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A2VDF0 (FUCM_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 60. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Fucose mutarotase

EC=5.1.3.n2
Gene names
Name:FUOM
Synonyms:C10orf125
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length154 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Involved in the interconversion between alpha- and beta-L-fucoses. L-Fucose (6-deoxy-L-galactose) exists as alpha-L-fucose (29.5%) and beta-L-fucose (70.5%), the beta-form is metabolized through the salvage pathway. GDP-L-fucose formed either by the de novo or salvage pathways is transported into the endoplasmic reticulum, where it serves as a substrate for N- and O-glycosylations by fucosyltransferases. Fucosylated structures expressed on cell surfaces or secreted in biological fluids are believed to play a critical role in cell-cell adhesion and recognition processes. Ref.5

Catalytic activity

Alpha-L-fucose = beta-L-fucose. Ref.5

Subunit structure

Mainly homodimer, but exists also as homotetramer, homooctamer, and homodecamer. The homodimeric form seems catalytically inactive By similarity.

Sequence similarities

Belongs to the RbsD / FucU family.

Sequence caution

The sequence CAH70284.1 differs from that shown. Reason: Erroneous gene model prediction.

The sequence CAH70285.1 differs from that shown. Reason: Erroneous gene model prediction.

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: A2VDF0-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: A2VDF0-2)

The sequence of this isoform differs from the canonical sequence as follows:
     134-134: E → C
     135-154: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 154154Fucose mutarotase
PRO_0000286553

Sites

Active site241Proton donor By similarity
Active site691 By similarity
Active site1201 By similarity
Binding site321Substrate By similarity
Binding site791Substrate By similarity
Binding site1201Substrate By similarity
Binding site1381Substrate By similarity
Binding site1401Substrate By similarity

Natural variations

Alternative sequence1341E → C in isoform 2.
VSP_025080
Alternative sequence135 – 15420Missing in isoform 2.
VSP_025081

Experimental info

Sequence conflict811L → P in BAC85178. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified May 15, 2007. Version 2.
Checksum: 96F76613566F4A6E

FASTA15416,765
        10         20         30         40         50         60 
MVALKGVPAL LSPELLYALA RMGHGDEIVL ADLNFPASSI CQCGPMEIRA DGLGIPQLLE 

        70         80         90        100        110        120 
AVLKLLPLDT YVESPAAVME LVPSDKERGL QTPVWTEYES ILRRAGCVRA LAKIERFEFY 

       130        140        150 
ERAKKAFAVV ATGETALYGN LILRKGVLAL NPLL 

« Hide

Isoform 2 [UniParc].

Checksum: FAC93FCEE630E7CC
Show »

FASTA13414,604

References

« Hide 'large scale' references
[1]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
Tissue: Macrophage.
[2]"The DNA sequence and comparative analysis of human chromosome 10."
Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J. expand/collapse author list , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.
Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-140 (ISOFORM 1).
[4]The Cancer Genome Anatomy Project (CGAP) at the National Cancer Institute
Submitted (FEB-1998) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 95-154 (ISOFORM 1).
[5]"Characterization and role of fucose mutarotase in mammalian cells."
Park D., Ryu K.S., Choi D., Kwak J., Park C.
Glycobiology 17:955-962(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, CATALYTIC ACTIVITY.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AK129527 mRNA. Translation: BAC85178.1.
AL360181 Genomic DNA. Translation: CAH70284.1. Sequence problems.
AL360181 Genomic DNA. Translation: CAH70285.1. Sequence problems.
BC129818 mRNA. Translation: AAI29819.1.
BC129819 mRNA. Translation: AAI29820.1.
AI333356 mRNA. No translation available.
RefSeqNP_001091953.1. NM_001098483.1.
NP_940874.2. NM_198472.2.
UniGeneHs.155823.

3D structure databases

ProteinModelPortalA2VDF0.
SMRA2VDF0. Positions 1-148.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000357540.

PTM databases

PhosphoSiteA2VDF0.

Proteomic databases

PaxDbA2VDF0.
PRIDEA2VDF0.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000278025; ENSP00000278025; ENSG00000148803. [A2VDF0-2]
ENST00000368552; ENSP00000357540; ENSG00000148803. [A2VDF0-1]
GeneID282969.
KEGGhsa:282969.
UCSCuc001lms.2. human. [A2VDF0-2]
uc001lmt.2. human. [A2VDF0-1]

Organism-specific databases

CTD282969.
GeneCardsGC10M135169.
HGNCHGNC:24733. FUOM.
HPAHPA039207.
neXtProtNX_A2VDF0.
PharmGKBPA134972390.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG4154.
HOVERGENHBG107698.
InParanoidA2VDF0.
OMAGETAKYG.
OrthoDBEOG7K0ZDZ.
PhylomeDBA2VDF0.
TreeFamTF324689.

Gene expression databases

BgeeA2VDF0.
CleanExHS_C10orf125.
GenevestigatorA2VDF0.

Family and domain databases

Gene3D3.40.1650.10. 1 hit.
InterProIPR023750. RbsD-like.
IPR007721. RbsD_FucU.
[Graphical view]
PfamPF05025. RbsD_FucU. 1 hit.
[Graphical view]
SUPFAMSSF102546. SSF102546. 1 hit.
ProtoNetSearch...

Other

GenomeRNAi282969.
NextBio93539.
PROA2VDF0.

Entry information

Entry nameFUCM_HUMAN
AccessionPrimary (citable) accession number: A2VDF0
Secondary accession number(s): A1L300 expand/collapse secondary AC list , Q5VWY2, Q5VWY3, Q6ZPD2
Entry history
Integrated into UniProtKB/Swiss-Prot: May 15, 2007
Last sequence update: May 15, 2007
Last modified: April 16, 2014
This is version 60 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human chromosome 10

Human chromosome 10: entries, gene names and cross-references to MIM