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Protein

Transmembrane protein 131-like

Gene

KIAA0922

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Isoform 1: Membrane-associated form that antagonizes canonical Wnt signaling by triggering lysosome-dependent degradation of Wnt-activated LRP6. Regulates thymocyte proliferation.1 Publication

GO - Biological processi

  • negative regulation of canonical Wnt signaling pathway Source: UniProtKB
  • negative regulation of immature T cell proliferation in thymus Source: UniProtKB
  • Wnt signaling pathway Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Wnt signaling pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Transmembrane protein 131-like
Gene namesi
Name:KIAA0922
Synonyms:TMEM131L
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

HGNCiHGNC:29146. KIAA0922.

Subcellular locationi

Isoform 1 :
Isoform 5 :

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini41 – 869ExtracellularSequence analysisAdd BLAST829
Transmembranei870 – 890HelicalSequence analysisAdd BLAST21
Topological domaini891 – 1609CytoplasmicSequence analysisAdd BLAST719

GO - Cellular componenti

  • cytoplasm Source: UniProtKB
  • endoplasmic reticulum Source: UniProtKB-SubCell
  • integral component of membrane Source: UniProtKB-KW
  • plasma membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Endoplasmic reticulum, Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000121210.
PharmGKBiPA128394615.

Polymorphism and mutation databases

BioMutaiKIAA0922.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 40Sequence analysisAdd BLAST40
ChainiPRO_000032886541 – 1609Transmembrane protein 131-likeAdd BLAST1569

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi343N-linked (GlcNAc...)Sequence analysis1
Glycosylationi439N-linked (GlcNAc...)Sequence analysis1
Glycosylationi522N-linked (GlcNAc...)Sequence analysis1
Glycosylationi593N-linked (GlcNAc...)Sequence analysis1
Glycosylationi709N-linked (GlcNAc...)Sequence analysis1
Glycosylationi846N-linked (GlcNAc...)Sequence analysis1
Modified residuei1122PhosphoserineCombined sources1

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiA2VDJ0.
PaxDbiA2VDJ0.
PRIDEiA2VDJ0.

PTM databases

iPTMnetiA2VDJ0.
PhosphoSitePlusiA2VDJ0.
SwissPalmiA2VDJ0.

Expressioni

Tissue specificityi

Expressed in thymocytes.1 Publication

Developmental stagei

During intrathymic development, transcript levels strongly increase from pro-DN1 thymocytes to DN3a cells, in which they peak, and drop immediately after beta-selection in their DN3b successors. The subcellular location of the protein also varies, from punctate cytoplasmic structures in DN1 and DN2 cells to large crescent-shaped membrane structures in DN3 cells, which preferentially localize in cell-to-cell contact zones.1 Publication

Gene expression databases

BgeeiENSG00000121210.
CleanExiHS_KIAA0922.
ExpressionAtlasiA2VDJ0. baseline and differential.
GenevisibleiA2VDJ0. HS.

Organism-specific databases

HPAiHPA043472.
HPA048443.

Interactioni

Protein-protein interaction databases

BioGridi116844. 11 interactors.
IntActiA2VDJ0. 1 interactor.
STRINGi9606.ENSP00000386787.

Structurei

3D structure databases

ProteinModelPortaliA2VDJ0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni696 – 916Required for Wnt-signaling inhibition and LRP6 degradation1 PublicationAdd BLAST221

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi910 – 913Poly-Ser4
Compositional biasi1302 – 1331Ser-richAdd BLAST30

Sequence similaritiesi

Belongs to the TMEM131 family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3620. Eukaryota.
ENOG410Z7NH. LUCA.
GeneTreeiENSGT00530000063614.
HOVERGENiHBG108533.
InParanoidiA2VDJ0.
OMAiKTSFRII.
OrthoDBiEOG091G0HKE.
PhylomeDBiA2VDJ0.
TreeFamiTF321435.

Family and domain databases

InterProiIPR022113. TMEM131-like.
[Graphical view]
PfamiPF12371. TMEM131_like. 1 hit.
[Graphical view]

Sequences (5)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 5 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: A2VDJ0-1) [UniParc]FASTAAdd to basket
Also known as: L1 Publication

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAGLRRPQPG CYCRTAAAVN LLLGVFQVLL PCCRPGGAQG QAIEPLPNVV
60 70 80 90 100
ELWQAEEGEL LLPTQGDSEE GLEEPSQEQS FSDKLFSGKG LHFQPSVLDF
110 120 130 140 150
GIQFLGHPVA KILHAYNPSR DSEVVVNSVF AAAGHFHVPP VPCRVIPAMG
160 170 180 190 200
KTSFRIIFLP TEEGSIESSL FINTSSYGVL SYHVSGIGTR RISTEGSAKQ
210 220 230 240 250
LPNAYFLLPK VQSIQLSQMQ AETTNTSLLQ VQLECSLHNK VCQQLKGCYL
260 270 280 290 300
ESDDVLRLQM SIMVTMENFS KEFEENTQHL LDHLSIVYVA TDESETSDDS
310 320 330 340 350
AVNMYILHSG NSLIWIQDIR HFSQRDALSL QFEPVLLPTS TTNFTKIASF
360 370 380 390 400
TCKATSCDSG IIEDVKKTTH TPTLKACLFS SVAQGYFRMD SSATQFHIET
410 420 430 440 450
HENTSGLWSI WYRNHFDRSV VLNDVFLSKE TKHMLKILNF TGPLFLPPGC
460 470 480 490 500
WNIFSLKLAV KDIAINLFTN VFLTTNIGAI FAIPLQIYSA PTKEGSLGFE
510 520 530 540 550
VIAHCGMHYF MGKSKAGNPN WNGSLSLDQS TWNVDSELAN KLYERWKKYK
560 570 580 590 600
NGDVCKRNVL GTTRFAHLKK SKESESFVFF LPRLIAEPGL MLNFSATALR
610 620 630 640 650
SRMIKYFVVQ NPSSWPVSLQ LLPLSLYPKP EALVHLLHRW FGTDMQMINF
660 670 680 690 700
TTGEFQLTEA CPYLGTHSEE SRFGILHLHL QPLEMKRVGV VFTPADYGKV
710 720 730 740 750
TSLILIRNNL TVIDMIGVEG FGARELLKVG GRLPGAGGSL RFKVPESTLM
760 770 780 790 800
DCRRQLKDSK QILSITKNFK VENIGPLPIT VSSLKINGYN CQGYGFEVLD
810 820 830 840 850
CHQFSLDPNT SRDISIVFTP DFTSSWVIRD LSLVTAADLE FRFTLNVTLP
860 870 880 890 900
HHLLPLCADV VPGPSWEESF WRLTVFFVSL SLLGVILIAF QQAQYILMEF
910 920 930 940 950
MKTRQRQNAS SSSQQNNGPM DVISPHSYKS NCKNFLDTYG PSDKGRGKNC
960 970 980 990 1000
LPVNTPQSRI QNAAKRSPAT YGHSQKKHKC SVYYSKHKTS TAAASSTSTT
1010 1020 1030 1040 1050
TEEKQTSPLG SSLPAAKEDI CTDAMRENWI SLRYASGINV NLQKNLTLPK
1060 1070 1080 1090 1100
NLLNKEENTL KNTIVFSNPS SECSMKEGIQ TCMFPKETDI KTSENTAEFK
1110 1120 1130 1140 1150
ERELCPLKTS KKLPENHLPR NSPQYHQPDL PEISRKNNGN NQQVPVKNEV
1160 1170 1180 1190 1200
DHCENLKKVD TKPSSEKKIH KTSREDMFSE KQDIPFVEQE DPYRKKKLQE
1210 1220 1230 1240 1250
KREGNLQNLN WSKSRTCRKN KKRGVAPVSR PPEQSDLKLV CSDFERSELS
1260 1270 1280 1290 1300
SDINVRSWCI QESTREVCKA DAEIASSLPA AQREAEGYYQ KPEKKCVDKF
1310 1320 1330 1340 1350
CSDSSSDCGS SSGSVRASRG SWGSWSSTSS SDGDKKPMVD AQHFLPAGDS
1360 1370 1380 1390 1400
VSQNDFPSEA PISLNLSHNI CNPMTVNSLP QYAEPSCPSL PAGPTGVEED
1410 1420 1430 1440 1450
KGLYSPGDLW PTPPVCVTSS LNCTLENGVP CVIQESAPVH NSFIDWSATC
1460 1470 1480 1490 1500
EGQFSSAYCP LELNDYNAFP EENMNYANGF PCPADVQTDF IDHNSQSTWN
1510 1520 1530 1540 1550
TPPNMPAAWG HASFISSPPY LTSTRSLSPM SGLFGSIWAP QSDVYENCCP
1560 1570 1580 1590 1600
INPTTEHSTH MENQAVVCKE YYPGFNPFRA YMNLDIWTTT ANRNANFPLS

RDSSYCGNV
Length:1,609
Mass (Da):179,339
Last modified:April 8, 2008 - v2
Checksum:i7F9D2EC0BC959210
GO
Isoform 2 (identifier: A2VDJ0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-370: Missing.
     371-380: TPTLKACLFS → MLLVLECVLF

Note: No experimental confirmation available.
Show »
Length:1,239
Mass (Da):138,688
Checksum:iCB9238E5A0D84146
GO
Isoform 3 (identifier: A2VDJ0-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     353-353: K → KA
     557-640: Missing.

Note: No experimental confirmation available.
Show »
Length:1,526
Mass (Da):169,707
Checksum:i31C5F68FD8A4EBA5
GO
Isoform 4 (identifier: A2VDJ0-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     353-353: K → KA

Note: No experimental confirmation available.
Show »
Length:1,610
Mass (Da):179,410
Checksum:i5D46F0BE83EB56CE
GO
Isoform 5 (identifier: A2VDJ0-6) [UniParc]FASTAAdd to basket
Also known as: S1 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     1-148: Missing.
     353-353: K → KA

Note: No experimental confirmation available.
Show »
Length:1,462
Mass (Da):163,518
Checksum:iA83EFE7797FC2590
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti171F → S in BAG52515 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_042551604I → V.Corresponds to variant rs7669418dbSNPEnsembl.1
Natural variantiVAR_042552645M → T.1 PublicationCorresponds to variant rs17370297dbSNPEnsembl.1
Natural variantiVAR_0425531110S → Y.Corresponds to variant rs755078dbSNPEnsembl.1
Natural variantiVAR_0425541254N → S.Corresponds to variant rs35018723dbSNPEnsembl.1
Natural variantiVAR_0425551392A → P.Corresponds to variant rs35543386dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0328261 – 370Missing in isoform 2. 1 PublicationAdd BLAST370
Alternative sequenceiVSP_0576331 – 148Missing in isoform 5. Add BLAST148
Alternative sequenceiVSP_032827353K → KA in isoform 3, isoform 4 and isoform 5. 3 Publications1
Alternative sequenceiVSP_032828371 – 380TPTLKACLFS → MLLVLECVLF in isoform 2. 1 Publication10
Alternative sequenceiVSP_032829557 – 640Missing in isoform 3. 1 PublicationAdd BLAST84

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL136932 mRNA. Translation: CAB66866.1.
AC106865 Genomic DNA. No translation available.
AC116648 Genomic DNA. No translation available.
CH471056 Genomic DNA. Translation: EAX04957.1.
CH471056 Genomic DNA. Translation: EAX04958.1.
AK092270 mRNA. Translation: BAG52515.1.
BC044932 mRNA. Translation: AAH44932.1.
BC131505 mRNA. Translation: AAI31506.1.
AB023139 mRNA. Translation: BAA76766.1.
CCDSiCCDS3783.2. [A2VDJ0-1]
CCDS47148.1. [A2VDJ0-5]
RefSeqiNP_001124479.1. NM_001131007.1. [A2VDJ0-5]
NP_056011.3. NM_015196.3. [A2VDJ0-1]
UniGeneiHs.732450.

Genome annotation databases

EnsembliENST00000409663; ENSP00000386574; ENSG00000121210. [A2VDJ0-1]
ENST00000409959; ENSP00000386787; ENSG00000121210. [A2VDJ0-5]
GeneIDi23240.
KEGGihsa:23240.
UCSCiuc003inm.5. human. [A2VDJ0-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL136932 mRNA. Translation: CAB66866.1.
AC106865 Genomic DNA. No translation available.
AC116648 Genomic DNA. No translation available.
CH471056 Genomic DNA. Translation: EAX04957.1.
CH471056 Genomic DNA. Translation: EAX04958.1.
AK092270 mRNA. Translation: BAG52515.1.
BC044932 mRNA. Translation: AAH44932.1.
BC131505 mRNA. Translation: AAI31506.1.
AB023139 mRNA. Translation: BAA76766.1.
CCDSiCCDS3783.2. [A2VDJ0-1]
CCDS47148.1. [A2VDJ0-5]
RefSeqiNP_001124479.1. NM_001131007.1. [A2VDJ0-5]
NP_056011.3. NM_015196.3. [A2VDJ0-1]
UniGeneiHs.732450.

3D structure databases

ProteinModelPortaliA2VDJ0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116844. 11 interactors.
IntActiA2VDJ0. 1 interactor.
STRINGi9606.ENSP00000386787.

PTM databases

iPTMnetiA2VDJ0.
PhosphoSitePlusiA2VDJ0.
SwissPalmiA2VDJ0.

Polymorphism and mutation databases

BioMutaiKIAA0922.

Proteomic databases

MaxQBiA2VDJ0.
PaxDbiA2VDJ0.
PRIDEiA2VDJ0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000409663; ENSP00000386574; ENSG00000121210. [A2VDJ0-1]
ENST00000409959; ENSP00000386787; ENSG00000121210. [A2VDJ0-5]
GeneIDi23240.
KEGGihsa:23240.
UCSCiuc003inm.5. human. [A2VDJ0-1]

Organism-specific databases

CTDi23240.
GeneCardsiKIAA0922.
H-InvDBHIX0004579.
HGNCiHGNC:29146. KIAA0922.
HPAiHPA043472.
HPA048443.
MIMi616243. gene.
neXtProtiNX_A2VDJ0.
OpenTargetsiENSG00000121210.
PharmGKBiPA128394615.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3620. Eukaryota.
ENOG410Z7NH. LUCA.
GeneTreeiENSGT00530000063614.
HOVERGENiHBG108533.
InParanoidiA2VDJ0.
OMAiKTSFRII.
OrthoDBiEOG091G0HKE.
PhylomeDBiA2VDJ0.
TreeFamiTF321435.

Miscellaneous databases

ChiTaRSiKIAA0922. human.
GeneWikiiKIAA0922.
GenomeRNAii23240.
PROiA2VDJ0.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000121210.
CleanExiHS_KIAA0922.
ExpressionAtlasiA2VDJ0. baseline and differential.
GenevisibleiA2VDJ0. HS.

Family and domain databases

InterProiIPR022113. TMEM131-like.
[Graphical view]
PfamiPF12371. TMEM131_like. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiT131L_HUMAN
AccessioniPrimary (citable) accession number: A2VDJ0
Secondary accession number(s): B3KRV3
, D3DP10, Q7LGA7, Q86Y92, Q8WU56, Q9H065, Q9Y2D7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: April 8, 2008
Last modified: November 30, 2016
This is version 81 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.