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Protein
Submitted name:

Telomerase reverse transcriptase

Gene

tert

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  • DNA binding Source: InterPro
  • telomerase activity Source: ZFIN
  • telomerase RNA reverse transcriptase activity Source: InterPro

GO - Biological processi

  • age-dependent general metabolic decline Source: ZFIN
  • erythrocyte maturation Source: ZFIN
  • hemopoiesis Source: ZFIN
  • intestinal epithelial structure maintenance Source: ZFIN
  • spermatogenesis Source: ZFIN
  • telomere maintenance via telomerase Source: ZFIN
Complete GO annotation...

Keywords - Molecular functioni

Nucleotidyltransferase, RNA-directed DNA polymeraseImported, Transferase

Names & Taxonomyi

Protein namesi
Submitted name:
Telomerase reverse transcriptaseImported
Gene namesi
Name:tertImported
Synonyms:TERTImported
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)Imported
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio

Organism-specific databases

ZFINiZDB-GENE-080405-1. tert.

Subcellular locationi

GO - Cellular componenti

  • nucleus Source: ZFIN
Complete GO annotation...

PTM / Processingi

Proteomic databases

PaxDbiA2THE9.

Interactioni

Protein-protein interaction databases

STRINGi7955.ENSDARP00000124988.

Structurei

3D structure databases

ProteinModelPortaliA2THE9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini585 – 903319Reverse transcriptaseInterPro annotationAdd
BLAST

Sequence similaritiesi

Contains 1 reverse transcriptase domain.UniRule annotation

Phylogenomic databases

eggNOGiKOG1005. Eukaryota.
ENOG410XQJH. LUCA.
HOGENOMiHOG000148780.
HOVERGENiHBG000460.
KOiK11126.

Family and domain databases

InterProiIPR000477. RT_dom.
IPR021891. Telomerase_RBD.
IPR003545. Telomerase_RT.
[Graphical view]
PANTHERiPTHR12066:SF0. PTHR12066:SF0. 1 hit.
PfamiPF00078. RVT_1. 1 hit.
PF12009. Telomerase_RBD. 1 hit.
[Graphical view]
PRINTSiPR01365. TELOMERASERT.
SMARTiSM00975. Telomerase_RBD. 1 hit.
[Graphical view]
PROSITEiPS50878. RT_POL. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A2THE9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSGQYSTDGG FRPVLEILRS LYPVVQTLEE FTDGLQFPDG RKPVLLEETD
60 70 80 90 100
GARFKKLLSG LIVCAYTPPQ LRVPAQLSTL PEVLAFTLNH IKRKKLRNVL
110 120 130 140 150
GFGYQCSDVT TSSDPFRFHG DVSQTAASIS TSEVWKRINQ RLGTEVTRYL
160 170 180 190 200
LQDCAVFTTV PPSCVLQVCG EPVYDLLMPR SWSGFFLSNS DNERISGAMR
210 220 230 240 250
KFPAVQKTVA ISKKRTRDNE KYISVKRRRV KETVNNNNGN YRSLCFAISK
260 270 280 290 300
KRAIDNEENI SLKRRRMEET DQVAKIRNEN HESQSFAISK KRARDNEENI
310 320 330 340 350
SLKRQRMEEI DQVAKIRNEN HGSQSWKPAD QRPPRPSQCS IRVLSMLYNG
360 370 380 390 400
RGMKNFLLNR KLKGVGGARR MQGEDLVRMI FLQSESNDSK PKKLPKRFFA
410 420 430 440 450
MVPLFSRLLR QHRKCPYRLF LQRKCAGNPD VKDMESLLKS HSSPYRVYLF
460 470 480 490 500
VRECLRHIIP HELWGCQENQ LHFLSNVKNF LLLGKFERLT LVQLMWRMKV
510 520 530 540 550
QACHWLGPKK RQCASEHRYR EWMLGQCMGW MLSGFVVGLV RAQFYITESM
560 570 580 590 600
GHKHTLRFYR GDVWSRLQDQ AFRAHLCKGQ WRPLSPSQAL KVPNSAVTSR
610 620 630 640 650
IRFIPKTSSM RPITRLSGSR DTLQYFQSCV RVLQNVLSVC VREAPGPMGS
660 670 680 690 700
TVWGWQDIHR RLQDFSPQQK SSPRPLYFVK VDVSGAYDSL PHLKLVEVLK
710 720 730 740 750
EVLGPFAEQS FFLRQYSSVW SDPTRGLRKR FCTKAEMSEP LNMKGFVVDE
760 770 780 790 800
QVSGRLHDAI LVERHSSEVR GGDVFQFFQK MLCSYVIHYD QQMFRQVCGI
810 820 830 840 850
PQGSSVSSLL CNLCYGHMEK ALLKDIAKGG CLMRLIDDFL LITPHLSKAT
860 870 880 890 900
EFLTTLLSGV PDYGCQINPQ KVAVNFPVCV SWVNSGVSVL PSSCLFPWCG
910 920 930 940 950
LMIHTHTLDV YKDYSRYDGL SLRYSLTLGS AHSPSTVMKK LLSVLSIKST
960 970 980 990 1000
DIFLDLRLNS VEAVYRSLYK LILLQALRFH ACVRSLPLGQ SVNRNPSFFL
1010 1020 1030 1040 1050
KMIWRMTRVT NKLLTHINKG LPVCSVDSGG VLQSEAVQLL FCLAFETLFR
1060 1070 1080 1090
RFRSVYHCLI PALHKRKRAL QRELCGITLA RVRQASSPRI PLDFSMRV
Length:1,098
Mass (Da):125,987
Last modified:March 6, 2007 - v1
Checksum:i466F3E0C78D54366
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EF202140 mRNA. Translation: ABM92944.1.
RefSeqiNP_001077335.1. NM_001083866.1.
UniGeneiDr.87388.

Genome annotation databases

GeneIDi796551.
KEGGidre:796551.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EF202140 mRNA. Translation: ABM92944.1.
RefSeqiNP_001077335.1. NM_001083866.1.
UniGeneiDr.87388.

3D structure databases

ProteinModelPortaliA2THE9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7955.ENSDARP00000124988.

Proteomic databases

PaxDbiA2THE9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi796551.
KEGGidre:796551.

Organism-specific databases

CTDi7015.
ZFINiZDB-GENE-080405-1. tert.

Phylogenomic databases

eggNOGiKOG1005. Eukaryota.
ENOG410XQJH. LUCA.
HOGENOMiHOG000148780.
HOVERGENiHBG000460.
KOiK11126.

Family and domain databases

InterProiIPR000477. RT_dom.
IPR021891. Telomerase_RBD.
IPR003545. Telomerase_RT.
[Graphical view]
PANTHERiPTHR12066:SF0. PTHR12066:SF0. 1 hit.
PfamiPF00078. RVT_1. 1 hit.
PF12009. Telomerase_RBD. 1 hit.
[Graphical view]
PRINTSiPR01365. TELOMERASERT.
SMARTiSM00975. Telomerase_RBD. 1 hit.
[Graphical view]
PROSITEiPS50878. RT_POL. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiA2THE9_DANRE
AccessioniPrimary (citable) accession number: A2THE9
Entry historyi
Integrated into UniProtKB/TrEMBL: March 6, 2007
Last sequence update: March 6, 2007
Last modified: July 6, 2016
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.