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A2VDK6

- WASF2_BOVIN

UniProt

A2VDK6 - WASF2_BOVIN

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Protein

Wiskott-Aldrich syndrome protein family member 2

Gene

WASF2

Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

Downstream effector molecule involved in the transmission of signals from tyrosine kinase receptors and small GTPases to the actin cytoskeleton. Promotes formation of actin filaments. Part of the WAVE complex that regulates lamellipodia formation. The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex (By similarity).By similarity

GO - Biological processi

  1. actin cytoskeleton organization Source: Ensembl
  2. actin filament-based movement Source: Ensembl
  3. ameboidal cell migration Source: Ensembl
  4. angiogenesis Source: Ensembl
  5. endocytosis Source: Ensembl
  6. lamellipodium assembly Source: Ensembl
  7. lamellipodium morphogenesis Source: Ensembl
  8. megakaryocyte development Source: Ensembl
  9. negative regulation of stress fiber assembly Source: Ensembl
  10. positive regulation of lamellipodium assembly Source: Ensembl
  11. Rac protein signal transduction Source: Ensembl
Complete GO annotation...

Keywords - Ligandi

Actin-binding

Enzyme and pathway databases

ReactomeiREACT_211475. Regulation of actin dynamics for phagocytic cup formation.
REACT_246299. VEGFA-VEGFR2 Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Wiskott-Aldrich syndrome protein family member 2
Short name:
WASP family protein member 2
Gene namesi
Name:WASF2
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
ProteomesiUP000009136: Chromosome 2

Subcellular locationi

Cytoplasmcytoskeleton By similarity. Cell projectionlamellipodium By similarity
Note: At the interface between the lamellipodial actin meshwork and the membrane.By similarity

GO - Cellular componenti

  1. cell-cell junction Source: Ensembl
  2. cytoskeleton Source: UniProtKB-KW
  3. early endosome Source: Ensembl
  4. extracellular vesicular exosome Source: Ensembl
  5. lamellipodium Source: Ensembl
  6. ruffle Source: Ensembl
  7. SCAR complex Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cell projection, Cytoplasm, Cytoskeleton

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 493493Wiskott-Aldrich syndrome protein family member 2PRO_0000284948Add
BLAST

Proteomic databases

PRIDEiA2VDK6.

Interactioni

Subunit structurei

Binds actin and the Arp2/3 complex. Interacts with BAIAP2. Component of the WAVE2 complex composed of ABI1, CYFIP1/SRA1, NCKAP1/NAP1 and WASF2/WAVE2. Directly interacts with BRK1 (By similarity).By similarity

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000024447.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini431 – 44818WH2PROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi266 – 2694Poly-Pro
Compositional biasi313 – 32210Poly-Pro
Compositional biasi327 – 3326Poly-Pro
Compositional biasi341 – 3444Poly-Pro
Compositional biasi358 – 3658Poly-Pro
Compositional biasi373 – 3764Poly-Pro
Compositional biasi385 – 40016Poly-ProAdd
BLAST

Domaini

Binds and activates the Arp2/3 complex via the C-terminal domain. Interacts with actin via the WH2 domain (By similarity).By similarity

Sequence similaritiesi

Belongs to the SCAR/WAVE family.Curated
Contains 1 WH2 domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiNOG299696.
GeneTreeiENSGT00730000110593.
HOGENOMiHOG000021456.
HOVERGENiHBG058482.
InParanoidiA2VDK6.
KOiK05748.
OMAiPPQSDSI.
OrthoDBiEOG7VHSXK.
TreeFamiTF315031.

Family and domain databases

InterProiIPR028288. SCAR/WAVE_fam.
IPR003124. WH2_dom.
[Graphical view]
PANTHERiPTHR12902. PTHR12902. 1 hit.
PfamiPF02205. WH2. 1 hit.
[Graphical view]
SMARTiSM00246. WH2. 1 hit.
[Graphical view]
PROSITEiPS51082. WH2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A2VDK6-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MPLVTRNIEP RHLCRQTLPS VRSELECMTN ITLANVIRQL GSLSKYAEDI
60 70 80 90 100
FGELFTQANT FASRVSSLAE RVDRLQVKVT QLDPKEEEVS LQGINTRKAF
110 120 130 140 150
RSSTVQDQKL FDRNSLPIPV LETYNTCDTP PPLNNLTPYR DDGKEALKFY
160 170 180 190 200
TDPSYFFDLW KEKMLQDTKD IMKEKRKHRK EKKDNPNRGN VNPRKIKTRK
210 220 230 240 250
EEWEKMKMGQ EFVESKEKPS RYPPTLVYQN GSIGSVENVD AGNYPPPPQS
260 270 280 290 300
DSISPPSPSF SEDNLPPPPA EFSYPADNNQ RAGLKRSSVV SPSHPPPAPP
310 320 330 340 350
LGSAPGPKPG FAPPPAPPPP PPMINTPPPP PPGGFGSPAT PPPPSPPSFP
360 370 380 390 400
PHPDFAAPPP PPPPPAVDYS TLPPPPLSQS AGGAPPPPPP PPPPGPPPPP
410 420 430 440 450
FSGADGQLAA PPPPLSDTTK PKSSLPPVSD ARSDLLSAIR QGFQLRRVEE
460 470 480 490
QREQEKRDVV GNDVATILSR RIAVEYSDSE DDSSEFDEDE WSD
Length:493
Mass (Da):54,031
Last modified:March 20, 2007 - v1
Checksum:i67DFD8519C2788FE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC133284 mRNA. Translation: AAI33285.1.
RefSeqiNP_001074980.1. NM_001081511.1.
XP_005203144.1. XM_005203087.1.
XP_005203145.1. XM_005203088.1.
UniGeneiBt.38300.

Genome annotation databases

EnsembliENSBTAT00000024447; ENSBTAP00000024447; ENSBTAG00000018374.
GeneIDi504482.
KEGGibta:504482.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC133284 mRNA. Translation: AAI33285.1 .
RefSeqi NP_001074980.1. NM_001081511.1.
XP_005203144.1. XM_005203087.1.
XP_005203145.1. XM_005203088.1.
UniGenei Bt.38300.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9913.ENSBTAP00000024447.

Proteomic databases

PRIDEi A2VDK6.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSBTAT00000024447 ; ENSBTAP00000024447 ; ENSBTAG00000018374 .
GeneIDi 504482.
KEGGi bta:504482.

Organism-specific databases

CTDi 10163.

Phylogenomic databases

eggNOGi NOG299696.
GeneTreei ENSGT00730000110593.
HOGENOMi HOG000021456.
HOVERGENi HBG058482.
InParanoidi A2VDK6.
KOi K05748.
OMAi PPQSDSI.
OrthoDBi EOG7VHSXK.
TreeFami TF315031.

Enzyme and pathway databases

Reactomei REACT_211475. Regulation of actin dynamics for phagocytic cup formation.
REACT_246299. VEGFA-VEGFR2 Pathway.

Miscellaneous databases

NextBioi 20866684.

Family and domain databases

InterProi IPR028288. SCAR/WAVE_fam.
IPR003124. WH2_dom.
[Graphical view ]
PANTHERi PTHR12902. PTHR12902. 1 hit.
Pfami PF02205. WH2. 1 hit.
[Graphical view ]
SMARTi SM00246. WH2. 1 hit.
[Graphical view ]
PROSITEi PS51082. WH2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. NIH - Mammalian Gene Collection (MGC) project
    Submitted (FEB-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Hereford.
    Tissue: Fetal pons.

Entry informationi

Entry nameiWASF2_BOVIN
AccessioniPrimary (citable) accession number: A2VDK6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 1, 2007
Last sequence update: March 20, 2007
Last modified: November 26, 2014
This is version 51 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3