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A2T929 (RXRAA_DANRE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 3, 2013. Version 47. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Retinoic acid receptor RXR-alpha-A
Alternative name(s):
Nuclear receptor subfamily 2 group B member 1-A
RXRalpha-B
Retinoid X receptor alpha-A
Gene names
Name:rxraa
Synonyms:nr2b1a
OrganismDanio rerio (Zebrafish) (Brachydanio rerio) [Reference proteome]
Taxonomic identifier7955 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Actinopterygii › Neopterygii › Teleostei › Ostariophysi › Cypriniformes › Cyprinidae › Danio

Protein attributes

Sequence length430 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The rar/rxr heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. The high affinity ligand for rxrs is 9-cis retinoic acid By similarity.

Subunit structure

Homodimer By similarity. Heterodimer; with a rar molecule By similarity. Binds DNA preferentially as a rar/rxr heterodimer By similarity.

Subcellular location

Nucleus By similarity.

Developmental stage

Expressed both maternally and zygotically. In the embryo, expressed in the posterior hindbrain and anterior spinal cord at the 5-somite stage, with expression increasing through to the 15-somite stage. At the 15-somite stage, also expressed in the tail bud region. At the 18-somite stage, also found in the third neural crest stream. Ref.1 Ref.3

Domain

Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding domain.

Sequence similarities

Belongs to the nuclear hormone receptor family. NR2 subfamily.

Contains 1 nuclear receptor DNA-binding domain.

Sequence caution

The sequence ABM89229.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 430430Retinoic acid receptor RXR-alpha-A
PRO_0000287896

Regions

DNA binding100 – 17576Nuclear receptor
Zinc finger103 – 12321NR C4-type
Zinc finger139 – 15820NR C4-type
Region1 – 9999Modulating By similarity UniProtKB P10276
Region176 – 19217Hinge By similarity UniProtKB P28700
Region193 – 430238Ligand-binding By similarity UniProtKB P28700
Compositional bias4 – 7269Ser-rich

Sequences

Sequence LengthMass (Da)Tools
A2T929 [UniParc].

Last modified May 15, 2007. Version 2.
Checksum: 362DBD748A24191F

FASTA43047,471
        10         20         30         40         50         60 
MHPSLLSPTS LGPSGSLHSP ISTLSSPMNG LGSPFSVISS PMGPHSMASP GVGYGPSISP 

        70         80         90        100        110        120 
QLNSHMNSVS SSEDIKPPLG LNGVMKVPAQ PSGTPLSLTK HICAICGDRS SGKHYGVYSC 

       130        140        150        160        170        180 
EGCKGFFKRT VRKDLTYTCR DNKDCVIDKR QRNRCQYCRY QKCLAMGMKR EAVQEERQRA 

       190        200        210        220        230        240 
KERSENEVES TSSANEDMPV EKILEAELAV EPKTETYIET NVPMPSNSPN DPVTNICQAA 

       250        260        270        280        290        300 
DKQLFTLVEW AKRIPHFSEL PLDDQVILLR AGWNELLIAS FSHRSIAVKD GILLATGLHV 

       310        320        330        340        350        360 
HRNSAHSAGV GAIFDRVLTE LVSKMRDMQM DKTELGCLRA IVLFNPDSKG LSNPGEVEAL 

       370        380        390        400        410        420 
REKVYASLEA YCKHKYPEQP GRFAKLLLRL PALRSIGLKC LEHLFFFKLI GDTPIDTFLM 

       430 
EMLEAPHQMT

« Hide

References

[1]"Comparison of the expression patterns of newly identified zebrafish retinoic acid and retinoid X receptors."
Waxman J.S., Yelon D.
Dev. Dyn. 236:587-595(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-312, DEVELOPMENTAL STAGE.
[2]"Nuclear receptors expression during zebrafish development reveals an unsuspected link with nervous system and retina development."
Bertrand S., Sachs L., Bardet P.-L., Bonnelye E., Dufraisse M., Escriva H., Haramis A.-P., Marchand O., Safi R., Vanacker J.-M., Zelus D., Thisse C., Thisse B., Laudet V.
Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 66-430.
[3]"Unexpected novel relational links uncovered by extensive developmental profiling of nuclear receptor expression."
Bertrand S., Thisse B., Tavares R., Sachs L., Chaumot A., Bardet P.-L., Escriva H., Duffraisse M., Marchand O., Safi R., Thisse C., Laudet V.
PLoS Genet. 3:E188-E188(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: DEVELOPMENTAL STAGE.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		EF028132 mRNA. Translation: ABM89229.1. Different initiation.
DQ017629 mRNA. Translation: AAY85284.1.
IPIIPI00994409.
UniGeneDr.87467.

3D structure databases

ProteinModelPortalA2T929.
SMRA2T929. Positions 97-179, 193-430.
ModBaseSearch...

Protein-protein interaction databases

STRING7955.ENSDARP00000074930.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Organism-specific databases

ZFINZDB-GENE-070314-2. rxraa.

Phylogenomic databases

eggNOGNOG327099.
HOGENOMHOG000260821.
HOVERGENHBG005606.
InParanoidA2T929.
OrthoDBEOG4SJ5DV.

Family and domain databases

Gene3D1.10.565.10. 1 hit.
3.30.50.10. 1 hit.
InterProIPR021780. Nuc_recep-AF1.
IPR008946. Nucl_hormone_rcpt_ligand-bd.
IPR000536. Nucl_hrmn_rcpt_lig-bd_core.
IPR000003. Retinoid-X_rcpt/HNF4.
IPR001723. Str_hrmn_rcpt.
IPR001628. Znf_hrmn_rcpt.
IPR013088. Znf_NHR/GATA.
[Graphical view]
PfamPF00104. Hormone_recep. 1 hit.
PF11825. Nuc_recep-AF1. 1 hit.
PF00105. zf-C4. 1 hit.
[Graphical view]
PRINTSPR00545. RETINOIDXR.
PR00398. STRDHORMONER.
PR00047. STROIDFINGER.
SMARTSM00430. HOLI. 1 hit.
SM00399. ZnF_C4. 1 hit.
[Graphical view]
SUPFAMSSF48508. Str_ncl_receptor. 1 hit.
PROSITEPS00031. NUCLEAR_REC_DBD_1. 1 hit.
PS51030. NUCLEAR_REC_DBD_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameRXRAA_DANRE
AccessionPrimary (citable) accession number: A2T929
Secondary accession number(s): Q1L677
Entry history
Integrated into UniProtKB/Swiss-Prot: May 15, 2007
Last sequence update: May 15, 2007
Last modified: April 3, 2013
This is version 47 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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