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A2T748

- HXD8_PANTR

UniProt

A2T748 - HXD8_PANTR

Protein

Homeobox protein Hox-D8

Gene

HOXD8

Organism
Pan troglodytes (Chimpanzee)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 54 (01 Oct 2014)
      Sequence version 1 (06 Mar 2007)
      Previous versions | rss
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    Functioni

    Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi197 – 25660HomeoboxPROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. sequence-specific DNA binding Source: InterPro
    2. sequence-specific DNA binding transcription factor activity Source: InterPro

    GO - Biological processi

    1. anterior/posterior pattern specification Source: Ensembl
    2. negative regulation of transcription from RNA polymerase II promoter Source: Ensembl
    3. skeletal system morphogenesis Source: Ensembl
    4. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Developmental protein

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Homeobox protein Hox-D8
    Gene namesi
    Name:HOXD8
    OrganismiPan troglodytes (Chimpanzee)
    Taxonomic identifieri9598 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaePan
    ProteomesiUP000002277: Unplaced

    Subcellular locationi

    Nucleus PROSITE-ProRule annotation

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 290290Homeobox protein Hox-D8PRO_0000285438Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi9598.ENSPTRP00000054685.

    Structurei

    3D structure databases

    ProteinModelPortaliA2T748.
    SMRiA2T748. Positions 197-262.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi15 – 239Poly-Ala
    Compositional biasi45 – 506Poly-Ala
    Compositional biasi109 – 12315Poly-ProAdd
    BLAST

    Sequence similaritiesi

    Belongs to the Antp homeobox family.Curated
    Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Homeobox

    Phylogenomic databases

    eggNOGiNOG314669.
    HOGENOMiHOG000231181.
    HOVERGENiHBG016849.
    InParanoidiA2T748.
    KOiK09308.
    OMAiGQEYFHP.
    OrthoDBiEOG780RP4.
    TreeFamiTF316310.

    Family and domain databases

    Gene3Di1.10.10.60. 1 hit.
    InterProiIPR001827. Homeobox_Antennapedia_CS.
    IPR017970. Homeobox_CS.
    IPR001356. Homeobox_dom.
    IPR020479. Homeobox_metazoa.
    IPR009057. Homeodomain-like.
    [Graphical view]
    PfamiPF00046. Homeobox. 1 hit.
    [Graphical view]
    PRINTSiPR00024. HOMEOBOX.
    SMARTiSM00389. HOX. 1 hit.
    [Graphical view]
    SUPFAMiSSF46689. SSF46689. 1 hit.
    PROSITEiPS00032. ANTENNAPEDIA. 1 hit.
    PS00027. HOMEOBOX_1. 1 hit.
    PS50071. HOMEOBOX_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A2T748-1 [UniParc]FASTAAdd to Basket

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    MSSYFVNPLY SKYKAAAAAA AAAGEAINPT YYDCHFVPEV GGRHAAAAAA    50
    LQLYGNSAAG FPHAPPQAHA HPHPSPPPSG TGCGGRDGRG QEYFHPGGGS 100
    PAAAYQAAPP PPPHPPPPPP PPPCGGIACH GEPAKFYGYD NLQRQPIFTT 150
    QQEAELVQYP DCKSSSGNIG EDPDHLNQSS SPSQMFPWMR PQAAPGRRRG 200
    RQTYSRFQTL ELEKEFLFNP YLTRKRRIEV SHALALTERQ VKIWFQNRRM 250
    KWKKENNKDK FPVSRQEVKD GETKKEAQEL EEDRAEGLTN 290
    Length:290
    Mass (Da):31,925
    Last modified:March 6, 2007 - v1
    Checksum:iFE487F7CD11ABCF4
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DQ977370 Genomic DNA. Translation: ABM92003.1.
    RefSeqiNP_001074950.1. NM_001081481.1.
    UniGeneiPtr.6551.

    Genome annotation databases

    EnsembliENSPTRT00000062132; ENSPTRP00000054685; ENSPTRG00000012669.
    GeneIDi459763.
    KEGGiptr:459763.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DQ977370 Genomic DNA. Translation: ABM92003.1 .
    RefSeqi NP_001074950.1. NM_001081481.1.
    UniGenei Ptr.6551.

    3D structure databases

    ProteinModelPortali A2T748.
    SMRi A2T748. Positions 197-262.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9598.ENSPTRP00000054685.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSPTRT00000062132 ; ENSPTRP00000054685 ; ENSPTRG00000012669 .
    GeneIDi 459763.
    KEGGi ptr:459763.

    Organism-specific databases

    CTDi 3234.

    Phylogenomic databases

    eggNOGi NOG314669.
    HOGENOMi HOG000231181.
    HOVERGENi HBG016849.
    InParanoidi A2T748.
    KOi K09308.
    OMAi GQEYFHP.
    OrthoDBi EOG780RP4.
    TreeFami TF316310.

    Miscellaneous databases

    NextBioi 20839830.

    Family and domain databases

    Gene3Di 1.10.10.60. 1 hit.
    InterProi IPR001827. Homeobox_Antennapedia_CS.
    IPR017970. Homeobox_CS.
    IPR001356. Homeobox_dom.
    IPR020479. Homeobox_metazoa.
    IPR009057. Homeodomain-like.
    [Graphical view ]
    Pfami PF00046. Homeobox. 1 hit.
    [Graphical view ]
    PRINTSi PR00024. HOMEOBOX.
    SMARTi SM00389. HOX. 1 hit.
    [Graphical view ]
    SUPFAMi SSF46689. SSF46689. 1 hit.
    PROSITEi PS00032. ANTENNAPEDIA. 1 hit.
    PS00027. HOMEOBOX_1. 1 hit.
    PS50071. HOMEOBOX_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Positive selection in transcription factor genes on the human lineage."
      Nickel G.C., Tefft D.L., Trevarthen K., Funt J., Adams M.D.
      Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

    Entry informationi

    Entry nameiHXD8_PANTR
    AccessioniPrimary (citable) accession number: A2T748
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 1, 2007
    Last sequence update: March 6, 2007
    Last modified: October 1, 2014
    This is version 54 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Vertebrate homeotic Hox proteins
      Nomenclature of vertebrate homeotic Hox proteins and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3