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A2T6F8

- HXC10_MACNE

UniProt

A2T6F8 - HXC10_MACNE

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Protein
Homeobox protein Hox-C10
Gene
HOXC10
Organism
Macaca nemestrina (Pig-tailed macaque)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis By similarity.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi268 – 32760Homeobox
Add
BLAST

GO - Molecular functioni

  1. sequence-specific DNA binding Source: InterPro
  2. sequence-specific DNA binding transcription factor activity Source: InterPro

GO - Biological processi

  1. multicellular organismal development Source: UniProtKB-KW
  2. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein Hox-C10
Gene namesi
Name:HOXC10
OrganismiMacaca nemestrina (Pig-tailed macaque)
Taxonomic identifieri9545 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniCercopithecidaeCercopithecinaeMacaca

Subcellular locationi

Nucleus By similarity

GO - Cellular componenti

  1. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 342342Homeobox protein Hox-C10
PRO_0000285430Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei189 – 1891Phosphoserine By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PRIDEiA2T6F8.

Structurei

3D structure databases

ProteinModelPortaliA2T6F8.
SMRiA2T6F8. Positions 257-329.

Family & Domainsi

Sequence similaritiesi

Belongs to the Abd-B homeobox family.

Keywords - Domaini

Homeobox

Phylogenomic databases

HOVERGENiHBG052934.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSiPR00024. HOMEOBOX.
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A2T6F8-1 [UniParc]FASTAAdd to Basket

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MTCPRNVTPN SYAEPLAAPG GGERYSRSAG MYMQSGSDFN CGVMRGCGLA    50
PSLSKRDEGG SPSLTLNTYP SYLSQLDSWG DPKAAYRLEQ PVGRPLSSCS 100
YPPSVKEENV CCMYSAEKRA KSGPEAALYS HPLPESCLGE HEVPVPSYYR 150
ASPSYSALDK TPHCSGANDF EAPFEQRASL NPRAEHLESP QLGGKVSFPE 200
TPKSDNQTPS PSEIKTEQSL AGPKGSPSES EKERAKTADC SPDTSDNEAK 250
EEIKAENTTG NWLTAKSGRK KRCPYTKHQT LELEKEFLFN MYLTRERRLE 300
ISKTINLTDR QVKIWFQNRR MKLKKMNREN RIRELTSNFN FT 342
Length:342
Mass (Da):38,119
Last modified:March 6, 2007 - v1
Checksum:i2223A4C632601DDF
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DQ977071 Genomic DNA. Translation: ABM88006.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DQ977071 Genomic DNA. Translation: ABM88006.1 .

3D structure databases

ProteinModelPortali A2T6F8.
SMRi A2T6F8. Positions 257-329.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi A2T6F8.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Phylogenomic databases

HOVERGENi HBG052934.

Family and domain databases

Gene3Di 1.10.10.60. 1 hit.
InterProi IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
[Graphical view ]
Pfami PF00046. Homeobox. 1 hit.
[Graphical view ]
PRINTSi PR00024. HOMEOBOX.
SMARTi SM00389. HOX. 1 hit.
[Graphical view ]
SUPFAMi SSF46689. SSF46689. 1 hit.
PROSITEi PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Positive selection in transcription factor genes on the human lineage."
    Nickel G.C., Tefft D.L., Trevarthen K., Funt J., Adams M.D.
    Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Entry informationi

Entry nameiHXC10_MACNE
AccessioniPrimary (citable) accession number: A2T6F8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 1, 2007
Last sequence update: March 6, 2007
Last modified: February 19, 2014
This is version 34 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. Vertebrate homeotic Hox proteins
    Nomenclature of vertebrate homeotic Hox proteins and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi