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A2VDF0

- FUCM_HUMAN

UniProt

A2VDF0 - FUCM_HUMAN

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Protein

Fucose mutarotase

Gene
FUOM, C10orf125
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Involved in the interconversion between alpha- and beta-L-fucoses. L-Fucose (6-deoxy-L-galactose) exists as alpha-L-fucose (29.5%) and beta-L-fucose (70.5%), the beta-form is metabolized through the salvage pathway. GDP-L-fucose formed either by the de novo or salvage pathways is transported into the endoplasmic reticulum, where it serves as a substrate for N- and O-glycosylations by fucosyltransferases. Fucosylated structures expressed on cell surfaces or secreted in biological fluids are believed to play a critical role in cell-cell adhesion and recognition processes.1 Publication

Catalytic activityi

Alpha-L-fucose = beta-L-fucose.1 Publication

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei24 – 241Proton donor By similarity
Binding sitei32 – 321Substrate By similarity
Active sitei69 – 691 By similarity
Binding sitei79 – 791Substrate By similarity
Active sitei120 – 1201 By similarity
Binding sitei120 – 1201Substrate By similarity
Binding sitei138 – 1381Substrate By similarity
Binding sitei140 – 1401Substrate By similarity

GO - Molecular functioni

  1. fucose binding Source: UniProtKB
  2. racemase and epimerase activity, acting on carbohydrates and derivatives Source: UniProtKB

GO - Biological processi

  1. fucose metabolic process Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Enzyme and pathway databases

BioCyciRETL1328306-WGS:GSTH-6705-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Fucose mutarotase (EC:5.1.3.n2)
Gene namesi
Name:FUOM
Synonyms:C10orf125
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 10

Organism-specific databases

HGNCiHGNC:24733. FUOM.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134972390.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 154154Fucose mutarotasePRO_0000286553Add
BLAST

Proteomic databases

MaxQBiA2VDF0.
PaxDbiA2VDF0.
PRIDEiA2VDF0.

PTM databases

PhosphoSiteiA2VDF0.

Expressioni

Gene expression databases

BgeeiA2VDF0.
CleanExiHS_C10orf125.
GenevestigatoriA2VDF0.

Organism-specific databases

HPAiHPA039207.

Interactioni

Subunit structurei

Mainly homodimer, but exists also as homotetramer, homooctamer, and homodecamer. The homodimeric form seems catalytically inactive By similarity.

Protein-protein interaction databases

STRINGi9606.ENSP00000357540.

Structurei

3D structure databases

ProteinModelPortaliA2VDF0.
SMRiA2VDF0. Positions 1-148.

Family & Domainsi

Sequence similaritiesi

Belongs to the RbsD / FucU family.

Phylogenomic databases

eggNOGiCOG4154.
HOVERGENiHBG107698.
InParanoidiA2VDF0.
KOiK02431.
OMAiCAVICRR.
OrthoDBiEOG7K0ZDZ.
PhylomeDBiA2VDF0.
TreeFamiTF324689.

Family and domain databases

Gene3Di3.40.1650.10. 1 hit.
InterProiIPR023750. RbsD-like.
IPR007721. RbsD_FucU.
[Graphical view]
PfamiPF05025. RbsD_FucU. 1 hit.
[Graphical view]
SUPFAMiSSF102546. SSF102546. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: A2VDF0-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MVALKGVPAL LSPELLYALA RMGHGDEIVL ADLNFPASSI CQCGPMEIRA    50
DGLGIPQLLE AVLKLLPLDT YVESPAAVME LVPSDKERGL QTPVWTEYES 100
ILRRAGCVRA LAKIERFEFY ERAKKAFAVV ATGETALYGN LILRKGVLAL 150
NPLL 154
Length:154
Mass (Da):16,765
Last modified:May 15, 2007 - v2
Checksum:i96F76613566F4A6E
GO
Isoform 2 (identifier: A2VDF0-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     134-134: E → C
     135-154: Missing.

Show »
Length:134
Mass (Da):14,604
Checksum:iFAC93FCEE630E7CC
GO

Sequence cautioni

The sequence CAH70284.1 differs from that shown. Reason: Erroneous gene model prediction.
The sequence CAH70285.1 differs from that shown. Reason: Erroneous gene model prediction.

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei134 – 1341E → C in isoform 2. VSP_025080
Alternative sequencei135 – 15420Missing in isoform 2. VSP_025081Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti81 – 811L → P in BAC85178. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK129527 mRNA. Translation: BAC85178.1.
AL360181 Genomic DNA. Translation: CAH70284.1. Sequence problems.
AL360181 Genomic DNA. Translation: CAH70285.1. Sequence problems.
BC129818 mRNA. Translation: AAI29819.1.
BC129819 mRNA. Translation: AAI29820.1.
AI333356 mRNA. No translation available.
CCDSiCCDS44499.1. [A2VDF0-1]
CCDS7680.1. [A2VDF0-2]
RefSeqiNP_001091953.1. NM_001098483.1. [A2VDF0-1]
NP_940874.2. NM_198472.2. [A2VDF0-2]
UniGeneiHs.155823.

Genome annotation databases

EnsembliENST00000278025; ENSP00000278025; ENSG00000148803. [A2VDF0-2]
ENST00000368552; ENSP00000357540; ENSG00000148803. [A2VDF0-1]
GeneIDi282969.
KEGGihsa:282969.
UCSCiuc001lms.2. human. [A2VDF0-2]
uc001lmt.2. human. [A2VDF0-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK129527 mRNA. Translation: BAC85178.1 .
AL360181 Genomic DNA. Translation: CAH70284.1 . Sequence problems.
AL360181 Genomic DNA. Translation: CAH70285.1 . Sequence problems.
BC129818 mRNA. Translation: AAI29819.1 .
BC129819 mRNA. Translation: AAI29820.1 .
AI333356 mRNA. No translation available.
CCDSi CCDS44499.1. [A2VDF0-1 ]
CCDS7680.1. [A2VDF0-2 ]
RefSeqi NP_001091953.1. NM_001098483.1. [A2VDF0-1 ]
NP_940874.2. NM_198472.2. [A2VDF0-2 ]
UniGenei Hs.155823.

3D structure databases

ProteinModelPortali A2VDF0.
SMRi A2VDF0. Positions 1-148.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000357540.

PTM databases

PhosphoSitei A2VDF0.

Proteomic databases

MaxQBi A2VDF0.
PaxDbi A2VDF0.
PRIDEi A2VDF0.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000278025 ; ENSP00000278025 ; ENSG00000148803 . [A2VDF0-2 ]
ENST00000368552 ; ENSP00000357540 ; ENSG00000148803 . [A2VDF0-1 ]
GeneIDi 282969.
KEGGi hsa:282969.
UCSCi uc001lms.2. human. [A2VDF0-2 ]
uc001lmt.2. human. [A2VDF0-1 ]

Organism-specific databases

CTDi 282969.
GeneCardsi GC10M135169.
HGNCi HGNC:24733. FUOM.
HPAi HPA039207.
neXtProti NX_A2VDF0.
PharmGKBi PA134972390.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG4154.
HOVERGENi HBG107698.
InParanoidi A2VDF0.
KOi K02431.
OMAi CAVICRR.
OrthoDBi EOG7K0ZDZ.
PhylomeDBi A2VDF0.
TreeFami TF324689.

Enzyme and pathway databases

BioCyci RETL1328306-WGS:GSTH-6705-MONOMER.

Miscellaneous databases

GenomeRNAii 282969.
NextBioi 93539.
PROi A2VDF0.

Gene expression databases

Bgeei A2VDF0.
CleanExi HS_C10orf125.
Genevestigatori A2VDF0.

Family and domain databases

Gene3Di 3.40.1650.10. 1 hit.
InterProi IPR023750. RbsD-like.
IPR007721. RbsD_FucU.
[Graphical view ]
Pfami PF05025. RbsD_FucU. 1 hit.
[Graphical view ]
SUPFAMi SSF102546. SSF102546. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Macrophage.
  2. "The DNA sequence and comparative analysis of human chromosome 10."
    Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J.
    , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.
    Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-140 (ISOFORM 1).
  4. The Cancer Genome Anatomy Project (CGAP) at the National Cancer Institute
    Submitted (FEB-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 95-154 (ISOFORM 1).
  5. "Characterization and role of fucose mutarotase in mammalian cells."
    Park D., Ryu K.S., Choi D., Kwak J., Park C.
    Glycobiology 17:955-962(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, CATALYTIC ACTIVITY.

Entry informationi

Entry nameiFUCM_HUMAN
AccessioniPrimary (citable) accession number: A2VDF0
Secondary accession number(s): A1L300
, Q5VWY2, Q5VWY3, Q6ZPD2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 15, 2007
Last sequence update: May 15, 2007
Last modified: September 3, 2014
This is version 63 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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