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A2TC44

- ACDH_SPHYA

UniProt

A2TC44 - ACDH_SPHYA

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Protein

Acetaldehyde dehydrogenase

Gene
xylQ
Organism
Sphingobium yanoikuyae (Sphingomonas yanoikuyae)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the conversion of acetaldehyde to acetyl-CoA, using NAD+ and coenzyme A. Is the final enzyme in the meta-cleavage pathway for the degradation of aromatic compounds By similarity.UniRule annotation

Catalytic activityi

Acetaldehyde + CoA + NAD+ = acetyl-CoA + NADH.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei129 – 1291Acyl-thioester intermediate By similarity
Binding sitei287 – 2871NAD By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi11 – 144NAD By similarity
Nucleotide bindingi160 – 1689NAD By similarity

GO - Molecular functioni

  1. acetaldehyde dehydrogenase (acetylating) activity Source: UniProtKB-HAMAP
  2. NAD binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. aromatic compound catabolic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Aromatic hydrocarbons catabolism

Keywords - Ligandi

NAD

Names & Taxonomyi

Protein namesi
Recommended name:
Acetaldehyde dehydrogenase (EC:1.2.1.10)
Alternative name(s):
Acetaldehyde dehydrogenase [acetylating]
Gene namesi
Name:xylQ
OrganismiSphingobium yanoikuyae (Sphingomonas yanoikuyae)
Taxonomic identifieri13690 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaSphingomonadalesSphingomonadaceaeSphingobium

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 312312Acetaldehyde dehydrogenaseUniRule annotationPRO_0000387745Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliA2TC44.
SMRiA2TC44. Positions 3-307.

Family & Domainsi

Sequence similaritiesi

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
HAMAPiMF_01657. Ac_ald_DH_ac.
InterProiIPR003361. Acetaldehyde_dehydrogenase.
IPR015426. Acetylaldehyde_DH_C.
IPR016040. NAD(P)-bd_dom.
IPR000534. Semialdehyde_DH_NAD-bd.
[Graphical view]
PfamiPF09290. AcetDehyd-dimer. 1 hit.
PF01118. Semialdhyde_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF015689. Actaldh_dh_actl. 1 hit.
SMARTiSM00859. Semialdhyde_dh. 1 hit.
[Graphical view]
TIGRFAMsiTIGR03215. ac_ald_DH_ac. 1 hit.

Sequencei

Sequence statusi: Complete.

A2TC44-1 [UniParc]FASTAAdd to Basket

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MTKMKCAIIG SGNIGTDLMI KLLKGSDTLE LAAVVGIDPA SEGLAMARER    50
GVATTHEGIE GLRKLPAYPE IGIAFDATSA YAHKEHDAAL QADGKLVVDL 100
TPAAIGPFFV PPVGGVLDSE IRNVNMVTCG GQATIPIVAA VSRVTPVHYA 150
EIVASVSSRS AGPGTRANID EFTRTTAQAI EIVGGAGRGR AIIILNPAEP 200
PMIMRDTIFT LTDQVDEDAI RASVKEMVET VQAYVPGYRL KQEVQFERFG 250
SNRPLKIPGY GEFVGLKTSV FLEVEGAGDY LPKYSGNLDI MTAAAKAAGE 300
RLAQQRLEKV AA 312
Length:312
Mass (Da):33,009
Last modified:March 6, 2007 - v1
Checksum:iC4E7509F7F064B2D
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
EF151283 Genomic DNA. Translation: ABM79796.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
EF151283 Genomic DNA. Translation: ABM79796.1 .

3D structure databases

ProteinModelPortali A2TC44.
SMRi A2TC44. Positions 3-307.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

Gene3Di 3.40.50.720. 1 hit.
HAMAPi MF_01657. Ac_ald_DH_ac.
InterProi IPR003361. Acetaldehyde_dehydrogenase.
IPR015426. Acetylaldehyde_DH_C.
IPR016040. NAD(P)-bd_dom.
IPR000534. Semialdehyde_DH_NAD-bd.
[Graphical view ]
Pfami PF09290. AcetDehyd-dimer. 1 hit.
PF01118. Semialdhyde_dh. 1 hit.
[Graphical view ]
PIRSFi PIRSF015689. Actaldh_dh_actl. 1 hit.
SMARTi SM00859. Semialdhyde_dh. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR03215. ac_ald_DH_ac. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Identification, cloning, and characterization of a multicomponent biphenyl dioxygenase from Sphingobium yanoikuyae B1."
    Chadhain S.M., Moritz E.M., Kim E., Zylstra G.J.
    J. Ind. Microbiol. Biotechnol. 34:605-613(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: DSM 6900 / JCM 10274 / B1.

Entry informationi

Entry nameiACDH_SPHYA
AccessioniPrimary (citable) accession number: A2TC44
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 3, 2009
Last sequence update: March 6, 2007
Last modified: February 19, 2014
This is version 35 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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