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Protein

Neurolysin, mitochondrial

Gene

NLN

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Hydrolyzes oligopeptides such as neurotensin, bradykinin and dynorphin A.By similarity

Catalytic activityi

Preferential cleavage in neurotensin: 10-Pro-|-Tyr-11.

Cofactori

Zn2+By similarityNote: Binds 1 zinc ion per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi497Zinc; catalyticPROSITE-ProRule annotation1
Active sitei498PROSITE-ProRule annotation1
Metal bindingi501Zinc; catalyticPROSITE-ProRule annotation1
Metal bindingi504Zinc; catalyticPROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Metalloprotease, Protease
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Neurolysin, mitochondrial (EC:3.4.24.16)
Alternative name(s):
Microsomal endopeptidase
Short name:
MEP
Mitochondrial oligopeptidase M
Neurotensin endopeptidase
Gene namesi
Name:NLN
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Unplaced

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 37MitochondrionAdd BLAST37
ChainiPRO_000031904738 – 704Neurolysin, mitochondrialAdd BLAST667

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei664N6-acetyllysineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiA2VDQ5
PRIDEiA2VDQ5

Interactioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000022482

Structurei

3D structure databases

ProteinModelPortaliA2VDQ5
SMRiA2VDQ5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase M3 family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG2089 Eukaryota
COG0339 LUCA
HOGENOMiHOG000245985
HOVERGENiHBG000238
InParanoidiA2VDQ5
KOiK01393

Family and domain databases

Gene3Di1.10.1370.10, 2 hits
1.20.1050.40, 1 hit
3.40.390.10, 1 hit
InterProiView protein in InterPro
IPR024079 MetalloPept_cat_dom_sf
IPR024077 Neurolysin/TOP_dom2
IPR024080 Neurolysin/TOP_N
IPR001567 Pept_M3A_M3B
PfamiView protein in Pfam
PF01432 Peptidase_M3, 1 hit
PROSITEiView protein in PROSITE
PS00142 ZINC_PROTEASE, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

A2VDQ5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIVQCLLAVR GLHRVGGSRI LFRMTLGREE MSPLQAMSSY MAAGRNVLRW
60 70 80 90 100
DLSPEQIKTR TEELISQTKQ VYDAIGMRDI KEVTYENCLQ ALADIEVKYI
110 120 130 140 150
VERTMLDFPQ HVSSDKEVRA ASTEADKRLS RFDIEMSMRQ DIFLRIVHLK
160 170 180 190 200
ETCDLEKIKP EARRYLEKSV KMGKRNGLHL PEQVQNEIKA MKKRMSELCI
210 220 230 240 250
DFNKNLNEDD TFLVFSKAEL GALPDDFINS LEKTDGDKYK ITLKYPHYFP
260 270 280 290 300
VMKKCCVPET RRKMEMAFNT RCKEENTVIL QQLLPLRAEV ARLLGYSTHA
310 320 330 340 350
DFVLEMNTAK STRHVTAFLD DLSQKLKPLG EAEREFILNL KKKECKERGF
360 370 380 390 400
EYDGKINAWD LHYYMTQTEE LKYSVDQETL KEYFPIEVVT EGLLNIYQEL
410 420 430 440 450
LGLSFEQVTD AHVWNKSVTL YTVKDKATGE VLGQFYLDLY PREGKYNHAA
460 470 480 490 500
CFGLQPGCLL PDGSRMMSVA ALVVNFSQPL AGRPSLLRHD EVRTYFHEFG
510 520 530 540 550
HVMHQICAQT DFARFSGTNV ETDFVEVPSQ MLENWVWDAD SLRRLSKHYR
560 570 580 590 600
HGSPITDDLL EKLVASRLVN TGLLTLRQIV LSKVDQSLHT NTALDAASEY
610 620 630 640 650
AKYCTEILGV AATPGTNMPA TFGHLAGGYD GQYYGYLWSE VFSMDMFYSC
660 670 680 690 700
FKKEGIMNPE VGMKYRNLIL KPGGSLDGMD MLQNFLTREP NQKAFLMSRG

LPAP
Length:704
Mass (Da):80,728
Last modified:March 20, 2007 - v1
Checksum:iF53622A4F7116FC8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC133350 mRNA Translation: AAI33351.1
RefSeqiNP_001029161.2, NM_001033989.2
UniGeneiBt.40554

Genome annotation databases

GeneIDi538650
KEGGibta:538650

Similar proteinsi

Entry informationi

Entry nameiNEUL_BOVIN
AccessioniPrimary (citable) accession number: A2VDQ5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: March 20, 2007
Last modified: March 28, 2018
This is version 70 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families
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