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A2SXS5

- MEN1_CANFA

UniProt

A2SXS5 - MEN1_CANFA

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Protein
Menin
Gene
MEN1
Organism
Canis familiaris (Dog) (Canis lupus familiaris)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

Essential component of a MLL/SET1 histone methyltransferase (HMT) complex, a complex that specifically methylates 'Lys-4' of histone H3 (H3K4). Functions as a transcriptional regulator. Binds to the TERT promoter and represses telomerase expression. Plays a role in TGFB1-mediated inhibition of cell-proliferation, possibly regulating SMAD3 transcriptional activity. Represses JUND-mediated transcriptional activation on AP1 sites, as well as that mediated by NFKB subunit RELA. Positively regulates HOXC8 and HOXC6 gene expression. May be involved in normal hematopoiesis through the activation of HOXA9 expression. May be involved in DNA repair By similarity.

GO - Molecular functioni

  1. Y-form DNA binding Source: Ensembl
  2. chromatin binding Source: Ensembl
  3. double-stranded DNA binding Source: Ensembl
  4. four-way junction DNA binding Source: Ensembl
  5. histone-lysine N-methyltransferase activity Source: Ensembl
  6. sequence-specific DNA binding Source: Ensembl
  7. transcription regulatory region DNA binding Source: Ensembl

GO - Biological processi

  1. MAPK cascade Source: Ensembl
  2. cell cycle arrest Source: Ensembl
  3. cellular response to DNA damage stimulus Source: Ensembl
  4. chromatin remodeling Source: Ensembl
  5. embryonic skeletal system morphogenesis Source: Ensembl
  6. hemopoiesis Source: Ensembl
  7. leukocyte homeostasis Source: Ensembl
  8. maternal process involved in female pregnancy Source: Ensembl
  9. negative regulation of JNK cascade Source: Ensembl
  10. negative regulation of cell proliferation Source: Ensembl
  11. negative regulation of cyclin-dependent protein serine/threonine kinase activity Source: Ensembl
  12. negative regulation of organ growth Source: Ensembl
  13. negative regulation of osteoblast differentiation Source: Ensembl
  14. negative regulation of sequence-specific DNA binding transcription factor activity Source: Ensembl
  15. negative regulation of telomerase activity Source: Ensembl
  16. negative regulation of transcription from RNA polymerase II promoter Source: Ensembl
  17. osteoblast development Source: Ensembl
  18. osteoblast fate commitment Source: Ensembl
  19. palate development Source: Ensembl
  20. positive regulation of apoptotic process Source: Ensembl
  21. positive regulation of cell division Source: Ensembl
  22. positive regulation of cysteine-type endopeptidase activity involved in apoptotic process Source: Ensembl
  23. positive regulation of histone methylation Source: Ensembl
  24. positive regulation of osteoblast differentiation Source: Ensembl
  25. positive regulation of protein binding Source: Ensembl
  26. positive regulation of transcription from RNA polymerase II promoter Source: Ensembl
  27. positive regulation of transforming growth factor beta receptor signaling pathway Source: Ensembl
  28. response to UV Source: Ensembl
  29. response to gamma radiation Source: Ensembl
  30. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Chromatin regulator, Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

ReactomeiREACT_175274. SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription.
REACT_210055. formation of the beta-catenin:TCF transactivating complex.
REACT_220177. deactivation of the beta-catenin transactivating complex.

Names & Taxonomyi

Protein namesi
Recommended name:
Menin
Gene namesi
Name:MEN1
OrganismiCanis familiaris (Dog) (Canis lupus familiaris)
Taxonomic identifieri9615 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaCanidaeCanis
ProteomesiUP000002254: Chromosome 18

Subcellular locationi

Nucleus By similarity

GO - Cellular componenti

  1. chromatin Source: Ensembl
  2. cleavage furrow Source: Ensembl
  3. cytosol Source: Ensembl
  4. histone methyltransferase complex Source: Ensembl
  5. nuclear matrix Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 615615Menin
PRO_0000408472Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei599 – 5991Phosphothreonine By similarity

Keywords - PTMi

Phosphoprotein

Interactioni

Subunit structurei

Component of the MLL-HCF complex, at least composed of KMT2A/MLL1, MEN1, ASH2L, RBBP5, DPY30, WDR5, HCFC1 and HCFC2 By similarity. Component of the menin-associated histone methyltransferase complex, at least composed of KMT2B/MLL4, MEN1, ASH2L, RBBP5, DPY30 and WDR5 By similarity. Interacts with POLR2B By similarity. Interacts with POLR2A phosphorylated at 'Ser-5', but not with the unphosphorylated, nor 'Ser-2' phosphorylated POLR2A forms By similarity. Interacts with FANCD2 and DBF4 By similarity. Interacts with SMAD3, but not with SMAD2, nor SMAD4 By similarity. Directly interacts with NFKB1, NFKB2 and RELA. Interacts with JUND By similarity.

Protein-protein interaction databases

STRINGi9615.ENSCAFP00000020909.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni219 – 395177Interaction with FANCD2 By similarity
Add
BLAST

Phylogenomic databases

eggNOGiNOG67412.
GeneTreeiENSGT00390000014237.
HOGENOMiHOG000007225.
HOVERGENiHBG000208.
InParanoidiA2SXS5.
KOiK14970.
OMAiPYMYLAG.
OrthoDBiEOG7QC7WH.
TreeFamiTF323888.

Family and domain databases

InterProiIPR007747. Menin.
[Graphical view]
PANTHERiPTHR12693. PTHR12693. 1 hit.
PfamiPF05053. Menin. 1 hit.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: A2SXS5-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MGLKAAQKTL FPLRSIDDVV RLFAAELGRE EPDLVLLSLV LGFVEHFLAV    50
NRVIPTNVPE LTFQPSPAPD PPGGLTYFPV ADLSIIAALY ARFTAQIRGA 100
VDLSLYPREG GVSSRELVKK VSDVIWNSLS RSYFKDRAHI QSLFSFITGW 150
SPTGTKLDSS GVAFAVVGAC QALGLRDVHL ALSEDHAWVV FGPNGEQTAE 200
VTWHGKGNED RRGQTVNAGV AERSWLYLKG SYMRCDRKME VAFMVCAINP 250
SIDLHTDSLE LLQLQQKLLW LLYDLGHLER YPMALGNLAD LEELEPTPGR 300
PDPLTLYHKG IASAKTYYRD EHIYPYMYLA GYHCRNRNVR EALQAWADTA 350
TVIQDYNYCR EDEEIYKEFF EVANDVIPNL LKEAASLLEA GEERPGEQTQ 400
GVQSQGSALQ DPECFAHLLR FYDGICKWEE GSPTPVLHVG WATFLVQSLG 450
RFEGQVRQKV RIVSREAEAA EAEELWGEEA REGRRRGPRR ESKPEEPPPP 500
KKPALDKGPG GGQGAMSGPP RKPPGTVPGT ARGPEGGSTA PAPAPAASPP 550
PEGPVLTFQS EKMKGMKELL VATKINSSAI KLQLTAQSQV QMKKQKVSTP 600
SDYTLSFLKR QRKGL 615
Length:615
Mass (Da):67,962
Last modified:March 6, 2007 - v1
Checksum:i52FB0491302AC165
GO
Isoform 2 (identifier: A2SXS5-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     150-154: Missing.

Note: Gene prediction based on similarity to human ortholog.

Show »
Length:610
Mass (Da):67,434
Checksum:i071D4C293176D637
GO
Isoform 3 (identifier: A2SXS5-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     401-455: Missing.

Note: Gene prediction based on similarity to mouse ortholog.

Show »
Length:560
Mass (Da):61,887
Checksum:iE97DA5DAFE831AB9
GO
Isoform 4 (identifier: A2SXS5-4) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     150-154: Missing.
     401-455: Missing.

Note: Gene prediction.

Show »
Length:555
Mass (Da):61,358
Checksum:i7D58AA09F422AB8E
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei150 – 1545Missing in isoform 2 and isoform 4.
VSP_041101
Alternative sequencei401 – 45555Missing in isoform 3 and isoform 4.
VSP_041102Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DQ366289 mRNA. Translation: ABD16380.1.
RefSeqiNP_001074977.1. NM_001081508.1. [A2SXS5-1]
UniGeneiCfa.21138.

Genome annotation databases

EnsembliENSCAFT00000022520; ENSCAFP00000020909; ENSCAFG00000014185. [A2SXS5-2]
ENSCAFT00000022521; ENSCAFP00000020910; ENSCAFG00000014185. [A2SXS5-3]
GeneIDi483758.
KEGGicfa:483758.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DQ366289 mRNA. Translation: ABD16380.1 .
RefSeqi NP_001074977.1. NM_001081508.1. [A2SXS5-1 ]
UniGenei Cfa.21138.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9615.ENSCAFP00000020909.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSCAFT00000022520 ; ENSCAFP00000020909 ; ENSCAFG00000014185 . [A2SXS5-2 ]
ENSCAFT00000022521 ; ENSCAFP00000020910 ; ENSCAFG00000014185 . [A2SXS5-3 ]
GeneIDi 483758.
KEGGi cfa:483758.

Organism-specific databases

CTDi 4221.

Phylogenomic databases

eggNOGi NOG67412.
GeneTreei ENSGT00390000014237.
HOGENOMi HOG000007225.
HOVERGENi HBG000208.
InParanoidi A2SXS5.
KOi K14970.
OMAi PYMYLAG.
OrthoDBi EOG7QC7WH.
TreeFami TF323888.

Enzyme and pathway databases

Reactomei REACT_175274. SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription.
REACT_210055. formation of the beta-catenin:TCF transactivating complex.
REACT_220177. deactivation of the beta-catenin transactivating complex.

Miscellaneous databases

NextBioi 20858110.

Family and domain databases

InterProi IPR007747. Menin.
[Graphical view ]
PANTHERi PTHR12693. PTHR12693. 1 hit.
Pfami PF05053. Menin. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Inheritance, mode of inheritance, and candidate genes for primary hyperparathyroidism in Keeshonden."
    Goldstein R.E., Atwater D.Z., Cazolli D.M., Goldstein O., Wade C.M., Lindblad-Toh K.
    J. Vet. Intern. Med. 21:199-203(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).

Entry informationi

Entry nameiMEN1_CANFA
AccessioniPrimary (citable) accession number: A2SXS5
Secondary accession number(s): E2RDP0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 31, 2011
Last sequence update: March 6, 2007
Last modified: September 3, 2014
This is version 46 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

External Data

Dasty 3

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