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A2VDT1

- TP4A3_BOVIN

UniProt

A2VDT1 - TP4A3_BOVIN

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Protein

Protein tyrosine phosphatase type IVA 3

Gene

PTP4A3

Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

Protein tyrosine phosphatase which stimulates progression from G1 into S phase during mitosis. Enhances cell proliferation, cell motility and invasive activity, and promotes cancer metastasis. May be involved in the progression of cardiac hypertrophy by inhibiting intracellular calcium mobilization in response to angiotensin II (By similarity).By similarity

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.

Enzyme regulationi

Inhibited by sodium orthovanadate and peroxovanadium compounds, and by pentamidine.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei72 – 721Proton donorBy similarity
Active sitei104 – 1041Phosphocysteine intermediateBy similarity
Binding sitei110 – 1101SubstrateBy similarity

GO - Molecular functioni

  1. protein tyrosine phosphatase activity Source: UniProtKB-EC
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase

Names & Taxonomyi

Protein namesi
Recommended name:
Protein tyrosine phosphatase type IVA 3 (EC:3.1.3.48)
Alternative name(s):
Protein-tyrosine phosphatase 4a3
Gene namesi
Name:PTP4A3
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
ProteomesiUP000009136: Chromosome 14

Subcellular locationi

GO - Cellular componenti

  1. endosome Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Endosome, Membrane

Pathology & Biotechi

Keywords - Diseasei

Proto-oncogene

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 170170Protein tyrosine phosphatase type IVA 3PRO_0000329024Add
BLAST
Propeptidei171 – 1733Removed in mature formBy similarityPRO_0000396734

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi49 ↔ 104By similarity
Modified residuei170 – 1701Cysteine methyl esterBy similarity
Lipidationi170 – 1701S-farnesyl cysteineBy similarity

Post-translational modificationi

Farnesylated. Farnesylation is required for membrane targeting. Unfarnesylated forms are shifted into the nucleus (By similarity).By similarity

Keywords - PTMi

Disulfide bond, Lipoprotein, Methylation, Prenylation

Proteomic databases

PRIDEiA2VDT1.

Interactioni

Subunit structurei

Interacts with tubulin.By similarity

Structurei

3D structure databases

ProteinModelPortaliA2VDT1.
SMRiA2VDT1. Positions 1-169.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini82 – 14867Tyrosine-protein phosphataseAdd
BLAST

Sequence similaritiesi

Phylogenomic databases

GeneTreeiENSGT00390000009788.
HOVERGENiHBG071295.
InParanoidiA2VDT1.
KOiK18041.
OMAiKAKFCDD.
OrthoDBiEOG7C8GJD.
TreeFamiTF313384.

Family and domain databases

Gene3Di3.90.190.10. 1 hit.
InterProiIPR029021. Prot-tyrosine_phosphatase-like.
IPR000387. Tyr/Dual-sp_Pase.
IPR000242. Tyr_Pase_rcpt/non-rcpt.
[Graphical view]
PfamiPF00102. Y_phosphatase. 1 hit.
[Graphical view]
SUPFAMiSSF52799. SSF52799. 1 hit.
PROSITEiPS50056. TYR_PHOSPHATASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

A2VDT1-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MARMNRPAPV EVSYKNMRFL ITHNPTNATL SSFIEDLKKY GATTVVRVCE
60 70 80 90 100
VTYDKAPLEK DGITVVDWPF DDGAPPPGKV VEDWLSLLKN KFCDDPGSCV
110 120 130 140 150
AVHCVAGLGR APVLVALALI ESGMKYEDAI QFIRQKRRGA INSKQLTYLE
160 170
KYRPKQRLRF KDPHAHKTKC CIM
Length:173
Mass (Da):19,511
Last modified:March 20, 2007 - v1
Checksum:i439BEBE1BCC16B94
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC133386 mRNA. Translation: AAI33387.1.
RefSeqiNP_001077235.1. NM_001083766.1.
XP_005215180.1. XM_005215123.1.
XP_005215181.1. XM_005215124.1.
UniGeneiBt.101302.
Bt.56029.

Genome annotation databases

EnsembliENSBTAT00000064455; ENSBTAP00000056281; ENSBTAG00000046467.
GeneIDi100137722.
KEGGibta:100137722.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC133386 mRNA. Translation: AAI33387.1 .
RefSeqi NP_001077235.1. NM_001083766.1.
XP_005215180.1. XM_005215123.1.
XP_005215181.1. XM_005215124.1.
UniGenei Bt.101302.
Bt.56029.

3D structure databases

ProteinModelPortali A2VDT1.
SMRi A2VDT1. Positions 1-169.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi A2VDT1.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSBTAT00000064455 ; ENSBTAP00000056281 ; ENSBTAG00000046467 .
GeneIDi 100137722.
KEGGi bta:100137722.

Organism-specific databases

CTDi 11156.

Phylogenomic databases

GeneTreei ENSGT00390000009788.
HOVERGENi HBG071295.
InParanoidi A2VDT1.
KOi K18041.
OMAi KAKFCDD.
OrthoDBi EOG7C8GJD.
TreeFami TF313384.

Miscellaneous databases

NextBioi 20789426.

Family and domain databases

Gene3Di 3.90.190.10. 1 hit.
InterProi IPR029021. Prot-tyrosine_phosphatase-like.
IPR000387. Tyr/Dual-sp_Pase.
IPR000242. Tyr_Pase_rcpt/non-rcpt.
[Graphical view ]
Pfami PF00102. Y_phosphatase. 1 hit.
[Graphical view ]
SUPFAMi SSF52799. SSF52799. 1 hit.
PROSITEi PS50056. TYR_PHOSPHATASE_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. NIH - Mammalian Gene Collection (MGC) project
    Submitted (FEB-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Hereford.
    Tissue: Fetal muscle.

Entry informationi

Entry nameiTP4A3_BOVIN
AccessioniPrimary (citable) accession number: A2VDT1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: March 20, 2007
Last modified: October 29, 2014
This is version 46 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3