Reviewed, UniProtKB/Swiss-Prot A2T388 (NU1C_ANGEV)

Names and origin

Protein names

Recommended name:
    NAD(P)H-quinone oxidoreductase subunit 1, chloroplastic
    EC=1.6.5.-
Alternative name(s):
    NAD(P)H dehydrogenase subunit 1
      Short name=NDH subunit 1
    NADH-plastoquinone oxidoreductase subunit 1

Gene names

Name:

ndhA

Encoded on

Plastid; Chloroplast

Organism

Angiopteris evecta (Mule's foot fern) (Giant fern)

Taxonomic identifier

13825 [NCBI]

Taxonomic lineage

Eukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Moniliformopses › Filicophyta › Marattiopsida › Marattiales › Marattiaceae › Angiopteris

Protein attributes

Sequence length	369 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	NDH shuttles electrons from NAD(P)H:plastoquinone, via FMN and iron-sulfur (Fe-S) centers, to quinones in the photosynthetic chain and possibly in a chloroplast respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation, and thus conserves the redox energy in a proton gradient By similarity.
Catalytic activity	NAD(P)H + plastoquinone = NAD(P)+ + plastoquinol. HAMAP MF_01350
Subunit structure	NDH is composed of at least 16 different subunits, 5 of which are encoded in the nucleus By similarity.
Subcellular location	Plastid › chloroplast thylakoid membrane; Multi-pass membrane protein By similarity.
Sequence similarities	Belongs to the complex I subunit 1 family.

Ontologies

Keywords
Cellular component	Chloroplast Membrane Plastid Thylakoid
Domain	Transmembrane
Ligand	NAD NADP Plastoquinone
Molecular function	Oxidoreductase
PTM	Quinone
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: HAMAP
Cellular component	chloroplast thylakoid membrane Inferred from electronic annotation. Source: UniProtKB-SubCell integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	oxidoreductase activity Inferred from electronic annotation. Source: UniProtKB-KW quinone binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 369	369	NAD(P)H-quinone oxidoreductase subunit 1, chloroplastic HAMAP MF_01350		PRO_0000298864
Regions
	Transmembrane	29 – 49	21	Potential
	Transmembrane	97 – 117	21	Potential
	Transmembrane	129 – 149	21	Potential
	Transmembrane	167 – 187	21	Potential
	Transmembrane	205 – 225	21	Potential
	Transmembrane	255 – 275	21	Potential
	Transmembrane	305 – 325	21	Potential
	Transmembrane	348 – 368	21	Potential

Sequences

	Sequence		Length	Mass (Da)
	A2T388-1 [UniParc]. Last modified March 6, 2007. Version 1. Checksum: CEED504F2B4792FF	FASTA	369	40,604
	10 20 30 40 50 60 MVLDITGVEK QGIILFSESE LSKEFLELIW IIVSILTTIV GVTLGVLVIV WLERKISAGI 70 80 90 100 110 120 QQRIGPEYAG PLGIIQALAD GIKLLLKEDV IPARGDIWLF NVGPAIVVIP VFLSYLVIPF 130 140 150 160 170 180 GKHIILADLG IGVFFWIAVS SIAPLGLLMA GYGSNNKYSF LGGLRAAAQS ISYEIPLALC 190 200 210 220 230 240 VLSISLLSNS LSTVDIVDAQ SKYGLLGWNL WRQPIGFLIF FISSLAECER LPFDPPEAEE 250 260 270 280 290 300 ELVAGYQTEY SGIKFGLFYV GSYLNLLVSS LFVTVLYLGG WDLSIPFLPT SNQLTWILTN 310 320 330 340 350 360 GTFDIINAII GIIITLTKAY LFLFVSIMTR WTLPRVRIDQ LLDLGWKFLL PVALGNLLLT ASFQILLLD

References

[1]	"The complete plastid genome sequence of Angiopteris evecta (G. Forst.) Hoffm. (Marattiaceae)." Roper J.M., Hansen S.K., Wolf P.G., Karol K.G., Mandoli D.F., Everett K.D.E., Kuehl J.V., Boore J.L. Am. Fern J. 97:95-106(2007) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	DQ821119 Genomic DNA. Translation: ABG79655.1.
RefSeq	YP_001023756.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	4788147.
Family and domain databases
HAMAP	MF_01350. [Tree]
InterPro	IPR001694. NADH_UbQ_OxRdtase_su1. IPR018086. NADH_UbQ_OxRdtase_su1_CS. [Graphical view]
PANTHER	PTHR11432. Resp_NADH_DH_1. 1 hit.
Pfam	PF00146. NADHdh. 1 hit. [Graphical view]
PROSITE	PS00667. COMPLEX1_ND1_1. 1 hit. PS00668. COMPLEX1_ND1_2. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

NU1C_ANGEV

Accession

Primary (citable) accession number: A2T388

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 21, 2007
Last sequence update:	March 6, 2007
Last modified:	June 16, 2009
This is version 16 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)