Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Molybdenum cofactor sulfurase

Gene

mocos

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Sulfurates the molybdenum cofactor. Sulfation of molybdenum is essential for xanthine dehydrogenase (XDH) and aldehyde oxidase (ADO) enzymes in which molybdenum cofactor is liganded by 1 oxygen and 1 sulfur atom in active form.UniRule annotation

Catalytic activityi

Molybdenum cofactor + L-cysteine + reduced acceptor + 2 H+ = thio-molybdenum cofactor + L-alanine + H2O + oxidized acceptor.UniRule annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei422 – 4221UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Molybdenum cofactor biosynthesis

Keywords - Ligandi

Pyridoxal phosphate

Names & Taxonomyi

Protein namesi
Recommended name:
Molybdenum cofactor sulfuraseUniRule annotation (EC:2.8.1.9UniRule annotation)
Short name:
MCSUniRule annotation
Short name:
MOSUniRule annotation
Short name:
MoCo sulfuraseUniRule annotation
Alternative name(s):
Molybdenum cofactor sulfurtransferaseUniRule annotation
Gene namesi
Name:mocos
ORF Names:zgc:110784
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Unplaced

Organism-specific databases

ZFINiZDB-GENE-050327-94. mocos.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 831831Molybdenum cofactor sulfurasePRO_0000369362Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei262 – 2621N6-(pyridoxal phosphate)lysineUniRule annotation

Structurei

3D structure databases

ProteinModelPortaliA2VD33.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini651 – 823173MOSCUniRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. MOCOS subfamily.UniRule annotation
Contains 1 MOSC domain.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000029698.
InParanoidiA2VD33.
PhylomeDBiA2VD33.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
HAMAPiMF_03050. MOCOS.
InterProiIPR000192. Aminotrans_V_dom.
IPR005302. MoCF_Sase_C.
IPR028886. MoCo_sulfurase.
IPR005303. MOSC_N.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
IPR011037. Pyrv_Knase-like_insert_dom.
[Graphical view]
PfamiPF00266. Aminotran_5. 1 hit.
PF03473. MOSC. 1 hit.
PF03476. MOSC_N. 1 hit.
[Graphical view]
SUPFAMiSSF50800. SSF50800. 2 hits.
SSF53383. SSF53383. 2 hits.
PROSITEiPS51340. MOSC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A2VD33-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDTRSLQDFQ DLCTFDVFKS FGHYYGYGVD QQALIDQEFK RIKGVTYLDH
60 70 80 90 100
AGTTLFPESL IKGFHDDISR NVYGNPHSHN SSSRLTHDTV ESVRYKILAH
110 120 130 140 150
FNTSPEDYSV IFTSGCTAAL KLVADTFPWK PMSNKEPGSQ FCYLTDNHTS
160 170 180 190 200
VVGIRGATAL QGVGTISVSP REVETRARNK TQTNGEEECS TPHLFCYPAQ
210 220 230 240 250
SNFSGRKYSL SYVKGIQSQQ LYPACEHHGQ WFVLLDAACF VSCSPLDLSQ
260 270 280 290 300
YPADFVPISF YKMFGFPTGL GALLVRNEAA EVLRKTYFGG GTAAAYLVEE
310 320 330 340 350
NYFIPKPNLA SRFEDGTISF LDIISLHHGF ETLQKLTGSM TNIQLHTFGL
360 370 380 390 400
ARYTYTVLSC LCHSNGKHVA QIYCDNDFQS IAEQGAIINF SLLDCHGRTV
410 420 430 440 450
GYSQVDKMAS LFNIHIRTGC FCNTGACQHY LAISNQNVKS NLHAGHICGD
460 470 480 490 500
NIDLVDGRPT GSLRVSFGYM SSFEDCQNFL RFVVNCFVDK PLILDQTKLA
510 520 530 540 550
KLNSAAPIEP SSSYSPSPDR MAVSEVTMSK DGKKDGSSCT LTNLFIFPVK
560 570 580 590 600
SCASFEVTEW PLGPQGLLYD RLWMVVNENG VCLSQKREPK LCLIQPVVCL
610 620 630 640 650
AANTLKLQIS GSEAITVPLD PSLEKSDLRT SQSKVCGDRV QTVDCGEEVS
660 670 680 690 700
AWLSEFLGKP CRLIRQRPEF LRDMKFGQGD CCPTPLSLVN EAQFLLINRA
710 720 730 740 750
SVCFLQEAIA NRYNSDNEET WRDTEQLVQR FRANLVISAQ EPFAEDNWSH
760 770 780 790 800
LTIGNTQFQV IGKCGRCQMI GVDQKTATRT QEPLRSLSEC RSGKVTFGVY
810 820 830
LAHQSARNST HPVLSIGSHV IPKISDSTDK F
Length:831
Mass (Da):92,399
Last modified:April 14, 2009 - v2
Checksum:iF9F03CED6EDA87C2
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti69 – 691S → P in AAH91876 (Ref. 2) Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX323467 Genomic DNA. No translation available.
CR759794 Genomic DNA. No translation available.
BC091876 mRNA. Translation: AAH91876.1.
BC129285 mRNA. Translation: AAI29286.1.
UniGeneiDr.159558.
Dr.160757.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX323467 Genomic DNA. No translation available.
CR759794 Genomic DNA. No translation available.
BC091876 mRNA. Translation: AAH91876.1.
BC129285 mRNA. Translation: AAI29286.1.
UniGeneiDr.159558.
Dr.160757.

3D structure databases

ProteinModelPortaliA2VD33.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

ZFINiZDB-GENE-050327-94. mocos.

Phylogenomic databases

HOGENOMiHOG000029698.
InParanoidiA2VD33.
PhylomeDBiA2VD33.

Miscellaneous databases

PROiA2VD33.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
HAMAPiMF_03050. MOCOS.
InterProiIPR000192. Aminotrans_V_dom.
IPR005302. MoCF_Sase_C.
IPR028886. MoCo_sulfurase.
IPR005303. MOSC_N.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
IPR011037. Pyrv_Knase-like_insert_dom.
[Graphical view]
PfamiPF00266. Aminotran_5. 1 hit.
PF03473. MOSC. 1 hit.
PF03476. MOSC_N. 1 hit.
[Graphical view]
SUPFAMiSSF50800. SSF50800. 2 hits.
SSF53383. SSF53383. 2 hits.
PROSITEiPS51340. MOSC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The zebrafish reference genome sequence and its relationship to the human genome."
    Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M., Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I., Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.
    , White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y., Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B., Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S., Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M., Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J., Clee C., Oliver K., Clark R., Riddle C., Eliott D., Threadgold G., Harden G., Ware D., Mortimer B., Kerry G., Heath P., Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S., Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J., Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J., Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D., McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E., Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A., Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P., Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J., Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E., Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C., Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C., Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M., Oberlander M., Rudolph-Geiger S., Teucke M., Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M., Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M., de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C., Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.
    Nature 496:498-503(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Tuebingen.
  2. NIH - Zebrafish Gene Collection (ZGC) project
    Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Embryo and Intestine.

Entry informationi

Entry nameiMOCOS_DANRE
AccessioniPrimary (citable) accession number: A2VD33
Secondary accession number(s): Q58EJ4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: April 14, 2009
Last modified: January 20, 2016
This is version 57 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.