A2VDF0 (FUCM_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Fucose mutarotase
EC=5.1.3.n2

Gene names

Name:	FUOM
Synonyms:	C10orf125

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	154 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Involved in the interconversion between alpha- and beta-L-fucoses. L-Fucose (6-deoxy-L-galactose) exists as alpha-L-fucose (29.5%) and beta-L-fucose (70.5%), the beta-form is metabolized through the salvage pathway. GDP-L-fucose formed either by the de novo or salvage pathways is transported into the endoplasmic reticulum, where it serves as a substrate for N- and O-glycosylations by fucosyltransferases. Fucosylated structures expressed on cell surfaces or secreted in biological fluids are believed to play a critical role in cell-cell adhesion and recognition processes. Ref.5
Catalytic activity	Alpha-L-fucose = beta-L-fucose. Ref.5
Subunit structure	Mainly homodimer, but exists also as homotetramer, homooctamer, and homodecamer. The homodimeric form seems catalytically inactive By similarity.
Sequence similarities	Belongs to the RbsD / FucU family.
Sequence caution	The sequence CAH70284.1 differs from that shown. Reason: Erroneous gene model prediction. The sequence CAH70285.1 differs from that shown. Reason: Erroneous gene model prediction.

Ontologies

Keywords
Coding sequence diversity	Alternative splicing
Molecular function	Isomerase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	fucose metabolic process Inferred from sequence or structural similarity. Source: UniProtKB
Molecular_function	fucose binding Inferred from sequence or structural similarity. Source: UniProtKB racemase and epimerase activity, acting on carbohydrates and derivatives Inferred from sequence or structural similarity. Source: UniProtKB
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: A2VDF0-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: A2VDF0-2)

The sequence of this isoform differs from the canonical sequence as follows:
     134-134: E → C
     135-154: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 154	154	Fucose mutarotase		PRO_0000286553
Sites
	Active site	24	1	Proton donor By similarity
	Active site	69	1	By similarity
	Active site	120	1	By similarity
	Binding site	32	1	Substrate By similarity
	Binding site	79	1	Substrate By similarity
	Binding site	120	1	Substrate By similarity
	Binding site	138	1	Substrate By similarity
	Binding site	140	1	Substrate By similarity
Natural variations
	Alternative sequence	134	1	E → C in isoform 2.		VSP_025080
	Alternative sequence	135 – 154	20	Missing in isoform 2.		VSP_025081
Experimental info
	Sequence conflict	81	1	L → P in BAC85178. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified May 15, 2007. Version 2. Checksum: 96F76613566F4A6E	FASTA	154	16,765
	10 20 30 40 50 60 MVALKGVPAL LSPELLYALA RMGHGDEIVL ADLNFPASSI CQCGPMEIRA DGLGIPQLLE 70 80 90 100 110 120 AVLKLLPLDT YVESPAAVME LVPSDKERGL QTPVWTEYES ILRRAGCVRA LAKIERFEFY 130 140 150 ERAKKAFAVV ATGETALYGN LILRKGVLAL NPLL
	Isoform 2 [UniParc]. Checksum: FAC93FCEE630E7CC	FASTA	134	14,604
	10 20 30 40 50 60 MVALKGVPAL LSPELLYALA RMGHGDEIVL ADLNFPASSI CQCGPMEIRA DGLGIPQLLE 70 80 90 100 110 120 AVLKLLPLDT YVESPAAVME LVPSDKERGL QTPVWTEYES ILRRAGCVRA LAKIERFEFY 130 ERAKKAFAVV ATGC

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). Tissue: Macrophage.
[2]	"The DNA sequence and comparative analysis of human chromosome 10." Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J. , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J. Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-140 (ISOFORM 1).
[4]	The Cancer Genome Anatomy Project (CGAP) at the National Cancer Institute Submitted (FEB-1998) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 95-154 (ISOFORM 1).
[5]	"Characterization and role of fucose mutarotase in mammalian cells." Park D., Ryu K.S., Choi D., Kwak J., Park C. Glycobiology 17:955-962(2007) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, CATALYTIC ACTIVITY.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AK129527 mRNA. Translation: BAC85178.1. AL360181 Genomic DNA. Translation: CAH70284.1. Sequence problems. AL360181 Genomic DNA. Translation: CAH70285.1. Sequence problems. BC129818 mRNA. Translation: AAI29819.1. BC129819 mRNA. Translation: AAI29820.1. AI333356 mRNA. No translation available.
IPI	IPI00815895. IPI00845372.
RefSeq	NP_001091953.1. NM_001098483.1. NP_940874.2. NM_198472.2.
UniGene	Hs.155823.
3D structure databases
ProteinModelPortal	A2VDF0.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000357540.
PTM databases
PhosphoSite	A2VDF0.
Proteomic databases
PaxDb	A2VDF0.
PRIDE	A2VDF0.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000278025; ENSP00000278025; ENSG00000148803. ENST00000368551; ENSP00000357539; ENSG00000148803. ENST00000368552; ENSP00000357540; ENSG00000148803. ENST00000447176; ENSP00000413379; ENSG00000148803.
GeneID	282969.
KEGG	hsa:282969.
UCSC	uc001lms.2. human. uc001lmt.2. human.
Organism-specific databases
CTD	282969.
GeneCards	GC10M135169.
HGNC	HGNC:24733. FUOM.
HPA	HPA039207.
neXtProt	NX_A2VDF0.
PharmGKB	PA134972390.
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG4154.
HOVERGEN	HBG107698.
InParanoid	A2VDF0.
OMA	LADLNFP.
Gene expression databases
Bgee	A2VDF0.
CleanEx	HS_C10orf125.
Genevestigator	A2VDF0.
Family and domain databases
Gene3D	3.40.1650.10. 1 hit.
InterPro	IPR023750. RbsD-like. IPR007721. RbsD_FucU. [Graphical view]
Pfam	PF05025. RbsD_FucU. 1 hit. [Graphical view]
SUPFAM	SSF102546. RbsD_FucU. 1 hit.
ProtoNet	Search...
Other
GenomeRNAi	282969.
NextBio	93539.

Entry information

Entry name

FUCM_HUMAN

Accession

Primary (citable) accession number: A2VDF0
Secondary accession number(s): A1L300 , Q5VWY2, Q5VWY3, Q6ZPD2

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 15, 2007
Last sequence update:	May 15, 2007
Last modified:	May 1, 2013
This is version 52 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.