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A2T3M0 (NSP1_ROTAP) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 26. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Non-structural protein 1

Short name=NSP1
Alternative name(s):
NCVP2
Non-structural RNA-binding protein 53
Short name=NS53
OrganismRotavirus A (isolate Cow/South Africa/Offal agent/1965 G8-P6[1]-Ix-Rx-Cx-Mx-A11-N2-Tx-Ex-Hx) (RV-A)
Taxonomic identifier578837 [NCBI]
Taxonomic lineageVirusesdsRNA virusesReoviridaeSedoreovirinaeRotavirusRotavirus A
Virus hostBos taurus (Bovine) [TaxID: 9913]

Protein attributes

Sequence length491 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Seems to induce the proteasome-dependent degradation of IRF3, IRF5 and IRF7, thereby antagonizing the cellular interferon response and establishment of the antiviral state. Binds and targets IRF3 early post-infection and suppresses IRF3 nuclear translocation By similarity.

Subunit structure

Interacts (via C-terminus) with host IRF3; this interaction leads to IRF3 degradation. Interacts with host IRF7; this interaction leads to IRF7 degradation By similarity.

Subcellular location

Host cytoplasmhost cytoskeleton By similarity.

Domain

The zinc-finger domain is important, but not sufficient for binding and degrading IRF3. It is sometimes described as a RING zinc-finger, but it is atypical and it is unclear whether it is related with ubiquitin ligase activity By similarity.

Sequence similarities

Belongs to the rotavirus A NSP1 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 491491Non-structural protein 1
PRO_0000369067

Regions

Zinc finger42 – 7938 Potential
Region1 – 8181RNA-binding By similarity
Region82 – 17695Important for cytoskeleton localization By similarity
Region316 – 491176Interaction with IRF3 By similarity

Sequences

Sequence LengthMass (Da)Tools
A2T3M0 [UniParc].

Last modified March 6, 2007. Version 1.
Checksum: A72F995A7289CD26

FASTA49158,660
        10         20         30         40         50         60 
MATFKDACYH YRKISKLNSS ILKLGANDEW RPAPITKFKG WCLDCCQYTN LTYCRGCALY 

        70         80         90        100        110        120 
HVCQWCSQYN RCFLDEEPHL LRMRTFKNTI SKEDIENLLN MYDTLFPIHE KIVNKFINNV 

       130        140        150        160        170        180 
KQRKCRNEYL LEWYNHLLLP FTLQALTIQL ENNTYYIFGY YDCMEQENQT PFNFVNLVSN 

       190        200        210        220        230        240 
YDKLLLDDKN FNRMAYLPPI LQQEYALRYF SKSRFLDKPN RGLKRNDFSD NLMEDRHSPT 

       250        260        270        280        290        300 
SLMQVIRNCV AKHLDDSEWN KACTQVTNAK NYMEVMNSAY TEHYSVSQRC KLYTKNKLNT 

       310        320        330        340        350        360 
LSRLTKPNYI LSNHETCALN VHNCKWCQIT SCYKIWEDFR IKKIYNNVLD FIRALSKSNG 

       370        380        390        400        410        420 
MAGHCSSQER IYRYIPKLFL IYDEEQWTES VNSLFKCLEP VEISEVEYVL FDHEINWEVR 

       430        440        450        460        470        480 
GLILQCMNGS IPRILNLSDV RLILSSLIYD WFDIRYMRDT PMITSTTNEL RKLNKKNELI 

       490 
DEYDLELSDI E 

« Hide

References

[1]"Genome heterogeneity of SA11 rotavirus due to reassortment with 'O' agent."
Small C., Barro M., Brown T.L., Patton J.T.
Virology 359:415-424(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
DQ838595 Genomic RNA. Translation: ABG75769.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

InterProIPR002148. Rotavirus_NSP1.
[Graphical view]
PfamPF00981. Rota_NS53. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameNSP1_ROTAP
AccessionPrimary (citable) accession number: A2T3M0
Entry history
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: March 6, 2007
Last modified: February 19, 2014
This is version 26 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families