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Protein

DNA polymerase II large subunit

Gene

polC

Organism
Methanocorpusculum labreanum (strain ATCC 43576 / DSM 4855 / Z)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Possesses two activities: a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3'- to 5'-direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase (By similarity).By similarity

Catalytic activityi

Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).UniRule annotation
Exonucleolytic cleavage in the 3'- to 5'-direction to yield nucleoside 5'-phosphates.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding, DNA-directed DNA polymerase, Exonuclease, Hydrolase, Multifunctional enzyme, Nuclease, Nucleotidyltransferase, Transferase
Biological processDNA replication

Enzyme and pathway databases

BioCyciMLAB410358:G1G83-1815-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
DNA polymerase II large subunitUniRule annotation (EC:2.7.7.7UniRule annotation)
Short name:
Pol IIUniRule annotation
Alternative name(s):
Exodeoxyribonuclease large subunitUniRule annotation (EC:3.1.11.1UniRule annotation)
Gene namesi
Name:polCUniRule annotation
Ordered Locus Names:Mlab_1699
OrganismiMethanocorpusculum labreanum (strain ATCC 43576 / DSM 4855 / Z)
Taxonomic identifieri410358 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanomicrobiaMethanomicrobialesMethanocorpusculaceaeMethanocorpusculum
Proteomesi
  • UP000000365 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002946871 – 1141DNA polymerase II large subunitAdd BLAST1141

Interactioni

Subunit structurei

Heterodimer of a large subunit and a small subunit.UniRule annotation

Protein-protein interaction databases

STRINGi410358.Mlab_1699

Structurei

3D structure databases

SMRiA2SU54
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the archaeal DNA polymerase II family.UniRule annotation

Phylogenomic databases

eggNOGiarCOG04447 Archaea
COG1933 LUCA
HOGENOMiHOG000286435
KOiK02322
OMAiKRRNCDG
OrthoDBiPOG093Z06CT

Family and domain databases

HAMAPiMF_00324 DNApol_II_L_arch, 1 hit
InterProiView protein in InterPro
IPR004475 PolC_DP2
IPR016033 PolC_DP2_N
PANTHERiPTHR42210 PTHR42210, 2 hits
PfamiView protein in Pfam
PF03833 PolC_DP2, 1 hit
PIRSFiPIRSF016275 PolC_DP2, 1 hit
TIGRFAMsiTIGR00354 polC, 1 hit

Sequencei

Sequence statusi: Complete.

A2SU54-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAELVTSPAY RAYLDGLIAG LDRAMEIANK AKSLGVDPRP YVEIPIASDL
60 70 80 90 100
AGRVEALLGY KGVAAKIREL EDRMSREEAA LKIGDAFVGK EFGESTREDI
110 120 130 140 150
LDHAIRTSMA LLTEGVVAAP TEGIGKVAVR RNDDGTEYLS IYYAGPIRSA
160 170 180 190 200
GGTAQALSVL VGDYVRRLLN IDRYKPREEE IERYVEEIKQ YNNIQSMQYL
210 220 230 240 250
PKDDDIRLII RNCPICIDGE PTEQEEISGY RNLERVETNV VRGGMGLVIA
260 270 280 290 300
EGIGLKAPKI QKNVAKMNLD GWEWLEELIS GNTPAQEVEE EPGVHPKDKY
310 320 330 340 350
MRDMLAGRPS FSYPMRKGGF RFRLGRCRNT GLATCGFNPA TLHILDDYLA
360 370 380 390 400
VGTQMKVERP GKACGVVPCT DIEGPTVRLK SGELRRIDTL DDANKYYDQV
410 420 430 440 450
EYILDIGEIL ISFGEFMENN HVLMPPSYCE EWWIQEGGPR HPKNEAEALS
460 470 480 490 500
FVLEGAYLHP DYTWFWDDCS EGQLIFLSDK VAGTGSLREG VLYIPEDPAV
510 520 530 540 550
KSVLEELLVP HTVEEGFYVV RTPLALIMGL GLTDTLAKSP TWKTLPPFSN
560 570 580 590 600
GLSMAISLSG LKMRSKAGTR VGGRMGRPGK SAPRKMKPPV HVLFPIGESG
610 620 630 640 650
GMKRSIDNAA KICSSDSEEN FRGTSVTTGQ VEGLIQVQTG ERRCPKCGTV
660 670 680 690 700
TFKSRCADCG THTDAVYRCP HCNQLGEEGQ ESCPKCGANL VCSKESIVSL
710 720 730 740 750
GQEYAAALKN VGMSASSSPE LKGVRGLISR ERVVEPLEKG LLRAKNNIFV
760 770 780 790 800
FRDGTIRYDM IDLPLTHFRP AEVGVSVEKL RSIGYTQDMH GADLTDASQL
810 820 830 840 850
VELHPQDIMV SVDCGEYLVR VAAYVDELLE KVYGMEAFYH VKTPEDLVGH
860 870 880 890 900
LVMGLAPHTS AGVLARIVGF TKAKAGYAHP YYHAAKRRNC DGDEDCVMLL
910 920 930 940 950
MDGLLNFSRS FLPSTRGGTM DAPLVLTTTL NPKEVDKETL NVDVMPRYPL
960 970 980 990 1000
EVYTACLTYR APKEVGKFVD YVEKRVETPG QFEGFSFTHD TTDISEGPID
1010 1020 1030 1040 1050
TMYTNPILKG TADKIKAELG LADRIRAVDT NDLAERIINS HLMPDMIGNL
1060 1070 1080 1090 1100
RSFSKQAFRC PKCKTSYRRI PVSGKCNKCG GPVKATMHKG NVTKYLEISK
1110 1120 1130 1140
YMAEHYTLSD YTNQRIQVTE MNINSTFGEE EKVQMDLSDF F
Length:1,141
Mass (Da):126,420
Last modified:March 6, 2007 - v1
Checksum:iE52E99960EC631DD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000559 Genomic DNA Translation: ABN07860.1
RefSeqiWP_011834063.1, NC_008942.1

Genome annotation databases

EnsemblBacteriaiABN07860; ABN07860; Mlab_1699
GeneIDi4795011
KEGGimla:Mlab_1699

Similar proteinsi

Entry informationi

Entry nameiDP2L_METLZ
AccessioniPrimary (citable) accession number: A2SU54
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 10, 2007
Last sequence update: March 6, 2007
Last modified: February 28, 2018
This is version 59 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome