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A2VCL2

- CC162_HUMAN

UniProt

A2VCL2 - CC162_HUMAN

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Protein
Coiled-coil domain-containing protein 162
Gene
CCDC162P, C6orf184, C6orf185, CCDC162
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5 - Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Coiled-coil domain-containing protein 162
Alternative name(s):
Coiled-coil domain-containing protein 162 pseudogene
Gene namesi
Synonyms:C6orf184, C6orf185, CCDC162
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Unplaced

Organism-specific databases

HGNCiHGNC:21565. CCDC162P.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134914939.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 907907Coiled-coil domain-containing protein 162
PRO_0000307296Add
BLAST

Proteomic databases

PaxDbiA2VCL2.
PRIDEiA2VCL2.

Expressioni

Gene expression databases

GenevestigatoriA4QMU0.

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili476 – 55782 Reviewed prediction
Add
BLAST
Coiled coili737 – 81781 Reviewed prediction
Add
BLAST

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiNOG118606.
HOVERGENiHBG107657.
InParanoidiA4QMU0.
PhylomeDBiA2VCL2.

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform 3 (identifier: A2VCL2-3) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MFKTLPEKAA FKALKRTLQL IAPLHDIVAY LVSFAKLGNC PACFEFPRSP    50
NPLRGDWGGT EGIGSELQEL QNMIDSLQSP QDPIRVAQAL LLRREVIFLQ 100
FDAAVRHLIR RTFLAAGNVP AYQSVTDGMC HGLPALSNSL RKSIFASQLS 150
LPQPLDPRSL QAFELFPWRA FLEDGGPFPV MSNSPDTLEY NMQLCLCGLS 200
DRDRKVAHGE LVGVQLLLED VLSSYHVTME APQRQQATLG KNTQPDWSKV 250
PGFRSQFRSS PKTSELLEGL CDAVMSFALL RSFLILWKQL EVLKEHWGRL 300
KLQGQDINSV SLHKRFSELY ETDVLYPSMK AIARQMGKED EFEGFIVNNQ 350
SVLPPSGASE VEIKTHQLQK LLENCEIQMI QEVLRKVNRE MTLVLSEKCK 400
EECSLPTDLW KHQVMKENFS VSRPQIVEKF IQRLMNYQDD GVEITFRKDH 450
LEACLLSLGC DVMARECSNF ETYSMCYEHV LHHARQRLSQ KEQELDATQR 500
GQGPPEDSAG QIAELSHDMI MEITTLRAQL TDLEEVNLNL KKQIRKEVQE 550
EYEALVRALF ETCLHIKEKL DDNQLNLIQK VCELIGEVRT EGIDNMKDLK 600
KKWCSASPDE GMKENPAKEQ LWALEQDNCS LANLVCKVRS LGRWRLAVQQ 650
ACFQAQLSRT EKESIQSKKE YLRIKLMAER EVGLFRQQVL ALRQALARAQ 700
ADSARMWKQQ DSQAQLLKEL EHRVTQEALT QQQLHFMKTS RMEKLLEDVG 750
QKEQQLQLLS KEAERASKLG QLQQKKMKRD LHQMRSRLAQ ERSVKLDALQ 800
RAEELQGQLH DAQRSAVPMG SSGDLISQAQ YSPTSASTSS RYSQQRFLKT 850
NLKGSKITRW IQRPQTVPIK HKKRTDDVFL PNMAENVQLT AFQVQTAPSR 900
FPFRADW 907
Length:907
Mass (Da):103,842
Last modified:March 8, 2011 - v3
Checksum:iCB8F14BB82B470B4
GO
Isoform 1 (identifier: A2VCL2-1) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     194-195: LC → VG
     196-907: Missing.

Show »
Length:195
Mass (Da):21,641
Checksum:i72E77613EE2867C8
GO
Isoform 2 (identifier: A2VCL2-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     64-89: GSELQELQNMIDSLQSPQDPIRVAQA → EEHFWQLEMFLPTSLSQTACAMGYQH
     90-907: Missing.

Show »
Length:89
Mass (Da):10,015
Checksum:i2BA6849BDCA85DC5
GO

Sequence cautioni

The sequence CAI40699.1 differs from that shown. Reason: Erroneous gene model prediction.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti84 – 841I → T.
Corresponds to variant rs6927569 [ dbSNP | Ensembl ].
VAR_035404

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei64 – 8926GSELQ…RVAQA → EEHFWQLEMFLPTSLSQTAC AMGYQH in isoform 2.
VSP_028678Add
BLAST
Alternative sequencei90 – 907818Missing in isoform 2.
VSP_028679Add
BLAST
Alternative sequencei194 – 1952LC → VG in isoform 1.
VSP_040685
Alternative sequencei196 – 907712Missing in isoform 1.
VSP_040686Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti846 – 8461R → C in AAI28119. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL359711 Genomic DNA. Translation: CAI40699.1. Sequence problems.
BC107113 mRNA. Translation: AAI07114.1.
BC107114 mRNA. No translation available.
BC128118 mRNA. Translation: AAI28119.1.
UniGeneiHs.373914.
Hs.723571.

Genome annotation databases

UCSCiuc003ptb.1. human. [A2VCL2-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL359711 Genomic DNA. Translation: CAI40699.1 . Sequence problems.
BC107113 mRNA. Translation: AAI07114.1 .
BC107114 mRNA. No translation available.
BC128118 mRNA. Translation: AAI28119.1 .
UniGenei Hs.373914.
Hs.723571.

3D structure databases

ModBasei Search...

Proteomic databases

PaxDbi A2VCL2.
PRIDEi A2VCL2.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

UCSCi uc003ptb.1. human. [A2VCL2-1 ]

Organism-specific databases

GeneCardsi GC06P109613.
HGNCi HGNC:21565. CCDC162P.
neXtProti NX_A2VCL2.
PharmGKBi PA134914939.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG118606.
HOVERGENi HBG107657.
InParanoidi A4QMU0.
PhylomeDBi A2VCL2.

Miscellaneous databases

ChiTaRSi CCDC162P. human.
PROi A2VCL2.

Gene expression databases

Genevestigatori A4QMU0.

Family and domain databases

ProtoNeti Search...

Publicationsi

  1. "The DNA sequence and analysis of human chromosome 6."
    Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
    , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
    Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 521-899 (ISOFORM 3).

Entry informationi

Entry nameiCC162_HUMAN
AccessioniPrimary (citable) accession number: A2VCL2
Secondary accession number(s): A1A4V1
, A4QMU0, Q5JSU0, Q5JSU7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: March 8, 2011
Last modified: April 16, 2014
This is version 43 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations

External Data

Dasty 3

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