Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Neutral amino acid transporter A

Gene

SLC1A4

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Transporter for alanine, serine, cysteine, and threonine. Exhibits sodium dependence.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processSymport, Transport

Enzyme and pathway databases

ReactomeiR-BTA-352230 Amino acid transport across the plasma membrane

Names & Taxonomyi

Protein namesi
Recommended name:
Neutral amino acid transporter A
Alternative name(s):
SATT
Solute carrier family 1 member 4
Gene namesi
Name:SLC1A4
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 11

Organism-specific databases

VGNCiVGNC:34714 SLC1A4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 41CytoplasmicSequence analysisAdd BLAST41
Transmembranei42 – 62HelicalSequence analysisAdd BLAST21
Transmembranei88 – 108HelicalSequence analysisAdd BLAST21
Transmembranei119 – 139HelicalSequence analysisAdd BLAST21
Topological domaini140 – 216ExtracellularSequence analysisAdd BLAST77
Transmembranei217 – 237HelicalSequence analysisAdd BLAST21
Transmembranei257 – 277HelicalSequence analysisAdd BLAST21
Transmembranei298 – 318HelicalSequence analysisAdd BLAST21
Transmembranei328 – 348HelicalSequence analysisAdd BLAST21
Transmembranei373 – 393HelicalSequence analysisAdd BLAST21
Transmembranei418 – 438HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002844521 – 530Neutral amino acid transporter AAdd BLAST530

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineBy similarity1
Glycosylationi201N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei507PhosphoserineBy similarity1
Modified residuei525PhosphoserineBy similarity1
Modified residuei528PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiA2VDL4
PeptideAtlasiA2VDL4

Expressioni

Gene expression databases

BgeeiENSBTAG00000007763

Interactioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000010206

Structurei

3D structure databases

ProteinModelPortaliA2VDL4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3787 Eukaryota
COG1301 LUCA
GeneTreeiENSGT00760000119117
HOGENOMiHOG000208776
HOVERGENiHBG000080
InParanoidiA2VDL4
KOiK05615
OMAiISHIGER
OrthoDBiEOG091G0UCE
TreeFamiTF315206

Family and domain databases

InterProiView protein in InterPro
IPR001991 Na-dicarboxylate_symporter
IPR018107 Na-dicarboxylate_symporter_CS
IPR036458 Na:dicarbo_symporter_sf
PfamiView protein in Pfam
PF00375 SDF, 1 hit
SUPFAMiSSF118215 SSF118215, 2 hits
PROSITEiView protein in PROSITE
PS00713 NA_DICARBOXYL_SYMP_1, 1 hit
PS00714 NA_DICARBOXYL_SYMP_2, 1 hit

Sequencei

Sequence statusi: Complete.

A2VDL4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEKSSETNGY LDSAQEGPAA GPGEPGTTAR RAGRCAGFLR RHGLVLLTVS
60 70 80 90 100
GVVAGAGLGA ALRGLQLNRT QVTYLAFPGE MLLRMLRMII LPLVVCSLVS
110 120 130 140 150
GAASLDASSL GRLGGIAIAY FGLTTLGASA LAVALAFIIK PGSGSQTLQS
160 170 180 190 200
SDLGLEDSGP PPVPKETVDS FLDLTRNLFP SNLVVAAFRT YATDYREVTY
210 220 230 240 250
NTSAGKVTIE KIPIGTEIEG MNILGLVLFA LVLGVALKKL GSEGEELIRF
260 270 280 290 300
FNAFNEATMV LVSWIMWYVP VGIMFLVGSK IVEMKDIIML VTSLGKYIFT
310 320 330 340 350
SILGHFIHGG IVLPLIYFVF TRKNPFRFLL GLLTPFATAF ATCSSSATLP
360 370 380 390 400
SMMKCIEENN GVDKRISRFI LPIGATVNMD GAAIFQCVAA VFIAQLNNVE
410 420 430 440 450
LRAGQIFTIL VTATASSVGA AGVPAGGVLT IAIILEAIGL PTHDLSLILA
460 470 480 490 500
VDWIVDRTTT VVNVEGDALG AGILHHLNQK AMKRGEQELS EVKVEAIPNS
510 520 530
KSEEETSPLV THPNPTGPAA STPESKESVL
Length:530
Mass (Da):56,007
Last modified:March 20, 2007 - v1
Checksum:i49D94C07C2D602F3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC133295 mRNA Translation: AAI33296.1
RefSeqiNP_001075046.1, NM_001081577.1
UniGeneiBt.64772

Genome annotation databases

EnsembliENSBTAT00000010206; ENSBTAP00000010206; ENSBTAG00000007763
GeneIDi326577
KEGGibta:326577

Similar proteinsi

Entry informationi

Entry nameiSATT_BOVIN
AccessioniPrimary (citable) accession number: A2VDL4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 17, 2007
Last sequence update: March 20, 2007
Last modified: March 28, 2018
This is version 78 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Cookie policy

We would like to use anonymized google analytics cookies to gather statistics on how uniprot.org is used in aggregate. Learn more

UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health