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A2VDF0

- FUCM_HUMAN

UniProt

A2VDF0 - FUCM_HUMAN

Protein

Fucose mutarotase

Gene

FUOM

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Involved in the interconversion between alpha- and beta-L-fucoses. L-Fucose (6-deoxy-L-galactose) exists as alpha-L-fucose (29.5%) and beta-L-fucose (70.5%), the beta-form is metabolized through the salvage pathway. GDP-L-fucose formed either by the de novo or salvage pathways is transported into the endoplasmic reticulum, where it serves as a substrate for N- and O-glycosylations by fucosyltransferases. Fucosylated structures expressed on cell surfaces or secreted in biological fluids are believed to play a critical role in cell-cell adhesion and recognition processes.1 Publication

    Catalytic activityi

    Alpha-L-fucose = beta-L-fucose.1 Publication

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei24 – 241Proton donorBy similarity
    Binding sitei32 – 321SubstrateBy similarity
    Active sitei69 – 691By similarity
    Binding sitei79 – 791SubstrateBy similarity
    Active sitei120 – 1201By similarity
    Binding sitei120 – 1201SubstrateBy similarity
    Binding sitei138 – 1381SubstrateBy similarity
    Binding sitei140 – 1401SubstrateBy similarity

    GO - Molecular functioni

    1. fucose binding Source: UniProtKB
    2. racemase and epimerase activity, acting on carbohydrates and derivatives Source: UniProtKB

    GO - Biological processi

    1. fucose metabolic process Source: UniProtKB

    Keywords - Molecular functioni

    Isomerase

    Enzyme and pathway databases

    BioCyciRETL1328306-WGS:GSTH-6705-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Fucose mutarotase (EC:5.1.3.29)
    Gene namesi
    Name:FUOM
    Synonyms:C10orf125
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 10

    Organism-specific databases

    HGNCiHGNC:24733. FUOM.

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134972390.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 154154Fucose mutarotasePRO_0000286553Add
    BLAST

    Proteomic databases

    MaxQBiA2VDF0.
    PaxDbiA2VDF0.
    PRIDEiA2VDF0.

    PTM databases

    PhosphoSiteiA2VDF0.

    Expressioni

    Gene expression databases

    BgeeiA2VDF0.
    CleanExiHS_C10orf125.
    GenevestigatoriA2VDF0.

    Organism-specific databases

    HPAiHPA039207.

    Interactioni

    Subunit structurei

    Mainly homodimer, but exists also as homotetramer, homooctamer, and homodecamer. The homodimeric form seems catalytically inactive By similarity.By similarity

    Protein-protein interaction databases

    IntActiA2VDF0. 1 interaction.
    STRINGi9606.ENSP00000357540.

    Structurei

    3D structure databases

    ProteinModelPortaliA2VDF0.
    SMRiA2VDF0. Positions 1-148.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the RbsD / FucU family.Curated

    Phylogenomic databases

    eggNOGiCOG4154.
    HOVERGENiHBG107698.
    InParanoidiA2VDF0.
    KOiK02431.
    OMAiCAVICRR.
    OrthoDBiEOG7K0ZDZ.
    PhylomeDBiA2VDF0.
    TreeFamiTF324689.

    Family and domain databases

    Gene3Di3.40.1650.10. 1 hit.
    InterProiIPR023750. RbsD-like.
    IPR007721. RbsD_FucU.
    [Graphical view]
    PfamiPF05025. RbsD_FucU. 1 hit.
    [Graphical view]
    SUPFAMiSSF102546. SSF102546. 1 hit.

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: A2VDF0-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MVALKGVPAL LSPELLYALA RMGHGDEIVL ADLNFPASSI CQCGPMEIRA    50
    DGLGIPQLLE AVLKLLPLDT YVESPAAVME LVPSDKERGL QTPVWTEYES 100
    ILRRAGCVRA LAKIERFEFY ERAKKAFAVV ATGETALYGN LILRKGVLAL 150
    NPLL 154
    Length:154
    Mass (Da):16,765
    Last modified:May 15, 2007 - v2
    Checksum:i96F76613566F4A6E
    GO
    Isoform 2 (identifier: A2VDF0-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         134-134: E → C
         135-154: Missing.

    Show »
    Length:134
    Mass (Da):14,604
    Checksum:iFAC93FCEE630E7CC
    GO

    Sequence cautioni

    The sequence CAH70284.1 differs from that shown. Reason: Erroneous gene model prediction.
    The sequence CAH70285.1 differs from that shown. Reason: Erroneous gene model prediction.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti81 – 811L → P in BAC85178. (PubMed:14702039)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei134 – 1341E → C in isoform 2. 2 PublicationsVSP_025080
    Alternative sequencei135 – 15420Missing in isoform 2. 2 PublicationsVSP_025081Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK129527 mRNA. Translation: BAC85178.1.
    AL360181 Genomic DNA. Translation: CAH70284.1. Sequence problems.
    AL360181 Genomic DNA. Translation: CAH70285.1. Sequence problems.
    BC129818 mRNA. Translation: AAI29819.1.
    BC129819 mRNA. Translation: AAI29820.1.
    AI333356 mRNA. No translation available.
    CCDSiCCDS44499.1. [A2VDF0-1]
    CCDS7680.1. [A2VDF0-2]
    RefSeqiNP_001091953.1. NM_001098483.1. [A2VDF0-1]
    NP_940874.2. NM_198472.2. [A2VDF0-2]
    UniGeneiHs.155823.

    Genome annotation databases

    EnsembliENST00000278025; ENSP00000278025; ENSG00000148803. [A2VDF0-2]
    ENST00000368552; ENSP00000357540; ENSG00000148803. [A2VDF0-1]
    GeneIDi282969.
    KEGGihsa:282969.
    UCSCiuc001lms.2. human. [A2VDF0-2]
    uc001lmt.2. human. [A2VDF0-1]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK129527 mRNA. Translation: BAC85178.1 .
    AL360181 Genomic DNA. Translation: CAH70284.1 . Sequence problems.
    AL360181 Genomic DNA. Translation: CAH70285.1 . Sequence problems.
    BC129818 mRNA. Translation: AAI29819.1 .
    BC129819 mRNA. Translation: AAI29820.1 .
    AI333356 mRNA. No translation available.
    CCDSi CCDS44499.1. [A2VDF0-1 ]
    CCDS7680.1. [A2VDF0-2 ]
    RefSeqi NP_001091953.1. NM_001098483.1. [A2VDF0-1 ]
    NP_940874.2. NM_198472.2. [A2VDF0-2 ]
    UniGenei Hs.155823.

    3D structure databases

    ProteinModelPortali A2VDF0.
    SMRi A2VDF0. Positions 1-148.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi A2VDF0. 1 interaction.
    STRINGi 9606.ENSP00000357540.

    PTM databases

    PhosphoSitei A2VDF0.

    Proteomic databases

    MaxQBi A2VDF0.
    PaxDbi A2VDF0.
    PRIDEi A2VDF0.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000278025 ; ENSP00000278025 ; ENSG00000148803 . [A2VDF0-2 ]
    ENST00000368552 ; ENSP00000357540 ; ENSG00000148803 . [A2VDF0-1 ]
    GeneIDi 282969.
    KEGGi hsa:282969.
    UCSCi uc001lms.2. human. [A2VDF0-2 ]
    uc001lmt.2. human. [A2VDF0-1 ]

    Organism-specific databases

    CTDi 282969.
    GeneCardsi GC10M135169.
    HGNCi HGNC:24733. FUOM.
    HPAi HPA039207.
    neXtProti NX_A2VDF0.
    PharmGKBi PA134972390.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG4154.
    HOVERGENi HBG107698.
    InParanoidi A2VDF0.
    KOi K02431.
    OMAi CAVICRR.
    OrthoDBi EOG7K0ZDZ.
    PhylomeDBi A2VDF0.
    TreeFami TF324689.

    Enzyme and pathway databases

    BioCyci RETL1328306-WGS:GSTH-6705-MONOMER.

    Miscellaneous databases

    GenomeRNAii 282969.
    NextBioi 93539.
    PROi A2VDF0.

    Gene expression databases

    Bgeei A2VDF0.
    CleanExi HS_C10orf125.
    Genevestigatori A2VDF0.

    Family and domain databases

    Gene3Di 3.40.1650.10. 1 hit.
    InterProi IPR023750. RbsD-like.
    IPR007721. RbsD_FucU.
    [Graphical view ]
    Pfami PF05025. RbsD_FucU. 1 hit.
    [Graphical view ]
    SUPFAMi SSF102546. SSF102546. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Macrophage.
    2. "The DNA sequence and comparative analysis of human chromosome 10."
      Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J.
      , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.
      Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-140 (ISOFORM 1).
    4. The Cancer Genome Anatomy Project (CGAP) at the National Cancer Institute
      Submitted (FEB-1998) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 95-154 (ISOFORM 1).
    5. "Characterization and role of fucose mutarotase in mammalian cells."
      Park D., Ryu K.S., Choi D., Kwak J., Park C.
      Glycobiology 17:955-962(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, CATALYTIC ACTIVITY.

    Entry informationi

    Entry nameiFUCM_HUMAN
    AccessioniPrimary (citable) accession number: A2VDF0
    Secondary accession number(s): A1L300
    , Q5VWY2, Q5VWY3, Q6ZPD2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 15, 2007
    Last sequence update: May 15, 2007
    Last modified: October 1, 2014
    This is version 64 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 10
      Human chromosome 10: entries, gene names and cross-references to MIM
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3