true2009-04-142023-05-0350NSP3_ROTSHGenome heterogeneity of SA11 rotavirus due to reassortment with 'O' agent.Small C.Barro M.Brown T.L.Patton J.T.doi:10.1016/j.virol.2006.09.0242007Virology359415-424NUCLEOTIDE SEQUENCE [GENOMIC RNA]NSP3_rotavirusNonstructural RNA-binding proteinRotavirus non-structural protein NSP3, N-terminal domainROTA_A_NSP3ROTA_NSP3NSP3_N_rotavirusNSP3_sfRotavirus_NSP3Rota_NSP3NSP3 homodimerRotavirus nonstructural proteinsNon-structural protein 3NSP3NCVP4Non-structural RNA-binding protein 34NS34Plays an important role in stimulating the translation of viral mRNAs. These mRNAs are capped but not polyadenylated, instead terminating in a conserved sequence 'GACC' at the 3' that is recognized by NSP3, which competes with host PABPC1 for EIF4G1 binding. The interaction between NSP3 and host EIF4G1 stabilizes the EIF4E-EIF4G1 interaction, thereby facilitating the initiation of capped mRNA translation.Homodimer. Interacts (via the coiled-coil region) with host ZC3H7B (via LD motif). Interacts with host EIF4G1.Belongs to the rotavirus NSP3 family.Non-structural protein 3364251315RNA-binding149Dimerization150206Interaction with host ZC3H7B170234Interaction with host EIF4G12081662372008-01-15136425414afdd92a5431673e8b284573450129MLKMESTQQMAVSIINSSFEAAVVAATSALENMGIEYDYQDIYSRVKNKFDFVMDDSGVKNNLIGKAITIDQALNNKFGSAIRNRNWLADTSRAAKLDEDVNKLRMMLSSKGIDQKMRVLNACFSVKRIPGKSSSIIKCTKLMRDKLERGEVEVDDSFVDEKMEVDTIDWKSRYEQLEQRFESLKSRVNEKYNNWVLKARKMNENMHSLQNVISQQQAHIAELQVYNNKLERDLQNKIGSLTSSIEWYLRSMELDPEIKADIEQQINSIDAINPLHAFDDLESVIRNLISDYDKLFLMFKGLIQRCNYQYSFGCEtrue