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A2VDK6 (WASF2_BOVIN) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 47. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Wiskott-Aldrich syndrome protein family member 2

Short name=WASP family protein member 2
Gene names
Name:WASF2
OrganismBos taurus (Bovine) [Reference proteome]
Taxonomic identifier9913 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos

Protein attributes

Sequence length493 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Downstream effector molecule involved in the transmission of signals from tyrosine kinase receptors and small GTPases to the actin cytoskeleton. Promotes formation of actin filaments. Part of the WAVE complex that regulates lamellipodia formation. The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex By similarity.

Subunit structure

Binds actin and the Arp2/3 complex. Interacts with BAIAP2. Component of the WAVE2 complex composed of ABI1, CYFIP1/SRA1, NCKAP1/NAP1 and WASF2/WAVE2. Directly interacts with BRK1 By similarity.

Subcellular location

Cytoplasmcytoskeleton By similarity. Cell projectionlamellipodium By similarity. Note: At the interface between the lamellipodial actin meshwork and the membrane By similarity.

Domain

Binds and activates the Arp2/3 complex via the C-terminal domain. Interacts with actin via the WH2 domain By similarity.

Sequence similarities

Belongs to the SCAR/WAVE family.

Contains 1 WH2 domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 493493Wiskott-Aldrich syndrome protein family member 2
PRO_0000284948

Regions

Domain431 – 44818WH2
Compositional bias266 – 2694Poly-Pro
Compositional bias313 – 32210Poly-Pro
Compositional bias327 – 3326Poly-Pro
Compositional bias341 – 3444Poly-Pro
Compositional bias358 – 3658Poly-Pro
Compositional bias373 – 3764Poly-Pro
Compositional bias385 – 40016Poly-Pro

Sequences

Sequence LengthMass (Da)Tools
A2VDK6 [UniParc].

Last modified March 20, 2007. Version 1.
Checksum: 67DFD8519C2788FE

FASTA49354,031
        10         20         30         40         50         60 
MPLVTRNIEP RHLCRQTLPS VRSELECMTN ITLANVIRQL GSLSKYAEDI FGELFTQANT 

        70         80         90        100        110        120 
FASRVSSLAE RVDRLQVKVT QLDPKEEEVS LQGINTRKAF RSSTVQDQKL FDRNSLPIPV 

       130        140        150        160        170        180 
LETYNTCDTP PPLNNLTPYR DDGKEALKFY TDPSYFFDLW KEKMLQDTKD IMKEKRKHRK 

       190        200        210        220        230        240 
EKKDNPNRGN VNPRKIKTRK EEWEKMKMGQ EFVESKEKPS RYPPTLVYQN GSIGSVENVD 

       250        260        270        280        290        300 
AGNYPPPPQS DSISPPSPSF SEDNLPPPPA EFSYPADNNQ RAGLKRSSVV SPSHPPPAPP 

       310        320        330        340        350        360 
LGSAPGPKPG FAPPPAPPPP PPMINTPPPP PPGGFGSPAT PPPPSPPSFP PHPDFAAPPP 

       370        380        390        400        410        420 
PPPPPAVDYS TLPPPPLSQS AGGAPPPPPP PPPPGPPPPP FSGADGQLAA PPPPLSDTTK 

       430        440        450        460        470        480 
PKSSLPPVSD ARSDLLSAIR QGFQLRRVEE QREQEKRDVV GNDVATILSR RIAVEYSDSE 

       490 
DDSSEFDEDE WSD 

« Hide

References

[1]NIH - Mammalian Gene Collection (MGC) project
Submitted (FEB-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: Hereford.
Tissue: Fetal pons.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BC133284 mRNA. Translation: AAI33285.1.
RefSeqNP_001074980.1. NM_001081511.1.
XP_005203144.1. XM_005203087.1.
XP_005203145.1. XM_005203088.1.
UniGeneBt.38300.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9913.ENSBTAP00000024447.

Proteomic databases

PRIDEA2VDK6.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSBTAT00000024447; ENSBTAP00000024447; ENSBTAG00000018374.
GeneID504482.
KEGGbta:504482.

Organism-specific databases

CTD10163.

Phylogenomic databases

eggNOGNOG299696.
GeneTreeENSGT00730000110593.
HOGENOMHOG000021456.
HOVERGENHBG058482.
InParanoidA2VDK6.
KOK05748.
OMAPPQSDSI.
OrthoDBEOG7VHSXK.
TreeFamTF315031.

Family and domain databases

InterProIPR028288. SCAR/WAVE_fam.
IPR003124. WH2_dom.
[Graphical view]
PANTHERPTHR12902. PTHR12902. 1 hit.
PfamPF02205. WH2. 1 hit.
[Graphical view]
SMARTSM00246. WH2. 1 hit.
[Graphical view]
PROSITEPS51082. WH2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio20866684.

Entry information

Entry nameWASF2_BOVIN
AccessionPrimary (citable) accession number: A2VDK6
Entry history
Integrated into UniProtKB/Swiss-Prot: May 1, 2007
Last sequence update: March 20, 2007
Last modified: February 19, 2014
This is version 47 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families