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Protein

Protein kinase C-binding protein NELL2

Gene

nell2

Organism
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

Complete GO annotation...

Keywords - Ligandi

Calcium

Names & Taxonomyi

Protein namesi
Recommended name:
Protein kinase C-binding protein NELL2
Alternative name(s):
NEL-like protein 2
Gene namesi
Name:nell2
OrganismiXenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Taxonomic identifieri8364 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusSilurana
Proteomesi
  • UP000008143 Componenti: Unassembled WGS sequence

Organism-specific databases

XenbaseiXB-GENE-852641. nell2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19Sequence analysisAdd BLAST19
ChainiPRO_000035468520 – 814Protein kinase C-binding protein NELL2Add BLAST795

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi51N-linked (GlcNAc...)Sequence analysis1
Glycosylationi223N-linked (GlcNAc...)Sequence analysis1
Glycosylationi296N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi399 ↔ 411PROSITE-ProRule annotation
Disulfide bondi405 ↔ 420PROSITE-ProRule annotation
Disulfide bondi422 ↔ 436PROSITE-ProRule annotation
Disulfide bondi442 ↔ 455PROSITE-ProRule annotation
Disulfide bondi449 ↔ 464PROSITE-ProRule annotation
Disulfide bondi466 ↔ 478PROSITE-ProRule annotation
Disulfide bondi484 ↔ 497PROSITE-ProRule annotation
Disulfide bondi491 ↔ 506PROSITE-ProRule annotation
Disulfide bondi508 ↔ 519PROSITE-ProRule annotation
Glycosylationi515N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi523 ↔ 533PROSITE-ProRule annotation
Disulfide bondi527 ↔ 539PROSITE-ProRule annotation
Disulfide bondi541 ↔ 550PROSITE-ProRule annotation
Disulfide bondi557 ↔ 570PROSITE-ProRule annotation
Disulfide bondi564 ↔ 579PROSITE-ProRule annotation
Disulfide bondi581 ↔ 598PROSITE-ProRule annotation
Disulfide bondi604 ↔ 617PROSITE-ProRule annotation
Disulfide bondi611 ↔ 626PROSITE-ProRule annotation
Glycosylationi613N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi628 ↔ 634PROSITE-ProRule annotation
Glycosylationi633N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiA2VCU8.

Expressioni

Gene expression databases

BgeeiENSXETG00000014625.

Interactioni

Protein-protein interaction databases

STRINGi8364.ENSXETP00000032027.

Structurei

3D structure databases

ProteinModelPortaliA2VCU8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini53 – 226Laminin G-likeAdd BLAST174
Domaini270 – 329VWFC 1PROSITE-ProRule annotationAdd BLAST60
Domaini395 – 437EGF-like 1PROSITE-ProRule annotationAdd BLAST43
Domaini438 – 479EGF-like 2; calcium-bindingPROSITE-ProRule annotationAdd BLAST42
Domaini480 – 520EGF-like 3; calcium-bindingPROSITE-ProRule annotationAdd BLAST41
Domaini521 – 551EGF-like 4PROSITE-ProRule annotationAdd BLAST31
Domaini553 – 599EGF-like 5; calcium-bindingPROSITE-ProRule annotationAdd BLAST47
Domaini600 – 635EGF-like 6; calcium-bindingPROSITE-ProRule annotationAdd BLAST36
Domaini636 – 691VWFC 2PROSITE-ProRule annotationAdd BLAST56
Domaini696 – 754VWFC 3PROSITE-ProRule annotationAdd BLAST59

Sequence similaritiesi

Contains 6 EGF-like domains.PROSITE-ProRule annotation
Contains 1 laminin G-like domain.Curated
Contains 3 VWFC domains.PROSITE-ProRule annotation

Keywords - Domaini

EGF-like domain, Repeat, Signal

Phylogenomic databases

eggNOGiENOG410IR7C. Eukaryota.
ENOG410XSZA. LUCA.
GeneTreeiENSGT00810000125439.
HOGENOMiHOG000217920.
HOVERGENiHBG004805.
InParanoidiA2VCU8.
OMAiSHHPHTE.
OrthoDBiEOG091G01DI.
TreeFamiTF323325.

Family and domain databases

Gene3Di2.60.120.200. 1 hit.
InterProiIPR013320. ConA-like_dom.
IPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR000742. EGF-like_dom.
IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
IPR018097. EGF_Ca-bd_CS.
IPR009030. Growth_fac_rcpt_.
IPR001791. Laminin_G.
IPR001007. VWF_dom.
[Graphical view]
PfamiPF07645. EGF_CA. 4 hits.
PF02210. Laminin_G_2. 1 hit.
PF00093. VWC. 2 hits.
[Graphical view]
SMARTiSM00181. EGF. 6 hits.
SM00179. EGF_CA. 5 hits.
SM00282. LamG. 1 hit.
SM00210. TSPN. 1 hit.
SM00214. VWC. 3 hits.
SM00215. VWC_out. 2 hits.
[Graphical view]
SUPFAMiSSF49899. SSF49899. 1 hit.
SSF57184. SSF57184. 1 hit.
PROSITEiPS00010. ASX_HYDROXYL. 3 hits.
PS00022. EGF_1. 1 hit.
PS01186. EGF_2. 3 hits.
PS50026. EGF_3. 6 hits.
PS01187. EGF_CA. 3 hits.
PS01208. VWFC_1. 2 hits.
PS50184. VWFC_2. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

A2VCU8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEFILGIFCV IFCLRAGAGF GVDPSLQIDI FEDFQLGEAT PGVQQVQGFH
60 70 80 90 100
NRSKAFLFQD TSRSIKASAE TAERIFTKLR NKHEFTILVT LKQAMLNSGV
110 120 130 140 150
ILSIHHADHR YLELESSGHR NEVRLHYRSG SHRSQTEVFP YILADDKWHR
160 170 180 190 200
FSIAISASHL VLHIDCNKIY ERIVEKTFMD VPPGTALWVG QRNNVHGYFK
210 220 230 240 250
GIMQDLQIVV MPQGFISQCP DLNRTCPTCN DFHGLVQKIM ELQDILAKTS
260 270 280 290 300
AKLSRAEQRM NRLDQCYCER SCTVKGNIYR ELESWMDGCK KCTCTNGTAQ
310 320 330 340 350
CETLTCSVPN CLSGFAPAYV PGKCCKECQP VCMYQGQMYF EGEQEAVQSS
360 370 380 390 400
SGACVLFQCK SNTMQRIESP ECLPLNCPQS QHITLRSGCC KVCKGHDFCS
410 420 430 440 450
EGHNCVEYSI CKNLNDKAVC ICRDGFRALR EDSAYCEDID ECTEGRHYCR
460 470 480 490 500
ENTVCVNTPG SFMCVCQTGY LKIDDYSCTE HNECATNQHS CDENAVCYNT
510 520 530 540 550
VGGHNCVCQP GYTGNGTVCK AFCTDGCRNG GTCIAPNICA CPQGFTGPSC
560 570 580 590 600
EADIDECTEG FVQCDSRANC INLPGWYHCE CRDGYHDNGM FSLSGESCED
610 620 630 640 650
IDECATGRHS CSNDTVCFNL DGGFDCRCPH GKNCSGDCTH EGKIKHNGQI
660 670 680 690 700
WVLENDRCSV CSCQVGLVMC RRMVCDCENP TVDLFCCPEC DPRLSSQCLH
710 720 730 740 750
QSGELTYKSG DTWVQNCQQC RCLQGEVDCW PLPCPEIDCE FSVVPESECC
760 770 780 790 800
PRCISDPCQA DIIRNDITKT CVDETNVVRF TGSSWIKHGT ECTLCQCKNG
810
HMCCSVDPQC LQEL
Length:814
Mass (Da):90,762
Last modified:March 20, 2007 - v1
Checksum:i87EB9F240779A9B7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC128627 mRNA. Translation: AAI28628.1.
RefSeqiNP_001090754.1. NM_001097285.1.
UniGeneiStr.62624.

Genome annotation databases

EnsembliENSXETT00000032027; ENSXETP00000032027; ENSXETG00000014625.
GeneIDi100037839.
KEGGixtr:100037839.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC128627 mRNA. Translation: AAI28628.1.
RefSeqiNP_001090754.1. NM_001097285.1.
UniGeneiStr.62624.

3D structure databases

ProteinModelPortaliA2VCU8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi8364.ENSXETP00000032027.

Proteomic databases

PaxDbiA2VCU8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSXETT00000032027; ENSXETP00000032027; ENSXETG00000014625.
GeneIDi100037839.
KEGGixtr:100037839.

Organism-specific databases

CTDi4753.
XenbaseiXB-GENE-852641. nell2.

Phylogenomic databases

eggNOGiENOG410IR7C. Eukaryota.
ENOG410XSZA. LUCA.
GeneTreeiENSGT00810000125439.
HOGENOMiHOG000217920.
HOVERGENiHBG004805.
InParanoidiA2VCU8.
OMAiSHHPHTE.
OrthoDBiEOG091G01DI.
TreeFamiTF323325.

Gene expression databases

BgeeiENSXETG00000014625.

Family and domain databases

Gene3Di2.60.120.200. 1 hit.
InterProiIPR013320. ConA-like_dom.
IPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR000742. EGF-like_dom.
IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
IPR018097. EGF_Ca-bd_CS.
IPR009030. Growth_fac_rcpt_.
IPR001791. Laminin_G.
IPR001007. VWF_dom.
[Graphical view]
PfamiPF07645. EGF_CA. 4 hits.
PF02210. Laminin_G_2. 1 hit.
PF00093. VWC. 2 hits.
[Graphical view]
SMARTiSM00181. EGF. 6 hits.
SM00179. EGF_CA. 5 hits.
SM00282. LamG. 1 hit.
SM00210. TSPN. 1 hit.
SM00214. VWC. 3 hits.
SM00215. VWC_out. 2 hits.
[Graphical view]
SUPFAMiSSF49899. SSF49899. 1 hit.
SSF57184. SSF57184. 1 hit.
PROSITEiPS00010. ASX_HYDROXYL. 3 hits.
PS00022. EGF_1. 1 hit.
PS01186. EGF_2. 3 hits.
PS50026. EGF_3. 6 hits.
PS01187. EGF_CA. 3 hits.
PS01208. VWFC_1. 2 hits.
PS50184. VWFC_2. 3 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiNELL2_XENTR
AccessioniPrimary (citable) accession number: A2VCU8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 25, 2008
Last sequence update: March 20, 2007
Last modified: September 7, 2016
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.