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Protein

Neutral amino acid transporter A

Gene

SLC1A4

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Transporter for alanine, serine, cysteine, and threonine. Exhibits sodium dependence.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Symport, Transport

Enzyme and pathway databases

ReactomeiR-BTA-352230. Amino acid transport across the plasma membrane.

Names & Taxonomyi

Protein namesi
Recommended name:
Neutral amino acid transporter A
Alternative name(s):
SATT
Solute carrier family 1 member 4
Gene namesi
Name:SLC1A4
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 11

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 4141CytoplasmicSequence analysisAdd
BLAST
Transmembranei42 – 6221HelicalSequence analysisAdd
BLAST
Transmembranei88 – 10821HelicalSequence analysisAdd
BLAST
Transmembranei119 – 13921HelicalSequence analysisAdd
BLAST
Topological domaini140 – 21677ExtracellularSequence analysisAdd
BLAST
Transmembranei217 – 23721HelicalSequence analysisAdd
BLAST
Transmembranei257 – 27721HelicalSequence analysisAdd
BLAST
Transmembranei298 – 31821HelicalSequence analysisAdd
BLAST
Transmembranei328 – 34821HelicalSequence analysisAdd
BLAST
Transmembranei373 – 39321HelicalSequence analysisAdd
BLAST
Transmembranei418 – 43821HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 530530Neutral amino acid transporter APRO_0000284452Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionineBy similarity
Glycosylationi201 – 2011N-linked (GlcNAc...)Sequence analysis
Modified residuei507 – 5071PhosphoserineBy similarity
Modified residuei525 – 5251PhosphoserineBy similarity
Modified residuei528 – 5281PhosphoserineBy similarity

Keywords - PTMi

Acetylation, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiA2VDL4.
PeptideAtlasiA2VDL4.

Interactioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000010206.

Structurei

3D structure databases

ProteinModelPortaliA2VDL4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3787. Eukaryota.
COG1301. LUCA.
GeneTreeiENSGT00760000119117.
HOGENOMiHOG000208776.
HOVERGENiHBG000080.
InParanoidiA2VDL4.
KOiK05615.
OMAiITYLAFP.
OrthoDBiEOG7RV9G2.
TreeFamiTF315206.

Family and domain databases

Gene3Di1.10.3860.10. 2 hits.
InterProiIPR001991. Na-dicarboxylate_symporter.
IPR018107. Na-dicarboxylate_symporter_CS.
[Graphical view]
PANTHERiPTHR11958. PTHR11958. 1 hit.
PfamiPF00375. SDF. 1 hit.
[Graphical view]
PRINTSiPR00173. EDTRNSPORT.
SUPFAMiSSF118215. SSF118215. 2 hits.
PROSITEiPS00713. NA_DICARBOXYL_SYMP_1. 1 hit.
PS00714. NA_DICARBOXYL_SYMP_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A2VDL4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEKSSETNGY LDSAQEGPAA GPGEPGTTAR RAGRCAGFLR RHGLVLLTVS
60 70 80 90 100
GVVAGAGLGA ALRGLQLNRT QVTYLAFPGE MLLRMLRMII LPLVVCSLVS
110 120 130 140 150
GAASLDASSL GRLGGIAIAY FGLTTLGASA LAVALAFIIK PGSGSQTLQS
160 170 180 190 200
SDLGLEDSGP PPVPKETVDS FLDLTRNLFP SNLVVAAFRT YATDYREVTY
210 220 230 240 250
NTSAGKVTIE KIPIGTEIEG MNILGLVLFA LVLGVALKKL GSEGEELIRF
260 270 280 290 300
FNAFNEATMV LVSWIMWYVP VGIMFLVGSK IVEMKDIIML VTSLGKYIFT
310 320 330 340 350
SILGHFIHGG IVLPLIYFVF TRKNPFRFLL GLLTPFATAF ATCSSSATLP
360 370 380 390 400
SMMKCIEENN GVDKRISRFI LPIGATVNMD GAAIFQCVAA VFIAQLNNVE
410 420 430 440 450
LRAGQIFTIL VTATASSVGA AGVPAGGVLT IAIILEAIGL PTHDLSLILA
460 470 480 490 500
VDWIVDRTTT VVNVEGDALG AGILHHLNQK AMKRGEQELS EVKVEAIPNS
510 520 530
KSEEETSPLV THPNPTGPAA STPESKESVL
Length:530
Mass (Da):56,007
Last modified:March 20, 2007 - v1
Checksum:i49D94C07C2D602F3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC133295 mRNA. Translation: AAI33296.1.
RefSeqiNP_001075046.1. NM_001081577.1.
UniGeneiBt.64772.

Genome annotation databases

EnsembliENSBTAT00000010206; ENSBTAP00000010206; ENSBTAG00000007763.
GeneIDi326577.
KEGGibta:326577.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC133295 mRNA. Translation: AAI33296.1.
RefSeqiNP_001075046.1. NM_001081577.1.
UniGeneiBt.64772.

3D structure databases

ProteinModelPortaliA2VDL4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000010206.

Proteomic databases

PaxDbiA2VDL4.
PeptideAtlasiA2VDL4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000010206; ENSBTAP00000010206; ENSBTAG00000007763.
GeneIDi326577.
KEGGibta:326577.

Organism-specific databases

CTDi6509.

Phylogenomic databases

eggNOGiKOG3787. Eukaryota.
COG1301. LUCA.
GeneTreeiENSGT00760000119117.
HOGENOMiHOG000208776.
HOVERGENiHBG000080.
InParanoidiA2VDL4.
KOiK05615.
OMAiITYLAFP.
OrthoDBiEOG7RV9G2.
TreeFamiTF315206.

Enzyme and pathway databases

ReactomeiR-BTA-352230. Amino acid transport across the plasma membrane.

Family and domain databases

Gene3Di1.10.3860.10. 2 hits.
InterProiIPR001991. Na-dicarboxylate_symporter.
IPR018107. Na-dicarboxylate_symporter_CS.
[Graphical view]
PANTHERiPTHR11958. PTHR11958. 1 hit.
PfamiPF00375. SDF. 1 hit.
[Graphical view]
PRINTSiPR00173. EDTRNSPORT.
SUPFAMiSSF118215. SSF118215. 2 hits.
PROSITEiPS00713. NA_DICARBOXYL_SYMP_1. 1 hit.
PS00714. NA_DICARBOXYL_SYMP_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. NIH - Mammalian Gene Collection (MGC) project
    Submitted (FEB-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Hereford.
    Tissue: Brain cortex.

Entry informationi

Entry nameiSATT_BOVIN
AccessioniPrimary (citable) accession number: A2VDL4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 17, 2007
Last sequence update: March 20, 2007
Last modified: July 6, 2016
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.