ID   A2V6V6_BALAC            Unreviewed;       397 AA.
AC   A2V6V6;
DT   20-MAR-2007, integrated into UniProtKB/TrEMBL.
DT   20-MAR-2007, sequence version 1.
DT   22-FEB-2023, entry version 35.
DE   RecName: Full=Urea transporter {ECO:0000256|PIRNR:PIRNR016502};
OS   Balaenoptera acutorostrata (Common minke whale) (Balaena rostrata).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Mysticeti;
OC   Balaenopteridae; Balaenoptera.
OX   NCBI_TaxID=9767 {ECO:0000313|EMBL:BAF46914.1};
RN   [1] {ECO:0000313|EMBL:BAF46914.1}
RP   NUCLEOTIDE SEQUENCE.
RC   TISSUE=Kidney {ECO:0000313|EMBL:BAF46914.1};
RX   PubMed=18032079; DOI=10.1016/j.cbpb.2006.11.033;
RA   Birukawa N., Ando H., Goto M., Kanda N., Pastene L.A., Urano A.;
RT   "Molecular cloning of urea transporters from the kidneys of baleen and
RT   toothed whales.";
RL   Comp. Biochem. Physiol. B, Biochem. Mol. Biol. 149:227-235(2008).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=urea(in) = urea(out); Xref=Rhea:RHEA:32799, ChEBI:CHEBI:16199;
CC         Evidence={ECO:0000256|ARBA:ARBA00033993};
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC       Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC       {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the urea transporter family.
CC       {ECO:0000256|ARBA:ARBA00005914, ECO:0000256|PIRNR:PIRNR016502}.
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DR   EMBL; AB266067; BAF46914.1; -; mRNA.
DR   EMBL; AB266068; BAF46915.1; -; mRNA.
DR   AlphaFoldDB; A2V6V6; -.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015204; F:urea transmembrane transporter activity; IEA:InterPro.
DR   Gene3D; 1.10.3430.10; Ammonium transporter AmtB like domains; 1.
DR   InterPro; IPR029020; Ammonium/urea_transptr.
DR   InterPro; IPR004937; Urea_transporter.
DR   PANTHER; PTHR10464; UREA TRANSPORTER; 1.
DR   PANTHER; PTHR10464:SF6; UREA TRANSPORTER 2; 1.
DR   Pfam; PF03253; UT; 1.
DR   PIRSF; PIRSF016502; Urea_transporter; 1.
PE   2: Evidence at transcript level;
KW   Cell membrane {ECO:0000256|ARBA:ARBA00022475,
KW   ECO:0000256|PIRNR:PIRNR016502};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|PIRNR:PIRNR016502};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|PIRNR:PIRNR016502}.
FT   TRANSMEM        90..109
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        116..135
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        141..167
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        174..196
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        242..274
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        280..302
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        309..332
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        338..359
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   SITE            338
FT                   /note="Important for channel permeability"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR016502-1"
SQ   SEQUENCE   397 AA;  42935 MW;  4C12913B9E90A533 CRC64;
     MEKSSEIKVE TGISKTSWIQ SSLAASGKRV RKALGYITGE MKECGEGLKD KSPVLQFLGW
     VLRGVSQVMF VNNPLSGILI VLGLFVQNPW WAISGCLGTV VSTLTALSLS QDKSAIAAGL
     HGYNGVLVGL LMAVFSDKGD YYWWLLLPVI VMSVSCPILS SALGTIFSKW DLPVFTLPFN
     IAVTLYLAAT GHYNLFFPTK LLQPSSSMPN ITWSEVQVPL LLRAIPVGIG QVYGCDNPWT
     GGIFLIALFI SSPLICLHAA IGSAMGMLAA LTLATPFDSI YFGLCGFNST LACIAIGGMF
     YVITWQTHLL AVACALFAAY LGAALANVLS VFGLPPCTWP FCLSALTFLL LTTNNPAIYK
     LPLSKVTYPE ANRIYYLSQE KNRRASTITK YQAYDVS
//