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Protein

Doublecortin domain-containing protein 2B

Gene

DCDC2B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Doublecortin domain-containing protein 2B
Gene namesi
Name:DCDC2B
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000222046.2.
HGNCiHGNC:32576. DCDC2B.

Subcellular locationi

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000222046.
PharmGKBiPA145008541.

Polymorphism and mutation databases

BioMutaiDCDC2B.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003050081 – 349Doublecortin domain-containing protein 2BAdd BLAST349

Proteomic databases

PaxDbiA2VCK2.
PRIDEiA2VCK2.

PTM databases

iPTMnetiA2VCK2.
PhosphoSitePlusiA2VCK2.

Expressioni

Gene expression databases

BgeeiENSG00000222046.
CleanExiHS_DCDC2B.
GenevisibleiA2VCK2. HS.

Organism-specific databases

HPAiHPA045832.

Interactioni

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi127189. 12 interactors.
IntActiA2VCK2. 8 interactors.
STRINGi9606.ENSP00000386870.

Structurei

3D structure databases

ProteinModelPortaliA2VCK2.
SMRiA2VCK2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini9 – 91Doublecortin 1PROSITE-ProRule annotationAdd BLAST83
Domaini129 – 211Doublecortin 2PROSITE-ProRule annotationAdd BLAST83

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG3757. Eukaryota.
ENOG410ZE6Q. LUCA.
GeneTreeiENSGT00880000137957.
HOGENOMiHOG000082435.
HOVERGENiHBG051319.
InParanoidiA2VCK2.
OMAiFYARPQQ.
OrthoDBiEOG091G13U4.
PhylomeDBiA2VCK2.
TreeFamiTF338406.

Family and domain databases

CDDicd01617. DCX. 1 hit.
Gene3Di3.10.20.230. 2 hits.
InterProiView protein in InterPro
IPR003533. Doublecortin_dom.
IPR036572. Doublecortin_dom_sf.
PfamiView protein in Pfam
PF03607. DCX. 2 hits.
SMARTiView protein in SMART
SM00537. DCX. 2 hits.
SUPFAMiSSF89837. SSF89837. 2 hits.
PROSITEiView protein in PROSITE
PS50309. DC. 2 hits.

Sequencei

Sequence statusi: Complete.

A2VCK2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGGSPAAKR VVVYRNGDPF FPGSQLVVTQ RRFPTMEAFL CEVTSAVQAP
60 70 80 90 100
LAVRALYTPC HGHPVTNLAD LKNRGQYVAA GFERFHKLHY LPHRGKDPGG
110 120 130 140 150
KSCRLQGPPV TRHLCDGAIG RQLPAGAPSY IHVFRNGDLV SPPFSLKLSQ
160 170 180 190 200
AASQDWETVL KLLTEKVKLQ SGAVCKLCTL EGLPLSAGKE LVTGHYYVAV
210 220 230 240 250
GEDEFKDLPY LELLVPSPSL PRGCWQPPGS KSRPHRQGAQ GHRAQVTQPS
260 270 280 290 300
PKEPDRIKPS AFYARPQQTI QPRSKLPTLS FPSGVIGVYG APHRRKETAG
310 320 330 340
ALEVADDEDT QTEEPLDQRA AQIVEEALSL ENQPGAGAAI SASAPALPS
Length:349
Mass (Da):37,665
Last modified:March 20, 2007 - v1
Checksum:i57BBA0506F10F3F0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL049795 Genomic DNA. No translation available.
BC128073 mRNA. Translation: AAI28074.1.
CCDSiCCDS44100.1.
RefSeqiNP_001092904.1. NM_001099434.1.
UniGeneiHs.424588.

Genome annotation databases

EnsembliENST00000409358; ENSP00000386870; ENSG00000222046.
GeneIDi149069.
KEGGihsa:149069.
UCSCiuc001bun.2. human.

Similar proteinsi

Entry informationi

Entry nameiDCD2B_HUMAN
AccessioniPrimary (citable) accession number: A2VCK2
Secondary accession number(s): B7ZBC6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 2, 2007
Last sequence update: March 20, 2007
Last modified: October 25, 2017
This is version 77 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM