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A2SW69

- ANXA2_SHEEP

UniProt

A2SW69 - ANXA2_SHEEP

Protein

Annexin A2

Gene

ANXA2

Organism
Ovis aries (Sheep)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 44 (01 Oct 2014)
      Sequence version 1 (06 Mar 2007)
      Previous versions | rss
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    Functioni

    Calcium-regulated membrane-binding protein whose affinity for calcium is greatly enhanced by anionic phospholipids. It binds two calcium ions with high affinity By similarity.By similarity

    GO - Molecular functioni

    1. calcium-dependent phospholipid binding Source: UniProtKB-KW
    2. calcium ion binding Source: InterPro
    3. phospholipase inhibitor activity Source: InterPro

    GO - Biological processi

    1. positive regulation of vesicle fusion Source: Ensembl

    Keywords - Ligandi

    Calcium, Calcium/phospholipid-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Annexin A2
    Alternative name(s):
    Annexin-2
    Gene namesi
    Name:ANXA2
    Synonyms:ANX2
    OrganismiOvis aries (Sheep)
    Taxonomic identifieri9940 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeCaprinaeOvis
    ProteomesiUP000002356: Chromosome 7

    Subcellular locationi

    Secretedextracellular spaceextracellular matrixbasement membrane
    Note: In the lamina beneath the plasma membrane.By similarity

    GO - Cellular componenti

    1. basement membrane Source: UniProtKB-SubCell
    2. extracellular vesicular exosome Source: Ensembl
    3. lipid particle Source: Ensembl
    4. midbody Source: Ensembl

    Keywords - Cellular componenti

    Basement membrane, Extracellular matrix, Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedBy similarity
    Chaini2 – 339338Annexin A2PRO_0000288687Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylserineBy similarity
    Modified residuei24 – 241Phosphotyrosine; by SRCBy similarity
    Modified residuei26 – 261Phosphoserine; by PKCBy similarity
    Modified residuei49 – 491N6-acetyllysineBy similarity
    Modified residuei152 – 1521N6-acetyllysineBy similarity
    Modified residuei199 – 1991PhosphotyrosineBy similarity
    Modified residuei227 – 2271N6-acetyllysineBy similarity

    Post-translational modificationi

    ISGylated.By similarity

    Keywords - PTMi

    Acetylation, Phosphoprotein, Ubl conjugation

    Proteomic databases

    PRIDEiA2SW69.

    Expressioni

    Tissue specificityi

    Detected in myometrium.1 Publication

    Inductioni

    Up-regulated in myometrium upon progesterone treatment.1 Publication

    Interactioni

    Subunit structurei

    Heterotetramer containing 2 light chains of S100A10/p11 and 2 heavy chains of ANXA2/p36. Interacts with ATP1B1 and DYSF By similarity. Interacts with COCH By similarity.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliA2SW69.
    SMRiA2SW69. Positions 21-339.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati42 – 10261Annexin 1Add
    BLAST
    Repeati114 – 17461Annexin 2Add
    BLAST
    Repeati199 – 25961Annexin 3Add
    BLAST
    Repeati274 – 33461Annexin 4Add
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni2 – 2423S100A10-binding siteSequence AnalysisAdd
    BLAST

    Domaini

    A pair of annexin repeats may form one binding site for calcium and phospholipid.

    Sequence similaritiesi

    Belongs to the annexin family.Curated
    Contains 4 annexin repeats.Curated

    Keywords - Domaini

    Annexin, Repeat

    Phylogenomic databases

    GeneTreeiENSGT00680000099735.
    HOVERGENiHBG061815.

    Family and domain databases

    Gene3Di1.10.220.10. 4 hits.
    InterProiIPR001464. Annexin.
    IPR018502. Annexin_repeat.
    IPR018252. Annexin_repeat_CS.
    IPR002389. AnnexinII.
    [Graphical view]
    PANTHERiPTHR10502:SF18. PTHR10502:SF18. 1 hit.
    PfamiPF00191. Annexin. 4 hits.
    [Graphical view]
    PRINTSiPR00196. ANNEXIN.
    PR00198. ANNEXINII.
    SMARTiSM00335. ANX. 4 hits.
    [Graphical view]
    PROSITEiPS00223. ANNEXIN. 4 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    A2SW69-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSTVHEILCK LSLEGDHSTP PSAYGSVKAY TNFDAERDAL NIETAIKTKG    50
    VDEVTIVNIL TNRSNEQRQD IAFAYQRRTK KELASALKSA LSGHLETVIL 100
    GLLKTPAQYD ASELKASMKG LGTDEDSLIE IICSRTNQEL QEINRVYKEM 150
    YKTDLEKDIV SDTSGDFRKL MVALAKGRRA EDGSVIDYEL IDQDARDLYD 200
    AGVKRKGTDV PKWISIMTER SVCHLQKVFE RYKSYSPYDM LESIKKEVKG 250
    DLENAFLNLV QCIQNKPLYF ADRLYDSMKG KGTRDKVLIR IMVSRSEVDM 300
    LKIRSEFKKK YGKSLYYYIQ QDTKGDYQKA LLYLCGGDD 339
    Length:339
    Mass (Da):38,612
    Last modified:March 6, 2007 - v1
    Checksum:iAA8E2500F4138B3D
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DQ358998 mRNA. Translation: ABC94470.1.
    RefSeqiNP_001087257.1. NM_001093788.1.
    UniGeneiOar.5185.

    Genome annotation databases

    EnsembliENSOART00000022687; ENSOARP00000022381; ENSOARG00000020821.
    GeneIDi100048993.

    Cross-referencesi

    Web resourcesi

    Protein Spotlight

    Red velvet - Issue 86 of September 2007

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DQ358998 mRNA. Translation: ABC94470.1 .
    RefSeqi NP_001087257.1. NM_001093788.1.
    UniGenei Oar.5185.

    3D structure databases

    ProteinModelPortali A2SW69.
    SMRi A2SW69. Positions 21-339.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi A2SW69.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSOART00000022687 ; ENSOARP00000022381 ; ENSOARG00000020821 .
    GeneIDi 100048993.

    Organism-specific databases

    CTDi 302.

    Phylogenomic databases

    GeneTreei ENSGT00680000099735.
    HOVERGENi HBG061815.

    Family and domain databases

    Gene3Di 1.10.220.10. 4 hits.
    InterProi IPR001464. Annexin.
    IPR018502. Annexin_repeat.
    IPR018252. Annexin_repeat_CS.
    IPR002389. AnnexinII.
    [Graphical view ]
    PANTHERi PTHR10502:SF18. PTHR10502:SF18. 1 hit.
    Pfami PF00191. Annexin. 4 hits.
    [Graphical view ]
    PRINTSi PR00196. ANNEXIN.
    PR00198. ANNEXINII.
    SMARTi SM00335. ANX. 4 hits.
    [Graphical view ]
    PROSITEi PS00223. ANNEXIN. 4 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Separate and synergistic effect of progesterone and estradiol on induction of annexin 2 and its interaction protein p11 in pregnant sheep myometrium."
      Zhang Q., Wu W.X.
      J. Mol. Endocrinol. 38:441-454(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], INDUCTION, TISSUE SPECIFICITY, SUBUNIT.
      Tissue: Myometrium.

    Entry informationi

    Entry nameiANXA2_SHEEP
    AccessioniPrimary (citable) accession number: A2SW69
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 29, 2007
    Last sequence update: March 6, 2007
    Last modified: October 1, 2014
    This is version 44 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    It may cross-link plasma membrane phospholipids with actin and the cytoskeleton and be involved with exocytosis.

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Protein Spotlight
      Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3