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A2T929

- RXRAA_DANRE

UniProt

A2T929 - RXRAA_DANRE

Protein

Retinoic acid receptor RXR-alpha-A

Gene

rxraa

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 53 (01 Oct 2014)
      Sequence version 2 (15 May 2007)
      Previous versions | rss
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    Functioni

    Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The rar/rxr heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. The high affinity ligand for rxrs is 9-cis retinoic acid By similarity.By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi100 – 17576Nuclear receptorPROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri103 – 12321NR C4-typePROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri139 – 15820NR C4-typePROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. sequence-specific DNA binding Source: InterPro
    2. sequence-specific DNA binding transcription factor activity Source: InterPro
    3. steroid hormone receptor activity Source: InterPro
    4. zinc ion binding Source: InterPro

    GO - Biological processi

    1. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Receptor

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding, Metal-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Retinoic acid receptor RXR-alpha-A
    Alternative name(s):
    Nuclear receptor subfamily 2 group B member 1-A
    RXRalpha-B
    Retinoid X receptor alpha-A
    Gene namesi
    Name:rxraaImported
    Synonyms:nr2b1a
    OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
    Taxonomic identifieri7955 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
    ProteomesiUP000000437: Unplaced

    Organism-specific databases

    ZFINiZDB-GENE-070314-2. rxraa.

    Subcellular locationi

    Nucleus PROSITE-ProRule annotation

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 430430Retinoic acid receptor RXR-alpha-APRO_0000287896Add
    BLAST

    Expressioni

    Developmental stagei

    Expressed both maternally and zygotically. In the embryo, expressed in the posterior hindbrain and anterior spinal cord at the 5-somite stage, with expression increasing through to the 15-somite stage. At the 15-somite stage, also expressed in the tail bud region. At the 18-somite stage, also found in the third neural crest stream.2 Publications

    Interactioni

    Subunit structurei

    Homodimer. Heterodimer; with a rar molecule. Binds DNA preferentially as a rar/rxr heterodimer.By similarity

    Protein-protein interaction databases

    STRINGi7955.ENSDARP00000074930.

    Structurei

    3D structure databases

    ProteinModelPortaliA2T929.
    SMRiA2T929. Positions 97-179, 193-430.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni1 – 9999ModulatingBy similarityAdd
    BLAST
    Regioni176 – 19217HingeBy similarityAdd
    BLAST
    Regioni193 – 430238Ligand-bindingBy similarityAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi4 – 7269Ser-richSequence AnalysisAdd
    BLAST

    Domaini

    Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding domain.

    Sequence similaritiesi

    Belongs to the nuclear hormone receptor family. NR2 subfamily.Sequence Analysis
    Contains 1 nuclear receptor DNA-binding domain.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri103 – 12321NR C4-typePROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri139 – 15820NR C4-typePROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Zinc-finger

    Phylogenomic databases

    eggNOGiNOG327099.
    HOGENOMiHOG000260821.
    HOVERGENiHBG005606.
    InParanoidiA2T929.
    PhylomeDBiA2T929.

    Family and domain databases

    Gene3Di1.10.565.10. 1 hit.
    3.30.50.10. 1 hit.
    InterProiIPR021780. Nuc_recep-AF1.
    IPR008946. Nucl_hormone_rcpt_ligand-bd.
    IPR000536. Nucl_hrmn_rcpt_lig-bd_core.
    IPR000003. Retinoid-X_rcpt/HNF4.
    IPR001723. Str_hrmn_rcpt.
    IPR001628. Znf_hrmn_rcpt.
    IPR013088. Znf_NHR/GATA.
    [Graphical view]
    PfamiPF00104. Hormone_recep. 1 hit.
    PF11825. Nuc_recep-AF1. 1 hit.
    PF00105. zf-C4. 1 hit.
    [Graphical view]
    PRINTSiPR00545. RETINOIDXR.
    PR00398. STRDHORMONER.
    PR00047. STROIDFINGER.
    SMARTiSM00430. HOLI. 1 hit.
    SM00399. ZnF_C4. 1 hit.
    [Graphical view]
    SUPFAMiSSF48508. SSF48508. 1 hit.
    PROSITEiPS00031. NUCLEAR_REC_DBD_1. 1 hit.
    PS51030. NUCLEAR_REC_DBD_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A2T929-1 [UniParc]FASTAAdd to Basket

    « Hide

    MHPSLLSPTS LGPSGSLHSP ISTLSSPMNG LGSPFSVISS PMGPHSMASP    50
    GVGYGPSISP QLNSHMNSVS SSEDIKPPLG LNGVMKVPAQ PSGTPLSLTK 100
    HICAICGDRS SGKHYGVYSC EGCKGFFKRT VRKDLTYTCR DNKDCVIDKR 150
    QRNRCQYCRY QKCLAMGMKR EAVQEERQRA KERSENEVES TSSANEDMPV 200
    EKILEAELAV EPKTETYIET NVPMPSNSPN DPVTNICQAA DKQLFTLVEW 250
    AKRIPHFSEL PLDDQVILLR AGWNELLIAS FSHRSIAVKD GILLATGLHV 300
    HRNSAHSAGV GAIFDRVLTE LVSKMRDMQM DKTELGCLRA IVLFNPDSKG 350
    LSNPGEVEAL REKVYASLEA YCKHKYPEQP GRFAKLLLRL PALRSIGLKC 400
    LEHLFFFKLI GDTPIDTFLM EMLEAPHQMT 430
    Length:430
    Mass (Da):47,471
    Last modified:May 15, 2007 - v2
    Checksum:i362DBD748A24191F
    GO

    Sequence cautioni

    The sequence ABM89229.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    EF028132 mRNA. Translation: ABM89229.1. Different initiation.
    DQ017629 mRNA. Translation: AAY85284.1.
    UniGeneiDr.87467.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    EF028132 mRNA. Translation: ABM89229.1 . Different initiation.
    DQ017629 mRNA. Translation: AAY85284.1 .
    UniGenei Dr.87467.

    3D structure databases

    ProteinModelPortali A2T929.
    SMRi A2T929. Positions 97-179, 193-430.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 7955.ENSDARP00000074930.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Organism-specific databases

    ZFINi ZDB-GENE-070314-2. rxraa.

    Phylogenomic databases

    eggNOGi NOG327099.
    HOGENOMi HOG000260821.
    HOVERGENi HBG005606.
    InParanoidi A2T929.
    PhylomeDBi A2T929.

    Family and domain databases

    Gene3Di 1.10.565.10. 1 hit.
    3.30.50.10. 1 hit.
    InterProi IPR021780. Nuc_recep-AF1.
    IPR008946. Nucl_hormone_rcpt_ligand-bd.
    IPR000536. Nucl_hrmn_rcpt_lig-bd_core.
    IPR000003. Retinoid-X_rcpt/HNF4.
    IPR001723. Str_hrmn_rcpt.
    IPR001628. Znf_hrmn_rcpt.
    IPR013088. Znf_NHR/GATA.
    [Graphical view ]
    Pfami PF00104. Hormone_recep. 1 hit.
    PF11825. Nuc_recep-AF1. 1 hit.
    PF00105. zf-C4. 1 hit.
    [Graphical view ]
    PRINTSi PR00545. RETINOIDXR.
    PR00398. STRDHORMONER.
    PR00047. STROIDFINGER.
    SMARTi SM00430. HOLI. 1 hit.
    SM00399. ZnF_C4. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48508. SSF48508. 1 hit.
    PROSITEi PS00031. NUCLEAR_REC_DBD_1. 1 hit.
    PS51030. NUCLEAR_REC_DBD_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Comparison of the expression patterns of newly identified zebrafish retinoic acid and retinoid X receptors."
      Waxman J.S., Yelon D.
      Dev. Dyn. 236:587-595(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-312, DEVELOPMENTAL STAGE.
    2. "Nuclear receptors expression during zebrafish development reveals an unsuspected link with nervous system and retina development."
      Bertrand S., Sachs L., Bardet P.-L., Bonnelye E., Dufraisse M., Escriva H., Haramis A.-P., Marchand O., Safi R., Vanacker J.-M., Zelus D., Thisse C., Thisse B., Laudet V.
      Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 66-430.
    3. "Unexpected novel relational links uncovered by extensive developmental profiling of nuclear receptor expression."
      Bertrand S., Thisse B., Tavares R., Sachs L., Chaumot A., Bardet P.-L., Escriva H., Duffraisse M., Marchand O., Safi R., Thisse C., Laudet V.
      PLoS Genet. 3:E188-E188(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: DEVELOPMENTAL STAGE.

    Entry informationi

    Entry nameiRXRAA_DANRE
    AccessioniPrimary (citable) accession number: A2T929
    Secondary accession number(s): Q1L677
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 15, 2007
    Last sequence update: May 15, 2007
    Last modified: October 1, 2014
    This is version 53 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3