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A2V735

- TPM_CHIOP

UniProt

A2V735 - TPM_CHIOP

Protein

Tropomyosin

Gene

TM1

Organism
Chionoecetes opilio (Crab-beetle)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 20 (01 Oct 2014)
      Sequence version 1 (20 Mar 2007)
      Previous versions | rss
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    Functioni

    Tropomyosin, in association with the troponin complex, plays a central role in the calcium dependent regulation of muscle contraction.By similarity

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Tropomyosin1 Publication
    Alternative name(s):
    Tropomyosin, slow-tonic isoformImported1 Publication
    Short name:
    Tm-Chio-tonicImported
    Gene namesi
    Name:TM1By similarity
    OrganismiChionoecetes opilio (Crab-beetle)
    Taxonomic identifieri41210 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaCrustaceaMalacostracaEumalacostracaEucaridaDecapodaPleocyemataBrachyuraEubrachyuraMajoideaMajidaeChionoecetes

    Pathology & Biotechi

    Allergenic propertiesi

    Causes an allergic reaction in human.2 Publications

    Keywords - Diseasei

    Allergen

    Protein family/group databases

    Allergomei3807. Chi o 1.
    4087. Chi o 1.0101.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 284284TropomyosinPRO_0000398787Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei1 – 11N-acetylmethionine1 Publication

    Keywords - PTMi

    Acetylation

    Expressioni

    Tissue specificityi

    Expressed in leg muscle and chest protection muscle (at protein level).1 Publication

    Interactioni

    Subunit structurei

    Homodimer.1 Publication

    Structurei

    3D structure databases

    ProteinModelPortaliA2V735.
    SMRiA2V735. Positions 1-283.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili1 – 284284By similarityAdd
    BLAST

    Domaini

    The molecule is in a coiled coil structure that is formed by 2 polypeptide chains. The sequence exhibits a prominent seven-residues periodicity.Curated

    Sequence similaritiesi

    Belongs to the tropomyosin family.Sequence Analysis

    Keywords - Domaini

    Coiled coil, Repeat

    Family and domain databases

    InterProiIPR000533. Tropomyosin.
    [Graphical view]
    PfamiPF00261. Tropomyosin. 1 hit.
    [Graphical view]
    PRINTSiPR00194. TROPOMYOSIN.
    PROSITEiPS00326. TROPOMYOSIN. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A2V735-1 [UniParc]FASTAAdd to Basket

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    MDAIKKKMQA MKLEKDNAMD KADTLEQQNK EANLRAEKTE EEIRANQKKS    50
    QLVENELDHA QEQLSAATHK LVEKEKAFAN AEGEVAALNR RIQLLEEDLE 100
    RSEERLNTAT TKLAEASQAA DESERMRKVL ENRSLSDEER MDALENQLKE 150
    ARFLAEEADR KYDEVARKLA MVEADLERAE ERAESGESKI VELEEELRVV 200
    GNNLKSLEVS EEKANQREET YKEQIKTLAN KLKAAEARAE FAERSVQKLQ 250
    KEVDRLEDEL VNEKEKYKNI ADEMDQAFSE LSGF 284
    Length:284
    Mass (Da):32,675
    Last modified:March 20, 2007 - v1
    Checksum:i357A164032C6B96E
    GO

    Mass spectrometryi

    Molecular mass is 32733±6.5 Da from positions 1 - 284. Determined by MALDI. 1 Publication

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB270634 mRNA. Translation: BAF47267.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB270634 mRNA. Translation: BAF47267.1 .

    3D structure databases

    ProteinModelPortali A2V735.
    SMRi A2V735. Positions 1-283.
    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    Allergomei 3807. Chi o 1.
    4087. Chi o 1.0101.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    InterProi IPR000533. Tropomyosin.
    [Graphical view ]
    Pfami PF00261. Tropomyosin. 1 hit.
    [Graphical view ]
    PRINTSi PR00194. TROPOMYOSIN.
    PROSITEi PS00326. TROPOMYOSIN. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning of tropomyosins identified as allergens in six species of crustaceans."
      Motoyama K., Suma Y., Ishizaki S., Nagashima Y., Shiomi K.
      J. Agric. Food Chem. 55:985-991(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, ALLERGEN.
      Tissue: Muscle1 Publication.
    2. "Characterization and de novo sequencing of snow crab tropomyosin enzymatic peptides by both electrospary ionization and matrix-assisted laser desorption ionization QqToF tandemmass spectrometry."
      Abdel Rahman A.M., Lopata A.L., O'Hehir R.E., Robinson J.J., Banoub J.H., Helleur R.J.
      J. Mass Spectrom. 45:372-381(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 8-284, SUBUNIT, MASS SPECTROMETRY, ALLERGENICITY, ACETYLATION AT MET-1.
      Tissue: Muscle1 Publication.

    Entry informationi

    Entry nameiTPM_CHIOP
    AccessioniPrimary (citable) accession number: A2V735
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 5, 2010
    Last sequence update: March 20, 2007
    Last modified: October 1, 2014
    This is version 20 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)

    Miscellaneousi

    Keywords - Technical termi

    Direct protein sequencing

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3