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A2VDL6

- AT1A2_BOVIN

UniProt

A2VDL6 - AT1A2_BOVIN

Protein

Sodium/potassium-transporting ATPase subunit alpha-2

Gene

ATP1A2

Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 58 (01 Oct 2014)
      Sequence version 1 (20 Mar 2007)
      Previous versions | rss
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    Functioni

    This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium, providing the energy for active transport of various nutrients By similarity.By similarity

    Catalytic activityi

    ATP + H2O + Na+(In) + K+(Out) = ADP + phosphate + Na+(Out) + K+(In).

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei374 – 37414-aspartylphosphate intermediateBy similarity
    Metal bindingi714 – 7141MagnesiumBy similarity
    Metal bindingi718 – 7181MagnesiumBy similarity

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. metal ion binding Source: UniProtKB-KW
    3. sodium:potassium-exchanging ATPase activity Source: UniProtKB-EC

    GO - Biological processi

    1. adult locomotory behavior Source: Ensembl
    2. ATP biosynthetic process Source: InterPro
    3. locomotion Source: Ensembl
    4. negative regulation of cytosolic calcium ion concentration Source: Ensembl
    5. negative regulation of heart contraction Source: Ensembl
    6. negative regulation of striated muscle contraction Source: Ensembl
    7. neurotransmitter uptake Source: Ensembl
    8. regulation of blood pressure Source: Ensembl
    9. regulation of respiratory gaseous exchange by neurological system process Source: Ensembl
    10. regulation of smooth muscle contraction Source: Ensembl
    11. regulation of the force of heart contraction Source: Ensembl
    12. regulation of vasoconstriction Source: Ensembl
    13. visual learning Source: Ensembl

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    Ion transport, Potassium transport, Sodium transport, Sodium/potassium transport, Transport

    Keywords - Ligandi

    ATP-binding, Magnesium, Metal-binding, Nucleotide-binding, Potassium, Sodium

    Enzyme and pathway databases

    ReactomeiREACT_203452. Ion transport by P-type ATPases.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Sodium/potassium-transporting ATPase subunit alpha-2 (EC:3.6.3.9)
    Short name:
    Na(+)/K(+) ATPase alpha-2 subunit
    Alternative name(s):
    Sodium pump subunit alpha-2
    Gene namesi
    Name:ATP1A2
    OrganismiBos taurus (Bovine)
    Taxonomic identifieri9913 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
    ProteomesiUP000009136: Chromosome 3

    Subcellular locationi

    Membrane By similarity; Multi-pass membrane protein By similarity. Cell membrane By similarity; Multi-pass membrane protein By similarity

    GO - Cellular componenti

    1. cytoplasm Source: Ensembl
    2. integral component of membrane Source: UniProtKB-KW
    3. T-tubule Source: Ensembl

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Propeptidei1 – 55By similarityPRO_0000305981
    Chaini6 – 10201015Sodium/potassium-transporting ATPase subunit alpha-2PRO_0000305982Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei570 – 5701PhosphothreonineBy similarity
    Modified residuei587 – 5871PhosphoserineBy similarity
    Modified residuei940 – 9401Phosphoserine; by PKABy similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    PaxDbiA2VDL6.
    PRIDEiA2VDL6.

    Interactioni

    Subunit structurei

    Composed of three subunits: alpha (catalytic), beta and gamma.By similarity

    Protein-protein interaction databases

    STRINGi9913.ENSBTAP00000046095.

    Structurei

    3D structure databases

    ProteinModelPortaliA2VDL6.
    SMRiA2VDL6. Positions 25-1020.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini6 – 8580CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini107 – 12923ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini151 – 286136CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini307 – 31812ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini337 – 769433CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini790 – 79910ExtracellularSequence Analysis
    Topological domaini821 – 84020CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini864 – 91552ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini936 – 94813CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini968 – 98215ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini1004 – 102017CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei86 – 10621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei130 – 15021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei287 – 30620HelicalSequence AnalysisAdd
    BLAST
    Transmembranei319 – 33618HelicalSequence AnalysisAdd
    BLAST
    Transmembranei770 – 78920HelicalSequence AnalysisAdd
    BLAST
    Transmembranei800 – 82021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei841 – 86323HelicalSequence AnalysisAdd
    BLAST
    Transmembranei916 – 93520HelicalSequence AnalysisAdd
    BLAST
    Transmembranei949 – 96719HelicalSequence AnalysisAdd
    BLAST
    Transmembranei983 – 100321HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni80 – 823Interaction with phosphoinositide-3 kinaseBy similarity

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0474.
    GeneTreeiENSGT00560000076866.
    HOGENOMiHOG000265622.
    HOVERGENiHBG004298.
    InParanoidiA2VDL6.
    KOiK01539.
    OMAiIINIPLP.
    OrthoDBiEOG7327N0.
    TreeFamiTF312838.

    Family and domain databases

    Gene3Di1.20.1110.10. 2 hits.
    2.70.150.10. 2 hits.
    3.40.1110.10. 1 hit.
    InterProiIPR006068. ATPase_P-typ_cation-transptr_C.
    IPR004014. ATPase_P-typ_cation-transptr_N.
    IPR023299. ATPase_P-typ_cyto_domN.
    IPR005775. ATPase_P-typ_Na/K_IIC.
    IPR018303. ATPase_P-typ_P_site.
    IPR023298. ATPase_P-typ_TM_dom.
    IPR008250. ATPase_P-typ_transduc_dom_A.
    IPR001757. Cation_transp_P_typ_ATPase.
    IPR023214. HAD-like_dom.
    [Graphical view]
    PfamiPF00689. Cation_ATPase_C. 1 hit.
    PF00690. Cation_ATPase_N. 1 hit.
    PF00122. E1-E2_ATPase. 1 hit.
    PF00702. Hydrolase. 1 hit.
    [Graphical view]
    PRINTSiPR00119. CATATPASE.
    SMARTiSM00831. Cation_ATPase_N. 1 hit.
    [Graphical view]
    SUPFAMiSSF56784. SSF56784. 2 hits.
    SSF81660. SSF81660. 1 hit.
    TIGRFAMsiTIGR01106. ATPase-IIC_X-K. 1 hit.
    TIGR01494. ATPase_P-type. 2 hits.
    PROSITEiPS00154. ATPASE_E1_E2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    A2VDL6-1 [UniParc]FASTAAdd to Basket

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    MGRGAGREYS PAATTAENGG GKKKQKEKEL DELKKEVAMD DHKLSLDELG     50
    RKYQVDLSKG LTNQRAQDIL ARDGPNALTP PPTTPEWVKF CRQLFGGFSI 100
    LLWIGAILCF LAFGIQAAME DEPSNDNLYL GVVLAAVVIV TGCFSYYQEA 150
    KSSKIMDSFK NMVPQQALVV REGEKMQINA EEVVVGDLVE VKGGDRVPAD 200
    LRIISSHGCK VDNSSLTGES EPQTRSPEFT HENPLETRNI CFFSTNCVEG 250
    TARGIVIATG DRTVMGRIAT LASGLEVGRT PIAMEIEHFI QLITGVAVFL 300
    GVSFFVLSLI LGYSWLEAVI FLIGIIVANV PEGLLATVTV CLTLTAKRMA 350
    RKNCLVKNLE AVETLGSTST ICSDKTGTLT QNRMTVAHMW FDNQIHEADT 400
    TEDQSGATFD KRSPTWTALS RIAGLCNRAV FKAGQENISV SKRDTAGDAS 450
    ESALLKCIEL SCGSVRKMRD RNPKVAEIPF NSTNKYQLSI HEREDSPQSH 500
    VLVMKGAPER ILDRCSSILV QGKEIPLDKE MQDAFQNAYL ELGGLGERVL 550
    GFCQLNLPSA KFPRGFKFDT DELNFPTEKL CFVGLMSMID PPRAAVPDAV 600
    GKCRSAGIKV IMVTGDHPIT AKAIAKGVGI ISEGNETVED IAARLNIPVS 650
    QVNPREAKAC VVHGSDLKDM TSEQLDEILK NHTEIVFART SPQQKLIIVE 700
    GCQRQGAIVA VTGDGVNDSP ALKKADIGIA MGIAGSDVSK QAADMILLDD 750
    NFASIVTGVE EGRLIFDNLK KSIAYTLTSN IPEITPFLLF IIANIPLPLG 800
    TVTILCIDLG TDMVPAISLA YEAAESDIMK RQPRNPQTDK LVNERLISMA 850
    YGQIGMIQAL GGFFTYFVIL AENGFLPSRL LGIRLDWDDR SMNDLEDSYG 900
    QEWTYEQRKV VEFTCHTAFF ASIVVVQWAD LIICKTRRNS VFQQGMKNKI 950
    LIFGLLEETA LAAFLSYCPG MGVALRMYPL KVTWWFCAFP YSLLIFIYDE 1000
    VRKLILRRYP GGWVEKETYY 1020
    Length:1,020
    Mass (Da):112,179
    Last modified:March 20, 2007 - v1
    Checksum:i3A8497FA4B6F7BA2
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC133297 mRNA. Translation: AAI33298.1.
    RefSeqiNP_001074993.1. NM_001081524.1.
    UniGeneiBt.61145.

    Genome annotation databases

    EnsembliENSBTAT00000049161; ENSBTAP00000046095; ENSBTAG00000010551.
    GeneIDi515161.
    KEGGibta:515161.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC133297 mRNA. Translation: AAI33298.1 .
    RefSeqi NP_001074993.1. NM_001081524.1.
    UniGenei Bt.61145.

    3D structure databases

    ProteinModelPortali A2VDL6.
    SMRi A2VDL6. Positions 25-1020.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9913.ENSBTAP00000046095.

    Proteomic databases

    PaxDbi A2VDL6.
    PRIDEi A2VDL6.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSBTAT00000049161 ; ENSBTAP00000046095 ; ENSBTAG00000010551 .
    GeneIDi 515161.
    KEGGi bta:515161.

    Organism-specific databases

    CTDi 477.

    Phylogenomic databases

    eggNOGi COG0474.
    GeneTreei ENSGT00560000076866.
    HOGENOMi HOG000265622.
    HOVERGENi HBG004298.
    InParanoidi A2VDL6.
    KOi K01539.
    OMAi IINIPLP.
    OrthoDBi EOG7327N0.
    TreeFami TF312838.

    Enzyme and pathway databases

    Reactomei REACT_203452. Ion transport by P-type ATPases.

    Miscellaneous databases

    NextBioi 20871693.

    Family and domain databases

    Gene3Di 1.20.1110.10. 2 hits.
    2.70.150.10. 2 hits.
    3.40.1110.10. 1 hit.
    InterProi IPR006068. ATPase_P-typ_cation-transptr_C.
    IPR004014. ATPase_P-typ_cation-transptr_N.
    IPR023299. ATPase_P-typ_cyto_domN.
    IPR005775. ATPase_P-typ_Na/K_IIC.
    IPR018303. ATPase_P-typ_P_site.
    IPR023298. ATPase_P-typ_TM_dom.
    IPR008250. ATPase_P-typ_transduc_dom_A.
    IPR001757. Cation_transp_P_typ_ATPase.
    IPR023214. HAD-like_dom.
    [Graphical view ]
    Pfami PF00689. Cation_ATPase_C. 1 hit.
    PF00690. Cation_ATPase_N. 1 hit.
    PF00122. E1-E2_ATPase. 1 hit.
    PF00702. Hydrolase. 1 hit.
    [Graphical view ]
    PRINTSi PR00119. CATATPASE.
    SMARTi SM00831. Cation_ATPase_N. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56784. SSF56784. 2 hits.
    SSF81660. SSF81660. 1 hit.
    TIGRFAMsi TIGR01106. ATPase-IIC_X-K. 1 hit.
    TIGR01494. ATPase_P-type. 2 hits.
    PROSITEi PS00154. ATPASE_E1_E2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. NIH - Mammalian Gene Collection (MGC) project
      Submitted (FEB-2007) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: Hereford.
      Tissue: Brain cortex.

    Entry informationi

    Entry nameiAT1A2_BOVIN
    AccessioniPrimary (citable) accession number: A2VDL6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 2, 2007
    Last sequence update: March 20, 2007
    Last modified: October 1, 2014
    This is version 58 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3