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A2VCU8

- NELL2_XENTR

UniProt

A2VCU8 - NELL2_XENTR

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Protein

Protein kinase C-binding protein NELL2

Gene
nell2
Organism
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Status
Reviewed - Annotation score: 2 out of 5 - Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. calcium ion binding Source: InterPro
Complete GO annotation...

Keywords - Ligandi

Calcium

Names & Taxonomyi

Protein namesi
Recommended name:
Protein kinase C-binding protein NELL2
Alternative name(s):
NEL-like protein 2
Gene namesi
Name:nell2
OrganismiXenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Taxonomic identifieri8364 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusSilurana
ProteomesiUP000008143: Unplaced

Organism-specific databases

XenbaseiXB-GENE-852641. nell2.

Subcellular locationi

Secreted By similarity

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1919 Reviewed predictionAdd
BLAST
Chaini20 – 814795Protein kinase C-binding protein NELL2PRO_0000354685Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi51 – 511N-linked (GlcNAc...) Reviewed prediction
Glycosylationi223 – 2231N-linked (GlcNAc...) Reviewed prediction
Glycosylationi296 – 2961N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi399 ↔ 411 By similarity
Disulfide bondi405 ↔ 420 By similarity
Disulfide bondi422 ↔ 436 By similarity
Disulfide bondi442 ↔ 455 By similarity
Disulfide bondi449 ↔ 464 By similarity
Disulfide bondi466 ↔ 478 By similarity
Disulfide bondi484 ↔ 497 By similarity
Disulfide bondi491 ↔ 506 By similarity
Disulfide bondi508 ↔ 519 By similarity
Glycosylationi515 – 5151N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi523 ↔ 533 By similarity
Disulfide bondi527 ↔ 539 By similarity
Disulfide bondi541 ↔ 550 By similarity
Disulfide bondi557 ↔ 570 By similarity
Disulfide bondi564 ↔ 579 By similarity
Disulfide bondi581 ↔ 598 By similarity
Disulfide bondi604 ↔ 617 By similarity
Disulfide bondi611 ↔ 626 By similarity
Glycosylationi613 – 6131N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi628 ↔ 634 By similarity
Glycosylationi633 – 6331N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Disulfide bond, Glycoprotein

Expressioni

Gene expression databases

BgeeiA2VCU8.

Interactioni

Protein-protein interaction databases

STRINGi8364.ENSXETP00000032027.

Structurei

3D structure databases

ProteinModelPortaliA2VCU8.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini53 – 226174Laminin G-likeAdd
BLAST
Domaini270 – 32960VWFC 1Add
BLAST
Domaini395 – 43743EGF-like 1Add
BLAST
Domaini438 – 47942EGF-like 2; calcium-binding Reviewed predictionAdd
BLAST
Domaini480 – 52041EGF-like 3; calcium-binding Reviewed predictionAdd
BLAST
Domaini521 – 55131EGF-like 4Add
BLAST
Domaini553 – 59947EGF-like 5; calcium-binding Reviewed predictionAdd
BLAST
Domaini600 – 63536EGF-like 6; calcium-binding Reviewed predictionAdd
BLAST
Domaini636 – 69156VWFC 2Add
BLAST
Domaini696 – 75459VWFC 3Add
BLAST

Sequence similaritiesi

Contains 6 EGF-like domains.
Contains 3 VWFC domains.

Keywords - Domaini

EGF-like domain, Repeat, Signal

Phylogenomic databases

eggNOGiNOG253557.
GeneTreeiENSGT00750000117321.
HOGENOMiHOG000217920.
HOVERGENiHBG004805.
OMAiDTICFNL.
OrthoDBiEOG71VSRX.
TreeFamiTF323325.

Family and domain databases

Gene3Di2.60.120.200. 1 hit.
InterProiIPR008985. ConA-like_lec_gl_sf.
IPR013320. ConA-like_subgrp.
IPR000742. EG-like_dom.
IPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
IPR018097. EGF_Ca-bd_CS.
IPR009030. Growth_fac_rcpt_N_dom.
IPR001791. Laminin_G.
IPR001007. VWF_C.
[Graphical view]
PfamiPF07645. EGF_CA. 4 hits.
PF02210. Laminin_G_2. 1 hit.
PF00093. VWC. 2 hits.
[Graphical view]
SMARTiSM00181. EGF. 4 hits.
SM00179. EGF_CA. 2 hits.
SM00282. LamG. 1 hit.
SM00210. TSPN. 1 hit.
SM00214. VWC. 3 hits.
[Graphical view]
SUPFAMiSSF49899. SSF49899. 1 hit.
SSF57184. SSF57184. 1 hit.
PROSITEiPS00010. ASX_HYDROXYL. 3 hits.
PS00022. EGF_1. 1 hit.
PS01186. EGF_2. 3 hits.
PS50026. EGF_3. 6 hits.
PS01187. EGF_CA. 3 hits.
PS01208. VWFC_1. 2 hits.
PS50184. VWFC_2. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

A2VCU8-1 [UniParc]FASTAAdd to Basket

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MEFILGIFCV IFCLRAGAGF GVDPSLQIDI FEDFQLGEAT PGVQQVQGFH    50
NRSKAFLFQD TSRSIKASAE TAERIFTKLR NKHEFTILVT LKQAMLNSGV 100
ILSIHHADHR YLELESSGHR NEVRLHYRSG SHRSQTEVFP YILADDKWHR 150
FSIAISASHL VLHIDCNKIY ERIVEKTFMD VPPGTALWVG QRNNVHGYFK 200
GIMQDLQIVV MPQGFISQCP DLNRTCPTCN DFHGLVQKIM ELQDILAKTS 250
AKLSRAEQRM NRLDQCYCER SCTVKGNIYR ELESWMDGCK KCTCTNGTAQ 300
CETLTCSVPN CLSGFAPAYV PGKCCKECQP VCMYQGQMYF EGEQEAVQSS 350
SGACVLFQCK SNTMQRIESP ECLPLNCPQS QHITLRSGCC KVCKGHDFCS 400
EGHNCVEYSI CKNLNDKAVC ICRDGFRALR EDSAYCEDID ECTEGRHYCR 450
ENTVCVNTPG SFMCVCQTGY LKIDDYSCTE HNECATNQHS CDENAVCYNT 500
VGGHNCVCQP GYTGNGTVCK AFCTDGCRNG GTCIAPNICA CPQGFTGPSC 550
EADIDECTEG FVQCDSRANC INLPGWYHCE CRDGYHDNGM FSLSGESCED 600
IDECATGRHS CSNDTVCFNL DGGFDCRCPH GKNCSGDCTH EGKIKHNGQI 650
WVLENDRCSV CSCQVGLVMC RRMVCDCENP TVDLFCCPEC DPRLSSQCLH 700
QSGELTYKSG DTWVQNCQQC RCLQGEVDCW PLPCPEIDCE FSVVPESECC 750
PRCISDPCQA DIIRNDITKT CVDETNVVRF TGSSWIKHGT ECTLCQCKNG 800
HMCCSVDPQC LQEL 814
Length:814
Mass (Da):90,762
Last modified:March 20, 2007 - v1
Checksum:i87EB9F240779A9B7
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC128627 mRNA. Translation: AAI28628.1.
RefSeqiNP_001090754.1. NM_001097285.1.
UniGeneiStr.62624.

Genome annotation databases

EnsembliENSXETT00000032027; ENSXETP00000032027; ENSXETG00000014625.
GeneIDi100037839.
KEGGixtr:100037839.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC128627 mRNA. Translation: AAI28628.1 .
RefSeqi NP_001090754.1. NM_001097285.1.
UniGenei Str.62624.

3D structure databases

ProteinModelPortali A2VCU8.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 8364.ENSXETP00000032027.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSXETT00000032027 ; ENSXETP00000032027 ; ENSXETG00000014625 .
GeneIDi 100037839.
KEGGi xtr:100037839.

Organism-specific databases

CTDi 4753.
Xenbasei XB-GENE-852641. nell2.

Phylogenomic databases

eggNOGi NOG253557.
GeneTreei ENSGT00750000117321.
HOGENOMi HOG000217920.
HOVERGENi HBG004805.
OMAi DTICFNL.
OrthoDBi EOG71VSRX.
TreeFami TF323325.

Gene expression databases

Bgeei A2VCU8.

Family and domain databases

Gene3Di 2.60.120.200. 1 hit.
InterProi IPR008985. ConA-like_lec_gl_sf.
IPR013320. ConA-like_subgrp.
IPR000742. EG-like_dom.
IPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
IPR018097. EGF_Ca-bd_CS.
IPR009030. Growth_fac_rcpt_N_dom.
IPR001791. Laminin_G.
IPR001007. VWF_C.
[Graphical view ]
Pfami PF07645. EGF_CA. 4 hits.
PF02210. Laminin_G_2. 1 hit.
PF00093. VWC. 2 hits.
[Graphical view ]
SMARTi SM00181. EGF. 4 hits.
SM00179. EGF_CA. 2 hits.
SM00282. LamG. 1 hit.
SM00210. TSPN. 1 hit.
SM00214. VWC. 3 hits.
[Graphical view ]
SUPFAMi SSF49899. SSF49899. 1 hit.
SSF57184. SSF57184. 1 hit.
PROSITEi PS00010. ASX_HYDROXYL. 3 hits.
PS00022. EGF_1. 1 hit.
PS01186. EGF_2. 3 hits.
PS50026. EGF_3. 6 hits.
PS01187. EGF_CA. 3 hits.
PS01208. VWFC_1. 2 hits.
PS50184. VWFC_2. 3 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. NIH - Xenopus Gene Collection (XGC) project
    Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.

Entry informationi

Entry nameiNELL2_XENTR
AccessioniPrimary (citable) accession number: A2VCU8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 25, 2008
Last sequence update: March 20, 2007
Last modified: April 16, 2014
This is version 51 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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