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A2V735 (TPM_CHIOP) Reviewed, UniProtKB/Swiss-Prot

Last modified October 31, 2012. Version 19. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Tropomyosin
Alternative name(s):
Tropomyosin, slow-tonic isoform
Short name=Tm-Chio-tonic
Gene names
Name:TM1
OrganismChionoecetes opilio (Crab-beetle)
Taxonomic identifier41210 [NCBI]
Taxonomic lineageEukaryotaMetazoaEcdysozoaArthropodaCrustaceaMalacostracaEumalacostracaEucaridaDecapodaPleocyemataBrachyuraEubrachyuraMajoideaMajidaeChionoecetes

Protein attributes

Sequence length284 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Tropomyosin, in association with the troponin complex, plays a central role in the calcium dependent regulation of muscle contraction By similarity. UniProtKB Q22866

Subunit structure

Homodimer. Ref.2

Tissue specificity

Expressed in leg muscle and chest protection muscle (at protein level). Ref.1

Domain

The molecule is in a coiled coil structure that is formed by 2 polypeptide chains. The sequence exhibits a prominent seven-residues periodicity.

Allergenic properties

Causes an allergic reaction in human. Ref.1 Ref.2

Sequence similarities

Belongs to the tropomyosin family.

Mass spectrometry

Molecular mass is 32733±6.5 Da from positions 1 - 284. Determined by MALDI. Ref.2

Ontologies

Keywords
   DiseaseAllergen
   DomainCoiled coil
Repeat
   PTMAcetylation
   Technical termDirect protein sequencing
Gene Ontology (GO)
None. [Check GOA]

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 284284Tropomyosin
PRO_0000398787

Regions

Coiled coil1 – 284284 By similarity UniProtKB O44119

Amino acid modifications

Modified residue11N-acetylmethionine Ref.2

Sequences

Sequence LengthMass (Da)Tools
A2V735 [UniParc].

Last modified March 20, 2007. Version 1.
Checksum: 357A164032C6B96E

FASTA28432,675
        10         20         30         40         50         60 
MDAIKKKMQA MKLEKDNAMD KADTLEQQNK EANLRAEKTE EEIRANQKKS QLVENELDHA 

        70         80         90        100        110        120 
QEQLSAATHK LVEKEKAFAN AEGEVAALNR RIQLLEEDLE RSEERLNTAT TKLAEASQAA 

       130        140        150        160        170        180 
DESERMRKVL ENRSLSDEER MDALENQLKE ARFLAEEADR KYDEVARKLA MVEADLERAE 

       190        200        210        220        230        240 
ERAESGESKI VELEEELRVV GNNLKSLEVS EEKANQREET YKEQIKTLAN KLKAAEARAE 

       250        260        270        280 
FAERSVQKLQ KEVDRLEDEL VNEKEKYKNI ADEMDQAFSE LSGF 

« Hide

References

[1]"Molecular cloning of tropomyosins identified as allergens in six species of crustaceans."
Motoyama K., Suma Y., Ishizaki S., Nagashima Y., Shiomi K.
J. Agric. Food Chem. 55:985-991(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, ALLERGEN.
Tissue: Muscle.
[2]"Characterization and de novo sequencing of snow crab tropomyosin enzymatic peptides by both electrospary ionization and matrix-assisted laser desorption ionization QqToF tandemmass spectrometry."
Abdel Rahman A.M., Lopata A.L., O'Hehir R.E., Robinson J.J., Banoub J.H., Helleur R.J.
J. Mass Spectrom. 45:372-381(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE OF 8-284, SUBUNIT, MASS SPECTROMETRY, ALLERGENICITY, ACETYLATION AT MET-1.
Tissue: Muscle.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB270634 mRNA. Translation: BAF47267.1.

3D structure databases

ProteinModelPortalA2V735.
SMRA2V735. Positions 1-283.
ModBaseSearch...
MobiDBSearch...

Protein family/group databases

Allergome3807. Chi o 1.
4087. Chi o 1.0101.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

InterProIPR000533. Tropomyosin.
[Graphical view]
PfamPF00261. Tropomyosin. 1 hit.
[Graphical view]
PRINTSPR00194. TROPOMYOSIN.
PROSITEPS00326. TROPOMYOSIN. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameTPM_CHIOP
AccessionPrimary (citable) accession number: A2V735
Entry history
Integrated into UniProtKB/Swiss-Prot: October 5, 2010
Last sequence update: March 20, 2007
Last modified: October 31, 2012
This is version 19 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)

Relevant documents

SIMILARITY comments

Index of protein domains and families