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A2VCL2

- CC162_HUMAN

UniProt

A2VCL2 - CC162_HUMAN

Protein

Coiled-coil domain-containing protein 162

Gene

CCDC162P

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 44 (01 Oct 2014)
      Sequence version 3 (08 Mar 2011)
      Previous versions | rss
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    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Coiled-coil domain-containing protein 162
    Alternative name(s):
    Coiled-coil domain-containing protein 162 pseudogene
    Gene namesi
    Name:CCDC162P
    Synonyms:C6orf184, C6orf185, CCDC162
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Unplaced

    Organism-specific databases

    HGNCiHGNC:21565. CCDC162P.

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134914939.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 907907Coiled-coil domain-containing protein 162PRO_0000307296Add
    BLAST

    Proteomic databases

    PaxDbiA2VCL2.
    PRIDEiA2VCL2.

    Expressioni

    Gene expression databases

    GenevestigatoriA4QMU0.

    Family & Domainsi

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili476 – 55782Sequence AnalysisAdd
    BLAST
    Coiled coili737 – 81781Sequence AnalysisAdd
    BLAST

    Keywords - Domaini

    Coiled coil

    Phylogenomic databases

    eggNOGiNOG118606.
    HOVERGENiHBG107657.
    InParanoidiA4QMU0.
    PhylomeDBiA2VCL2.

    Sequences (3)i

    Sequence statusi: Complete.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 3 (identifier: A2VCL2-3) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MFKTLPEKAA FKALKRTLQL IAPLHDIVAY LVSFAKLGNC PACFEFPRSP    50
    NPLRGDWGGT EGIGSELQEL QNMIDSLQSP QDPIRVAQAL LLRREVIFLQ 100
    FDAAVRHLIR RTFLAAGNVP AYQSVTDGMC HGLPALSNSL RKSIFASQLS 150
    LPQPLDPRSL QAFELFPWRA FLEDGGPFPV MSNSPDTLEY NMQLCLCGLS 200
    DRDRKVAHGE LVGVQLLLED VLSSYHVTME APQRQQATLG KNTQPDWSKV 250
    PGFRSQFRSS PKTSELLEGL CDAVMSFALL RSFLILWKQL EVLKEHWGRL 300
    KLQGQDINSV SLHKRFSELY ETDVLYPSMK AIARQMGKED EFEGFIVNNQ 350
    SVLPPSGASE VEIKTHQLQK LLENCEIQMI QEVLRKVNRE MTLVLSEKCK 400
    EECSLPTDLW KHQVMKENFS VSRPQIVEKF IQRLMNYQDD GVEITFRKDH 450
    LEACLLSLGC DVMARECSNF ETYSMCYEHV LHHARQRLSQ KEQELDATQR 500
    GQGPPEDSAG QIAELSHDMI MEITTLRAQL TDLEEVNLNL KKQIRKEVQE 550
    EYEALVRALF ETCLHIKEKL DDNQLNLIQK VCELIGEVRT EGIDNMKDLK 600
    KKWCSASPDE GMKENPAKEQ LWALEQDNCS LANLVCKVRS LGRWRLAVQQ 650
    ACFQAQLSRT EKESIQSKKE YLRIKLMAER EVGLFRQQVL ALRQALARAQ 700
    ADSARMWKQQ DSQAQLLKEL EHRVTQEALT QQQLHFMKTS RMEKLLEDVG 750
    QKEQQLQLLS KEAERASKLG QLQQKKMKRD LHQMRSRLAQ ERSVKLDALQ 800
    RAEELQGQLH DAQRSAVPMG SSGDLISQAQ YSPTSASTSS RYSQQRFLKT 850
    NLKGSKITRW IQRPQTVPIK HKKRTDDVFL PNMAENVQLT AFQVQTAPSR 900
    FPFRADW 907
    Length:907
    Mass (Da):103,842
    Last modified:March 8, 2011 - v3
    Checksum:iCB8F14BB82B470B4
    GO
    Isoform 1 (identifier: A2VCL2-1) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         194-195: LC → VG
         196-907: Missing.

    Show »
    Length:195
    Mass (Da):21,641
    Checksum:i72E77613EE2867C8
    GO
    Isoform 2 (identifier: A2VCL2-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         64-89: GSELQELQNMIDSLQSPQDPIRVAQA → EEHFWQLEMFLPTSLSQTACAMGYQH
         90-907: Missing.

    Show »
    Length:89
    Mass (Da):10,015
    Checksum:i2BA6849BDCA85DC5
    GO

    Sequence cautioni

    The sequence CAI40699.1 differs from that shown. Reason: Erroneous gene model prediction.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti846 – 8461R → C in AAI28119. (PubMed:15489334)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti84 – 841I → T.
    Corresponds to variant rs6927569 [ dbSNP | Ensembl ].
    VAR_035404

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei64 – 8926GSELQ…RVAQA → EEHFWQLEMFLPTSLSQTAC AMGYQH in isoform 2. 1 PublicationVSP_028678Add
    BLAST
    Alternative sequencei90 – 907818Missing in isoform 2. 1 PublicationVSP_028679Add
    BLAST
    Alternative sequencei194 – 1952LC → VG in isoform 1. 1 PublicationVSP_040685
    Alternative sequencei196 – 907712Missing in isoform 1. 1 PublicationVSP_040686Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL359711 Genomic DNA. Translation: CAI40699.1. Sequence problems.
    BC107113 mRNA. Translation: AAI07114.1.
    BC107114 mRNA. No translation available.
    BC128118 mRNA. Translation: AAI28119.1.
    UniGeneiHs.373914.
    Hs.723571.

    Genome annotation databases

    UCSCiuc003ptb.1. human. [A2VCL2-1]

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL359711 Genomic DNA. Translation: CAI40699.1 . Sequence problems.
    BC107113 mRNA. Translation: AAI07114.1 .
    BC107114 mRNA. No translation available.
    BC128118 mRNA. Translation: AAI28119.1 .
    UniGenei Hs.373914.
    Hs.723571.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PaxDbi A2VCL2.
    PRIDEi A2VCL2.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    UCSCi uc003ptb.1. human. [A2VCL2-1 ]

    Organism-specific databases

    GeneCardsi GC06P109613.
    HGNCi HGNC:21565. CCDC162P.
    neXtProti NX_A2VCL2.
    PharmGKBi PA134914939.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG118606.
    HOVERGENi HBG107657.
    InParanoidi A4QMU0.
    PhylomeDBi A2VCL2.

    Miscellaneous databases

    ChiTaRSi CCDC162P. human.
    PROi A2VCL2.

    Gene expression databases

    Genevestigatori A4QMU0.

    Family and domain databases

    ProtoNeti Search...

    Publicationsi

    1. "The DNA sequence and analysis of human chromosome 6."
      Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
      , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
      Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 521-899 (ISOFORM 3).

    Entry informationi

    Entry nameiCC162_HUMAN
    AccessioniPrimary (citable) accession number: A2VCL2
    Secondary accession number(s): A1A4V1
    , A4QMU0, Q5JSU0, Q5JSU7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 23, 2007
    Last sequence update: March 8, 2011
    Last modified: October 1, 2014
    This is version 44 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 6
      Human chromosome 6: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations

    External Data

    Dasty 3