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A2SXS5 (MEN1_CANFA) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 43. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry infoCustomize order

Names and origin

Protein namesRecommended name:
Menin
Gene names
Name:MEN1
OrganismCanis familiaris (Dog) (Canis lupus familiaris) [Reference proteome]
Taxonomic identifier9615 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaCanidaeCanis

Protein attributes

Sequence length615 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Essential component of a MLL/SET1 histone methyltransferase (HMT) complex, a complex that specifically methylates 'Lys-4' of histone H3 (H3K4). Functions as a transcriptional regulator. Binds to the TERT promoter and represses telomerase expression. Plays a role in TGFB1-mediated inhibition of cell-proliferation, possibly regulating SMAD3 transcriptional activity. Represses JUND-mediated transcriptional activation on AP1 sites, as well as that mediated by NFKB subunit RELA. Positively regulates HOXC8 and HOXC6 gene expression. May be involved in normal hematopoiesis through the activation of HOXA9 expression. May be involved in DNA repair By similarity.

Subunit structure

Component of the MLL-HCF complex, at least composed of KMT2A/MLL1, MEN1, ASH2L, RBBP5, DPY30, WDR5, HCFC1 and HCFC2 By similarity. Component of the menin-associated histone methyltransferase complex, at least composed of KMT2B/MLL4, MEN1, ASH2L, RBBP5, DPY30 and WDR5 By similarity. Interacts with POLR2B By similarity. Interacts with POLR2A phosphorylated at 'Ser-5', but not with the unphosphorylated, nor 'Ser-2' phosphorylated POLR2A forms By similarity. Interacts with FANCD2 and DBF4 By similarity. Interacts with SMAD3, but not with SMAD2, nor SMAD4 By similarity. Directly interacts with NFKB1, NFKB2 and RELA. Interacts with JUND By similarity.

Subcellular location

Nucleus By similarity.

Ontologies

Keywords
   Biological processTranscription
Transcription regulation
   Cellular componentNucleus
   Coding sequence diversityAlternative splicing
   LigandDNA-binding
   Molecular functionChromatin regulator
Repressor
   PTMPhosphoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processMAPK cascade

Inferred from electronic annotation. Source: Ensembl

cell cycle arrest

Inferred from electronic annotation. Source: Ensembl

cellular response to DNA damage stimulus

Inferred from electronic annotation. Source: Ensembl

chromatin remodeling

Inferred from electronic annotation. Source: Ensembl

embryonic skeletal system morphogenesis

Inferred from electronic annotation. Source: Ensembl

hemopoiesis

Inferred from electronic annotation. Source: Ensembl

leukocyte homeostasis

Inferred from electronic annotation. Source: Ensembl

maternal process involved in female pregnancy

Inferred from electronic annotation. Source: Ensembl

negative regulation of JNK cascade

Inferred from electronic annotation. Source: Ensembl

negative regulation of cell proliferation

Inferred from electronic annotation. Source: Ensembl

negative regulation of cyclin-dependent protein serine/threonine kinase activity

Inferred from electronic annotation. Source: Ensembl

negative regulation of organ growth

Inferred from electronic annotation. Source: Ensembl

negative regulation of osteoblast differentiation

Inferred from electronic annotation. Source: Ensembl

negative regulation of sequence-specific DNA binding transcription factor activity

Inferred from electronic annotation. Source: Ensembl

negative regulation of telomerase activity

Inferred from electronic annotation. Source: Ensembl

negative regulation of transcription from RNA polymerase II promoter

Inferred from electronic annotation. Source: Ensembl

osteoblast development

Inferred from electronic annotation. Source: Ensembl

osteoblast fate commitment

Inferred from electronic annotation. Source: Ensembl

palate development

Inferred from electronic annotation. Source: Ensembl

positive regulation of apoptotic process

Inferred from electronic annotation. Source: Ensembl

positive regulation of cell division

Inferred from electronic annotation. Source: Ensembl

positive regulation of cysteine-type endopeptidase activity involved in apoptotic process

Inferred from electronic annotation. Source: Ensembl

positive regulation of histone methylation

Inferred from electronic annotation. Source: Ensembl

positive regulation of osteoblast differentiation

Inferred from electronic annotation. Source: Ensembl

positive regulation of protein binding

Inferred from electronic annotation. Source: Ensembl

positive regulation of transcription from RNA polymerase II promoter

Inferred from electronic annotation. Source: Ensembl

positive regulation of transforming growth factor beta receptor signaling pathway

Inferred from electronic annotation. Source: Ensembl

response to UV

Inferred from electronic annotation. Source: Ensembl

response to gamma radiation

Inferred from electronic annotation. Source: Ensembl

transcription, DNA-templated

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentchromatin

Inferred from electronic annotation. Source: Ensembl

cleavage furrow

Inferred from electronic annotation. Source: Ensembl

cytosol

Inferred from electronic annotation. Source: Ensembl

histone methyltransferase complex

Inferred from electronic annotation. Source: Ensembl

nuclear matrix

Inferred from electronic annotation. Source: Ensembl

   Molecular_functionY-form DNA binding

Inferred from electronic annotation. Source: Ensembl

chromatin binding

Inferred from electronic annotation. Source: Ensembl

double-stranded DNA binding

Inferred from electronic annotation. Source: Ensembl

four-way junction DNA binding

Inferred from electronic annotation. Source: Ensembl

histone-lysine N-methyltransferase activity

Inferred from electronic annotation. Source: Ensembl

sequence-specific DNA binding

Inferred from electronic annotation. Source: Ensembl

transcription regulatory region DNA binding

Inferred from electronic annotation. Source: Ensembl

Complete GO annotation...

Alternative products

This entry describes 4 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: A2SXS5-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: A2SXS5-2)

The sequence of this isoform differs from the canonical sequence as follows:
     150-154: Missing.
Note: Gene prediction based on similarity to human ortholog.
Isoform 3 (identifier: A2SXS5-3)

The sequence of this isoform differs from the canonical sequence as follows:
     401-455: Missing.
Note: Gene prediction based on similarity to mouse ortholog.
Isoform 4 (identifier: A2SXS5-4)

The sequence of this isoform differs from the canonical sequence as follows:
     150-154: Missing.
     401-455: Missing.
Note: Gene prediction.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 615615Menin
PRO_0000408472

Regions

Region219 – 395177Interaction with FANCD2 By similarity

Amino acid modifications

Modified residue5991Phosphothreonine By similarity

Natural variations

Alternative sequence150 – 1545Missing in isoform 2 and isoform 4.
VSP_041101
Alternative sequence401 – 45555Missing in isoform 3 and isoform 4.
VSP_041102

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified March 6, 2007. Version 1.
Checksum: 52FB0491302AC165

FASTA61567,962
        10         20         30         40         50         60 
MGLKAAQKTL FPLRSIDDVV RLFAAELGRE EPDLVLLSLV LGFVEHFLAV NRVIPTNVPE 

        70         80         90        100        110        120 
LTFQPSPAPD PPGGLTYFPV ADLSIIAALY ARFTAQIRGA VDLSLYPREG GVSSRELVKK 

       130        140        150        160        170        180 
VSDVIWNSLS RSYFKDRAHI QSLFSFITGW SPTGTKLDSS GVAFAVVGAC QALGLRDVHL 

       190        200        210        220        230        240 
ALSEDHAWVV FGPNGEQTAE VTWHGKGNED RRGQTVNAGV AERSWLYLKG SYMRCDRKME 

       250        260        270        280        290        300 
VAFMVCAINP SIDLHTDSLE LLQLQQKLLW LLYDLGHLER YPMALGNLAD LEELEPTPGR 

       310        320        330        340        350        360 
PDPLTLYHKG IASAKTYYRD EHIYPYMYLA GYHCRNRNVR EALQAWADTA TVIQDYNYCR 

       370        380        390        400        410        420 
EDEEIYKEFF EVANDVIPNL LKEAASLLEA GEERPGEQTQ GVQSQGSALQ DPECFAHLLR 

       430        440        450        460        470        480 
FYDGICKWEE GSPTPVLHVG WATFLVQSLG RFEGQVRQKV RIVSREAEAA EAEELWGEEA 

       490        500        510        520        530        540 
REGRRRGPRR ESKPEEPPPP KKPALDKGPG GGQGAMSGPP RKPPGTVPGT ARGPEGGSTA 

       550        560        570        580        590        600 
PAPAPAASPP PEGPVLTFQS EKMKGMKELL VATKINSSAI KLQLTAQSQV QMKKQKVSTP 

       610 
SDYTLSFLKR QRKGL 

« Hide

Isoform 2 [UniParc].

Checksum: 071D4C293176D637
Show »

FASTA61067,434
Isoform 3 [UniParc].

Checksum: E97DA5DAFE831AB9
Show »

FASTA56061,887
Isoform 4 [UniParc].

Checksum: 7D58AA09F422AB8E
Show »

FASTA55561,358

References

[1]"Inheritance, mode of inheritance, and candidate genes for primary hyperparathyroidism in Keeshonden."
Goldstein R.E., Atwater D.Z., Cazolli D.M., Goldstein O., Wade C.M., Lindblad-Toh K.
J. Vet. Intern. Med. 21:199-203(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
DQ366289 mRNA. Translation: ABD16380.1.
RefSeqNP_001074977.1. NM_001081508.1.
UniGeneCfa.21138.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9615.ENSCAFP00000020909.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSCAFT00000022520; ENSCAFP00000020909; ENSCAFG00000014185. [A2SXS5-2]
ENSCAFT00000022521; ENSCAFP00000020910; ENSCAFG00000014185. [A2SXS5-3]
GeneID483758.
KEGGcfa:483758.

Organism-specific databases

CTD4221.

Phylogenomic databases

eggNOGNOG67412.
GeneTreeENSGT00390000014237.
HOGENOMHOG000007225.
HOVERGENHBG000208.
InParanoidA2SXS5.
KOK14970.
OMAPYMYLAG.
OrthoDBEOG7QC7WH.
TreeFamTF323888.

Family and domain databases

InterProIPR007747. Menin.
[Graphical view]
PANTHERPTHR12693. PTHR12693. 1 hit.
PfamPF05053. Menin. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio20858110.

Entry information

Entry nameMEN1_CANFA
AccessionPrimary (citable) accession number: A2SXS5
Secondary accession number(s): E2RDP0
Entry history
Integrated into UniProtKB/Swiss-Prot: May 31, 2011
Last sequence update: March 6, 2007
Last modified: April 16, 2014
This is version 43 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program