A2VCK2 (DCD2B_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Doublecortin domain-containing protein 2B

Gene names

Name:

DCDC2B

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	349 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Sequence similarities

Contains 2 doublecortin domains.

Ontologies

Keywords
Domain	Repeat
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	intracellular signal transduction Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 349	349	Doublecortin domain-containing protein 2B		PRO_0000305008
Regions
	Domain	9 – 91	83	Doublecortin 1
	Domain	129 – 211	83	Doublecortin 2

Sequences

	Sequence		Length	Mass (Da)
	A2VCK2 [UniParc]. Last modified March 20, 2007. Version 1. Checksum: 57BBA0506F10F3F0	FASTA	349	37,665
	10 20 30 40 50 60 MAGGSPAAKR VVVYRNGDPF FPGSQLVVTQ RRFPTMEAFL CEVTSAVQAP LAVRALYTPC 70 80 90 100 110 120 HGHPVTNLAD LKNRGQYVAA GFERFHKLHY LPHRGKDPGG KSCRLQGPPV TRHLCDGAIG 130 140 150 160 170 180 RQLPAGAPSY IHVFRNGDLV SPPFSLKLSQ AASQDWETVL KLLTEKVKLQ SGAVCKLCTL 190 200 210 220 230 240 EGLPLSAGKE LVTGHYYVAV GEDEFKDLPY LELLVPSPSL PRGCWQPPGS KSRPHRQGAQ 250 260 270 280 290 300 GHRAQVTQPS PKEPDRIKPS AFYARPQQTI QPRSKLPTLS FPSGVIGVYG APHRRKETAG 310 320 330 340 ALEVADDEDT QTEEPLDQRA AQIVEEALSL ENQPGAGAAI SASAPALPS

References

[1]

"The DNA sequence and biological annotation of human chromosome 1." Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R. Nature 441:315-321(2006) [PubMed: 16710414] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

[2]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	AL049795 Genomic DNA. Translation: CAX15004.1. BC128073 mRNA. Translation: AAI28074.1.
IPI	IPI00739883.
RefSeq	NP_001092904.1. NM_001099434.1.
UniGene	Hs.424588.
3D structure databases
ProteinModelPortal	A2VCK2.
SMR	A2VCK2. Positions 2-93, 122-217.
ModBase	Search...
Proteomic databases
PRIDE	A2VCK2.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000409358; ENSP00000386870; ENSG00000222046.
GeneID	149069.
KEGG	hsa:149069.
UCSC	uc001bun.2. human.
Organism-specific databases
CTD	149069.
GeneCards	GC01P032675.
HGNC	HGNC:32576. DCDC2B.
HPA	HPA045832.
neXtProt	NX_A2VCK2.
PharmGKB	PA145008541.
GenAtlas	Search...
Phylogenomic databases
eggNOG	maNOG21146.
GeneTree	ENSGT00510000046928.
HOGENOM	HBG506463.
HOVERGEN	HBG051319.
InParanoid	A2VCK2.
OMA	EFKALPY.
OrthoDB	EOG4CNQRK.
Gene expression databases
Bgee	A2VCK2.
CleanEx	HS_DCDC2B.
Genevestigator	A2VCK2.
Family and domain databases
InterPro	IPR003533. Doublecortin_dom. [Graphical view]
Gene3D	G3DSA:3.10.20.230. Doublecortin_dom. 2 hits.
Pfam	PF03607. DCX. 2 hits. [Graphical view]
SMART	SM00537. DCX. 2 hits. [Graphical view]
SUPFAM	SSF89837. Doublecortin_dom. 2 hits.
PROSITE	PS50309. DC. 2 hits. [Graphical view]
ProtoNet	Search...
Other
NextBio	86065.

Entry information

Entry name

DCD2B_HUMAN

Accession

Primary (citable) accession number: A2VCK2
Secondary accession number(s): B7ZBC6

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 2, 2007
Last sequence update:	March 20, 2007
Last modified:	January 25, 2012
This is version 38 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.