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Protein

Mediator of RNA polymerase II transcription subunit 13-like

Gene

zgc:153454

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Component of the Mediator complex, a coactivator involved in regulated gene transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActivator, Repressor
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Mediator of RNA polymerase II transcription subunit 13-like
Alternative name(s):
Thyroid hormone receptor-associated protein complex 240 kDa component-like protein
Gene namesi
ORF Names:zgc:153454
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Unplaced

Organism-specific databases

ZFINiZDB-GENE-030131-3529. med13b.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003142411 – 2102Mediator of RNA polymerase II transcription subunit 13-likeAdd BLAST2102

Proteomic databases

PaxDbiA2VCZ5.
PeptideAtlasiA2VCZ5.
PRIDEiA2VCZ5.

Interactioni

Subunit structurei

Component of the Mediator complex.By similarity

Protein-protein interaction databases

STRINGi7955.ENSDARP00000101475.

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi1165 – 1169LXXLL motif 15
Motifi1254 – 1258LXXLL motif 25

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi533 – 596Pro-richAdd BLAST64
Compositional biasi1416 – 1502Ser-richAdd BLAST87

Sequence similaritiesi

Belongs to the Mediator complex subunit 13 family.Curated

Phylogenomic databases

eggNOGiKOG3600. Eukaryota.
ENOG410XPV2. LUCA.
HOGENOMiHOG000012893.
HOVERGENiHBG058069.
InParanoidiA2VCZ5.
KOiK15164.
PhylomeDBiA2VCZ5.

Family and domain databases

InterProiView protein in InterPro
IPR009401. Mediator_Med13.
IPR021643. Mediator_Med13_N_met/fun.
PfamiView protein in Pfam
PF06333. Med13_C. 1 hit.
PF11597. Med13_N. 1 hit.

Sequencei

Sequence statusi: Complete.

A2VCZ5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSCFVPNGA SLEDCHSNLF CLADLTGIKW KCFVWQGPTS SPILFPVTEE
60 70 80 90 100
DPILCSFSRC LKADVLSVWR RHQTPGRREL WIFWWGDDPN FAELVHHDLS
110 120 130 140 150
CNEDGSWESG LTYECRTLLF KAIHNLLERC LMNRSFVRIG KWFVKPYEKD
160 170 180 190 200
EKPINKSEHL SCSFTFFVHG DSNVCTSVEI NQHQPVYLLS EEHLTLAQQS
210 220 230 240 250
SSSVQVILSP YGLSGTLTGQ SFKLSDPPTQ KLIEEWKQFY PIGPNTKEVT
260 270 280 290 300
DDKMDDLDWE DDSLAAVEVV VAGVRMVYPA SLVLVAQSDI PLVATVSSSS
310 320 330 340 350
SSGSYAGAPH NQLVHGDTGI SSVTLTPPTS PEEAQAVSQP AQKWVKLSAM
360 370 380 390 400
SGVFSVDSSS HHGGKIPRRL ASQMVERVWQ ECNINRAQNK RKFSTMSNGV
410 420 430 440 450
CEEETDKASV WDFVESSQRS QCSCSRLKNQ KQRACSTPGH PPSAGQPPQP
460 470 480 490 500
STKHKMAEKL EKGDKQQKRP LTPFHHRSSL CEEQPSLEQG ESVHRLCLQG
510 520 530 540 550
HEDSRYPSLH HADVTSSKTP MLHSSADEMA GSPQPPPLSP HPCERMEEPA
560 570 580 590 600
DGMKSSSSPL HQHFYPPSSE PCLEPQKPPD ESTLDPLPLP CPPPYPETLE
610 620 630 640 650
ATIYVGSAIN PNEDTTHNPW KYFRVPGGRN SDFHTPHLPV VAHFEDGNRT
660 670 680 690 700
GGQDGIVSIT EMMSSSKRPL KVSEELVKMY EHKKNQYLSS AVCDEDPEQE
710 720 730 740 750
SDPYAFEEGD EEFNFSDKDK KSGPEREAGK KAKREDGSSS SDDAQGSGGS
760 770 780 790 800
KPLPTTSLIH ETDLVVSIND LDNLFNSDED DLTQPGSRRA AGGAEEKFGG
810 820 830 840 850
KEPKPAAPDP LPCCADLHQM FPTPPSLDQG YSPINMGNTE SAAGLSLLDG
860 870 880 890 900
AMSGNFKMEV EEGFCSPKPS EIKDFSYVFK PESCQALIGC SLYAPLKTLP
910 920 930 940 950
SQCLLPVKLP EECVYRPSWT VGKLGMLQPM AAMTFLNKDS NIPSVGSVVE
960 970 980 990 1000
QEQSCTPQTH NTFMSNSAPP SNSGAGILPS PATPRISAPT PRTPRTPRTP
1010 1020 1030 1040 1050
RGPASVQGSL KYENSDLNSP ASTPSTCRPL SSVEPATVPS IPEAHSLYVT
1060 1070 1080 1090 1100
LILSESVMNL FKDCNFDSCC ICVCNMNITG ADVGIYISDP NMDSQYSSMD
1110 1120 1130 1140 1150
PCSCGFSAVM NRRYGNGAGL FLEDELDIMG RGSDAAREIE KHFEAVRAAS
1160 1170 1180 1190 1200
LKRGTVLEEQ VPDDLMLLLQ DLCTNPFSPI IRPDLLGTVI KSPIRLEERD
1210 1220 1230 1240 1250
YYSDCYMALE HGRQFMDNMS GGKVDETLVK SSSLHHWAKR NAFDMSMLFS
1260 1270 1280 1290 1300
QDVLRMLLSL QPVLQDTIQK KRSVRSWGVQ GPLTWQQFHK MAGRGSYGTD
1310 1320 1330 1340 1350
ESPEPLPIPT LLVGYEYDYV VLSPFALPYW EKLLLDPYSS QRDVGYMVVC
1360 1370 1380 1390 1400
PDNEALLNGA KTFFRDLTAV YESCRLGQHR PIAKSHADGI VTVSDAGSKA
1410 1420 1430 1440 1450
LTDQTLIDWL PKTINSSSSS EALNKLKLYA HVCRHDLASC LASQSLDGSL
1460 1470 1480 1490 1500
LTQRNPASSS QTSSSSSPVT TAQNVTPTTN SNSNTNTNTT PTSTSTSSSS
1510 1520 1530 1540 1550
SSCPQGVGNM PSSKPNTIPP FGAQGLQSSQ QSGGQSAGTL GDATSATSQP
1560 1570 1580 1590 1600
QVPSEPAEST MEREKVGVPT DGDSHAVTYP PAIVIYIVNP FSYEENCQGS
1610 1620 1630 1640 1650
SSSVWTIALL RCYLEMLQLL PPHIRNAVYV QIIPSQYLLQ PVWSEERHIY
1660 1670 1680 1690 1700
AQHLKSLAFS VYTQCRRRLP TSTNVKTLTG FGPGLAIDTA LQSKERPQCL
1710 1720 1730 1740 1750
HLYAPPFVLA PVKDKQTELG ETFGEAAQKY NVLFVAYCLS HDQRWLLASC
1760 1770 1780 1790 1800
TDQYGELLET CVISIDVPNR ARRKKGSARR QGLQKLWEWC LDLVQMTSLP
1810 1820 1830 1840 1850
WRIVIGRLGR IGHGELRDWS ILLSRRNLQS LGRRLKEMCR MCGISAADSP
1860 1870 1880 1890 1900
SILSTCLVAM EPQASFVIMP DSVSTGSVFG RSTTLNMQTS QLNTPQDTSC
1910 1920 1930 1940 1950
THILVFPTSA GLQAFSDVTD GMGGMDGILD LFAENDLVDP DLINIIPNSP
1960 1970 1980 1990 2000
TTSPVHSPGS HYHHGGDGSK GQGTDRMESH DESPNILQQP MALGYFVSTA
2010 2020 2030 2040 2050
KAGPLPDWFW SSCPQAKNQC PLFLKASLHL NVSSVQSDEL LHSKHSHPLD
2060 2070 2080 2090 2100
SSHTSDVLRF VLEQYNALSW LTCDPATQDR RSCLPVHFVV LNQMYNFIMN

ML
Length:2,102
Mass (Da):230,992
Last modified:March 20, 2007 - v1
Checksum:iEB09861E48DCFDE7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC129032 mRNA. Translation: AAI29033.1.
RefSeqiNP_001077307.1. NM_001083838.1.
UniGeneiDr.36004.

Genome annotation databases

GeneIDi564707.
KEGGidre:564707.

Similar proteinsi

Entry informationi

Entry nameiMD13L_DANRE
AccessioniPrimary (citable) accession number: A2VCZ5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: March 20, 2007
Last modified: October 5, 2016
This is version 60 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Caution

This sequence is encoded by a gene on chromosome 15 and is unlikely to be the med13 ortholog because it shows similarity but not synteny with human MED13. The chromosome 10 med13 gene identified by PubMed:17208216 is distinct from this entry.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families