Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

A2TIL1 (GSHR_CALJA) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 49. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Glutathione reductase, mitochondrial

Short name=GR
Short name=GRase
EC=1.8.1.7
Gene names
Name:GSR
OrganismCallithrix jacchus (White-tufted-ear marmoset) [Reference proteome]
Taxonomic identifier9483 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniPlatyrrhiniCebidaeCallitrichinaeCallithrix

Protein attributes

Sequence length522 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Maintains high levels of reduced glutathione in the cytosol By similarity.

Catalytic activity

2 glutathione + NADP+ = glutathione disulfide + NADPH.

Cofactor

Binds 1 FAD per subunit By similarity.

Subunit structure

Homodimer; disulfide-linked By similarity.

Subcellular location

Isoform Mitochondrial: Mitochondrion By similarity.

Isoform Cytoplasmic: Cytoplasm By similarity.

Sequence similarities

Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.

Alternative products

This entry describes 2 isoforms produced by alternative initiation. [Align] [Select]
Isoform Mitochondrial (identifier: A2TIL1-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform Cytoplasmic (identifier: A2TIL1-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-43: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Transit peptide1 – 4343Mitochondrion Potential
Chain44 – 522479Glutathione reductase, mitochondrial
PRO_0000314948

Regions

Nucleotide binding94 – 1029FAD By similarity

Sites

Active site5111Proton acceptor By similarity

Amino acid modifications

Modified residue971N6-acetyllysine By similarity
Disulfide bond102 ↔ 107Redox-active By similarity
Disulfide bond134Interchain By similarity

Natural variations

Alternative sequence1 – 4343Missing in isoform Cytoplasmic.
VSP_030441

Sequences

Sequence LengthMass (Da)Tools
Isoform Mitochondrial [UniParc].

Last modified March 6, 2007. Version 1.
Checksum: A952357C8E8E0E86

FASTA52256,193
        10         20         30         40         50         60 
MALLPRALSS GGRPSWRRAA RASRGFPLPL PFPAAATHAL SRAMACRQEP QPQGPPPSAG 

        70         80         90        100        110        120 
AVVSYDYLVI GGGSGGLASA RRAAELGARA AVVESHKLGG TCVNVGCVPK KVMWNTAVHS 

       130        140        150        160        170        180 
EFLHDHGDYG FSSCEGKFNW RVIKEKRDTY VSRLNTIYQN NLTKAHIEII HGHAVFTSDT 

       190        200        210        220        230        240 
KPTIEVSGRK YTAPHILIAT GGMPSSPHES QIPGASLGIT SDGFFELEEL PSRSVIVGAG 

       250        260        270        280        290        300 
YIAVEIAGIL SALGSKTSLM IRHDKVLRSF DSMISTNCTE ELENAGVEVL KFSQVKEVKK 

       310        320        330        340        350        360 
TSSGLEVSLV TAVPGRLPVM TTISDVDCLL WAIGRDPNSK GLSLNKLGIK TDDKGHIIVD 

       370        380        390        400        410        420 
EFQNTNVKGI YAVGDVCGKA LLTPVAIAAG RKLAHRLFEN KEDSKLDYNN IPTVVFSHPP 

       430        440        450        460        470        480 
IGTVGLTEDE AIHKYGKENV KIYSTSFTPM YHAVTKRKTK CVMKMVCAYE EEKVVGIHMQ 

       490        500        510        520 
GLGCDEMLQG FAVAVKMGAT KADFDNTVAI HPTSSEELVP LR 

« Hide

Isoform Cytoplasmic [UniParc].

Checksum: 49B2B4DA8179C17C
Show »

FASTA47951,670

References

[1]"Free radical scavenging enzymes in Callithrix jacchus."
Atanasova S., von Ahsen N., Schlumbohm C., Wieland E., Oellerich M., Armstrong V.
Submitted (JAN-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
EF203010 mRNA. Translation: ABN05297.1.
RefSeqNP_001171974.1. NM_001185045.1.

3D structure databases

ProteinModelPortalA2TIL1.
SMRA2TIL1. Positions 61-522.
ModBaseSearch...
MobiDBSearch...

Proteomic databases

PRIDEA2TIL1.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID100393824.

Organism-specific databases

CTD2936.

Phylogenomic databases

HOGENOMHOG000276712.
HOVERGENHBG004959.

Family and domain databases

Gene3D3.30.390.30. 1 hit.
InterProIPR016156. FAD/NAD-linked_Rdtase_dimer.
IPR013027. FAD_pyr_nucl-diS_OxRdtase.
IPR006322. Glutathione_Rdtase_euk/bac.
IPR004099. Pyr_nucl-diS_OxRdtase_dimer.
IPR023753. Pyr_nucl-diS_OxRdtase_FAD/NAD.
IPR012999. Pyr_OxRdtase_I_AS.
IPR001327. Pyr_OxRdtase_NAD-bd_dom.
[Graphical view]
PfamPF00070. Pyr_redox. 1 hit.
PF07992. Pyr_redox_2. 1 hit.
PF02852. Pyr_redox_dim. 1 hit.
[Graphical view]
PRINTSPR00368. FADPNR.
SUPFAMSSF55424. SSF55424. 1 hit.
TIGRFAMsTIGR01421. gluta_reduc_1. 1 hit.
PROSITEPS00076. PYRIDINE_REDOX_1. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameGSHR_CALJA
AccessionPrimary (citable) accession number: A2TIL1
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: March 6, 2007
Last modified: February 19, 2014
This is version 49 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families