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A2VDK6

- WASF2_BOVIN

UniProt

A2VDK6 - WASF2_BOVIN

Protein

Wiskott-Aldrich syndrome protein family member 2

Gene

WASF2

Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 49 (01 Oct 2014)
      Sequence version 1 (20 Mar 2007)
      Previous versions | rss
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    Functioni

    Downstream effector molecule involved in the transmission of signals from tyrosine kinase receptors and small GTPases to the actin cytoskeleton. Promotes formation of actin filaments. Part of the WAVE complex that regulates lamellipodia formation. The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex By similarity.By similarity

    GO - Biological processi

    1. actin cytoskeleton organization Source: Ensembl
    2. actin filament-based movement Source: Ensembl
    3. ameboidal cell migration Source: Ensembl
    4. angiogenesis Source: Ensembl
    5. endocytosis Source: Ensembl
    6. lamellipodium assembly Source: Ensembl
    7. lamellipodium morphogenesis Source: Ensembl
    8. megakaryocyte development Source: Ensembl
    9. Rac protein signal transduction Source: Ensembl

    Keywords - Ligandi

    Actin-binding

    Enzyme and pathway databases

    ReactomeiREACT_211475. Regulation of actin dynamics for phagocytic cup formation.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Wiskott-Aldrich syndrome protein family member 2
    Short name:
    WASP family protein member 2
    Gene namesi
    Name:WASF2
    OrganismiBos taurus (Bovine)
    Taxonomic identifieri9913 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
    ProteomesiUP000009136: Chromosome 2

    Subcellular locationi

    Cytoplasmcytoskeleton By similarity. Cell projectionlamellipodium By similarity
    Note: At the interface between the lamellipodial actin meshwork and the membrane.By similarity

    GO - Cellular componenti

    1. cytoskeleton Source: UniProtKB-SubCell
    2. early endosome Source: Ensembl
    3. lamellipodium Source: UniProtKB-SubCell
    4. ruffle Source: Ensembl

    Keywords - Cellular componenti

    Cell projection, Cytoplasm, Cytoskeleton

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 493493Wiskott-Aldrich syndrome protein family member 2PRO_0000284948Add
    BLAST

    Proteomic databases

    PRIDEiA2VDK6.

    Interactioni

    Subunit structurei

    Binds actin and the Arp2/3 complex. Interacts with BAIAP2. Component of the WAVE2 complex composed of ABI1, CYFIP1/SRA1, NCKAP1/NAP1 and WASF2/WAVE2. Directly interacts with BRK1 By similarity.By similarity

    Protein-protein interaction databases

    STRINGi9913.ENSBTAP00000024447.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini431 – 44818WH2PROSITE-ProRule annotationAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi266 – 2694Poly-Pro
    Compositional biasi313 – 32210Poly-Pro
    Compositional biasi327 – 3326Poly-Pro
    Compositional biasi341 – 3444Poly-Pro
    Compositional biasi358 – 3658Poly-Pro
    Compositional biasi373 – 3764Poly-Pro
    Compositional biasi385 – 40016Poly-ProAdd
    BLAST

    Domaini

    Binds and activates the Arp2/3 complex via the C-terminal domain. Interacts with actin via the WH2 domain By similarity.By similarity

    Sequence similaritiesi

    Belongs to the SCAR/WAVE family.Curated
    Contains 1 WH2 domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG299696.
    GeneTreeiENSGT00730000110593.
    HOGENOMiHOG000021456.
    HOVERGENiHBG058482.
    InParanoidiA2VDK6.
    KOiK05748.
    OMAiPPQSDSI.
    OrthoDBiEOG7VHSXK.
    TreeFamiTF315031.

    Family and domain databases

    InterProiIPR028288. SCAR/WAVE_fam.
    IPR003124. WH2_dom.
    [Graphical view]
    PANTHERiPTHR12902. PTHR12902. 1 hit.
    PfamiPF02205. WH2. 1 hit.
    [Graphical view]
    SMARTiSM00246. WH2. 1 hit.
    [Graphical view]
    PROSITEiPS51082. WH2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A2VDK6-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPLVTRNIEP RHLCRQTLPS VRSELECMTN ITLANVIRQL GSLSKYAEDI    50
    FGELFTQANT FASRVSSLAE RVDRLQVKVT QLDPKEEEVS LQGINTRKAF 100
    RSSTVQDQKL FDRNSLPIPV LETYNTCDTP PPLNNLTPYR DDGKEALKFY 150
    TDPSYFFDLW KEKMLQDTKD IMKEKRKHRK EKKDNPNRGN VNPRKIKTRK 200
    EEWEKMKMGQ EFVESKEKPS RYPPTLVYQN GSIGSVENVD AGNYPPPPQS 250
    DSISPPSPSF SEDNLPPPPA EFSYPADNNQ RAGLKRSSVV SPSHPPPAPP 300
    LGSAPGPKPG FAPPPAPPPP PPMINTPPPP PPGGFGSPAT PPPPSPPSFP 350
    PHPDFAAPPP PPPPPAVDYS TLPPPPLSQS AGGAPPPPPP PPPPGPPPPP 400
    FSGADGQLAA PPPPLSDTTK PKSSLPPVSD ARSDLLSAIR QGFQLRRVEE 450
    QREQEKRDVV GNDVATILSR RIAVEYSDSE DDSSEFDEDE WSD 493
    Length:493
    Mass (Da):54,031
    Last modified:March 20, 2007 - v1
    Checksum:i67DFD8519C2788FE
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC133284 mRNA. Translation: AAI33285.1.
    RefSeqiNP_001074980.1. NM_001081511.1.
    XP_005203144.1. XM_005203087.1.
    XP_005203145.1. XM_005203088.1.
    UniGeneiBt.38300.

    Genome annotation databases

    EnsembliENSBTAT00000024447; ENSBTAP00000024447; ENSBTAG00000018374.
    GeneIDi504482.
    KEGGibta:504482.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC133284 mRNA. Translation: AAI33285.1 .
    RefSeqi NP_001074980.1. NM_001081511.1.
    XP_005203144.1. XM_005203087.1.
    XP_005203145.1. XM_005203088.1.
    UniGenei Bt.38300.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9913.ENSBTAP00000024447.

    Proteomic databases

    PRIDEi A2VDK6.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSBTAT00000024447 ; ENSBTAP00000024447 ; ENSBTAG00000018374 .
    GeneIDi 504482.
    KEGGi bta:504482.

    Organism-specific databases

    CTDi 10163.

    Phylogenomic databases

    eggNOGi NOG299696.
    GeneTreei ENSGT00730000110593.
    HOGENOMi HOG000021456.
    HOVERGENi HBG058482.
    InParanoidi A2VDK6.
    KOi K05748.
    OMAi PPQSDSI.
    OrthoDBi EOG7VHSXK.
    TreeFami TF315031.

    Enzyme and pathway databases

    Reactomei REACT_211475. Regulation of actin dynamics for phagocytic cup formation.

    Miscellaneous databases

    NextBioi 20866684.

    Family and domain databases

    InterProi IPR028288. SCAR/WAVE_fam.
    IPR003124. WH2_dom.
    [Graphical view ]
    PANTHERi PTHR12902. PTHR12902. 1 hit.
    Pfami PF02205. WH2. 1 hit.
    [Graphical view ]
    SMARTi SM00246. WH2. 1 hit.
    [Graphical view ]
    PROSITEi PS51082. WH2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. NIH - Mammalian Gene Collection (MGC) project
      Submitted (FEB-2007) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: Hereford.
      Tissue: Fetal pons.

    Entry informationi

    Entry nameiWASF2_BOVIN
    AccessioniPrimary (citable) accession number: A2VDK6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 1, 2007
    Last sequence update: March 20, 2007
    Last modified: October 1, 2014
    This is version 49 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3