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A2SXS5

- MEN1_CANFA

UniProt

A2SXS5 - MEN1_CANFA

Protein

Menin

Gene

MEN1

Organism
Canis familiaris (Dog) (Canis lupus familiaris)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 47 (01 Oct 2014)
      Sequence version 1 (06 Mar 2007)
      Previous versions | rss
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    Functioni

    Essential component of a MLL/SET1 histone methyltransferase (HMT) complex, a complex that specifically methylates 'Lys-4' of histone H3 (H3K4). Functions as a transcriptional regulator. Binds to the TERT promoter and represses telomerase expression. Plays a role in TGFB1-mediated inhibition of cell-proliferation, possibly regulating SMAD3 transcriptional activity. Represses JUND-mediated transcriptional activation on AP1 sites, as well as that mediated by NFKB subunit RELA. Positively regulates HOXC8 and HOXC6 gene expression. May be involved in normal hematopoiesis through the activation of HOXA9 expression. May be involved in DNA repair By similarity.By similarity

    GO - Molecular functioni

    1. chromatin binding Source: Ensembl
    2. double-stranded DNA binding Source: Ensembl
    3. four-way junction DNA binding Source: Ensembl
    4. histone-lysine N-methyltransferase activity Source: Ensembl
    5. sequence-specific DNA binding Source: Ensembl
    6. transcription regulatory region DNA binding Source: Ensembl
    7. Y-form DNA binding Source: Ensembl

    GO - Biological processi

    1. cell cycle arrest Source: Ensembl
    2. cellular response to DNA damage stimulus Source: Ensembl
    3. chromatin remodeling Source: Ensembl
    4. embryonic skeletal system morphogenesis Source: Ensembl
    5. hemopoiesis Source: Ensembl
    6. leukocyte homeostasis Source: Ensembl
    7. MAPK cascade Source: Ensembl
    8. maternal process involved in female pregnancy Source: Ensembl
    9. negative regulation of cell proliferation Source: Ensembl
    10. negative regulation of cyclin-dependent protein serine/threonine kinase activity Source: Ensembl
    11. negative regulation of JNK cascade Source: Ensembl
    12. negative regulation of organ growth Source: Ensembl
    13. negative regulation of osteoblast differentiation Source: Ensembl
    14. negative regulation of sequence-specific DNA binding transcription factor activity Source: Ensembl
    15. negative regulation of telomerase activity Source: Ensembl
    16. negative regulation of transcription from RNA polymerase II promoter Source: Ensembl
    17. osteoblast development Source: Ensembl
    18. osteoblast fate commitment Source: Ensembl
    19. palate development Source: Ensembl
    20. positive regulation of apoptotic process Source: Ensembl
    21. positive regulation of cell division Source: Ensembl
    22. positive regulation of cysteine-type endopeptidase activity involved in apoptotic process Source: Ensembl
    23. positive regulation of histone methylation Source: Ensembl
    24. positive regulation of osteoblast differentiation Source: Ensembl
    25. positive regulation of protein binding Source: Ensembl
    26. positive regulation of transcription from RNA polymerase II promoter Source: Ensembl
    27. positive regulation of transforming growth factor beta receptor signaling pathway Source: Ensembl
    28. response to gamma radiation Source: Ensembl
    29. response to UV Source: Ensembl
    30. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Chromatin regulator, Repressor

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding

    Enzyme and pathway databases

    ReactomeiREACT_175274. SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription.
    REACT_210055. formation of the beta-catenin:TCF transactivating complex.
    REACT_220177. deactivation of the beta-catenin transactivating complex.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Menin
    Gene namesi
    Name:MEN1
    OrganismiCanis familiaris (Dog) (Canis lupus familiaris)
    Taxonomic identifieri9615 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaCanidaeCanis
    ProteomesiUP000002254: Chromosome 18

    Subcellular locationi

    Nucleus By similarity

    GO - Cellular componenti

    1. chromatin Source: Ensembl
    2. cleavage furrow Source: Ensembl
    3. cytosol Source: Ensembl
    4. histone methyltransferase complex Source: Ensembl
    5. nuclear matrix Source: Ensembl

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 615615MeninPRO_0000408472Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei599 – 5991PhosphothreonineBy similarity

    Keywords - PTMi

    Phosphoprotein

    Interactioni

    Subunit structurei

    Component of the MLL-HCF complex, at least composed of KMT2A/MLL1, MEN1, ASH2L, RBBP5, DPY30, WDR5, HCFC1 and HCFC2 By similarity. Component of the menin-associated histone methyltransferase complex, at least composed of KMT2B/MLL4, MEN1, ASH2L, RBBP5, DPY30 and WDR5 By similarity. Interacts with POLR2B By similarity. Interacts with POLR2A phosphorylated at 'Ser-5', but not with the unphosphorylated, nor 'Ser-2' phosphorylated POLR2A forms By similarity. Interacts with FANCD2 and DBF4 By similarity. Interacts with SMAD3, but not with SMAD2, nor SMAD4 By similarity. Directly interacts with NFKB1, NFKB2 and RELA. Interacts with JUND By similarity.By similarity

    Protein-protein interaction databases

    STRINGi9615.ENSCAFP00000020909.

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni219 – 395177Interaction with FANCD2By similarityAdd
    BLAST

    Phylogenomic databases

    eggNOGiNOG67412.
    GeneTreeiENSGT00390000014237.
    HOGENOMiHOG000007225.
    HOVERGENiHBG000208.
    InParanoidiA2SXS5.
    KOiK14970.
    OMAiPYMYLAG.
    OrthoDBiEOG7QC7WH.
    TreeFamiTF323888.

    Family and domain databases

    InterProiIPR007747. Menin.
    [Graphical view]
    PANTHERiPTHR12693. PTHR12693. 1 hit.
    PfamiPF05053. Menin. 1 hit.
    [Graphical view]

    Sequences (4)i

    Sequence statusi: Complete.

    This entry describes 4 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: A2SXS5-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MGLKAAQKTL FPLRSIDDVV RLFAAELGRE EPDLVLLSLV LGFVEHFLAV    50
    NRVIPTNVPE LTFQPSPAPD PPGGLTYFPV ADLSIIAALY ARFTAQIRGA 100
    VDLSLYPREG GVSSRELVKK VSDVIWNSLS RSYFKDRAHI QSLFSFITGW 150
    SPTGTKLDSS GVAFAVVGAC QALGLRDVHL ALSEDHAWVV FGPNGEQTAE 200
    VTWHGKGNED RRGQTVNAGV AERSWLYLKG SYMRCDRKME VAFMVCAINP 250
    SIDLHTDSLE LLQLQQKLLW LLYDLGHLER YPMALGNLAD LEELEPTPGR 300
    PDPLTLYHKG IASAKTYYRD EHIYPYMYLA GYHCRNRNVR EALQAWADTA 350
    TVIQDYNYCR EDEEIYKEFF EVANDVIPNL LKEAASLLEA GEERPGEQTQ 400
    GVQSQGSALQ DPECFAHLLR FYDGICKWEE GSPTPVLHVG WATFLVQSLG 450
    RFEGQVRQKV RIVSREAEAA EAEELWGEEA REGRRRGPRR ESKPEEPPPP 500
    KKPALDKGPG GGQGAMSGPP RKPPGTVPGT ARGPEGGSTA PAPAPAASPP 550
    PEGPVLTFQS EKMKGMKELL VATKINSSAI KLQLTAQSQV QMKKQKVSTP 600
    SDYTLSFLKR QRKGL 615
    Length:615
    Mass (Da):67,962
    Last modified:March 6, 2007 - v1
    Checksum:i52FB0491302AC165
    GO
    Isoform 2 (identifier: A2SXS5-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         150-154: Missing.

    Note: Gene prediction based on similarity to human ortholog.

    Show »
    Length:610
    Mass (Da):67,434
    Checksum:i071D4C293176D637
    GO
    Isoform 3 (identifier: A2SXS5-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         401-455: Missing.

    Note: Gene prediction based on similarity to mouse ortholog.

    Show »
    Length:560
    Mass (Da):61,887
    Checksum:iE97DA5DAFE831AB9
    GO
    Isoform 4 (identifier: A2SXS5-4) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         150-154: Missing.
         401-455: Missing.

    Note: Gene prediction.

    Show »
    Length:555
    Mass (Da):61,358
    Checksum:i7D58AA09F422AB8E
    GO

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei150 – 1545Missing in isoform 2 and isoform 4. CuratedVSP_041101
    Alternative sequencei401 – 45555Missing in isoform 3 and isoform 4. CuratedVSP_041102Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DQ366289 mRNA. Translation: ABD16380.1.
    RefSeqiNP_001074977.1. NM_001081508.1. [A2SXS5-1]
    UniGeneiCfa.21138.

    Genome annotation databases

    EnsembliENSCAFT00000022520; ENSCAFP00000020909; ENSCAFG00000014185. [A2SXS5-2]
    ENSCAFT00000022521; ENSCAFP00000020910; ENSCAFG00000014185. [A2SXS5-3]
    GeneIDi483758.
    KEGGicfa:483758.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DQ366289 mRNA. Translation: ABD16380.1 .
    RefSeqi NP_001074977.1. NM_001081508.1. [A2SXS5-1 ]
    UniGenei Cfa.21138.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9615.ENSCAFP00000020909.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSCAFT00000022520 ; ENSCAFP00000020909 ; ENSCAFG00000014185 . [A2SXS5-2 ]
    ENSCAFT00000022521 ; ENSCAFP00000020910 ; ENSCAFG00000014185 . [A2SXS5-3 ]
    GeneIDi 483758.
    KEGGi cfa:483758.

    Organism-specific databases

    CTDi 4221.

    Phylogenomic databases

    eggNOGi NOG67412.
    GeneTreei ENSGT00390000014237.
    HOGENOMi HOG000007225.
    HOVERGENi HBG000208.
    InParanoidi A2SXS5.
    KOi K14970.
    OMAi PYMYLAG.
    OrthoDBi EOG7QC7WH.
    TreeFami TF323888.

    Enzyme and pathway databases

    Reactomei REACT_175274. SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription.
    REACT_210055. formation of the beta-catenin:TCF transactivating complex.
    REACT_220177. deactivation of the beta-catenin transactivating complex.

    Miscellaneous databases

    NextBioi 20858110.

    Family and domain databases

    InterProi IPR007747. Menin.
    [Graphical view ]
    PANTHERi PTHR12693. PTHR12693. 1 hit.
    Pfami PF05053. Menin. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Inheritance, mode of inheritance, and candidate genes for primary hyperparathyroidism in Keeshonden."
      Goldstein R.E., Atwater D.Z., Cazolli D.M., Goldstein O., Wade C.M., Lindblad-Toh K.
      J. Vet. Intern. Med. 21:199-203(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).

    Entry informationi

    Entry nameiMEN1_CANFA
    AccessioniPrimary (citable) accession number: A2SXS5
    Secondary accession number(s): E2RDP0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 31, 2011
    Last sequence update: March 6, 2007
    Last modified: October 1, 2014
    This is version 47 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    External Data

    Dasty 3