EC=3.1.3.48; DE AltName: Full=Protein-tyrosine phosphatase 4a3; DE Flags: Precursor; GN Name=PTP4A3; OS Bos taurus (Bovine). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; OC Bovinae; Bos. OX NCBI_TaxID=9913; RN [1] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC STRAIN=Hereford; TISSUE=Fetal muscle; RG NIH - Mammalian Gene Collection (MGC) project; RL Submitted (FEB-2007) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: Protein tyrosine phosphatase which stimulates progression CC from G1 into S phase during mitosis. Enhances cell proliferation, cell CC motility and invasive activity, and promotes cancer metastasis. May be CC involved in the progression of cardiac hypertrophy by inhibiting CC intracellular calcium mobilization in response to angiotensin II (By CC similarity). {ECO:0000250}. CC -!- CATALYTIC ACTIVITY: CC Reaction=H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + CC phosphate; Xref=Rhea:RHEA:10684, Rhea:RHEA-COMP:10136, Rhea:RHEA- CC COMP:10137, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:46858, CC ChEBI:CHEBI:82620; EC=3.1.3.48; CC -!- ACTIVITY REGULATION: Inhibited by sodium orthovanadate and CC peroxovanadium compounds, and by pentamidine. {ECO:0000250}. CC -!- SUBUNIT: Interacts with tubulin. {ECO:0000250}. CC -!- SUBCELLULAR LOCATION: Cell membrane. Early endosome {ECO:0000250}. CC -!- PTM: Farnesylated. Farnesylation is required for membrane targeting. CC Unfarnesylated forms are shifted into the nucleus (By similarity). CC {ECO:0000250}. CC -!- SIMILARITY: Belongs to the protein-tyrosine phosphatase family. CC {ECO:0000305}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; BC133386; AAI33387.1; -; mRNA. DR RefSeq; NP_001077235.1; NM_001083766.1. DR RefSeq; XP_005215180.1; XM_005215123.3. DR RefSeq; XP_005215181.1; XM_005215124.3. DR RefSeq; XP_010810118.1; XM_010811816.2. DR RefSeq; XP_015329814.1; XM_015474328.1. DR AlphaFoldDB; A2VDT1; -. DR SMR; A2VDT1; -. DR STRING; 9913.ENSBTAP00000056717; -. DR PaxDb; 9913-ENSBTAP00000056281; -. DR Ensembl; ENSBTAT00000064455.2; ENSBTAP00000056281.1; ENSBTAG00000046467.2. DR Ensembl; ENSBTAT00000086143.1; ENSBTAP00000056717.1; ENSBTAG00000046467.2. DR GeneID; 100137722; -. DR KEGG; bta:100137722; -. DR CTD; 11156; -. DR VEuPathDB; HostDB:ENSBTAG00000046467; -. DR VGNC; VGNC:33525; PTP4A3. DR eggNOG; KOG2836; Eukaryota. DR GeneTree; ENSGT00940000159581; -. DR HOGENOM; CLU_099263_1_0_1; -. DR InParanoid; A2VDT1; -. DR OMA; FKDPQNH; -. DR OrthoDB; 117411at2759; -. DR TreeFam; TF313384; -. DR Proteomes; UP000009136; Chromosome 14. DR Bgee; ENSBTAG00000046467; Expressed in infraspinatus muscle and 103 other cell types or tissues. DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central. DR GO; GO:0005769; C:early endosome; IEA:UniProtKB-SubCell. DR GO; GO:0005634; C:nucleus; IBA:GO_Central. DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. DR GO; GO:0004725; F:protein tyrosine phosphatase activity; IBA:GO_Central. DR GO; GO:1990830; P:cellular response to leukemia inhibitory factor; IEA:Ensembl. DR GO; GO:0016311; P:dephosphorylation; IEA:InterPro. DR GO; GO:0043542; P:endothelial cell migration; IBA:GO_Central. DR GO; GO:0007219; P:Notch signaling pathway; IEA:Ensembl. DR GO; GO:1904951; P:positive regulation of establishment of protein localization; IEA:Ensembl. DR GO; GO:1901224; P:positive regulation of non-canonical NF-kappaB signal transduction; IEA:Ensembl. DR GO; GO:0043117; P:positive regulation of vascular permeability; IEA:Ensembl. DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:Ensembl. DR GO; GO:1900746; P:regulation of vascular endothelial growth factor signaling pathway; IEA:Ensembl. DR Gene3D; 3.90.190.10; Protein tyrosine phosphatase superfamily; 1. DR InterPro; IPR029021; Prot-tyrosine_phosphatase-like. DR InterPro; IPR000242; PTP_cat. DR InterPro; IPR003595; Tyr_Pase_cat. DR InterPro; IPR000387; Tyr_Pase_dom. DR InterPro; IPR020422; TYR_PHOSPHATASE_DUAL_dom. DR PANTHER; PTHR23339:SF119; PROTEIN TYROSINE PHOSPHATASE TYPE IVA 3; 1. DR PANTHER; PTHR23339; TYROSINE SPECIFIC PROTEIN PHOSPHATASE AND DUAL SPECIFICITY PROTEIN PHOSPHATASE; 1. DR Pfam; PF00102; Y_phosphatase; 1. DR SMART; SM00404; PTPc_motif; 1. DR SUPFAM; SSF52799; (Phosphotyrosine protein) phosphatases II; 1. DR PROSITE; PS50056; TYR_PHOSPHATASE_2; 1. DR PROSITE; PS50054; TYR_PHOSPHATASE_DUAL; 1. PE 2: Evidence at transcript level; KW Cell membrane; Disulfide bond; Endosome; Hydrolase; Lipoprotein; Membrane; KW Methylation; Prenylation; Protein phosphatase; Proto-oncogene; KW Reference proteome. FT CHAIN 1..170 FT /note="Protein tyrosine phosphatase type IVA 3" FT /id="PRO_0000329024" FT PROPEP 171..173 FT /note="Removed in mature form" FT /evidence="ECO:0000250" FT /id="PRO_0000396734" FT DOMAIN 8..161 FT /note="Tyrosine-protein phosphatase" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00160" FT ACT_SITE 72 FT /note="Proton donor" FT /evidence="ECO:0000250" FT ACT_SITE 104 FT /note="Phosphocysteine intermediate" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00160" FT BINDING 110 FT /ligand="substrate" FT /evidence="ECO:0000250" FT MOD_RES 170 FT /note="Cysteine methyl ester" FT /evidence="ECO:0000250" FT LIPID 170 FT /note="S-farnesyl cysteine" FT /evidence="ECO:0000250" FT DISULFID 49..104 FT /evidence="ECO:0000250" SQ SEQUENCE 173 AA; 19511 MW; 439BEBE1BCC16B94 CRC64; MARMNRPAPV EVSYKNMRFL ITHNPTNATL SSFIEDLKKY GATTVVRVCE VTYDKAPLEK DGITVVDWPF DDGAPPPGKV VEDWLSLLKN KFCDDPGSCV AVHCVAGLGR APVLVALALI ESGMKYEDAI QFIRQKRRGA INSKQLTYLE KYRPKQRLRF KDPHAHKTKC CIM //