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A2T3M0

- NSP1_ROTAP

UniProt

A2T3M0 - NSP1_ROTAP

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Protein
Non-structural protein 1
Gene
N/A
Organism
Rotavirus A (isolate Cow/South Africa/Offal agent/1965 G8-P6[1]-Ix-Rx-Cx-Mx-A11-N2-Tx-Ex-Hx) (RV-A)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Seems to induce the proteasome-dependent degradation of IRF3, IRF5 and IRF7, thereby antagonizing the cellular interferon response and establishment of the antiviral state. Binds and targets IRF3 early post-infection and suppresses IRF3 nuclear translocation By similarity.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri42 – 7938 Reviewed prediction
Add
BLAST

GO - Molecular functioni

  1. RNA binding Source: UniProtKB-KW
  2. metal ion binding Source: UniProtKB-KW
Complete GO annotation...

GO - Biological processi

  1. suppression by virus of host IRF3 activity Source: UniProtKB-KW
  2. suppression by virus of host IRF7 activity Source: UniProtKB-KW
  3. suppression by virus of host NF-kappaB transcription factor activity Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Host-virus interaction, Inhibition of host innate immune response by virus, Inhibition of host IRF3 by virus, Inhibition of host IRF7 by virus, Inhibition of host NF-kappa-B by virus, Inhibition of host RLR pathway by virus, Interferon antiviral system evasion, Viral immunoevasion

Keywords - Ligandi

Metal-binding, RNA-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Non-structural protein 1
Short name:
NSP1
Alternative name(s):
NCVP2
Non-structural RNA-binding protein 53
Short name:
NS53
OrganismiRotavirus A (isolate Cow/South Africa/Offal agent/1965 G8-P6[1]-Ix-Rx-Cx-Mx-A11-N2-Tx-Ex-Hx) (RV-A)
Taxonomic identifieri578837 [NCBI]
Taxonomic lineageiVirusesdsRNA virusesReoviridaeSedoreovirinaeRotavirusRotavirus A
Virus hostiBos taurus (Bovine) [TaxID: 9913]

Subcellular locationi

GO - Cellular componenti

  1. host cell cytoplasm Source: UniProtKB-KW
  2. host cytoskeleton Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Host cytoplasm, Host cytoskeleton

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 491491Non-structural protein 1
PRO_0000369067Add
BLAST

Interactioni

Subunit structurei

Interacts (via C-terminus) with host IRF3; this interaction leads to IRF3 degradation. Interacts with host IRF7; this interaction leads to IRF7 degradation By similarity.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 8181RNA-binding By similarity
Add
BLAST
Regioni82 – 17695Important for cytoskeleton localization By similarity
Add
BLAST
Regioni316 – 491176Interaction with IRF3 By similarity
Add
BLAST

Domaini

The zinc-finger domain is important, but not sufficient for binding and degrading IRF3. It is sometimes described as a RING zinc-finger, but it is atypical and it is unclear whether it is related with ubiquitin ligase activity By similarity.

Sequence similaritiesi

Belongs to the rotavirus A NSP1 family.

Keywords - Domaini

Zinc-finger

Family and domain databases

InterProiIPR002148. Rotavirus_NSP1.
[Graphical view]
PfamiPF00981. Rota_NS53. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A2T3M0-1 [UniParc]FASTAAdd to Basket

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MATFKDACYH YRKISKLNSS ILKLGANDEW RPAPITKFKG WCLDCCQYTN    50
LTYCRGCALY HVCQWCSQYN RCFLDEEPHL LRMRTFKNTI SKEDIENLLN 100
MYDTLFPIHE KIVNKFINNV KQRKCRNEYL LEWYNHLLLP FTLQALTIQL 150
ENNTYYIFGY YDCMEQENQT PFNFVNLVSN YDKLLLDDKN FNRMAYLPPI 200
LQQEYALRYF SKSRFLDKPN RGLKRNDFSD NLMEDRHSPT SLMQVIRNCV 250
AKHLDDSEWN KACTQVTNAK NYMEVMNSAY TEHYSVSQRC KLYTKNKLNT 300
LSRLTKPNYI LSNHETCALN VHNCKWCQIT SCYKIWEDFR IKKIYNNVLD 350
FIRALSKSNG MAGHCSSQER IYRYIPKLFL IYDEEQWTES VNSLFKCLEP 400
VEISEVEYVL FDHEINWEVR GLILQCMNGS IPRILNLSDV RLILSSLIYD 450
WFDIRYMRDT PMITSTTNEL RKLNKKNELI DEYDLELSDI E 491
Length:491
Mass (Da):58,660
Last modified:March 6, 2007 - v1
Checksum:iA72F995A7289CD26
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DQ838595 Genomic RNA. Translation: ABG75769.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DQ838595 Genomic RNA. Translation: ABG75769.1 .

3D structure databases

ModBasei Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

InterProi IPR002148. Rotavirus_NSP1.
[Graphical view ]
Pfami PF00981. Rota_NS53. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Genome heterogeneity of SA11 rotavirus due to reassortment with 'O' agent."
    Small C., Barro M., Brown T.L., Patton J.T.
    Virology 359:415-424(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].

Entry informationi

Entry nameiNSP1_ROTAP
AccessioniPrimary (citable) accession number: A2T3M0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: March 6, 2007
Last modified: February 19, 2014
This is version 26 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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