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A2VDQ5

- NEUL_BOVIN

UniProt

A2VDQ5 - NEUL_BOVIN

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Protein
Neurolysin, mitochondrial
Gene
NLN
Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Hydrolyzes oligopeptides such as neurotensin, bradykinin and dynorphin A By similarity.

Catalytic activityi

Preferential cleavage in neurotensin: 10-Pro-|-Tyr-11.

Cofactori

Binds 1 zinc ion per subunit By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi497 – 4971Zinc; catalytic By similarity
Active sitei498 – 4981 By similarity
Metal bindingi501 – 5011Zinc; catalytic By similarity
Metal bindingi504 – 5041Zinc; catalytic By similarity

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. metalloendopeptidase activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Metalloprotease, Protease

Keywords - Ligandi

Metal-binding, Zinc

Protein family/group databases

MEROPSiM03.002.

Names & Taxonomyi

Protein namesi
Recommended name:
Neurolysin, mitochondrial (EC:3.4.24.16)
Alternative name(s):
Microsomal endopeptidase
Short name:
MEP
Mitochondrial oligopeptidase M
Neurotensin endopeptidase
Gene namesi
Name:NLN
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
ProteomesiUP000009136: Unplaced

Subcellular locationi

Mitochondrion intermembrane space By similarity. Cytoplasm By similarity

GO - Cellular componenti

  1. mitochondrial intermembrane space Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 3737Mitochondrion
Add
BLAST
Chaini38 – 704667Neurolysin, mitochondrial
PRO_0000319047Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei664 – 6641N6-acetyllysine By similarity

Keywords - PTMi

Acetylation

Proteomic databases

PRIDEiA2VDQ5.

Interactioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000022482.

Structurei

3D structure databases

ProteinModelPortaliA2VDQ5.
SMRiA2VDQ5. Positions 37-701.

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase M3 family.

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiCOG0339.
HOGENOMiHOG000245985.
HOVERGENiHBG000238.
InParanoidiA2VDQ5.
KOiK01393.

Family and domain databases

Gene3Di1.10.1370.10. 2 hits.
1.20.1050.40. 1 hit.
3.40.390.10. 1 hit.
InterProiIPR024079. MetalloPept_cat_dom.
IPR024077. Neurolysin/TOP_dom2.
IPR024080. Neurolysin/TOP_N.
IPR001567. Pept_M3A_M3B.
[Graphical view]
PfamiPF01432. Peptidase_M3. 1 hit.
[Graphical view]
PROSITEiPS00142. ZINC_PROTEASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

A2VDQ5-1 [UniParc]FASTAAdd to Basket

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MIVQCLLAVR GLHRVGGSRI LFRMTLGREE MSPLQAMSSY MAAGRNVLRW    50
DLSPEQIKTR TEELISQTKQ VYDAIGMRDI KEVTYENCLQ ALADIEVKYI 100
VERTMLDFPQ HVSSDKEVRA ASTEADKRLS RFDIEMSMRQ DIFLRIVHLK 150
ETCDLEKIKP EARRYLEKSV KMGKRNGLHL PEQVQNEIKA MKKRMSELCI 200
DFNKNLNEDD TFLVFSKAEL GALPDDFINS LEKTDGDKYK ITLKYPHYFP 250
VMKKCCVPET RRKMEMAFNT RCKEENTVIL QQLLPLRAEV ARLLGYSTHA 300
DFVLEMNTAK STRHVTAFLD DLSQKLKPLG EAEREFILNL KKKECKERGF 350
EYDGKINAWD LHYYMTQTEE LKYSVDQETL KEYFPIEVVT EGLLNIYQEL 400
LGLSFEQVTD AHVWNKSVTL YTVKDKATGE VLGQFYLDLY PREGKYNHAA 450
CFGLQPGCLL PDGSRMMSVA ALVVNFSQPL AGRPSLLRHD EVRTYFHEFG 500
HVMHQICAQT DFARFSGTNV ETDFVEVPSQ MLENWVWDAD SLRRLSKHYR 550
HGSPITDDLL EKLVASRLVN TGLLTLRQIV LSKVDQSLHT NTALDAASEY 600
AKYCTEILGV AATPGTNMPA TFGHLAGGYD GQYYGYLWSE VFSMDMFYSC 650
FKKEGIMNPE VGMKYRNLIL KPGGSLDGMD MLQNFLTREP NQKAFLMSRG 700
LPAP 704
Length:704
Mass (Da):80,728
Last modified:March 20, 2007 - v1
Checksum:iF53622A4F7116FC8
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC133350 mRNA. Translation: AAI33351.1.
RefSeqiNP_001029161.2. NM_001033989.2.
UniGeneiBt.40554.

Genome annotation databases

GeneIDi538650.
KEGGibta:538650.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC133350 mRNA. Translation: AAI33351.1 .
RefSeqi NP_001029161.2. NM_001033989.2.
UniGenei Bt.40554.

3D structure databases

ProteinModelPortali A2VDQ5.
SMRi A2VDQ5. Positions 37-701.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9913.ENSBTAP00000022482.

Protein family/group databases

MEROPSi M03.002.

Proteomic databases

PRIDEi A2VDQ5.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 538650.
KEGGi bta:538650.

Organism-specific databases

CTDi 57486.

Phylogenomic databases

eggNOGi COG0339.
HOGENOMi HOG000245985.
HOVERGENi HBG000238.
InParanoidi A2VDQ5.
KOi K01393.

Miscellaneous databases

NextBioi 20877494.

Family and domain databases

Gene3Di 1.10.1370.10. 2 hits.
1.20.1050.40. 1 hit.
3.40.390.10. 1 hit.
InterProi IPR024079. MetalloPept_cat_dom.
IPR024077. Neurolysin/TOP_dom2.
IPR024080. Neurolysin/TOP_N.
IPR001567. Pept_M3A_M3B.
[Graphical view ]
Pfami PF01432. Peptidase_M3. 1 hit.
[Graphical view ]
PROSITEi PS00142. ZINC_PROTEASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. NIH - Mammalian Gene Collection (MGC) project
    Submitted (FEB-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Hereford.
    Tissue: Hypothalamus.

Entry informationi

Entry nameiNEUL_BOVIN
AccessioniPrimary (citable) accession number: A2VDQ5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: March 20, 2007
Last modified: May 14, 2014
This is version 53 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi