A2SU05 (AROA_METLZ) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Probable 3-phosphoshikimate 1-carboxyvinyltransferase
EC=2.5.1.19

Alternative name(s):
5-enolpyruvylshikimate-3-phosphate synthase
Short name=EPSP synthase
Short name=EPSPS

Gene names

Name:	aroA
Ordered Locus Names:	Mlab_1650

Organism

Methanocorpusculum labreanum (strain ATCC 43576 / DSM 4855 / Z) [Complete proteome] [HAMAP]

Taxonomic identifier

410358 [NCBI]

Taxonomic lineage

Archaea › Euryarchaeota › Methanomicrobia › Methanomicrobiales › Methanocorpusculaceae › Methanocorpusculum

Protein attributes

Sequence length	422 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	Phosphoenolpyruvate + 3-phosphoshikimate = phosphate + 5-O-(1-carboxyvinyl)-3-phosphoshikimate. HAMAP MF_00210
Pathway	Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 6/7. HAMAP MF_00210
Subunit structure	Monomer By similarity. HAMAP MF_00210
Subcellular location	Cytoplasm By similarity HAMAP MF_00210.
Sequence similarities	Belongs to the EPSP synthase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Aromatic amino acid biosynthesis
Cellular component	Cytoplasm
Molecular function	Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	aromatic amino acid family biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	3-phosphoshikimate 1-carboxyvinyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 422	422	Probable 3-phosphoshikimate 1-carboxyvinyltransferase HAMAP MF_00210		PRO_1000012451

Sequences

	Sequence		Length	Mass (Da)
	A2SU05 [UniParc]. Last modified March 6, 2007. Version 1. Checksum: 8D25B3B249EB9BEB	FASTA	422	43,626
	10 20 30 40 50 60 MKLIVSRSQI SGCVHAPPSK SHTHRAFLLA SLAKGESVVL SPLLGEDTLA TLSAVKALGA 70 80 90 100 110 120 NVCEGDDRIT IQGGNLHAPL PKGTVINCKN SGTSIRMLAG IASRLDGTTE FTGDASLCSR 130 140 150 160 170 180 PMKPLLDALS ELGAGVTSDN GCAPFTITGP VSGGDVHIRG DVSSQFISGL LISAPLGKAD 190 200 210 220 230 240 TRIHLTTPLT SKPYVDMTIS AMKKHGVSVE TIEDGYLVRS GQVYSSEDVQ VGGDYSSAAF 250 260 270 280 290 300 LFAAAALAGE IAVSGLDPAD PQGDQVVISI LETFGAGVVR DGENVTIRKA ALKAADIDLA 310 320 330 340 350 360 NAPDLFPIIA VLASQAKGTS RLYGAAHLRF KESDRIMSTV LFLRSMGADI SETEDGCIVT 370 380 390 400 410 420 GPANLSGANV TTFGDHRIMM ASAVAGLIAD STTTVDDAGC CAVSYPGFVK DMQKLGADMR EE

References

[1]

"Complete genome sequence of Methanocorpusculum labreanum type strain Z." Anderson I.J., Sieprawska-Lupa M., Goltsman E., Lapidus A., Copeland A., Glavina Del Rio T., Tice H., Dalin E., Barry K., Pitluck S., Hauser L., Land M., Lucas S., Richardson P., Whitman W.B., Kyrpides N.C. Stand. Genomic Sci. 1:197-203(2009) [PubMed: 21304657] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 43576 / DSM 4855 / Z.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000559 Genomic DNA. Translation: ABN07811.1.
RefSeq	YP_001031078.1. NC_008942.1.
3D structure databases
ProteinModelPortal	A2SU05.
ModBase	Search...
Protein-protein interaction databases
STRING	A2SU05.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	4795407.
GenomeReviews	Gene locus Mlab_1650 in contig CP000559_GR.
KEGG	mla:Mlab_1650.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	arNOG05032.
HOGENOM	HBG646626.
OMA	RLRIKEC.
PhylomeDB	A2SU05.
Enzyme and pathway databases
BioCyc	MLAB410358:MLAB_1650-MONOMER.
Family and domain databases
HAMAP	MF_00210. EPSP_synth. [Tree]
InterPro	IPR001986. Enolpyruvate_Tfrase_dom. IPR006264. EPSP_synthase. IPR023193. EPSP_synthase_CS. IPR013792. RNA3'P_cycl/enolpyr_Trfase_a/b. [Graphical view]
Gene3D	G3DSA:3.65.10.10. EPSP_synthase. 2 hits.
KO	K00800.
Pfam	PF00275. EPSP_synthase. 1 hit. [Graphical view]
PIRSF	PIRSF000505. EPSPS. 1 hit.
SUPFAM	SSF55205. RNA3'_cycl/enolpyr_transf_A/B. 1 hit.
TIGRFAMs	TIGR01356. AroA. 1 hit.
PROSITE	PS00104. EPSP_SYNTHASE_1. 1 hit. PS00885. EPSP_SYNTHASE_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

AROA_METLZ

Accession

Primary (citable) accession number: A2SU05

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	March 6, 2007
Last modified:	November 16, 2011
This is version 39 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program