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A2VCL2 (CC162_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 43. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Coiled-coil domain-containing protein 162
Alternative name(s):
Coiled-coil domain-containing protein 162 pseudogene
Gene names
Name:CCDC162P
Synonyms:C6orf184, C6orf185, CCDC162
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length907 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Sequence caution

The sequence CAI40699.1 differs from that shown. Reason: Erroneous gene model prediction.

Ontologies

Keywords
   Coding sequence diversityAlternative splicing
Polymorphism
   DomainCoiled coil
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
None. [Check GOA]

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]
Isoform 3 (identifier: A2VCL2-3)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 1 (identifier: A2VCL2-1)

The sequence of this isoform differs from the canonical sequence as follows:
     194-195: LC → VG
     196-907: Missing.
Isoform 2 (identifier: A2VCL2-2)

The sequence of this isoform differs from the canonical sequence as follows:
     64-89: GSELQELQNMIDSLQSPQDPIRVAQA → EEHFWQLEMFLPTSLSQTACAMGYQH
     90-907: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 907907Coiled-coil domain-containing protein 162
PRO_0000307296

Regions

Coiled coil476 – 55782 Potential
Coiled coil737 – 81781 Potential

Natural variations

Alternative sequence64 – 8926GSELQ…RVAQA → EEHFWQLEMFLPTSLSQTAC AMGYQH in isoform 2.
VSP_028678
Alternative sequence90 – 907818Missing in isoform 2.
VSP_028679
Alternative sequence194 – 1952LC → VG in isoform 1.
VSP_040685
Alternative sequence196 – 907712Missing in isoform 1.
VSP_040686
Natural variant841I → T.
Corresponds to variant rs6927569 [ dbSNP | Ensembl ].
VAR_035404

Experimental info

Sequence conflict8461R → C in AAI28119. Ref.2

Sequences

Sequence LengthMass (Da)Tools
Isoform 3 [UniParc].

Last modified March 8, 2011. Version 3.
Checksum: CB8F14BB82B470B4

FASTA907103,842
        10         20         30         40         50         60 
MFKTLPEKAA FKALKRTLQL IAPLHDIVAY LVSFAKLGNC PACFEFPRSP NPLRGDWGGT 

        70         80         90        100        110        120 
EGIGSELQEL QNMIDSLQSP QDPIRVAQAL LLRREVIFLQ FDAAVRHLIR RTFLAAGNVP 

       130        140        150        160        170        180 
AYQSVTDGMC HGLPALSNSL RKSIFASQLS LPQPLDPRSL QAFELFPWRA FLEDGGPFPV 

       190        200        210        220        230        240 
MSNSPDTLEY NMQLCLCGLS DRDRKVAHGE LVGVQLLLED VLSSYHVTME APQRQQATLG 

       250        260        270        280        290        300 
KNTQPDWSKV PGFRSQFRSS PKTSELLEGL CDAVMSFALL RSFLILWKQL EVLKEHWGRL 

       310        320        330        340        350        360 
KLQGQDINSV SLHKRFSELY ETDVLYPSMK AIARQMGKED EFEGFIVNNQ SVLPPSGASE 

       370        380        390        400        410        420 
VEIKTHQLQK LLENCEIQMI QEVLRKVNRE MTLVLSEKCK EECSLPTDLW KHQVMKENFS 

       430        440        450        460        470        480 
VSRPQIVEKF IQRLMNYQDD GVEITFRKDH LEACLLSLGC DVMARECSNF ETYSMCYEHV 

       490        500        510        520        530        540 
LHHARQRLSQ KEQELDATQR GQGPPEDSAG QIAELSHDMI MEITTLRAQL TDLEEVNLNL 

       550        560        570        580        590        600 
KKQIRKEVQE EYEALVRALF ETCLHIKEKL DDNQLNLIQK VCELIGEVRT EGIDNMKDLK 

       610        620        630        640        650        660 
KKWCSASPDE GMKENPAKEQ LWALEQDNCS LANLVCKVRS LGRWRLAVQQ ACFQAQLSRT 

       670        680        690        700        710        720 
EKESIQSKKE YLRIKLMAER EVGLFRQQVL ALRQALARAQ ADSARMWKQQ DSQAQLLKEL 

       730        740        750        760        770        780 
EHRVTQEALT QQQLHFMKTS RMEKLLEDVG QKEQQLQLLS KEAERASKLG QLQQKKMKRD 

       790        800        810        820        830        840 
LHQMRSRLAQ ERSVKLDALQ RAEELQGQLH DAQRSAVPMG SSGDLISQAQ YSPTSASTSS 

       850        860        870        880        890        900 
RYSQQRFLKT NLKGSKITRW IQRPQTVPIK HKKRTDDVFL PNMAENVQLT AFQVQTAPSR 


FPFRADW 

« Hide

Isoform 1 [UniParc].

Checksum: 72E77613EE2867C8
Show »

FASTA19521,641
Isoform 2 [UniParc].

Checksum: 2BA6849BDCA85DC5
Show »

FASTA8910,015

References

[1]"The DNA sequence and analysis of human chromosome 6."
Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D. expand/collapse author list , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 521-899 (ISOFORM 3).

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AL359711 Genomic DNA. Translation: CAI40699.1. Sequence problems.
BC107113 mRNA. Translation: AAI07114.1.
BC107114 mRNA. No translation available.
BC128118 mRNA. Translation: AAI28119.1.
UniGeneHs.373914.
Hs.723571.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Proteomic databases

PaxDbA2VCL2.
PRIDEA2VCL2.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

UCSCuc003ptb.1. human. [A2VCL2-1]

Organism-specific databases

GeneCardsGC06P109613.
HGNCHGNC:21565. CCDC162P.
neXtProtNX_A2VCL2.
PharmGKBPA134914939.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG118606.
HOVERGENHBG107657.
InParanoidA4QMU0.
PhylomeDBA2VCL2.

Gene expression databases

GenevestigatorA4QMU0.

Family and domain databases

ProtoNetSearch...

Other

ChiTaRSCCDC162P. human.
PROA2VCL2.

Entry information

Entry nameCC162_HUMAN
AccessionPrimary (citable) accession number: A2VCL2
Secondary accession number(s): A1A4V1 expand/collapse secondary AC list , A4QMU0, Q5JSU0, Q5JSU7
Entry history
Integrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: March 8, 2011
Last modified: April 16, 2014
This is version 43 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 6

Human chromosome 6: entries, gene names and cross-references to MIM