A2T748 (HXD8_PANTR) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Homeobox protein Hox-D8

Gene names

Name:

HOXD8

Organism

Pan troglodytes (Chimpanzee) [Reference proteome]

Taxonomic identifier

9598 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Pan

Protein attributes

Sequence length	290 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis By similarity.
Subcellular location	Nucleus By similarity.
Sequence similarities	Belongs to the Antp homeobox family. Contains 1 homeobox DNA-binding domain.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Domain	Homeobox
Ligand	DNA-binding
Molecular function	Developmental protein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	anterior/posterior pattern specification Inferred from electronic annotation. Source: Compara negative regulation of transcription from RNA polymerase II promoter Inferred from electronic annotation. Source: Compara skeletal system morphogenesis Inferred from electronic annotation. Source: Compara transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	sequence-specific DNA binding Inferred from electronic annotation. Source: InterPro sequence-specific DNA binding transcription factor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 290	290	Homeobox protein Hox-D8		PRO_0000285438
Regions
	DNA binding	197 – 256	60	Homeobox
	Compositional bias	15 – 23	9	Poly-Ala
	Compositional bias	45 – 50	6	Poly-Ala
	Compositional bias	109 – 123	15	Poly-Pro

Sequences

	Sequence		Length	Mass (Da)
	A2T748 [UniParc]. Last modified March 6, 2007. Version 1. Checksum: FE487F7CD11ABCF4	FASTA	290	31,925
	10 20 30 40 50 60 MSSYFVNPLY SKYKAAAAAA AAAGEAINPT YYDCHFVPEV GGRHAAAAAA LQLYGNSAAG 70 80 90 100 110 120 FPHAPPQAHA HPHPSPPPSG TGCGGRDGRG QEYFHPGGGS PAAAYQAAPP PPPHPPPPPP 130 140 150 160 170 180 PPPCGGIACH GEPAKFYGYD NLQRQPIFTT QQEAELVQYP DCKSSSGNIG EDPDHLNQSS 190 200 210 220 230 240 SPSQMFPWMR PQAAPGRRRG RQTYSRFQTL ELEKEFLFNP YLTRKRRIEV SHALALTERQ 250 260 270 280 290 VKIWFQNRRM KWKKENNKDK FPVSRQEVKD GETKKEAQEL EEDRAEGLTN

References

[1]	"Positive selection in transcription factor genes on the human lineage." Nickel G.C., Tefft D.L., Trevarthen K., Funt J., Adams M.D. Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	DQ977370 Genomic DNA. Translation: ABM92003.1.
RefSeq	NP_001074950.1. NM_001081481.1.
UniGene	Ptr.6551.
3D structure databases
ProteinModelPortal	A2T748.
SMR	A2T748. Positions 197-262.
ModBase	Search...
Protein-protein interaction databases
STRING	9598.ENSPTRP00000054685.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSPTRT00000062132; ENSPTRP00000054685; ENSPTRG00000012669.
GeneID	459763.
KEGG	ptr:459763.
Organism-specific databases
CTD	3234.
Phylogenomic databases
eggNOG	NOG314669.
GeneTree	ENSGT00700000104332.
HOGENOM	HOG000231181.
HOVERGEN	HBG016849.
InParanoid	A2T748.
KO	K09308.
OMA	GQEYFHP.
OrthoDB	EOG4H464V.
Family and domain databases
Gene3D	1.10.10.60. 1 hit.
InterPro	IPR001827. Homeobox_Antennapedia_CS. IPR017970. Homeobox_CS. IPR020479. Homeobox_metazoa. IPR001356. Homeodomain. IPR009057. Homeodomain-like. [Graphical view]
Pfam	PF00046. Homeobox. 1 hit. [Graphical view]
PRINTS	PR00024. HOMEOBOX.
SMART	SM00389. HOX. 1 hit. [Graphical view]
SUPFAM	SSF46689. Homeodomain_like. 1 hit.
PROSITE	PS00032. ANTENNAPEDIA. 1 hit. PS00027. HOMEOBOX_1. 1 hit. PS50071. HOMEOBOX_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	20839830.

Entry information

Entry name

HXD8_PANTR

Accession

Primary (citable) accession number: A2T748

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 1, 2007
Last sequence update:	March 6, 2007
Last modified:	April 3, 2013
This is version 48 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program