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Protein

ETS homologous factor

Gene

EHF

Organism
Pan troglodytes (Chimpanzee)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Transcriptional activator that may play a role in regulating epithelial cell differentiation and proliferation. May act as a repressor for a specific subset of ETS/AP-1-responsive genes, and as a modulator of the nuclear response to mitogen-activated protein kinase signaling cascades. Binds to DNA sequences containing the consensus nucleotide core sequence GGAA. Involved in regulation of TNFRSF10B/DR5 expression through Ets-binding sequences on the TNFRSF10B/DR5 promoter (By similarity).By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi207 – 28983ETSPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
ETS homologous factor
Alternative name(s):
ETS domain-containing transcription factor
Gene namesi
Name:EHF
OrganismiPan troglodytes (Chimpanzee)
Taxonomic identifieri9598 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaePan
Proteomesi
  • UP000002277 Componenti: Chromosome 11

Subcellular locationi

  • Nucleus PROSITE-ProRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 300300ETS homologous factorPRO_0000285519Add
BLAST

Proteomic databases

PaxDbiA2T737.

Interactioni

Protein-protein interaction databases

STRINGi9598.ENSPTRP00000006078.

Structurei

3D structure databases

ProteinModelPortaliA2T737.
SMRiA2T737. Positions 208-299.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini29 – 11587PNTPROSITE-ProRule annotationAdd
BLAST

Domaini

The PNT domain acts as a transcriptional activator.By similarity

Sequence similaritiesi

Belongs to the ETS family.Curated
Contains 1 ETS DNA-binding domain.PROSITE-ProRule annotation
Contains 1 PNT (pointed) domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG3804. Eukaryota.
ENOG4111K4J. LUCA.
GeneTreeiENSGT00760000118996.
HOGENOMiHOG000232188.
HOVERGENiHBG074143.
InParanoidiA2T737.
KOiK17102.
OMAiPFQEFDV.
OrthoDBiEOG7M0NRR.
TreeFamiTF318679.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
1.10.150.50. 1 hit.
InterProiIPR033071. EHF.
IPR000418. Ets_dom.
IPR003118. Pointed_dom.
IPR013761. SAM/pointed.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PANTHERiPTHR11849:SF171. PTHR11849:SF171. 2 hits.
PfamiPF00178. Ets. 1 hit.
PF02198. SAM_PNT. 1 hit.
[Graphical view]
PRINTSiPR00454. ETSDOMAIN.
SMARTiSM00413. ETS. 1 hit.
SM00251. SAM_PNT. 1 hit.
[Graphical view]
SUPFAMiSSF46785. SSF46785. 1 hit.
SSF47769. SSF47769. 1 hit.
PROSITEiPS50061. ETS_DOMAIN_3. 1 hit.
PS51433. PNT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A2T737-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MILEGGGVMN LNPGNNLLHQ PPAWTDSYST CNVSSGFFGG QWHEIHPQYW
60 70 80 90 100
TKYQVWEWLQ HLLDTNQLDA SCIPFQEFDI NGEHLCSMSL QEFTRAAGTA
110 120 130 140 150
GQLLYSNLQH LKWNGQCSSD LFQSTHNVIV KTEQTEPSIV NTWKDENYLY
160 170 180 190 200
DTNYGSTVDL LDSKTFCRAQ ISMTTTSHLP VAESPDMKKE QDPPAKCHTK
210 220 230 240 250
KHNPRGTHLW EFIRDILLNP DKNPGLIKWE DRSEGVFRFL KSEAVAQLWG
260 270 280 290 300
KKKNNSSMTY EKLSRAMRYY YKREILERVD GRRLVYKFGK NARGWRENEN
Length:300
Mass (Da):34,833
Last modified:March 6, 2007 - v1
Checksum:i03E64D383DDD67BE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ977366 Genomic DNA. Translation: ABM91992.1.
RefSeqiNP_001075037.1. NM_001081568.1.
XP_009458439.1. XM_009460164.1.
XP_009458440.1. XM_009460165.1.
XP_009458441.1. XM_009460166.1.
UniGeneiPtr.6570.

Genome annotation databases

EnsembliENSPTRT00000006591; ENSPTRP00000006078; ENSPTRG00000003498.
GeneIDi739336.
KEGGiptr:739336.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ977366 Genomic DNA. Translation: ABM91992.1.
RefSeqiNP_001075037.1. NM_001081568.1.
XP_009458439.1. XM_009460164.1.
XP_009458440.1. XM_009460165.1.
XP_009458441.1. XM_009460166.1.
UniGeneiPtr.6570.

3D structure databases

ProteinModelPortaliA2T737.
SMRiA2T737. Positions 208-299.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9598.ENSPTRP00000006078.

Proteomic databases

PaxDbiA2T737.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSPTRT00000006591; ENSPTRP00000006078; ENSPTRG00000003498.
GeneIDi739336.
KEGGiptr:739336.

Organism-specific databases

CTDi26298.

Phylogenomic databases

eggNOGiKOG3804. Eukaryota.
ENOG4111K4J. LUCA.
GeneTreeiENSGT00760000118996.
HOGENOMiHOG000232188.
HOVERGENiHBG074143.
InParanoidiA2T737.
KOiK17102.
OMAiPFQEFDV.
OrthoDBiEOG7M0NRR.
TreeFamiTF318679.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
1.10.150.50. 1 hit.
InterProiIPR033071. EHF.
IPR000418. Ets_dom.
IPR003118. Pointed_dom.
IPR013761. SAM/pointed.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PANTHERiPTHR11849:SF171. PTHR11849:SF171. 2 hits.
PfamiPF00178. Ets. 1 hit.
PF02198. SAM_PNT. 1 hit.
[Graphical view]
PRINTSiPR00454. ETSDOMAIN.
SMARTiSM00413. ETS. 1 hit.
SM00251. SAM_PNT. 1 hit.
[Graphical view]
SUPFAMiSSF46785. SSF46785. 1 hit.
SSF47769. SSF47769. 1 hit.
PROSITEiPS50061. ETS_DOMAIN_3. 1 hit.
PS51433. PNT. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Positive selection in transcription factor genes on the human lineage."
    Nickel G.C., Tefft D.L., Trevarthen K., Funt J., Adams M.D.
    Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Entry informationi

Entry nameiEHF_PANTR
AccessioniPrimary (citable) accession number: A2T737
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 1, 2007
Last sequence update: March 6, 2007
Last modified: June 8, 2016
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.