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Protein

Integral membrane protein 2C

Gene

ITM2C

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Negative regulator of beta amyloid peptide production. May inhibit the processing of APP by blocking its access to alpha- and beta-secretase. Binding to the beta-secretase-cleaved APP C-terminal fragment is negligible, suggesting that ITM2C is a poor gamma-secretase cleavage inhibitor. May play a role in TNF-induced cell death and neuronal differentiation (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Integral membrane protein 2C
Cleaved into the following chain:
Gene namesi
Name:ITM2C
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 2

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei59 – 7921Helical; Signal-anchor for type II membrane proteinSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Lysosome, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 271271Integral membrane protein 2CPRO_0000295294Add
BLAST
Peptidei247 – 27125CT-BRI3PRO_0000295295Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei41 – 411PhosphothreonineBy similarity
Disulfide bondi167 ↔ 226By similarity
Glycosylationi173 – 1731N-linked (GlcNAc...)Sequence analysis

Post-translational modificationi

Type I membrane-bound, as well as soluble, furin has a pre-eminent role in ITM2C proteolytic processing. PCSK7 and PCSK5 may also be involved although to a lesser extent. The soluble form of PCSK7 is incapable of processing ITM2C. Fails to undergo shedding by ADAM10 and intramembanaire cleavage by SPPL2B (By similarity).By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei246 – 2472Cleavage; by furinBy similarity

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiA2VDN0.
PRIDEiA2VDN0.

Expressioni

Gene expression databases

BgeeiENSBTAG00000017855.

Interactioni

Subunit structurei

Interacts with BACE1. Interacts with APP. Interacts with STMN2 (By similarity).By similarity

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000023734.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini140 – 23495BRICHOSPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the ITM2 family.Curated
Contains 1 BRICHOS domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4681. Eukaryota.
ENOG410XRNN. LUCA.
GeneTreeiENSGT00390000005162.
HOGENOMiHOG000231259.
HOVERGENiHBG059373.
InParanoidiA2VDN0.
KOiK18265.
OMAiNPRMLIE.
OrthoDBiEOG091G0E78.
TreeFamiTF317770.

Family and domain databases

InterProiIPR007084. BRICHOS_dom.
[Graphical view]
PfamiPF04089. BRICHOS. 1 hit.
[Graphical view]
SMARTiSM01039. BRICHOS. 1 hit.
[Graphical view]
PROSITEiPS50869. BRICHOS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

A2VDN0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVKISFQPAV AGIKGDKADK ASASASASAP APTPAAEILL TPAREERPPY
60 70 80 90 100
QRYKKGGSVG GVCYLSMGMV VLLMGLVFAS VYIYRYFFLA QLARDNFFHC
110 120 130 140 150
GVLYEDSLSS QAHTRMELEE DVKIYLEENY ERINVPVPQF GGGDPADIIH
160 170 180 190 200
DFQRGLTAYH DISLDKCYVI ELNTTIVLPP RNFWELLMNV KRGTYLPQTY
210 220 230 240 250
IIQEEMVVTE HVSDKEALGS FIYHLCSGKD TYRLRRRATR RRINKREAKN
260 270
CNAIRHFENT FVVETLICGV V
Length:271
Mass (Da):30,673
Last modified:March 20, 2007 - v1
Checksum:i178C9807DF6C59E3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC133321 mRNA. Translation: AAI33322.1.
RefSeqiNP_001075007.1. NM_001081538.1.
UniGeneiBt.61120.

Genome annotation databases

EnsembliENSBTAT00000023734; ENSBTAP00000023734; ENSBTAG00000017855.
GeneIDi539959.
KEGGibta:539959.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC133321 mRNA. Translation: AAI33322.1.
RefSeqiNP_001075007.1. NM_001081538.1.
UniGeneiBt.61120.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000023734.

Proteomic databases

PaxDbiA2VDN0.
PRIDEiA2VDN0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000023734; ENSBTAP00000023734; ENSBTAG00000017855.
GeneIDi539959.
KEGGibta:539959.

Organism-specific databases

CTDi81618.

Phylogenomic databases

eggNOGiKOG4681. Eukaryota.
ENOG410XRNN. LUCA.
GeneTreeiENSGT00390000005162.
HOGENOMiHOG000231259.
HOVERGENiHBG059373.
InParanoidiA2VDN0.
KOiK18265.
OMAiNPRMLIE.
OrthoDBiEOG091G0E78.
TreeFamiTF317770.

Gene expression databases

BgeeiENSBTAG00000017855.

Family and domain databases

InterProiIPR007084. BRICHOS_dom.
[Graphical view]
PfamiPF04089. BRICHOS. 1 hit.
[Graphical view]
SMARTiSM01039. BRICHOS. 1 hit.
[Graphical view]
PROSITEiPS50869. BRICHOS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiITM2C_BOVIN
AccessioniPrimary (citable) accession number: A2VDN0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 24, 2007
Last sequence update: March 20, 2007
Last modified: September 7, 2016
This is version 51 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.