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Protein

DNA polymerase II large subunit

Gene

polC

Organism
Methanocorpusculum labreanum (strain ATCC 43576 / DSM 4855 / Z)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Possesses two activities: a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3'- to 5'-direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase (By similarity).By similarity

Catalytic activityi

Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).UniRule annotation
Degradation of single-stranded DNA. It acts progressively in a 3'- to 5'-direction, releasing nucleoside 5'-phosphates.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

DNA-directed DNA polymerase, Exonuclease, Hydrolase, Nuclease, Nucleotidyltransferase, Transferase

Keywords - Biological processi

DNA replication

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

BioCyciMLAB410358:GH7C-1765-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
DNA polymerase II large subunitUniRule annotation (EC:2.7.7.7UniRule annotation)
Short name:
Pol IIUniRule annotation
Gene namesi
Name:polCUniRule annotation
Ordered Locus Names:Mlab_1699
OrganismiMethanocorpusculum labreanum (strain ATCC 43576 / DSM 4855 / Z)
Taxonomic identifieri410358 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanomicrobiaMethanomicrobialesMethanocorpusculaceaeMethanocorpusculum
Proteomesi
  • UP000000365 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 11411141DNA polymerase II large subunitPRO_0000294687Add
BLAST

Interactioni

Subunit structurei

Heterodimer of a large subunit and a small subunit.UniRule annotation

Protein-protein interaction databases

STRINGi410358.Mlab_1699.

Family & Domainsi

Sequence similaritiesi

Belongs to the archaeal DNA polymerase II family.UniRule annotation

Phylogenomic databases

eggNOGiarCOG04447. Archaea.
COG1933. LUCA.
HOGENOMiHOG000286435.
KOiK02322.
OMAiRNCDGDE.

Family and domain databases

HAMAPiMF_00324. DNApol_II_L_arch. 1 hit.
InterProiIPR004475. PolC_DP2.
IPR016033. PolC_DP2_N.
[Graphical view]
PfamiPF03833. PolC_DP2. 1 hit.
[Graphical view]
PIRSFiPIRSF016275. PolC_DP2. 1 hit.
TIGRFAMsiTIGR00354. polC. 1 hit.

Sequencei

Sequence statusi: Complete.

A2SU54-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAELVTSPAY RAYLDGLIAG LDRAMEIANK AKSLGVDPRP YVEIPIASDL
60 70 80 90 100
AGRVEALLGY KGVAAKIREL EDRMSREEAA LKIGDAFVGK EFGESTREDI
110 120 130 140 150
LDHAIRTSMA LLTEGVVAAP TEGIGKVAVR RNDDGTEYLS IYYAGPIRSA
160 170 180 190 200
GGTAQALSVL VGDYVRRLLN IDRYKPREEE IERYVEEIKQ YNNIQSMQYL
210 220 230 240 250
PKDDDIRLII RNCPICIDGE PTEQEEISGY RNLERVETNV VRGGMGLVIA
260 270 280 290 300
EGIGLKAPKI QKNVAKMNLD GWEWLEELIS GNTPAQEVEE EPGVHPKDKY
310 320 330 340 350
MRDMLAGRPS FSYPMRKGGF RFRLGRCRNT GLATCGFNPA TLHILDDYLA
360 370 380 390 400
VGTQMKVERP GKACGVVPCT DIEGPTVRLK SGELRRIDTL DDANKYYDQV
410 420 430 440 450
EYILDIGEIL ISFGEFMENN HVLMPPSYCE EWWIQEGGPR HPKNEAEALS
460 470 480 490 500
FVLEGAYLHP DYTWFWDDCS EGQLIFLSDK VAGTGSLREG VLYIPEDPAV
510 520 530 540 550
KSVLEELLVP HTVEEGFYVV RTPLALIMGL GLTDTLAKSP TWKTLPPFSN
560 570 580 590 600
GLSMAISLSG LKMRSKAGTR VGGRMGRPGK SAPRKMKPPV HVLFPIGESG
610 620 630 640 650
GMKRSIDNAA KICSSDSEEN FRGTSVTTGQ VEGLIQVQTG ERRCPKCGTV
660 670 680 690 700
TFKSRCADCG THTDAVYRCP HCNQLGEEGQ ESCPKCGANL VCSKESIVSL
710 720 730 740 750
GQEYAAALKN VGMSASSSPE LKGVRGLISR ERVVEPLEKG LLRAKNNIFV
760 770 780 790 800
FRDGTIRYDM IDLPLTHFRP AEVGVSVEKL RSIGYTQDMH GADLTDASQL
810 820 830 840 850
VELHPQDIMV SVDCGEYLVR VAAYVDELLE KVYGMEAFYH VKTPEDLVGH
860 870 880 890 900
LVMGLAPHTS AGVLARIVGF TKAKAGYAHP YYHAAKRRNC DGDEDCVMLL
910 920 930 940 950
MDGLLNFSRS FLPSTRGGTM DAPLVLTTTL NPKEVDKETL NVDVMPRYPL
960 970 980 990 1000
EVYTACLTYR APKEVGKFVD YVEKRVETPG QFEGFSFTHD TTDISEGPID
1010 1020 1030 1040 1050
TMYTNPILKG TADKIKAELG LADRIRAVDT NDLAERIINS HLMPDMIGNL
1060 1070 1080 1090 1100
RSFSKQAFRC PKCKTSYRRI PVSGKCNKCG GPVKATMHKG NVTKYLEISK
1110 1120 1130 1140
YMAEHYTLSD YTNQRIQVTE MNINSTFGEE EKVQMDLSDF F
Length:1,141
Mass (Da):126,420
Last modified:March 6, 2007 - v1
Checksum:iE52E99960EC631DD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000559 Genomic DNA. Translation: ABN07860.1.
RefSeqiWP_011834063.1. NC_008942.1.

Genome annotation databases

EnsemblBacteriaiABN07860; ABN07860; Mlab_1699.
GeneIDi4795011.
KEGGimla:Mlab_1699.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000559 Genomic DNA. Translation: ABN07860.1.
RefSeqiWP_011834063.1. NC_008942.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi410358.Mlab_1699.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABN07860; ABN07860; Mlab_1699.
GeneIDi4795011.
KEGGimla:Mlab_1699.

Phylogenomic databases

eggNOGiarCOG04447. Archaea.
COG1933. LUCA.
HOGENOMiHOG000286435.
KOiK02322.
OMAiRNCDGDE.

Enzyme and pathway databases

BioCyciMLAB410358:GH7C-1765-MONOMER.

Family and domain databases

HAMAPiMF_00324. DNApol_II_L_arch. 1 hit.
InterProiIPR004475. PolC_DP2.
IPR016033. PolC_DP2_N.
[Graphical view]
PfamiPF03833. PolC_DP2. 1 hit.
[Graphical view]
PIRSFiPIRSF016275. PolC_DP2. 1 hit.
TIGRFAMsiTIGR00354. polC. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiDP2L_METLZ
AccessioniPrimary (citable) accession number: A2SU54
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 10, 2007
Last sequence update: March 6, 2007
Last modified: November 11, 2015
This is version 49 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Multifunctional enzyme, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.