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A2T748 (HXD8_PANTR) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 53. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Homeobox protein Hox-D8
Gene names
Name:HOXD8
OrganismPan troglodytes (Chimpanzee) [Reference proteome]
Taxonomic identifier9598 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaePan

Protein attributes

Sequence length290 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis By similarity.

Subcellular location

Nucleus By similarity.

Sequence similarities

Belongs to the Antp homeobox family.

Contains 1 homeobox DNA-binding domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 290290Homeobox protein Hox-D8
PRO_0000285438

Regions

DNA binding197 – 25660Homeobox
Compositional bias15 – 239Poly-Ala
Compositional bias45 – 506Poly-Ala
Compositional bias109 – 12315Poly-Pro

Sequences

Sequence LengthMass (Da)Tools
A2T748 [UniParc].

Last modified March 6, 2007. Version 1.
Checksum: FE487F7CD11ABCF4

FASTA29031,925
        10         20         30         40         50         60 
MSSYFVNPLY SKYKAAAAAA AAAGEAINPT YYDCHFVPEV GGRHAAAAAA LQLYGNSAAG 

        70         80         90        100        110        120 
FPHAPPQAHA HPHPSPPPSG TGCGGRDGRG QEYFHPGGGS PAAAYQAAPP PPPHPPPPPP 

       130        140        150        160        170        180 
PPPCGGIACH GEPAKFYGYD NLQRQPIFTT QQEAELVQYP DCKSSSGNIG EDPDHLNQSS 

       190        200        210        220        230        240 
SPSQMFPWMR PQAAPGRRRG RQTYSRFQTL ELEKEFLFNP YLTRKRRIEV SHALALTERQ 

       250        260        270        280        290 
VKIWFQNRRM KWKKENNKDK FPVSRQEVKD GETKKEAQEL EEDRAEGLTN 

« Hide

References

[1]"Positive selection in transcription factor genes on the human lineage."
Nickel G.C., Tefft D.L., Trevarthen K., Funt J., Adams M.D.
Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
DQ977370 Genomic DNA. Translation: ABM92003.1.
RefSeqNP_001074950.1. NM_001081481.1.
UniGenePtr.6551.

3D structure databases

ProteinModelPortalA2T748.
SMRA2T748. Positions 197-262.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9598.ENSPTRP00000054685.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSPTRT00000062132; ENSPTRP00000054685; ENSPTRG00000012669.
GeneID459763.
KEGGptr:459763.

Organism-specific databases

CTD3234.

Phylogenomic databases

eggNOGNOG314669.
HOGENOMHOG000231181.
HOVERGENHBG016849.
InParanoidA2T748.
KOK09308.
OMAGQEYFHP.
OrthoDBEOG780RP4.
TreeFamTF316310.

Family and domain databases

Gene3D1.10.10.60. 1 hit.
InterProIPR001827. Homeobox_Antennapedia_CS.
IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
[Graphical view]
PfamPF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSPR00024. HOMEOBOX.
SMARTSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMSSF46689. SSF46689. 1 hit.
PROSITEPS00032. ANTENNAPEDIA. 1 hit.
PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio20839830.

Entry information

Entry nameHXD8_PANTR
AccessionPrimary (citable) accession number: A2T748
Entry history
Integrated into UniProtKB/Swiss-Prot: May 1, 2007
Last sequence update: March 6, 2007
Last modified: February 19, 2014
This is version 53 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Vertebrate homeotic Hox proteins

Nomenclature of vertebrate homeotic Hox proteins and list of entries