Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Pentatricopeptide repeat-containing protein 1, mitochondrial

Gene

Ptcd1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Mitochondrial protein implicated in negative regulation of leucine tRNA levels, as well as negative regulation of mitochondria-encoded proteins and COX activity. Affects also the 3'-processing of mitochondrial tRNAs.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processtRNA processing

Names & Taxonomyi

Protein namesi
Recommended name:
Pentatricopeptide repeat-containing protein 1, mitochondrial
Gene namesi
Name:Ptcd1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 12

Organism-specific databases

RGDi1311473 Ptcd1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004201581 – 686Pentatricopeptide repeat-containing protein 1, mitochondrialAdd BLAST686

Proteomic databases

PaxDbiA2VD13
PeptideAtlasiA2VD13
PRIDEiA2VD13

Expressioni

Gene expression databases

BgeeiENSRNOG00000000987
ExpressionAtlasiA2VD13 baseline and differential
GenevisibleiA2VD13 RN

Interactioni

Subunit structurei

Associates with mitochondrial leucine tRNAs. Interacts with ELAC2.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000057644

Structurei

3D structure databases

ProteinModelPortaliA2VD13
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati124 – 160PPR 1Add BLAST37
Repeati161 – 195PPR 2Add BLAST35
Repeati196 – 234PPR 3Add BLAST39
Repeati235 – 269PPR 4Add BLAST35
Repeati270 – 306PPR 5Add BLAST37
Repeati508 – 542PPR 6Add BLAST35
Repeati575 – 609PPR 7Add BLAST35

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi46 – 51Poly-Ser6
Compositional biasi71 – 76Poly-Glu6
Compositional biasi109 – 114Poly-Glu6

Sequence similaritiesi

Belongs to the PTCD1 family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG4197 Eukaryota
ENOG410Z7Z7 LUCA
GeneTreeiENSGT00390000015597
HOGENOMiHOG000237315
HOVERGENiHBG053748
InParanoidiA2VD13
OMAiFRAYYKQ
OrthoDBiEOG091G02E4
TreeFamiTF324792

Family and domain databases

Gene3Di1.25.40.10, 3 hits
InterProiView protein in InterPro
IPR002885 Pentatricopeptide_repeat
IPR011990 TPR-like_helical_dom_sf
PfamiView protein in Pfam
PF13041 PPR_2, 1 hit
PF13812 PPR_3, 1 hit
TIGRFAMsiTIGR00756 PPR, 1 hit
PROSITEiView protein in PROSITE
PS51375 PPR, 7 hits

Sequencei

Sequence statusi: Complete.

A2VD13-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDLLRLSRLF SGPHPIGLSV LQRLDLLRST QWTGGREGPA WLRAASCSSS
60 70 80 90 100
SHQKRMSSLC SDSSTPVAPQ EEEEEESFGT LSEKFSSRRI FHKSTAQLYN
110 120 130 140 150
LKLKEQGVEE EELEPRLRQG GRNTPYWYFL QCKRLLKEGK LAEALDLFER
160 170 180 190 200
QMLKEERLQP LECNYTVLIG GCGRVGYLKK AFRLFNDMKK RDLEPSDATY
210 220 230 240 250
TALFNVCAES PWKDSALQSA LKLRQQLQAQ NFQLNLKTYH ALLKVAAKCA
260 270 280 290 300
DLRVCLEVFK EIIQKGHAVT EETFCFLLMG CIQDKKTGFR QAMQVWRQML
310 320 330 340 350
SLGIKPSRHG YNLLLGAARD CGLGDPEVAS RLLLTSQEET ILLQPPTGRR
360 370 380 390 400
LAGGKVQAKT RHGVSVKHVE ALERQLFLEP SHKLEGPPAF PEARETSRTQ
410 420 430 440 450
PEVETKAEPG HMGALAPLAL KPPDLELQVN LLSLGALSPA VVSFGTVATP
460 470 480 490 500
ADRLALMGGL EGFLGKMAEH RLQPDIKTLT LLAEVVEPGS PAESSLLSIL
510 520 530 540 550
DRHRVEADIT FFNTLIRKKS KLGDLEGAKA LLPILAKKGI VPNLRTFCNL
560 570 580 590 600
AIGCHRPRDG MQLLADMKKS QVTPNTHIYS TLINAALKKL DYTYLISILK
610 620 630 640 650
DMRRNSVPVN EVVIRQLEFA AQYPPTFDRY KEKNTYLEKI DGFRAYYKQW
660 670 680
LKVMPAEEPP HPWQEFRDKP VRNQVITENA GGLRDG
Length:686
Mass (Da):77,121
Last modified:March 20, 2007 - v1
Checksum:i626472E097FBCA11
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR06070420 Genomic DNA No translation available.
BC129116 mRNA Translation: AAI29117.1
RefSeqiXP_006248933.1, XM_006248871.1
UniGeneiRn.105071

Genome annotation databases

EnsembliENSRNOT00000076896; ENSRNOP00000068093; ENSRNOG00000000987
GeneIDi304278

Similar proteinsi

Entry informationi

Entry nameiPTCD1_RAT
AccessioniPrimary (citable) accession number: A2VD13
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 31, 2012
Last sequence update: March 20, 2007
Last modified: May 23, 2018
This is version 75 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health