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A2SW69

- ANXA2_SHEEP

UniProt

A2SW69 - ANXA2_SHEEP

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Protein

Annexin A2

Gene
ANXA2, ANX2
Organism
Ovis aries (Sheep)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Calcium-regulated membrane-binding protein whose affinity for calcium is greatly enhanced by anionic phospholipids. It binds two calcium ions with high affinity By similarity.

GO - Molecular functioni

  1. calcium-dependent phospholipid binding Source: UniProtKB-KW
  2. calcium ion binding Source: InterPro
  3. phospholipase inhibitor activity Source: InterPro

GO - Biological processi

  1. positive regulation of vesicle fusion Source: Ensembl
Complete GO annotation...

Keywords - Ligandi

Calcium, Calcium/phospholipid-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Annexin A2
Alternative name(s):
Annexin-2
Gene namesi
Name:ANXA2
Synonyms:ANX2
OrganismiOvis aries (Sheep)
Taxonomic identifieri9940 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeCaprinaeOvis
ProteomesiUP000002356: Chromosome 7

Subcellular locationi

Secretedextracellular spaceextracellular matrixbasement membrane
Note: In the lamina beneath the plasma membrane By similarity.

GO - Cellular componenti

  1. basement membrane Source: UniProtKB-SubCell
  2. extracellular vesicular exosome Source: Ensembl
  3. lipid particle Source: Ensembl
  4. midbody Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Basement membrane, Extracellular matrix, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed By similarity
Chaini2 – 339338Annexin A2PRO_0000288687Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylserine By similarity
Modified residuei24 – 241Phosphotyrosine; by SRC By similarity
Modified residuei26 – 261Phosphoserine; by PKC By similarity
Modified residuei49 – 491N6-acetyllysine By similarity
Modified residuei152 – 1521N6-acetyllysine By similarity
Modified residuei199 – 1991Phosphotyrosine By similarity
Modified residuei227 – 2271N6-acetyllysine By similarity

Post-translational modificationi

ISGylated By similarity.

Keywords - PTMi

Acetylation, Phosphoprotein, Ubl conjugation

Proteomic databases

PRIDEiA2SW69.

Expressioni

Tissue specificityi

Detected in myometrium.1 Publication

Inductioni

Up-regulated in myometrium upon progesterone treatment.1 Publication

Interactioni

Subunit structurei

Heterotetramer containing 2 light chains of S100A10/p11 and 2 heavy chains of ANXA2/p36. Interacts with ATP1B1 and DYSF By similarity. Interacts with COCH By similarity.1 Publication

Structurei

3D structure databases

ProteinModelPortaliA2SW69.
SMRiA2SW69. Positions 21-339.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati42 – 10261Annexin 1Add
BLAST
Repeati114 – 17461Annexin 2Add
BLAST
Repeati199 – 25961Annexin 3Add
BLAST
Repeati274 – 33461Annexin 4Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni2 – 2423S100A10-binding site Reviewed predictionAdd
BLAST

Domaini

A pair of annexin repeats may form one binding site for calcium and phospholipid.

Sequence similaritiesi

Belongs to the annexin family.
Contains 4 annexin repeats.

Keywords - Domaini

Annexin, Repeat

Phylogenomic databases

GeneTreeiENSGT00680000099735.
HOVERGENiHBG061815.

Family and domain databases

Gene3Di1.10.220.10. 4 hits.
InterProiIPR001464. Annexin.
IPR018502. Annexin_repeat.
IPR018252. Annexin_repeat_CS.
IPR002389. AnnexinII.
[Graphical view]
PANTHERiPTHR10502:SF18. PTHR10502:SF18. 1 hit.
PfamiPF00191. Annexin. 4 hits.
[Graphical view]
PRINTSiPR00196. ANNEXIN.
PR00198. ANNEXINII.
SMARTiSM00335. ANX. 4 hits.
[Graphical view]
PROSITEiPS00223. ANNEXIN. 4 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

A2SW69-1 [UniParc]FASTAAdd to Basket

« Hide

MSTVHEILCK LSLEGDHSTP PSAYGSVKAY TNFDAERDAL NIETAIKTKG    50
VDEVTIVNIL TNRSNEQRQD IAFAYQRRTK KELASALKSA LSGHLETVIL 100
GLLKTPAQYD ASELKASMKG LGTDEDSLIE IICSRTNQEL QEINRVYKEM 150
YKTDLEKDIV SDTSGDFRKL MVALAKGRRA EDGSVIDYEL IDQDARDLYD 200
AGVKRKGTDV PKWISIMTER SVCHLQKVFE RYKSYSPYDM LESIKKEVKG 250
DLENAFLNLV QCIQNKPLYF ADRLYDSMKG KGTRDKVLIR IMVSRSEVDM 300
LKIRSEFKKK YGKSLYYYIQ QDTKGDYQKA LLYLCGGDD 339
Length:339
Mass (Da):38,612
Last modified:March 6, 2007 - v1
Checksum:iAA8E2500F4138B3D
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DQ358998 mRNA. Translation: ABC94470.1.
RefSeqiNP_001087257.1. NM_001093788.1.
UniGeneiOar.5185.

Genome annotation databases

EnsembliENSOART00000022687; ENSOARP00000022381; ENSOARG00000020821.
GeneIDi100048993.

Cross-referencesi

Web resourcesi

Protein Spotlight

Red velvet - Issue 86 of September 2007

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DQ358998 mRNA. Translation: ABC94470.1 .
RefSeqi NP_001087257.1. NM_001093788.1.
UniGenei Oar.5185.

3D structure databases

ProteinModelPortali A2SW69.
SMRi A2SW69. Positions 21-339.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi A2SW69.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSOART00000022687 ; ENSOARP00000022381 ; ENSOARG00000020821 .
GeneIDi 100048993.

Organism-specific databases

CTDi 302.

Phylogenomic databases

GeneTreei ENSGT00680000099735.
HOVERGENi HBG061815.

Family and domain databases

Gene3Di 1.10.220.10. 4 hits.
InterProi IPR001464. Annexin.
IPR018502. Annexin_repeat.
IPR018252. Annexin_repeat_CS.
IPR002389. AnnexinII.
[Graphical view ]
PANTHERi PTHR10502:SF18. PTHR10502:SF18. 1 hit.
Pfami PF00191. Annexin. 4 hits.
[Graphical view ]
PRINTSi PR00196. ANNEXIN.
PR00198. ANNEXINII.
SMARTi SM00335. ANX. 4 hits.
[Graphical view ]
PROSITEi PS00223. ANNEXIN. 4 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Separate and synergistic effect of progesterone and estradiol on induction of annexin 2 and its interaction protein p11 in pregnant sheep myometrium."
    Zhang Q., Wu W.X.
    J. Mol. Endocrinol. 38:441-454(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], INDUCTION, TISSUE SPECIFICITY, SUBUNIT.
    Tissue: Myometrium.

Entry informationi

Entry nameiANXA2_SHEEP
AccessioniPrimary (citable) accession number: A2SW69
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: March 6, 2007
Last modified: July 9, 2014
This is version 43 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

It may cross-link plasma membrane phospholipids with actin and the cytoskeleton and be involved with exocytosis.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Protein Spotlight
    Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi