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Protein

Doublecortin domain-containing protein 2B

Gene

DCDC2B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

BioCyciZFISH:G66-32318-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Doublecortin domain-containing protein 2B
Gene namesi
Name:DCDC2B
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:32576. DCDC2B.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000222046.
PharmGKBiPA145008541.

Polymorphism and mutation databases

BioMutaiDCDC2B.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003050081 – 349Doublecortin domain-containing protein 2BAdd BLAST349

Proteomic databases

PaxDbiA2VCK2.
PRIDEiA2VCK2.

PTM databases

iPTMnetiA2VCK2.
PhosphoSitePlusiA2VCK2.

Expressioni

Gene expression databases

BgeeiENSG00000222046.
CleanExiHS_DCDC2B.
GenevisibleiA2VCK2. HS.

Organism-specific databases

HPAiHPA045832.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
BANPQ8N9N53EBI-10173222,EBI-744695
FHL3Q136435EBI-10173222,EBI-741101
KRT40Q6A1623EBI-10173222,EBI-10171697
MTUS2Q5JR593EBI-10173222,EBI-742948
RBPMSQ930623EBI-10173222,EBI-740322

Protein-protein interaction databases

BioGridi127189. 12 interactors.
IntActiA2VCK2. 7 interactors.
STRINGi9606.ENSP00000386870.

Structurei

3D structure databases

ProteinModelPortaliA2VCK2.
SMRiA2VCK2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini9 – 91Doublecortin 1PROSITE-ProRule annotationAdd BLAST83
Domaini129 – 211Doublecortin 2PROSITE-ProRule annotationAdd BLAST83

Sequence similaritiesi

Contains 2 doublecortin domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG3757. Eukaryota.
ENOG410ZE6Q. LUCA.
GeneTreeiENSGT00860000133725.
HOGENOMiHOG000082435.
HOVERGENiHBG051319.
InParanoidiA2VCK2.
OMAiFYARPQQ.
OrthoDBiEOG091G13U4.
PhylomeDBiA2VCK2.
TreeFamiTF338406.

Family and domain databases

CDDicd01617. DCX. 1 hit.
Gene3Di3.10.20.230. 2 hits.
InterProiIPR003533. Doublecortin_dom.
[Graphical view]
PfamiPF03607. DCX. 2 hits.
[Graphical view]
SMARTiSM00537. DCX. 2 hits.
[Graphical view]
PROSITEiPS50309. DC. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A2VCK2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGGSPAAKR VVVYRNGDPF FPGSQLVVTQ RRFPTMEAFL CEVTSAVQAP
60 70 80 90 100
LAVRALYTPC HGHPVTNLAD LKNRGQYVAA GFERFHKLHY LPHRGKDPGG
110 120 130 140 150
KSCRLQGPPV TRHLCDGAIG RQLPAGAPSY IHVFRNGDLV SPPFSLKLSQ
160 170 180 190 200
AASQDWETVL KLLTEKVKLQ SGAVCKLCTL EGLPLSAGKE LVTGHYYVAV
210 220 230 240 250
GEDEFKDLPY LELLVPSPSL PRGCWQPPGS KSRPHRQGAQ GHRAQVTQPS
260 270 280 290 300
PKEPDRIKPS AFYARPQQTI QPRSKLPTLS FPSGVIGVYG APHRRKETAG
310 320 330 340
ALEVADDEDT QTEEPLDQRA AQIVEEALSL ENQPGAGAAI SASAPALPS
Length:349
Mass (Da):37,665
Last modified:March 20, 2007 - v1
Checksum:i57BBA0506F10F3F0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL049795 Genomic DNA. Translation: CAX15004.1.
BC128073 mRNA. Translation: AAI28074.1.
CCDSiCCDS44100.1.
RefSeqiNP_001092904.1. NM_001099434.1.
UniGeneiHs.424588.

Genome annotation databases

EnsembliENST00000409358; ENSP00000386870; ENSG00000222046.
GeneIDi149069.
KEGGihsa:149069.
UCSCiuc001bun.2. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL049795 Genomic DNA. Translation: CAX15004.1.
BC128073 mRNA. Translation: AAI28074.1.
CCDSiCCDS44100.1.
RefSeqiNP_001092904.1. NM_001099434.1.
UniGeneiHs.424588.

3D structure databases

ProteinModelPortaliA2VCK2.
SMRiA2VCK2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi127189. 12 interactors.
IntActiA2VCK2. 7 interactors.
STRINGi9606.ENSP00000386870.

PTM databases

iPTMnetiA2VCK2.
PhosphoSitePlusiA2VCK2.

Polymorphism and mutation databases

BioMutaiDCDC2B.

Proteomic databases

PaxDbiA2VCK2.
PRIDEiA2VCK2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000409358; ENSP00000386870; ENSG00000222046.
GeneIDi149069.
KEGGihsa:149069.
UCSCiuc001bun.2. human.

Organism-specific databases

CTDi149069.
GeneCardsiDCDC2B.
HGNCiHGNC:32576. DCDC2B.
HPAiHPA045832.
neXtProtiNX_A2VCK2.
OpenTargetsiENSG00000222046.
PharmGKBiPA145008541.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3757. Eukaryota.
ENOG410ZE6Q. LUCA.
GeneTreeiENSGT00860000133725.
HOGENOMiHOG000082435.
HOVERGENiHBG051319.
InParanoidiA2VCK2.
OMAiFYARPQQ.
OrthoDBiEOG091G13U4.
PhylomeDBiA2VCK2.
TreeFamiTF338406.

Enzyme and pathway databases

BioCyciZFISH:G66-32318-MONOMER.

Miscellaneous databases

GenomeRNAii149069.
PROiA2VCK2.

Gene expression databases

BgeeiENSG00000222046.
CleanExiHS_DCDC2B.
GenevisibleiA2VCK2. HS.

Family and domain databases

CDDicd01617. DCX. 1 hit.
Gene3Di3.10.20.230. 2 hits.
InterProiIPR003533. Doublecortin_dom.
[Graphical view]
PfamiPF03607. DCX. 2 hits.
[Graphical view]
SMARTiSM00537. DCX. 2 hits.
[Graphical view]
PROSITEiPS50309. DC. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiDCD2B_HUMAN
AccessioniPrimary (citable) accession number: A2VCK2
Secondary accession number(s): B7ZBC6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 2, 2007
Last sequence update: March 20, 2007
Last modified: November 30, 2016
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.