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A2TC44 (ACDH_SPHYA) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 35. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Acetaldehyde dehydrogenase

EC=1.2.1.10
Alternative name(s):
Acetaldehyde dehydrogenase [acetylating]
Gene names
Name:xylQ
OrganismSphingobium yanoikuyae (Sphingomonas yanoikuyae)
Taxonomic identifier13690 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaSphingomonadalesSphingomonadaceaeSphingobium

Protein attributes

Sequence length312 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the conversion of acetaldehyde to acetyl-CoA, using NAD+ and coenzyme A. Is the final enzyme in the meta-cleavage pathway for the degradation of aromatic compounds By similarity. HAMAP-Rule MF_01657

Catalytic activity

Acetaldehyde + CoA + NAD+ = acetyl-CoA + NADH. HAMAP-Rule MF_01657

Sequence similarities

Belongs to the acetaldehyde dehydrogenase family.

Ontologies

Keywords
   Biological processAromatic hydrocarbons catabolism
   LigandNAD
   Molecular functionOxidoreductase
Gene Ontology (GO)
   Biological_processaromatic compound catabolic process

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Molecular_functionNAD binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

acetaldehyde dehydrogenase (acetylating) activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 312312Acetaldehyde dehydrogenase HAMAP-Rule MF_01657
PRO_0000387745

Regions

Nucleotide binding11 – 144NAD By similarity
Nucleotide binding160 – 1689NAD By similarity

Sites

Active site1291Acyl-thioester intermediate By similarity
Binding site2871NAD By similarity

Sequences

Sequence LengthMass (Da)Tools
A2TC44 [UniParc].

Last modified March 6, 2007. Version 1.
Checksum: C4E7509F7F064B2D

FASTA31233,009
        10         20         30         40         50         60 
MTKMKCAIIG SGNIGTDLMI KLLKGSDTLE LAAVVGIDPA SEGLAMARER GVATTHEGIE 

        70         80         90        100        110        120 
GLRKLPAYPE IGIAFDATSA YAHKEHDAAL QADGKLVVDL TPAAIGPFFV PPVGGVLDSE 

       130        140        150        160        170        180 
IRNVNMVTCG GQATIPIVAA VSRVTPVHYA EIVASVSSRS AGPGTRANID EFTRTTAQAI 

       190        200        210        220        230        240 
EIVGGAGRGR AIIILNPAEP PMIMRDTIFT LTDQVDEDAI RASVKEMVET VQAYVPGYRL 

       250        260        270        280        290        300 
KQEVQFERFG SNRPLKIPGY GEFVGLKTSV FLEVEGAGDY LPKYSGNLDI MTAAAKAAGE 

       310 
RLAQQRLEKV AA 

« Hide

References

[1]"Identification, cloning, and characterization of a multicomponent biphenyl dioxygenase from Sphingobium yanoikuyae B1."
Chadhain S.M., Moritz E.M., Kim E., Zylstra G.J.
J. Ind. Microbiol. Biotechnol. 34:605-613(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: DSM 6900 / JCM 10274 / B1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
EF151283 Genomic DNA. Translation: ABM79796.1.

3D structure databases

ProteinModelPortalA2TC44.
SMRA2TC44. Positions 3-307.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

Gene3D3.40.50.720. 1 hit.
HAMAPMF_01657. Ac_ald_DH_ac.
InterProIPR003361. Acetaldehyde_dehydrogenase.
IPR015426. Acetylaldehyde_DH_C.
IPR016040. NAD(P)-bd_dom.
IPR000534. Semialdehyde_DH_NAD-bd.
[Graphical view]
PfamPF09290. AcetDehyd-dimer. 1 hit.
PF01118. Semialdhyde_dh. 1 hit.
[Graphical view]
PIRSFPIRSF015689. Actaldh_dh_actl. 1 hit.
SMARTSM00859. Semialdhyde_dh. 1 hit.
[Graphical view]
TIGRFAMsTIGR03215. ac_ald_DH_ac. 1 hit.
ProtoNetSearch...

Entry information

Entry nameACDH_SPHYA
AccessionPrimary (citable) accession number: A2TC44
Entry history
Integrated into UniProtKB/Swiss-Prot: November 3, 2009
Last sequence update: March 6, 2007
Last modified: February 19, 2014
This is version 35 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families