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Protein

1-Cys peroxiredoxin PER1

Gene

PER1

Organism
Zea mays (Maize)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively (By similarity). Seems to contribute to the inhibition of germination during stress (By similarity).By similarity

Miscellaneous

The active site is a conserved redox-active cysteine residue, the peroxidatic cysteine (C(P)), which makes the nucleophilic attack on the peroxide substrate. The peroxide oxidizes the C(P)-SH to cysteine sulfenic acid (C(P)-SOH), which then reacts with another cysteine residue, the resolving cysteine (C(R)), to form a disulfide bridge. The disulfide is subsequently reduced by an appropriate electron donor to complete the catalytic cycle. In this 1-Cys peroxiredoxin, no C(R) is present and C(P) instead forms a disulfide with a cysteine from another protein or with a small thiol molecule.By similarity

Catalytic activityi

2 R'-SH + ROOH = R'-S-S-R' + H2O + ROH.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei46Cysteine sulfenic acid (-SOH) intermediateBy similarity1

GO - Molecular functioni

  • peroxidase activity Source: AgBase
  • peroxiredoxin activity Source: UniProtKB-EC

GO - Biological processi

  • cell redox homeostasis Source: InterPro
  • defense response to fungus Source: AgBase

Keywordsi

Molecular functionAntioxidant, Oxidoreductase, Peroxidase

Protein family/group databases

PeroxiBasei4964. Zm1CysPrx.

Names & Taxonomyi

Protein namesi
Recommended name:
1-Cys peroxiredoxin PER1 (EC:1.11.1.15)
Alternative name(s):
Rehydrin homolog
Thioredoxin peroxidase
Gene namesi
Name:PER1
Synonyms:PER-1
OrganismiZea mays (Maize)
Taxonomic identifieri4577 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaePACMAD cladePanicoideaeAndropogonodaeAndropogoneaeTripsacinaeZea
Proteomesi
  • UP000007305 Componenti: Unplaced

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Protein family/group databases

Allergomei9885. Zea m 32.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002851011 – 2291-Cys peroxiredoxin PER1Add BLAST229

Proteomic databases

PaxDbiA2SZW8.

Interactioni

Protein-protein interaction databases

STRINGi4577.GRMZM2G129761_P01.

Structurei

3D structure databases

ProteinModelPortaliA2SZW8.
SMRiA2SZW8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini4 – 173ThioredoxinPROSITE-ProRule annotationAdd BLAST170

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi205 – 228Bipartite nuclear localization signalSequence analysisAdd BLAST24

Sequence similaritiesi

Belongs to the peroxiredoxin family. Prx6 subfamily.Curated

Keywords - Domaini

Redox-active center

Phylogenomic databases

eggNOGiKOG0854. Eukaryota.
COG0450. LUCA.
HOGENOMiHOG000022346.
KOiK11188.

Family and domain databases

InterProiView protein in InterPro
IPR000866. AhpC/TSA.
IPR024706. Peroxiredoxin_AhpC-typ.
IPR019479. Peroxiredoxin_C.
IPR012336. Thioredoxin-like_fold.
IPR013766. Thioredoxin_domain.
PfamiView protein in Pfam
PF10417. 1-cysPrx_C. 1 hit.
PF00578. AhpC-TSA. 1 hit.
PIRSFiPIRSF000239. AHPC. 1 hit.
SUPFAMiSSF52833. SSF52833. 1 hit.
PROSITEiView protein in PROSITE
PS51352. THIOREDOXIN_2. 1 hit.

Sequencei

Sequence statusi: Complete.

A2SZW8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPGLTIGDTV PNLELDSTHG KIRIHDYVGD GYAIIFSHPA DFTPVCTTEM
60 70 80 90 100
AAMAGYAKEF EKRGVKLLGI SCDDVESHRQ WTKDVEAYGG KQQQQQATTT
110 120 130 140 150
KVTFPILADP ARDAIRQLNM VDPDEKDAAG RSMPSRALHV VGPDKAVKLS
160 170 180 190 200
FLYPATTGRN MDEVLRAVDS LLTAAKHGGK VATPANWKPG ECAVIAPGVS
210 220
DEEARKMFPQ GFETADLPSK KGYLRFTKV
Length:229
Mass (Da):24,905
Last modified:March 6, 2007 - v1
Checksum:i5423753AD1B778D7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ378060 mRNA. Translation: ABD24377.1.
RefSeqiNP_001105998.1. NM_001112528.1.
UniGeneiZm.11291.

Genome annotation databases

GeneIDi100037830.
KEGGizma:100037830.

Similar proteinsi

Entry informationi

Entry nameiREHY_MAIZE
AccessioniPrimary (citable) accession number: A2SZW8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 1, 2007
Last sequence update: March 6, 2007
Last modified: September 27, 2017
This is version 56 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families