A2T7F3 (HXA7_PANTR) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Homeobox protein Hox-A7

Gene names

Name:

HOXA7

Organism

Pan troglodytes (Chimpanzee)

Taxonomic identifier

9598 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Pan

Protein attributes

Sequence length	230 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis By similarity.
Subcellular location	Nucleus By similarity.
Sequence similarities	Belongs to the Antp homeobox family. Contains 1 homeobox DNA-binding domain.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Domain	Homeobox
Ligand	DNA-binding
Molecular function	Developmental protein
Gene Ontology (GO)
Biological process	multicellular organismal development Inferred from electronic annotation. Source: UniProtKB-KW transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	sequence-specific DNA binding Inferred from electronic annotation. Source: InterPro sequence-specific DNA binding transcription factor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 230	230	Homeobox protein Hox-A7		PRO_0000285421
Regions
	DNA binding	130 – 189	60	Homeobox
	Motif	119 – 124	6	Antp-type hexapeptide
	Compositional bias	157 – 160	4	Poly-Arg
	Compositional bias	196 – 199	4	Poly-Ala
	Compositional bias	214 – 230	17	Asp/Glu-rich (highly acidic)
	Compositional bias	223 – 230	8	Poly-Glu

Sequences

	Sequence		Length	Mass (Da)
	A2T7F3 [UniParc]. Last modified March 6, 2007. Version 1. Checksum: 4284CF2D0ECEC564	FASTA	230	25,294
	10 20 30 40 50 60 MSSSYYVNAL FSKYTAGASL FQNAEPTSCS FAPNSQRSGY GAGAGAFAST VPGLYNVNSP 70 80 90 100 110 120 LYXSPFASGY GLGADAYGNL PCASYDQNIP GLCSDLAKGA CDKADEGALH GAAEANFRIY 130 140 150 160 170 180 PWMRSSGPDR KRGRQTYTRY QTLELEKEFH FNRYLTRRRR IEIAHALCLT ERQIKIWFQN 190 200 210 220 230 RRMKWKKEHK DDGPTAAAAP EGAVPSAAAT AAADKADEED DDEEEEDEEE

References

[1]	"Positive selection in transcription factor genes on the human lineage." Nickel G.C., Tefft D.L., Trevarthen K., Funt J., Adams M.D. Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	DQ977437 Genomic DNA. Translation: ABM92108.1.
RefSeq	NP_001129067.1. NM_001135595.1.
UniGene	Ptr.6319.
3D structure databases
ProteinModelPortal	A2T7F3.
SMR	A2T7F3. Positions 130-193.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	745634.
KEGG	ptr:745634.
Organism-specific databases
CTD	3204.
Phylogenomic databases
eggNOG	prNOG04663.
GeneTree	ENSGT00600000084133.
HOVERGEN	HBG016849.
InParanoid	A2T7F3.
OrthoDB	EOG4C87V5.
Family and domain databases
InterPro	IPR001356. Homeobox. IPR017995. Homeobox_antennapedia. IPR001827. Homeobox_Antennapedia_CS. IPR017970. Homeobox_CS. IPR020479. Homeobox_eu. IPR009057. Homeodomain-like. IPR012287. Homeodomain-rel. [Graphical view]
Gene3D	G3DSA:1.10.10.60. Homeodomain-rel. 1 hit.
KO	K09307.
Pfam	PF00046. Homeobox. 1 hit. [Graphical view]
PRINTS	PR00025. ANTENNAPEDIA. PR00024. HOMEOBOX.
SMART	SM00389. HOX. 1 hit. [Graphical view]
SUPFAM	SSF46689. Homeodomain_like. 1 hit.
PROSITE	PS00032. ANTENNAPEDIA. 1 hit. PS00027. HOMEOBOX_1. 1 hit. PS50071. HOMEOBOX_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

HXA7_PANTR

Accession

Primary (citable) accession number: A2T7F3

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 1, 2007
Last sequence update:	March 6, 2007
Last modified:	December 14, 2011
This is version 38 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program