Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

A2VDT1 (TP4A3_BOVIN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 43. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Protein tyrosine phosphatase type IVA 3

EC=3.1.3.48
Alternative name(s):
Protein-tyrosine phosphatase 4a3
Gene names
Name:PTP4A3
OrganismBos taurus (Bovine) [Reference proteome]
Taxonomic identifier9913 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos

Protein attributes

Sequence length173 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Protein tyrosine phosphatase which stimulates progression from G1 into S phase during mitosis. Enhances cell proliferation, cell motility and invasive activity, and promotes cancer metastasis. May be involved in the progression of cardiac hypertrophy by inhibiting intracellular calcium mobilization in response to angiotensin II By similarity.

Catalytic activity

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.

Enzyme regulation

Inhibited by sodium orthovanadate and peroxovanadium compounds, and by pentamidine By similarity.

Subunit structure

Interacts with tubulin By similarity.

Subcellular location

Cell membrane. Early endosome By similarity.

Post-translational modification

Farnesylated. Farnesylation is required for membrane targeting. Unfarnesylated forms are shifted into the nucleus By similarity.

Sequence similarities

Belongs to the protein-tyrosine phosphatase family.

Contains 1 tyrosine-protein phosphatase domain.

Ontologies

Keywords
   Cellular componentCell membrane
Endosome
Membrane
   DiseaseProto-oncogene
   Molecular functionHydrolase
Protein phosphatase
   PTMDisulfide bond
Lipoprotein
Methylation
Prenylation
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentearly endosome

Inferred from electronic annotation. Source: UniProtKB-SubCell

plasma membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionprotein tyrosine phosphatase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 170170Protein tyrosine phosphatase type IVA 3
PRO_0000329024
Propeptide171 – 1733Removed in mature form By similarity
PRO_0000396734

Regions

Domain82 – 14867Tyrosine-protein phosphatase

Sites

Active site721Proton donor By similarity
Active site1041Phosphocysteine intermediate By similarity
Binding site1101Substrate By similarity

Amino acid modifications

Modified residue1701Cysteine methyl ester By similarity
Lipidation1701S-farnesyl cysteine By similarity
Disulfide bond49 ↔ 104 By similarity

Sequences

Sequence LengthMass (Da)Tools
A2VDT1 [UniParc].

Last modified March 20, 2007. Version 1.
Checksum: 439BEBE1BCC16B94

FASTA17319,511
        10         20         30         40         50         60 
MARMNRPAPV EVSYKNMRFL ITHNPTNATL SSFIEDLKKY GATTVVRVCE VTYDKAPLEK 

        70         80         90        100        110        120 
DGITVVDWPF DDGAPPPGKV VEDWLSLLKN KFCDDPGSCV AVHCVAGLGR APVLVALALI 

       130        140        150        160        170 
ESGMKYEDAI QFIRQKRRGA INSKQLTYLE KYRPKQRLRF KDPHAHKTKC CIM 

« Hide

References

[1]NIH - Mammalian Gene Collection (MGC) project
Submitted (FEB-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: Hereford.
Tissue: Fetal muscle.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BC133386 mRNA. Translation: AAI33387.1.
RefSeqNP_001077235.1. NM_001083766.1.
XP_005215180.1. XM_005215123.1.
XP_005215181.1. XM_005215124.1.
UniGeneBt.101302.
Bt.56029.

3D structure databases

ProteinModelPortalA2VDT1.
SMRA2VDT1. Positions 1-169.
ModBaseSearch...
MobiDBSearch...

Proteomic databases

PRIDEA2VDT1.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSBTAT00000064455; ENSBTAP00000056281; ENSBTAG00000046467.
GeneID100137722.
KEGGbta:100137722.

Organism-specific databases

CTD11156.

Phylogenomic databases

GeneTreeENSGT00390000009788.
HOVERGENHBG071295.
KOK18041.
OMAKAKFCDD.
OrthoDBEOG7C8GJD.
TreeFamTF313384.

Family and domain databases

InterProIPR000387. Tyr/Dual-sp_Pase.
IPR000242. Tyr_Pase_rcpt/non-rcpt.
[Graphical view]
PfamPF00102. Y_phosphatase. 1 hit.
[Graphical view]
PROSITEPS50056. TYR_PHOSPHATASE_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio20789426.

Entry information

Entry nameTP4A3_BOVIN
AccessionPrimary (citable) accession number: A2VDT1
Entry history
Integrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: March 20, 2007
Last modified: April 16, 2014
This is version 43 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families