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A2VCU8

- NELL2_XENTR

UniProt

A2VCU8 - NELL2_XENTR

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Protein

Protein kinase C-binding protein NELL2

Gene

nell2

Organism
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. calcium ion binding Source: InterPro
Complete GO annotation...

Keywords - Ligandi

Calcium

Names & Taxonomyi

Protein namesi
Recommended name:
Protein kinase C-binding protein NELL2
Alternative name(s):
NEL-like protein 2
Gene namesi
Name:nell2
OrganismiXenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Taxonomic identifieri8364 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusSilurana
ProteomesiUP000008143: Unplaced

Organism-specific databases

XenbaseiXB-GENE-852641. nell2.

Subcellular locationi

Secreted By similarity

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1919Sequence AnalysisAdd
BLAST
Chaini20 – 814795Protein kinase C-binding protein NELL2PRO_0000354685Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi51 – 511N-linked (GlcNAc...)Sequence Analysis
Glycosylationi223 – 2231N-linked (GlcNAc...)Sequence Analysis
Glycosylationi296 – 2961N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi399 ↔ 411PROSITE-ProRule annotation
Disulfide bondi405 ↔ 420PROSITE-ProRule annotation
Disulfide bondi422 ↔ 436PROSITE-ProRule annotation
Disulfide bondi442 ↔ 455PROSITE-ProRule annotation
Disulfide bondi449 ↔ 464PROSITE-ProRule annotation
Disulfide bondi466 ↔ 478PROSITE-ProRule annotation
Disulfide bondi484 ↔ 497PROSITE-ProRule annotation
Disulfide bondi491 ↔ 506PROSITE-ProRule annotation
Disulfide bondi508 ↔ 519PROSITE-ProRule annotation
Glycosylationi515 – 5151N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi523 ↔ 533PROSITE-ProRule annotation
Disulfide bondi527 ↔ 539PROSITE-ProRule annotation
Disulfide bondi541 ↔ 550PROSITE-ProRule annotation
Disulfide bondi557 ↔ 570PROSITE-ProRule annotation
Disulfide bondi564 ↔ 579PROSITE-ProRule annotation
Disulfide bondi581 ↔ 598PROSITE-ProRule annotation
Disulfide bondi604 ↔ 617PROSITE-ProRule annotation
Disulfide bondi611 ↔ 626PROSITE-ProRule annotation
Glycosylationi613 – 6131N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi628 ↔ 634PROSITE-ProRule annotation
Glycosylationi633 – 6331N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Expressioni

Gene expression databases

BgeeiA2VCU8.

Interactioni

Protein-protein interaction databases

STRINGi8364.ENSXETP00000032027.

Structurei

3D structure databases

ProteinModelPortaliA2VCU8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini53 – 226174Laminin G-likeAdd
BLAST
Domaini270 – 32960VWFC 1PROSITE-ProRule annotationAdd
BLAST
Domaini395 – 43743EGF-like 1PROSITE-ProRule annotationAdd
BLAST
Domaini438 – 47942EGF-like 2; calcium-bindingPROSITE-ProRule annotationAdd
BLAST
Domaini480 – 52041EGF-like 3; calcium-bindingPROSITE-ProRule annotationAdd
BLAST
Domaini521 – 55131EGF-like 4PROSITE-ProRule annotationAdd
BLAST
Domaini553 – 59947EGF-like 5; calcium-bindingPROSITE-ProRule annotationAdd
BLAST
Domaini600 – 63536EGF-like 6; calcium-bindingPROSITE-ProRule annotationAdd
BLAST
Domaini636 – 69156VWFC 2PROSITE-ProRule annotationAdd
BLAST
Domaini696 – 75459VWFC 3PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 6 EGF-like domains.PROSITE-ProRule annotation
Contains 1 laminin G-like domain.Curated
Contains 3 VWFC domains.PROSITE-ProRule annotation

Keywords - Domaini

EGF-like domain, Repeat, Signal

Phylogenomic databases

eggNOGiNOG253557.
GeneTreeiENSGT00750000117321.
HOGENOMiHOG000217920.
HOVERGENiHBG004805.
InParanoidiA2VCU8.
OMAiDTICFNL.
OrthoDBiEOG71VSRX.
TreeFamiTF323325.

Family and domain databases

Gene3Di2.60.120.200. 1 hit.
InterProiIPR013320. ConA-like_dom.
IPR000742. EG-like_dom.
IPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
IPR018097. EGF_Ca-bd_CS.
IPR009030. Growth_fac_rcpt_N_dom.
IPR001791. Laminin_G.
IPR001007. VWF_C.
[Graphical view]
PfamiPF07645. EGF_CA. 4 hits.
PF02210. Laminin_G_2. 1 hit.
PF00093. VWC. 2 hits.
[Graphical view]
SMARTiSM00181. EGF. 4 hits.
SM00179. EGF_CA. 2 hits.
SM00282. LamG. 1 hit.
SM00210. TSPN. 1 hit.
SM00214. VWC. 3 hits.
[Graphical view]
SUPFAMiSSF49899. SSF49899. 1 hit.
SSF57184. SSF57184. 1 hit.
PROSITEiPS00010. ASX_HYDROXYL. 3 hits.
PS00022. EGF_1. 1 hit.
PS01186. EGF_2. 3 hits.
PS50026. EGF_3. 6 hits.
PS01187. EGF_CA. 3 hits.
PS01208. VWFC_1. 2 hits.
PS50184. VWFC_2. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

A2VCU8-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MEFILGIFCV IFCLRAGAGF GVDPSLQIDI FEDFQLGEAT PGVQQVQGFH
60 70 80 90 100
NRSKAFLFQD TSRSIKASAE TAERIFTKLR NKHEFTILVT LKQAMLNSGV
110 120 130 140 150
ILSIHHADHR YLELESSGHR NEVRLHYRSG SHRSQTEVFP YILADDKWHR
160 170 180 190 200
FSIAISASHL VLHIDCNKIY ERIVEKTFMD VPPGTALWVG QRNNVHGYFK
210 220 230 240 250
GIMQDLQIVV MPQGFISQCP DLNRTCPTCN DFHGLVQKIM ELQDILAKTS
260 270 280 290 300
AKLSRAEQRM NRLDQCYCER SCTVKGNIYR ELESWMDGCK KCTCTNGTAQ
310 320 330 340 350
CETLTCSVPN CLSGFAPAYV PGKCCKECQP VCMYQGQMYF EGEQEAVQSS
360 370 380 390 400
SGACVLFQCK SNTMQRIESP ECLPLNCPQS QHITLRSGCC KVCKGHDFCS
410 420 430 440 450
EGHNCVEYSI CKNLNDKAVC ICRDGFRALR EDSAYCEDID ECTEGRHYCR
460 470 480 490 500
ENTVCVNTPG SFMCVCQTGY LKIDDYSCTE HNECATNQHS CDENAVCYNT
510 520 530 540 550
VGGHNCVCQP GYTGNGTVCK AFCTDGCRNG GTCIAPNICA CPQGFTGPSC
560 570 580 590 600
EADIDECTEG FVQCDSRANC INLPGWYHCE CRDGYHDNGM FSLSGESCED
610 620 630 640 650
IDECATGRHS CSNDTVCFNL DGGFDCRCPH GKNCSGDCTH EGKIKHNGQI
660 670 680 690 700
WVLENDRCSV CSCQVGLVMC RRMVCDCENP TVDLFCCPEC DPRLSSQCLH
710 720 730 740 750
QSGELTYKSG DTWVQNCQQC RCLQGEVDCW PLPCPEIDCE FSVVPESECC
760 770 780 790 800
PRCISDPCQA DIIRNDITKT CVDETNVVRF TGSSWIKHGT ECTLCQCKNG
810
HMCCSVDPQC LQEL
Length:814
Mass (Da):90,762
Last modified:March 20, 2007 - v1
Checksum:i87EB9F240779A9B7
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC128627 mRNA. Translation: AAI28628.1.
RefSeqiNP_001090754.1. NM_001097285.1.
UniGeneiStr.62624.

Genome annotation databases

EnsembliENSXETT00000032027; ENSXETP00000032027; ENSXETG00000014625.
GeneIDi100037839.
KEGGixtr:100037839.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC128627 mRNA. Translation: AAI28628.1 .
RefSeqi NP_001090754.1. NM_001097285.1.
UniGenei Str.62624.

3D structure databases

ProteinModelPortali A2VCU8.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 8364.ENSXETP00000032027.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSXETT00000032027 ; ENSXETP00000032027 ; ENSXETG00000014625 .
GeneIDi 100037839.
KEGGi xtr:100037839.

Organism-specific databases

CTDi 4753.
Xenbasei XB-GENE-852641. nell2.

Phylogenomic databases

eggNOGi NOG253557.
GeneTreei ENSGT00750000117321.
HOGENOMi HOG000217920.
HOVERGENi HBG004805.
InParanoidi A2VCU8.
OMAi DTICFNL.
OrthoDBi EOG71VSRX.
TreeFami TF323325.

Gene expression databases

Bgeei A2VCU8.

Family and domain databases

Gene3Di 2.60.120.200. 1 hit.
InterProi IPR013320. ConA-like_dom.
IPR000742. EG-like_dom.
IPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
IPR018097. EGF_Ca-bd_CS.
IPR009030. Growth_fac_rcpt_N_dom.
IPR001791. Laminin_G.
IPR001007. VWF_C.
[Graphical view ]
Pfami PF07645. EGF_CA. 4 hits.
PF02210. Laminin_G_2. 1 hit.
PF00093. VWC. 2 hits.
[Graphical view ]
SMARTi SM00181. EGF. 4 hits.
SM00179. EGF_CA. 2 hits.
SM00282. LamG. 1 hit.
SM00210. TSPN. 1 hit.
SM00214. VWC. 3 hits.
[Graphical view ]
SUPFAMi SSF49899. SSF49899. 1 hit.
SSF57184. SSF57184. 1 hit.
PROSITEi PS00010. ASX_HYDROXYL. 3 hits.
PS00022. EGF_1. 1 hit.
PS01186. EGF_2. 3 hits.
PS50026. EGF_3. 6 hits.
PS01187. EGF_CA. 3 hits.
PS01208. VWFC_1. 2 hits.
PS50184. VWFC_2. 3 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. NIH - Xenopus Gene Collection (XGC) project
    Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.

Entry informationi

Entry nameiNELL2_XENTR
AccessioniPrimary (citable) accession number: A2VCU8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 25, 2008
Last sequence update: March 20, 2007
Last modified: October 29, 2014
This is version 53 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3