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A2VDM8 (BAP1_BOVIN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 31. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Ubiquitin carboxyl-terminal hydrolase BAP1

EC=3.4.19.12
Alternative name(s):
BRCA1-associated protein 1
Gene names
Name:BAP1
OrganismBos taurus (Bovine) [Reference proteome]
Taxonomic identifier9913 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos

Protein attributes

Sequence length711 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Deubiquitinating enzyme that plays a key role in chromatin by mediating deubiquitination of histone H2A and HCFC1. Catalytic component of the PR-DUB complex, a complex that specifically mediates deubiquitination of histone H2A monoubiquitinated at 'Lys-119' (H2AK119ub1). Does not deubiquitinate monoubiquitinated histone H2B. Acts as a regulator of cell growth by mediating deubiquitination of HCFC1 N-terminal and C-terminal chains, with some specificity toward 'Lys-48'-linked polyubiquitin chains compared to 'Lys-63'-linked polyubiquitin chains. Deubiquitination of HCFC1 does not lead to increase stability of HCFC1. Interferes with the BRCA1 and BARD1 heterodimer activity by inhibiting their ability to mediate ubiquitination and autoubiquitination. It however does not mediate deubiquitination of BRCA1 and BARD1. Acts as a tumor suppressor By similarity.

Catalytic activity

Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

Subunit structure

Component of the PR-DUB complex, at least composed of BAP1 and ASXL1. Interacts with BRCA1 (via the RING finger). Interacts (via HBM-like motif) with HCFC1 By similarity.

Subcellular location

Cytoplasm By similarity. Nucleus By similarity. Note: Mainly nuclear. Binds to chromatin By similarity.

Sequence similarities

Belongs to the peptidase C12 family. BAP1 subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 711711Ubiquitin carboxyl-terminal hydrolase BAP1
PRO_0000395816

Regions

Region578 – 703126Interaction with BRCA1 By similarity
Coiled coil612 – 64332 Potential
Motif345 – 3484HBM-like motif By similarity
Motif699 – 7046Nuclear localization signal By similarity

Sites

Active site911Nucleophile By similarity
Active site1691Proton donor By similarity
Site1841Important for enzyme activity By similarity

Sequences

Sequence LengthMass (Da)Tools
A2VDM8 [UniParc].

Last modified March 20, 2007. Version 1.
Checksum: 31D9E5B4AF11C286

FASTA71178,333
        10         20         30         40         50         60 
MNKGWLELES DPGLFTLLVE DFGVKGVQVE EIYDLQSKCQ GPVYGFIFLF KWIEERRSRR 

        70         80         90        100        110        120 
KVSTLVDDTS VIDDDIVNNM FFAHQLIPNS CATHALLSVL LNCSNVDLGP TLSRMKDFTK 

       130        140        150        160        170        180 
GFSPESKGYA IGNAPELAKA HNSHARPEPR HLPEKQNGLS AVRTMEAFHF VSYVPITGRL 

       190        200        210        220        230        240 
FELDGLKVYP IDHGPWGEDE EWTDKARRVI MERIGLATAG IKYEARLHVL KVNRQTVLEA 

       250        260        270        280        290        300 
LQQLIRVTQP ELIQTHKSQE SQLPEESKPA SSKSPLALET SRAPVASEST HTDGVEEVAG 

       310        320        330        340        350        360 
SCPQAPTHSP PSKPKLVVKP PGSNINGVPP NPTPIVQRLP AFLDNHNYAK SPMQEEEDLA 

       370        380        390        400        410        420 
AGVGRSRVPV RPPQQYSDDE DDYEDEEEDD AQSTSSAIRY KRKGPGKPGP LSSSGDGQLS 

       430        440        450        460        470        480 
VLQPNTINVL AEKLKESQKD LSIPLSIKTS SGAGSPAVAV PTHSQPSPTP SNESTDTASE 

       490        500        510        520        530        540 
IGSAFNSPLR SPIRSANPTR PSSPVTSHIS KVLFGEDDSL LRVDCIRYNR AVRDLGPVIS 

       550        560        570        580        590        600 
TGLLHLAEDG VLSPLALTES GKGSSPSIRP SQGSQGSGSP EEKEVVEAVD SREKPGLVRP 

       610        620        630        640        650        660 
SESLNGEKYS PKELLALLKC VEAEIANYEA CLKEEVEKRK KFKIDDQRRT HNYDEFICTF 

       670        680        690        700        710 
ISMLAQEGML ANLVEQNISV RRRQGVSIGR LHKQRKPDRR KRSRPYKAKR Q 

« Hide

References

[1]NIH - Mammalian Gene Collection (MGC) project
Submitted (FEB-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: Hereford.
Tissue: Basal ganglia.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BC133317 mRNA. Translation: AAI33318.1.
RefSeqNP_001096019.1. NM_001102549.1.
UniGeneBt.20209.

3D structure databases

ProteinModelPortalA2VDM8.
ModBaseSearch...
MobiDBSearch...

Protein family/group databases

MEROPSC12.004.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID100124510.
KEGGbta:100124510.

Organism-specific databases

CTD8314.

Phylogenomic databases

HOVERGENHBG054042.
KOK08588.

Family and domain databases

Gene3D3.40.532.10. 1 hit.
InterProIPR001578. Peptidase_C12_UCH.
[Graphical view]
PANTHERPTHR10589. PTHR10589. 1 hit.
PfamPF01088. Peptidase_C12. 1 hit.
[Graphical view]
PRINTSPR00707. UBCTHYDRLASE.
ProtoNetSearch...

Other

NextBio20788729.

Entry information

Entry nameBAP1_BOVIN
AccessionPrimary (citable) accession number: A2VDM8
Entry history
Integrated into UniProtKB/Swiss-Prot: July 13, 2010
Last sequence update: March 20, 2007
Last modified: April 16, 2014
This is version 31 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Peptidase families

Classification of peptidase families and list of entries