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A2VCU8

- NELL2_XENTR

UniProt

A2VCU8 - NELL2_XENTR

Protein

Protein kinase C-binding protein NELL2

Gene

nell2

Organism
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 52 (01 Oct 2014)
      Sequence version 1 (20 Mar 2007)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. calcium ion binding Source: InterPro

    Keywords - Ligandi

    Calcium

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein kinase C-binding protein NELL2
    Alternative name(s):
    NEL-like protein 2
    Gene namesi
    Name:nell2
    OrganismiXenopus tropicalis (Western clawed frog) (Silurana tropicalis)
    Taxonomic identifieri8364 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusSilurana
    ProteomesiUP000008143: Unplaced

    Organism-specific databases

    XenbaseiXB-GENE-852641. nell2.

    Subcellular locationi

    Secreted By similarity

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1919Sequence AnalysisAdd
    BLAST
    Chaini20 – 814795Protein kinase C-binding protein NELL2PRO_0000354685Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi51 – 511N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi223 – 2231N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi296 – 2961N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi399 ↔ 411PROSITE-ProRule annotation
    Disulfide bondi405 ↔ 420PROSITE-ProRule annotation
    Disulfide bondi422 ↔ 436PROSITE-ProRule annotation
    Disulfide bondi442 ↔ 455PROSITE-ProRule annotation
    Disulfide bondi449 ↔ 464PROSITE-ProRule annotation
    Disulfide bondi466 ↔ 478PROSITE-ProRule annotation
    Disulfide bondi484 ↔ 497PROSITE-ProRule annotation
    Disulfide bondi491 ↔ 506PROSITE-ProRule annotation
    Disulfide bondi508 ↔ 519PROSITE-ProRule annotation
    Glycosylationi515 – 5151N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi523 ↔ 533PROSITE-ProRule annotation
    Disulfide bondi527 ↔ 539PROSITE-ProRule annotation
    Disulfide bondi541 ↔ 550PROSITE-ProRule annotation
    Disulfide bondi557 ↔ 570PROSITE-ProRule annotation
    Disulfide bondi564 ↔ 579PROSITE-ProRule annotation
    Disulfide bondi581 ↔ 598PROSITE-ProRule annotation
    Disulfide bondi604 ↔ 617PROSITE-ProRule annotation
    Disulfide bondi611 ↔ 626PROSITE-ProRule annotation
    Glycosylationi613 – 6131N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi628 ↔ 634PROSITE-ProRule annotation
    Glycosylationi633 – 6331N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Expressioni

    Gene expression databases

    BgeeiA2VCU8.

    Interactioni

    Protein-protein interaction databases

    STRINGi8364.ENSXETP00000032027.

    Structurei

    3D structure databases

    ProteinModelPortaliA2VCU8.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini53 – 226174Laminin G-likeAdd
    BLAST
    Domaini270 – 32960VWFC 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini395 – 43743EGF-like 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini438 – 47942EGF-like 2; calcium-bindingPROSITE-ProRule annotationAdd
    BLAST
    Domaini480 – 52041EGF-like 3; calcium-bindingPROSITE-ProRule annotationAdd
    BLAST
    Domaini521 – 55131EGF-like 4PROSITE-ProRule annotationAdd
    BLAST
    Domaini553 – 59947EGF-like 5; calcium-bindingPROSITE-ProRule annotationAdd
    BLAST
    Domaini600 – 63536EGF-like 6; calcium-bindingPROSITE-ProRule annotationAdd
    BLAST
    Domaini636 – 69156VWFC 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini696 – 75459VWFC 3PROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 6 EGF-like domains.PROSITE-ProRule annotation
    Contains 1 laminin G-like domain.Curated
    Contains 3 VWFC domains.PROSITE-ProRule annotation

    Keywords - Domaini

    EGF-like domain, Repeat, Signal

    Phylogenomic databases

    eggNOGiNOG253557.
    GeneTreeiENSGT00750000117321.
    HOGENOMiHOG000217920.
    HOVERGENiHBG004805.
    OMAiDTICFNL.
    OrthoDBiEOG71VSRX.
    TreeFamiTF323325.

    Family and domain databases

    Gene3Di2.60.120.200. 1 hit.
    InterProiIPR008985. ConA-like_lec_gl_sf.
    IPR013320. ConA-like_subgrp.
    IPR000742. EG-like_dom.
    IPR001881. EGF-like_Ca-bd_dom.
    IPR013032. EGF-like_CS.
    IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
    IPR018097. EGF_Ca-bd_CS.
    IPR009030. Growth_fac_rcpt_N_dom.
    IPR001791. Laminin_G.
    IPR001007. VWF_C.
    [Graphical view]
    PfamiPF07645. EGF_CA. 4 hits.
    PF02210. Laminin_G_2. 1 hit.
    PF00093. VWC. 2 hits.
    [Graphical view]
    SMARTiSM00181. EGF. 4 hits.
    SM00179. EGF_CA. 2 hits.
    SM00282. LamG. 1 hit.
    SM00210. TSPN. 1 hit.
    SM00214. VWC. 3 hits.
    [Graphical view]
    SUPFAMiSSF49899. SSF49899. 1 hit.
    SSF57184. SSF57184. 1 hit.
    PROSITEiPS00010. ASX_HYDROXYL. 3 hits.
    PS00022. EGF_1. 1 hit.
    PS01186. EGF_2. 3 hits.
    PS50026. EGF_3. 6 hits.
    PS01187. EGF_CA. 3 hits.
    PS01208. VWFC_1. 2 hits.
    PS50184. VWFC_2. 3 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    A2VCU8-1 [UniParc]FASTAAdd to Basket

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    MEFILGIFCV IFCLRAGAGF GVDPSLQIDI FEDFQLGEAT PGVQQVQGFH    50
    NRSKAFLFQD TSRSIKASAE TAERIFTKLR NKHEFTILVT LKQAMLNSGV 100
    ILSIHHADHR YLELESSGHR NEVRLHYRSG SHRSQTEVFP YILADDKWHR 150
    FSIAISASHL VLHIDCNKIY ERIVEKTFMD VPPGTALWVG QRNNVHGYFK 200
    GIMQDLQIVV MPQGFISQCP DLNRTCPTCN DFHGLVQKIM ELQDILAKTS 250
    AKLSRAEQRM NRLDQCYCER SCTVKGNIYR ELESWMDGCK KCTCTNGTAQ 300
    CETLTCSVPN CLSGFAPAYV PGKCCKECQP VCMYQGQMYF EGEQEAVQSS 350
    SGACVLFQCK SNTMQRIESP ECLPLNCPQS QHITLRSGCC KVCKGHDFCS 400
    EGHNCVEYSI CKNLNDKAVC ICRDGFRALR EDSAYCEDID ECTEGRHYCR 450
    ENTVCVNTPG SFMCVCQTGY LKIDDYSCTE HNECATNQHS CDENAVCYNT 500
    VGGHNCVCQP GYTGNGTVCK AFCTDGCRNG GTCIAPNICA CPQGFTGPSC 550
    EADIDECTEG FVQCDSRANC INLPGWYHCE CRDGYHDNGM FSLSGESCED 600
    IDECATGRHS CSNDTVCFNL DGGFDCRCPH GKNCSGDCTH EGKIKHNGQI 650
    WVLENDRCSV CSCQVGLVMC RRMVCDCENP TVDLFCCPEC DPRLSSQCLH 700
    QSGELTYKSG DTWVQNCQQC RCLQGEVDCW PLPCPEIDCE FSVVPESECC 750
    PRCISDPCQA DIIRNDITKT CVDETNVVRF TGSSWIKHGT ECTLCQCKNG 800
    HMCCSVDPQC LQEL 814
    Length:814
    Mass (Da):90,762
    Last modified:March 20, 2007 - v1
    Checksum:i87EB9F240779A9B7
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC128627 mRNA. Translation: AAI28628.1.
    RefSeqiNP_001090754.1. NM_001097285.1.
    UniGeneiStr.62624.

    Genome annotation databases

    EnsembliENSXETT00000032027; ENSXETP00000032027; ENSXETG00000014625.
    GeneIDi100037839.
    KEGGixtr:100037839.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC128627 mRNA. Translation: AAI28628.1 .
    RefSeqi NP_001090754.1. NM_001097285.1.
    UniGenei Str.62624.

    3D structure databases

    ProteinModelPortali A2VCU8.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 8364.ENSXETP00000032027.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSXETT00000032027 ; ENSXETP00000032027 ; ENSXETG00000014625 .
    GeneIDi 100037839.
    KEGGi xtr:100037839.

    Organism-specific databases

    CTDi 4753.
    Xenbasei XB-GENE-852641. nell2.

    Phylogenomic databases

    eggNOGi NOG253557.
    GeneTreei ENSGT00750000117321.
    HOGENOMi HOG000217920.
    HOVERGENi HBG004805.
    OMAi DTICFNL.
    OrthoDBi EOG71VSRX.
    TreeFami TF323325.

    Gene expression databases

    Bgeei A2VCU8.

    Family and domain databases

    Gene3Di 2.60.120.200. 1 hit.
    InterProi IPR008985. ConA-like_lec_gl_sf.
    IPR013320. ConA-like_subgrp.
    IPR000742. EG-like_dom.
    IPR001881. EGF-like_Ca-bd_dom.
    IPR013032. EGF-like_CS.
    IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
    IPR018097. EGF_Ca-bd_CS.
    IPR009030. Growth_fac_rcpt_N_dom.
    IPR001791. Laminin_G.
    IPR001007. VWF_C.
    [Graphical view ]
    Pfami PF07645. EGF_CA. 4 hits.
    PF02210. Laminin_G_2. 1 hit.
    PF00093. VWC. 2 hits.
    [Graphical view ]
    SMARTi SM00181. EGF. 4 hits.
    SM00179. EGF_CA. 2 hits.
    SM00282. LamG. 1 hit.
    SM00210. TSPN. 1 hit.
    SM00214. VWC. 3 hits.
    [Graphical view ]
    SUPFAMi SSF49899. SSF49899. 1 hit.
    SSF57184. SSF57184. 1 hit.
    PROSITEi PS00010. ASX_HYDROXYL. 3 hits.
    PS00022. EGF_1. 1 hit.
    PS01186. EGF_2. 3 hits.
    PS50026. EGF_3. 6 hits.
    PS01187. EGF_CA. 3 hits.
    PS01208. VWFC_1. 2 hits.
    PS50184. VWFC_2. 3 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. NIH - Xenopus Gene Collection (XGC) project
      Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain.

    Entry informationi

    Entry nameiNELL2_XENTR
    AccessioniPrimary (citable) accession number: A2VCU8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 25, 2008
    Last sequence update: March 20, 2007
    Last modified: October 1, 2014
    This is version 52 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3