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Protein

Protein tyrosine phosphatase type IVA 3

Gene

PTP4A3

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Protein tyrosine phosphatase which stimulates progression from G1 into S phase during mitosis. Enhances cell proliferation, cell motility and invasive activity, and promotes cancer metastasis. May be involved in the progression of cardiac hypertrophy by inhibiting intracellular calcium mobilization in response to angiotensin II (By similarity).By similarity

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.

Enzyme regulationi

Inhibited by sodium orthovanadate and peroxovanadium compounds, and by pentamidine.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei72Proton donorBy similarity1
Active sitei104Phosphocysteine intermediateBy similarity1
Binding sitei110SubstrateBy similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase

Names & Taxonomyi

Protein namesi
Recommended name:
Protein tyrosine phosphatase type IVA 3 (EC:3.1.3.48)
Alternative name(s):
Protein-tyrosine phosphatase 4a3
Gene namesi
Name:PTP4A3
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 14

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Endosome, Membrane

Pathology & Biotechi

Keywords - Diseasei

Proto-oncogene

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003290241 – 170Protein tyrosine phosphatase type IVA 3Add BLAST170
PropeptideiPRO_0000396734171 – 173Removed in mature formBy similarity3

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi49 ↔ 104By similarity
Modified residuei170Cysteine methyl esterBy similarity1
Lipidationi170S-farnesyl cysteineBy similarity1

Post-translational modificationi

Farnesylated. Farnesylation is required for membrane targeting. Unfarnesylated forms are shifted into the nucleus (By similarity).By similarity

Keywords - PTMi

Disulfide bond, Lipoprotein, Methylation, Prenylation

Proteomic databases

PaxDbiA2VDT1.
PRIDEiA2VDT1.

Expressioni

Gene expression databases

BgeeiENSBTAG00000046467.

Interactioni

Subunit structurei

Interacts with tubulin.By similarity

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000056281.

Structurei

3D structure databases

ProteinModelPortaliA2VDT1.
SMRiA2VDT1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini82 – 148Tyrosine-protein phosphataseAdd BLAST67

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG2836. Eukaryota.
ENOG4111I7J. LUCA.
GeneTreeiENSGT00390000009788.
HOVERGENiHBG071295.
InParanoidiA2VDT1.
KOiK18041.
OMAiKAKFCDD.
OrthoDBiEOG091G0MYM.
TreeFamiTF313384.

Family and domain databases

Gene3Di3.90.190.10. 1 hit.
InterProiIPR000340. Dual-sp_phosphatase_cat-dom.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR003595. Tyr_Pase_cat.
IPR000387. TYR_PHOSPHATASE_dom.
[Graphical view]
PfamiPF00782. DSPc. 1 hit.
[Graphical view]
SMARTiSM00404. PTPc_motif. 1 hit.
[Graphical view]
SUPFAMiSSF52799. SSF52799. 1 hit.
PROSITEiPS50056. TYR_PHOSPHATASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

A2VDT1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MARMNRPAPV EVSYKNMRFL ITHNPTNATL SSFIEDLKKY GATTVVRVCE
60 70 80 90 100
VTYDKAPLEK DGITVVDWPF DDGAPPPGKV VEDWLSLLKN KFCDDPGSCV
110 120 130 140 150
AVHCVAGLGR APVLVALALI ESGMKYEDAI QFIRQKRRGA INSKQLTYLE
160 170
KYRPKQRLRF KDPHAHKTKC CIM
Length:173
Mass (Da):19,511
Last modified:March 20, 2007 - v1
Checksum:i439BEBE1BCC16B94
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC133386 mRNA. Translation: AAI33387.1.
RefSeqiNP_001077235.1. NM_001083766.1.
XP_005215180.1. XM_005215123.3.
XP_005215181.1. XM_005215124.3.
XP_010810118.1. XM_010811816.2.
XP_015329814.1. XM_015474328.1.
UniGeneiBt.101302.
Bt.56029.

Genome annotation databases

EnsembliENSBTAT00000064455; ENSBTAP00000056281; ENSBTAG00000046467.
GeneIDi100137722.
KEGGibta:100137722.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC133386 mRNA. Translation: AAI33387.1.
RefSeqiNP_001077235.1. NM_001083766.1.
XP_005215180.1. XM_005215123.3.
XP_005215181.1. XM_005215124.3.
XP_010810118.1. XM_010811816.2.
XP_015329814.1. XM_015474328.1.
UniGeneiBt.101302.
Bt.56029.

3D structure databases

ProteinModelPortaliA2VDT1.
SMRiA2VDT1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000056281.

Proteomic databases

PaxDbiA2VDT1.
PRIDEiA2VDT1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000064455; ENSBTAP00000056281; ENSBTAG00000046467.
GeneIDi100137722.
KEGGibta:100137722.

Organism-specific databases

CTDi11156.

Phylogenomic databases

eggNOGiKOG2836. Eukaryota.
ENOG4111I7J. LUCA.
GeneTreeiENSGT00390000009788.
HOVERGENiHBG071295.
InParanoidiA2VDT1.
KOiK18041.
OMAiKAKFCDD.
OrthoDBiEOG091G0MYM.
TreeFamiTF313384.

Gene expression databases

BgeeiENSBTAG00000046467.

Family and domain databases

Gene3Di3.90.190.10. 1 hit.
InterProiIPR000340. Dual-sp_phosphatase_cat-dom.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR003595. Tyr_Pase_cat.
IPR000387. TYR_PHOSPHATASE_dom.
[Graphical view]
PfamiPF00782. DSPc. 1 hit.
[Graphical view]
SMARTiSM00404. PTPc_motif. 1 hit.
[Graphical view]
SUPFAMiSSF52799. SSF52799. 1 hit.
PROSITEiPS50056. TYR_PHOSPHATASE_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTP4A3_BOVIN
AccessioniPrimary (citable) accession number: A2VDT1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: March 20, 2007
Last modified: November 2, 2016
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.