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A2VDT1

- TP4A3_BOVIN

UniProt

A2VDT1 - TP4A3_BOVIN

Protein

Protein tyrosine phosphatase type IVA 3

Gene

PTP4A3

Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 45 (01 Oct 2014)
      Sequence version 1 (20 Mar 2007)
      Previous versions | rss
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    Functioni

    Protein tyrosine phosphatase which stimulates progression from G1 into S phase during mitosis. Enhances cell proliferation, cell motility and invasive activity, and promotes cancer metastasis. May be involved in the progression of cardiac hypertrophy by inhibiting intracellular calcium mobilization in response to angiotensin II By similarity.By similarity

    Catalytic activityi

    Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.

    Enzyme regulationi

    Inhibited by sodium orthovanadate and peroxovanadium compounds, and by pentamidine.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei72 – 721Proton donorBy similarity
    Active sitei104 – 1041Phosphocysteine intermediateBy similarity
    Binding sitei110 – 1101SubstrateBy similarity

    GO - Molecular functioni

    1. protein tyrosine phosphatase activity Source: UniProtKB-EC

    Keywords - Molecular functioni

    Hydrolase, Protein phosphatase

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein tyrosine phosphatase type IVA 3 (EC:3.1.3.48)
    Alternative name(s):
    Protein-tyrosine phosphatase 4a3
    Gene namesi
    Name:PTP4A3
    OrganismiBos taurus (Bovine)
    Taxonomic identifieri9913 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
    ProteomesiUP000009136: Chromosome 14

    Subcellular locationi

    GO - Cellular componenti

    1. early endosome Source: UniProtKB-SubCell
    2. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Endosome, Membrane

    Pathology & Biotechi

    Keywords - Diseasei

    Proto-oncogene

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 170170Protein tyrosine phosphatase type IVA 3PRO_0000329024Add
    BLAST
    Propeptidei171 – 1733Removed in mature formBy similarityPRO_0000396734

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi49 ↔ 104By similarity
    Modified residuei170 – 1701Cysteine methyl esterBy similarity
    Lipidationi170 – 1701S-farnesyl cysteineBy similarity

    Post-translational modificationi

    Farnesylated. Farnesylation is required for membrane targeting. Unfarnesylated forms are shifted into the nucleus By similarity.By similarity

    Keywords - PTMi

    Disulfide bond, Lipoprotein, Methylation, Prenylation

    Proteomic databases

    PRIDEiA2VDT1.

    Interactioni

    Subunit structurei

    Interacts with tubulin.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliA2VDT1.
    SMRiA2VDT1. Positions 1-169.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini82 – 14867Tyrosine-protein phosphataseAdd
    BLAST

    Sequence similaritiesi

    Phylogenomic databases

    GeneTreeiENSGT00390000009788.
    HOVERGENiHBG071295.
    KOiK18041.
    OMAiKAKFCDD.
    OrthoDBiEOG7C8GJD.
    TreeFamiTF313384.

    Family and domain databases

    Gene3Di3.90.190.10. 1 hit.
    InterProiIPR029021. Prot-tyrosine_phosphatase-like.
    IPR000387. Tyr/Dual-sp_Pase.
    IPR000242. Tyr_Pase_rcpt/non-rcpt.
    [Graphical view]
    PfamiPF00102. Y_phosphatase. 1 hit.
    [Graphical view]
    SUPFAMiSSF52799. SSF52799. 1 hit.
    PROSITEiPS50056. TYR_PHOSPHATASE_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    A2VDT1-1 [UniParc]FASTAAdd to Basket

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    MARMNRPAPV EVSYKNMRFL ITHNPTNATL SSFIEDLKKY GATTVVRVCE    50
    VTYDKAPLEK DGITVVDWPF DDGAPPPGKV VEDWLSLLKN KFCDDPGSCV 100
    AVHCVAGLGR APVLVALALI ESGMKYEDAI QFIRQKRRGA INSKQLTYLE 150
    KYRPKQRLRF KDPHAHKTKC CIM 173
    Length:173
    Mass (Da):19,511
    Last modified:March 20, 2007 - v1
    Checksum:i439BEBE1BCC16B94
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC133386 mRNA. Translation: AAI33387.1.
    RefSeqiNP_001077235.1. NM_001083766.1.
    XP_005215180.1. XM_005215123.1.
    XP_005215181.1. XM_005215124.1.
    UniGeneiBt.101302.
    Bt.56029.

    Genome annotation databases

    EnsembliENSBTAT00000064455; ENSBTAP00000056281; ENSBTAG00000046467.
    GeneIDi100137722.
    KEGGibta:100137722.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC133386 mRNA. Translation: AAI33387.1 .
    RefSeqi NP_001077235.1. NM_001083766.1.
    XP_005215180.1. XM_005215123.1.
    XP_005215181.1. XM_005215124.1.
    UniGenei Bt.101302.
    Bt.56029.

    3D structure databases

    ProteinModelPortali A2VDT1.
    SMRi A2VDT1. Positions 1-169.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi A2VDT1.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSBTAT00000064455 ; ENSBTAP00000056281 ; ENSBTAG00000046467 .
    GeneIDi 100137722.
    KEGGi bta:100137722.

    Organism-specific databases

    CTDi 11156.

    Phylogenomic databases

    GeneTreei ENSGT00390000009788.
    HOVERGENi HBG071295.
    KOi K18041.
    OMAi KAKFCDD.
    OrthoDBi EOG7C8GJD.
    TreeFami TF313384.

    Miscellaneous databases

    NextBioi 20789426.

    Family and domain databases

    Gene3Di 3.90.190.10. 1 hit.
    InterProi IPR029021. Prot-tyrosine_phosphatase-like.
    IPR000387. Tyr/Dual-sp_Pase.
    IPR000242. Tyr_Pase_rcpt/non-rcpt.
    [Graphical view ]
    Pfami PF00102. Y_phosphatase. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52799. SSF52799. 1 hit.
    PROSITEi PS50056. TYR_PHOSPHATASE_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. NIH - Mammalian Gene Collection (MGC) project
      Submitted (FEB-2007) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: Hereford.
      Tissue: Fetal muscle.

    Entry informationi

    Entry nameiTP4A3_BOVIN
    AccessioniPrimary (citable) accession number: A2VDT1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 8, 2008
    Last sequence update: March 20, 2007
    Last modified: October 1, 2014
    This is version 45 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3