ID   A2V6W2_PHYMC            Unreviewed;       149 AA.
AC   A2V6W2;
DT   20-MAR-2007, integrated into UniProtKB/TrEMBL.
DT   20-MAR-2007, sequence version 1.
DT   22-FEB-2023, entry version 31.
DE   SubName: Full=Urea transporter UT-A transcript variant {ECO:0000313|EMBL:BAF46920.1};
DE   Flags: Fragment;
OS   Physeter macrocephalus (Sperm whale) (Physeter catodon).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Odontoceti;
OC   Physeteridae; Physeter.
OX   NCBI_TaxID=9755 {ECO:0000313|EMBL:BAF46920.1};
RN   [1] {ECO:0000313|EMBL:BAF46920.1}
RP   NUCLEOTIDE SEQUENCE.
RC   TISSUE=Kidney {ECO:0000313|EMBL:BAF46920.1};
RX   PubMed=18032079; DOI=10.1016/j.cbpb.2006.11.033;
RA   Birukawa N., Ando H., Goto M., Kanda N., Pastene L.A., Urano A.;
RT   "Molecular cloning of urea transporters from the kidneys of baleen and
RT   toothed whales.";
RL   Comp. Biochem. Physiol. B, Biochem. Mol. Biol. 149:227-235(2008).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=urea(in) = urea(out); Xref=Rhea:RHEA:32799, ChEBI:CHEBI:16199;
CC         Evidence={ECO:0000256|ARBA:ARBA00033993};
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC       Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC       {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the urea transporter family.
CC       {ECO:0000256|ARBA:ARBA00005914}.
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DR   EMBL; AB266073; BAF46920.1; -; mRNA.
DR   AlphaFoldDB; A2V6W2; -.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015204; F:urea transmembrane transporter activity; IEA:InterPro.
DR   Gene3D; 1.10.3430.10; Ammonium transporter AmtB like domains; 2.
DR   InterPro; IPR029020; Ammonium/urea_transptr.
DR   InterPro; IPR004937; Urea_transporter.
DR   PANTHER; PTHR10464; UREA TRANSPORTER; 1.
DR   PANTHER; PTHR10464:SF6; UREA TRANSPORTER 2; 1.
DR   Pfam; PF03253; UT; 2.
PE   2: Evidence at transcript level;
KW   Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        44..63
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        70..89
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   NON_TER         1
FT                   /evidence="ECO:0000313|EMBL:BAF46920.1"
FT   NON_TER         149
FT                   /evidence="ECO:0000313|EMBL:BAF46920.1"
SQ   SEQUENCE   149 AA;  16166 MW;  CFD9E9779703EFF3 CRC64;
     TKLLQPSSSM PNITWSEVQV PLLLRAIPVG IGQVYGCDNP WTGGIFLIAL FISSPLICLH
     AAIGSAMGML AALFAAYLGA ALANVLSVFG LPPCTWPFCL SALTFLLLTT NNPAIYKLPL
     SKVTYPEANR IYYLSQEKNR RASTITKYQ
//