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A2T3T1 (NSP1_ROTTU) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 26. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Non-structural protein 1

Short name=NSP1
Alternative name(s):
NCVP2
Non-structural RNA-binding protein 53
Short name=NS53
OrganismRotavirus A (isolate Monkey/United States/TUCH/2003 G3-Px[24]-I9-R3-C3-M3-A9-Nx-Tx-Ex-Hx) (RV-A)
Taxonomic identifier444186 [NCBI]
Taxonomic lineageVirusesdsRNA virusesReoviridaeSedoreovirinaeRotavirusRotavirus A
Virus hostMacaca mulatta (Rhesus macaque) [TaxID: 9544]

Protein attributes

Sequence length492 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Seems to induce the proteasome-dependent degradation of IRF3, IRF5 and IRF7, thereby antagonizing the cellular interferon response and establishment of the antiviral state. Binds and targets IRF3 early post-infection and suppresses IRF3 nuclear translocation By similarity.

Subunit structure

Interacts (via C-terminus) with host IRF3; this interaction leads to IRF3 degradation. Interacts with host IRF7; this interaction leads to IRF7 degradation By similarity.

Subcellular location

Host cytoplasmhost cytoskeleton By similarity.

Domain

The zinc-finger domain is important, but not sufficient for binding and degrading IRF3. It is sometimes described as a RING zinc-finger, but it is atypical and it is unclear whether it is related with ubiquitin ligase activity By similarity.

Sequence similarities

Belongs to the rotavirus A NSP1 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 492492Non-structural protein 1
PRO_0000369077

Regions

Zinc finger42 – 7938 Potential
Region1 – 8181RNA-binding By similarity
Region82 – 17695Important for cytoskeleton localization By similarity
Region314 – 492179Interaction with IRF3 By similarity

Sequences

Sequence LengthMass (Da)Tools
A2T3T1 [UniParc].

Last modified March 6, 2007. Version 1.
Checksum: B69AECA5D67101C6

FASTA49257,836
        10         20         30         40         50         60 
MATFKDACFH YRRITKLNRE LLRIGANSVW TPVSSNKIRG WCIECCQLTE LTFCHGCSLA 

        70         80         90        100        110        120 
HVCQWCIQNK RCFLDNEPHL LKLRTFESPI TKEKLQCIID LYNLLFPISP GIINRFKKAV 

       130        140        150        160        170        180 
KQRKCRNESD KSWYNQLLLP ITLNAAVFKF HSREIYIFGF YEGSSACIDL PYRLVNCIDL 

       190        200        210        220        230        240 
YDKLLLDQIN FERMSCLPDK LQSIYANNYF KLSRLPSMKL KQVYYSDFSK QNLINKYKTK 

       250        260        270        280        290        300 
SRIVLRNLTE FTWDSQIDLH HDLINNKDKI LAALSTSSLK QFETHDLNLG RVKADIFELG 

       310        320        330        340        350        360 
HHCKPNYISS NHWQPASKIF QCKWCNVKYA FRDMDWKMES MYNELLSFLQ SCYKSNVNVG 

       370        380        390        400        410        420 
HCSSIESVYP LVKDMLWHSI TKYIDQTIEK LFDAMNPVQV NEQLVINFYW QIDIALYTHI 

       430        440        450        460        470        480 
KMILKTEALP FTFTLNQFNS IIKGIINQWC DVAELDLLPL CTEQTDKLVK LKEEGKLSEE 

       490 
YELLISDSED DD 

« Hide

References

[1]"Genome heterogeneity of SA11 rotavirus due to reassortment with 'O' agent."
Small C., Barro M., Brown T.L., Patton J.T.
Virology 359:415-424(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
DQ838651 Genomic RNA. Translation: ABG75830.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

InterProIPR002148. Rotavirus_NSP1.
[Graphical view]
PfamPF00981. Rota_NS53. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameNSP1_ROTTU
AccessionPrimary (citable) accession number: A2T3T1
Entry history
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: March 6, 2007
Last modified: February 19, 2014
This is version 26 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families