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A2TIL1

- GSHR_CALJA

UniProt

A2TIL1 - GSHR_CALJA

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Protein
Glutathione reductase, mitochondrial
Gene
GSR
Organism
Callithrix jacchus (White-tufted-ear marmoset)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Maintains high levels of reduced glutathione in the cytosol By similarity.

Catalytic activityi

2 glutathione + NADP+ = glutathione disulfide + NADPH.

Cofactori

Binds 1 FAD per subunit By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei511 – 5111Proton acceptor By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi94 – 1029FAD By similarity

GO - Molecular functioni

  1. NADP binding Source: InterPro
  2. flavin adenine dinucleotide binding Source: InterPro
  3. glutathione-disulfide reductase activity Source: UniProtKB-EC
Complete GO annotation...

GO - Biological processi

  1. cell redox homeostasis Source: InterPro
  2. glutathione metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

FAD, Flavoprotein, NADP

Names & Taxonomyi

Protein namesi
Recommended name:
Glutathione reductase, mitochondrial (EC:1.8.1.7)
Short name:
GR
Short name:
GRase
Gene namesi
Name:GSR
OrganismiCallithrix jacchus (White-tufted-ear marmoset)
Taxonomic identifieri9483 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniPlatyrrhiniCebidaeCallitrichinaeCallithrix
ProteomesiUP000008225: Unplaced

Subcellular locationi

GO - Cellular componenti

  1. mitochondrion Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 4343Mitochondrion Reviewed prediction
Add
BLAST
Chaini44 – 522479Glutathione reductase, mitochondrial
PRO_0000314948Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei97 – 971N6-acetyllysine By similarity
Disulfide bondi102 ↔ 107Redox-active By similarity
Disulfide bondi134 – 134Interchain By similarity

Keywords - PTMi

Acetylation, Disulfide bond

Proteomic databases

PRIDEiA2TIL1.

Interactioni

Subunit structurei

Homodimer; disulfide-linked By similarity.

Structurei

3D structure databases

ProteinModelPortaliA2TIL1.
SMRiA2TIL1. Positions 61-522.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Redox-active center, Transit peptide

Phylogenomic databases

HOGENOMiHOG000276712.
HOVERGENiHBG004959.

Family and domain databases

Gene3Di3.30.390.30. 1 hit.
InterProiIPR016156. FAD/NAD-linked_Rdtase_dimer.
IPR013027. FAD_pyr_nucl-diS_OxRdtase.
IPR006322. Glutathione_Rdtase_euk/bac.
IPR004099. Pyr_nucl-diS_OxRdtase_dimer.
IPR023753. Pyr_nucl-diS_OxRdtase_FAD/NAD.
IPR012999. Pyr_OxRdtase_I_AS.
IPR001327. Pyr_OxRdtase_NAD-bd_dom.
[Graphical view]
PfamiPF00070. Pyr_redox. 1 hit.
PF07992. Pyr_redox_2. 1 hit.
PF02852. Pyr_redox_dim. 1 hit.
[Graphical view]
PRINTSiPR00368. FADPNR.
SUPFAMiSSF55424. SSF55424. 1 hit.
TIGRFAMsiTIGR01421. gluta_reduc_1. 1 hit.
PROSITEiPS00076. PYRIDINE_REDOX_1. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative initiation. Align

Isoform Mitochondrial (identifier: A2TIL1-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MALLPRALSS GGRPSWRRAA RASRGFPLPL PFPAAATHAL SRAMACRQEP    50
QPQGPPPSAG AVVSYDYLVI GGGSGGLASA RRAAELGARA AVVESHKLGG 100
TCVNVGCVPK KVMWNTAVHS EFLHDHGDYG FSSCEGKFNW RVIKEKRDTY 150
VSRLNTIYQN NLTKAHIEII HGHAVFTSDT KPTIEVSGRK YTAPHILIAT 200
GGMPSSPHES QIPGASLGIT SDGFFELEEL PSRSVIVGAG YIAVEIAGIL 250
SALGSKTSLM IRHDKVLRSF DSMISTNCTE ELENAGVEVL KFSQVKEVKK 300
TSSGLEVSLV TAVPGRLPVM TTISDVDCLL WAIGRDPNSK GLSLNKLGIK 350
TDDKGHIIVD EFQNTNVKGI YAVGDVCGKA LLTPVAIAAG RKLAHRLFEN 400
KEDSKLDYNN IPTVVFSHPP IGTVGLTEDE AIHKYGKENV KIYSTSFTPM 450
YHAVTKRKTK CVMKMVCAYE EEKVVGIHMQ GLGCDEMLQG FAVAVKMGAT 500
KADFDNTVAI HPTSSEELVP LR 522
Length:522
Mass (Da):56,193
Last modified:March 6, 2007 - v1
Checksum:iA952357C8E8E0E86
GO
Isoform Cytoplasmic (identifier: A2TIL1-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-43: Missing.

Show »
Length:479
Mass (Da):51,670
Checksum:i49B2B4DA8179C17C
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 4343Missing in isoform Cytoplasmic.
VSP_030441Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
EF203010 mRNA. Translation: ABN05297.1.
RefSeqiNP_001171974.1. NM_001185045.1. [A2TIL1-1]

Genome annotation databases

GeneIDi100393824.

Keywords - Coding sequence diversityi

Alternative initiation

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
EF203010 mRNA. Translation: ABN05297.1 .
RefSeqi NP_001171974.1. NM_001185045.1. [A2TIL1-1 ]

3D structure databases

ProteinModelPortali A2TIL1.
SMRi A2TIL1. Positions 61-522.
ModBasei Search...

Proteomic databases

PRIDEi A2TIL1.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 100393824.

Organism-specific databases

CTDi 2936.

Phylogenomic databases

HOGENOMi HOG000276712.
HOVERGENi HBG004959.

Family and domain databases

Gene3Di 3.30.390.30. 1 hit.
InterProi IPR016156. FAD/NAD-linked_Rdtase_dimer.
IPR013027. FAD_pyr_nucl-diS_OxRdtase.
IPR006322. Glutathione_Rdtase_euk/bac.
IPR004099. Pyr_nucl-diS_OxRdtase_dimer.
IPR023753. Pyr_nucl-diS_OxRdtase_FAD/NAD.
IPR012999. Pyr_OxRdtase_I_AS.
IPR001327. Pyr_OxRdtase_NAD-bd_dom.
[Graphical view ]
Pfami PF00070. Pyr_redox. 1 hit.
PF07992. Pyr_redox_2. 1 hit.
PF02852. Pyr_redox_dim. 1 hit.
[Graphical view ]
PRINTSi PR00368. FADPNR.
SUPFAMi SSF55424. SSF55424. 1 hit.
TIGRFAMsi TIGR01421. gluta_reduc_1. 1 hit.
PROSITEi PS00076. PYRIDINE_REDOX_1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Free radical scavenging enzymes in Callithrix jacchus."
    Atanasova S., von Ahsen N., Schlumbohm C., Wieland E., Oellerich M., Armstrong V.
    Submitted (JAN-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiGSHR_CALJA
AccessioniPrimary (citable) accession number: A2TIL1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: March 6, 2007
Last modified: May 14, 2014
This is version 50 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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