Reviewed, UniProtKB/Swiss-Prot A2VD83 (GMPBB_XENLA)

Names and origin

Protein names

Recommended name:
    Mannose-1-phosphate guanyltransferase beta-B
    EC=2.7.7.13
Alternative name(s):
    GTP-mannose-1-phosphate guanylyltransferase beta-B
    GDP-mannose pyrophosphorylase B-B

Gene names

Name:

gmppb-B

Organism

Xenopus laevis (African clawed frog)

Taxonomic identifier

8355 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Amphibia › Batrachia › Anura › Mesobatrachia › Pipoidea › Pipidae › Xenopodinae › Xenopus › Xenopus

Protein attributes

Sequence length	360 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Catalytic activity	GTP + alpha-D-mannose 1-phosphate = diphosphate + GDP-mannose.
Pathway	Nucleotide-sugar biosynthesis; GDP-alpha-D-mannose biosynthesis; GDP-alpha-D-mannose from alpha-D-mannose 1-phosphate (GTP route): step 1/1.
Sequence similarities	Belongs to the transferase hexapeptide repeat family.

Ontologies

Keywords
Ligand	GTP-binding Nucleotide-binding
Molecular function	Nucleotidyltransferase Transferase
Gene Ontology (GO)
Biological process	biosynthetic process Inferred from electronic annotation. Source: InterPro
Molecular function	GTP binding Inferred from electronic annotation. Source: UniProtKB-KW mannose-1-phosphate guanylyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 360	360	Mannose-1-phosphate guanyltransferase beta-B		PRO_0000307167

Sequences

	Sequence		Length	Mass (Da)
	A2VD83-1 [UniParc]. Last modified March 20, 2007. Version 1. Checksum: 4B319B7BD4B58C4B	FASTA	360	40,152
	10 20 30 40 50 60 MKALILVGGY GTRLRPLTLS VPKPLVDFCN KPILLHQVEA LVKAGVTHVI LAVSYMSDML 70 80 90 100 110 120 EKEMKEQEKR LGIRISMSHE KEPLGTAGPL ALARELLTEN SEPFFVLNSD VICDFPFEDM 130 140 150 160 170 180 VRFHKHHGKE GTIVVTKVEE PSKYGVVIYE AESGRIQRFV EKPQVFVSNK INSGLYIFSP 190 200 210 220 230 240 AVLDRIQLRP TSIEKEIFPV MAQEGQLFAL ELQGFWMDIG QPKDFLTGMC MYLQSVRHKH 250 260 270 280 290 300 PERLHVGPGF TGNVLVDPTA KIGQNCSIGP NVTIGPGVTV EDGVRIKRCS IMKGSRLHSH 310 320 330 340 350 360 SWLQSSIVGW SSSVGQWVRM ENVTVLGEDV IVNDELYLNG ANVLPHKCIS ESVPEPRIIM

References

[1]	NIH - Xenopus Gene Collection (XGC) project Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Intestine.

Cross-references

Sequence databases
EMBLGenBankDDBJ	BC129595 mRNA. Translation: AAI29596.1.
RefSeq	NP_001091347.1.
UniGene	Xl.75262
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	100037186.
KEGG	xla:100037186.
Organism-specific databases
CTD	100037186.
Phylogenomic databases
HOVERGEN	A2VD83.
Enzyme and pathway databases
BRENDA	2.7.7.13. 648.
Family and domain databases
InterPro	IPR001451. Hexapep_transf. IPR018357. Hexapep_transf_CS. IPR005835. NTP_transferase. [Graphical view]
Pfam	PF00132. Hexapep. 2 hits. PF00483. NTP_transferase. 1 hit. [Graphical view]
PROSITE	PS00101. HEXAPEP_TRANSFERASES. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

GMPBB_XENLA

Accession

Primary (citable) accession number: A2VD83

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 23, 2007
Last sequence update:	March 20, 2007
Last modified:	September 22, 2009
This is version 19 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

Xenopus annotation project