Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Fucose mutarotase

Gene

FUOM

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Involved in the interconversion between alpha- and beta-L-fucoses. L-Fucose (6-deoxy-L-galactose) exists as alpha-L-fucose (29.5%) and beta-L-fucose (70.5%), the beta-form is metabolized through the salvage pathway. GDP-L-fucose formed either by the de novo or salvage pathways is transported into the endoplasmic reticulum, where it serves as a substrate for N- and O-glycosylations by fucosyltransferases. Fucosylated structures expressed on cell surfaces or secreted in biological fluids are believed to play a critical role in cell-cell adhesion and recognition processes.1 Publication

Catalytic activityi

Alpha-L-fucose = beta-L-fucose.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei24Proton donorBy similarity1
Binding sitei32SubstrateBy similarity1
Active sitei69By similarity1
Binding sitei79SubstrateBy similarity1
Active sitei120By similarity1
Binding sitei120SubstrateBy similarity1
Binding sitei138SubstrateBy similarity1
Binding sitei140SubstrateBy similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Enzyme and pathway databases

BRENDAi5.1.3.29. 2681.
ReactomeiR-HSA-6787639. GDP-fucose biosynthesis.

Names & Taxonomyi

Protein namesi
Recommended name:
Fucose mutarotase (EC:5.1.3.29)
Gene namesi
Name:FUOM
Synonyms:C10orf125
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

HGNCiHGNC:24733. FUOM.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000148803.
PharmGKBiPA134972390.

Polymorphism and mutation databases

BioMutaiFUOM.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002865531 – 154Fucose mutarotaseAdd BLAST154

Proteomic databases

MaxQBiA2VDF0.
PaxDbiA2VDF0.
PRIDEiA2VDF0.

PTM databases

iPTMnetiA2VDF0.
PhosphoSitePlusiA2VDF0.

Expressioni

Gene expression databases

BgeeiENSG00000148803.
CleanExiHS_C10orf125.
ExpressionAtlasiA2VDF0. baseline and differential.
GenevisibleiA2VDF0. HS.

Organism-specific databases

HPAiHPA039207.

Interactioni

Subunit structurei

Mainly homodimer, but exists also as homotetramer, homooctamer, and homodecamer. The homodimeric form seems catalytically inactive (By similarity).By similarity

Protein-protein interaction databases

BioGridi129427. 15 interactors.
IntActiA2VDF0. 1 interactor.
STRINGi9606.ENSP00000357540.

Structurei

3D structure databases

ProteinModelPortaliA2VDF0.
SMRiA2VDF0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the RbsD / FucU family.Curated

Phylogenomic databases

eggNOGiENOG410IXHP. Eukaryota.
COG4154. LUCA.
GeneTreeiENSGT00390000001197.
HOVERGENiHBG107698.
InParanoidiA2VDF0.
KOiK02431.
OMAiADLNFPA.
OrthoDBiEOG091G0QDH.
PhylomeDBiA2VDF0.
TreeFamiTF324689.

Family and domain databases

Gene3Di3.40.1650.10. 1 hit.
InterProiIPR023750. RbsD-like.
IPR007721. RbsD_FucU.
[Graphical view]
PfamiPF05025. RbsD_FucU. 1 hit.
[Graphical view]
SUPFAMiSSF102546. SSF102546. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: A2VDF0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MVALKGVPAL LSPELLYALA RMGHGDEIVL ADLNFPASSI CQCGPMEIRA
60 70 80 90 100
DGLGIPQLLE AVLKLLPLDT YVESPAAVME LVPSDKERGL QTPVWTEYES
110 120 130 140 150
ILRRAGCVRA LAKIERFEFY ERAKKAFAVV ATGETALYGN LILRKGVLAL

NPLL
Length:154
Mass (Da):16,765
Last modified:May 15, 2007 - v2
Checksum:i96F76613566F4A6E
GO
Isoform 2 (identifier: A2VDF0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     134-134: E → C
     135-154: Missing.

Show »
Length:134
Mass (Da):14,604
Checksum:iFAC93FCEE630E7CC
GO

Sequence cautioni

The sequence CAH70284 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence CAH70285 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti81L → P in BAC85178 (PubMed:14702039).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_025080134E → C in isoform 2. 2 Publications1
Alternative sequenceiVSP_025081135 – 154Missing in isoform 2. 2 PublicationsAdd BLAST20

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK129527 mRNA. Translation: BAC85178.1.
AL360181 Genomic DNA. Translation: CAH70284.1. Sequence problems.
AL360181 Genomic DNA. Translation: CAH70285.1. Sequence problems.
BC129818 mRNA. Translation: AAI29819.1.
BC129819 mRNA. Translation: AAI29820.1.
AI333356 mRNA. No translation available.
CCDSiCCDS44499.1. [A2VDF0-1]
CCDS7680.1. [A2VDF0-2]
RefSeqiNP_001091953.1. NM_001098483.2. [A2VDF0-1]
NP_001288756.1. NM_001301827.1.
NP_001288757.1. NM_001301828.1.
NP_940874.2. NM_198472.2. [A2VDF0-2]
UniGeneiHs.155823.

Genome annotation databases

EnsembliENST00000278025; ENSP00000278025; ENSG00000148803. [A2VDF0-1]
ENST00000368552; ENSP00000357540; ENSG00000148803. [A2VDF0-2]
GeneIDi282969.
KEGGihsa:282969.
UCSCiuc001lmt.3. human. [A2VDF0-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK129527 mRNA. Translation: BAC85178.1.
AL360181 Genomic DNA. Translation: CAH70284.1. Sequence problems.
AL360181 Genomic DNA. Translation: CAH70285.1. Sequence problems.
BC129818 mRNA. Translation: AAI29819.1.
BC129819 mRNA. Translation: AAI29820.1.
AI333356 mRNA. No translation available.
CCDSiCCDS44499.1. [A2VDF0-1]
CCDS7680.1. [A2VDF0-2]
RefSeqiNP_001091953.1. NM_001098483.2. [A2VDF0-1]
NP_001288756.1. NM_001301827.1.
NP_001288757.1. NM_001301828.1.
NP_940874.2. NM_198472.2. [A2VDF0-2]
UniGeneiHs.155823.

3D structure databases

ProteinModelPortaliA2VDF0.
SMRiA2VDF0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi129427. 15 interactors.
IntActiA2VDF0. 1 interactor.
STRINGi9606.ENSP00000357540.

PTM databases

iPTMnetiA2VDF0.
PhosphoSitePlusiA2VDF0.

Polymorphism and mutation databases

BioMutaiFUOM.

Proteomic databases

MaxQBiA2VDF0.
PaxDbiA2VDF0.
PRIDEiA2VDF0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000278025; ENSP00000278025; ENSG00000148803. [A2VDF0-1]
ENST00000368552; ENSP00000357540; ENSG00000148803. [A2VDF0-2]
GeneIDi282969.
KEGGihsa:282969.
UCSCiuc001lmt.3. human. [A2VDF0-1]

Organism-specific databases

CTDi282969.
GeneCardsiFUOM.
HGNCiHGNC:24733. FUOM.
HPAiHPA039207.
neXtProtiNX_A2VDF0.
OpenTargetsiENSG00000148803.
PharmGKBiPA134972390.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IXHP. Eukaryota.
COG4154. LUCA.
GeneTreeiENSGT00390000001197.
HOVERGENiHBG107698.
InParanoidiA2VDF0.
KOiK02431.
OMAiADLNFPA.
OrthoDBiEOG091G0QDH.
PhylomeDBiA2VDF0.
TreeFamiTF324689.

Enzyme and pathway databases

BRENDAi5.1.3.29. 2681.
ReactomeiR-HSA-6787639. GDP-fucose biosynthesis.

Miscellaneous databases

GenomeRNAii282969.
PROiA2VDF0.

Gene expression databases

BgeeiENSG00000148803.
CleanExiHS_C10orf125.
ExpressionAtlasiA2VDF0. baseline and differential.
GenevisibleiA2VDF0. HS.

Family and domain databases

Gene3Di3.40.1650.10. 1 hit.
InterProiIPR023750. RbsD-like.
IPR007721. RbsD_FucU.
[Graphical view]
PfamiPF05025. RbsD_FucU. 1 hit.
[Graphical view]
SUPFAMiSSF102546. SSF102546. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiFUCM_HUMAN
AccessioniPrimary (citable) accession number: A2VDF0
Secondary accession number(s): A1L300
, Q5VWY2, Q5VWY3, Q6ZPD2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 15, 2007
Last sequence update: May 15, 2007
Last modified: November 2, 2016
This is version 83 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.