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Protein

Anthranilate phosphoribosyltransferase

Gene

trpD

Organism
Methanocorpusculum labreanum (strain ATCC 43576 / DSM 4855 / Z)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the transfer of the phosphoribosyl group of 5-phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA).UniRule annotation

Catalytic activityi

N-(5-phospho-D-ribosyl)-anthranilate + diphosphate = anthranilate + 5-phospho-alpha-D-ribose 1-diphosphate.UniRule annotation

Cofactori

Mg2+UniRule annotationNote: Binds 2 magnesium ions per monomer.UniRule annotation

Pathwayi: L-tryptophan biosynthesis

This protein is involved in step 2 of the subpathway that synthesizes L-tryptophan from chorismate.UniRule annotation
Proteins known to be involved in the 5 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Anthranilate phosphoribosyltransferase (trpD)
  3. N-(5'-phosphoribosyl)anthranilate isomerase (trpF), N-(5'-phosphoribosyl)anthranilate isomerase (trpF)
  4. no protein annotated in this organism
  5. Tryptophan synthase alpha chain (trpA), Tryptophan synthase beta chain (trpB)
This subpathway is part of the pathway L-tryptophan biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-tryptophan from chorismate, the pathway L-tryptophan biosynthesis and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei81Anthranilate 1; via carbonyl oxygenUniRule annotation1
Binding sitei81Phosphoribosylpyrophosphate; via amide nitrogenUniRule annotation1
Binding sitei89PhosphoribosylpyrophosphateUniRule annotation1
Metal bindingi93Magnesium 1UniRule annotation1
Binding sitei112Anthranilate 1UniRule annotation1
Binding sitei121Phosphoribosylpyrophosphate; via amide nitrogenUniRule annotation1
Binding sitei167Anthranilate 2UniRule annotation1
Metal bindingi225Magnesium 2UniRule annotation1
Metal bindingi226Magnesium 1UniRule annotation1
Metal bindingi226Magnesium 2UniRule annotation1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Keywords - Biological processi

Amino-acid biosynthesis, Aromatic amino acid biosynthesis, Tryptophan biosynthesis

Keywords - Ligandi

Magnesium, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00035; UER00041.

Names & Taxonomyi

Protein namesi
Recommended name:
Anthranilate phosphoribosyltransferaseUniRule annotation (EC:2.4.2.18UniRule annotation)
Gene namesi
Name:trpDUniRule annotation
Ordered Locus Names:Mlab_1397
OrganismiMethanocorpusculum labreanum (strain ATCC 43576 / DSM 4855 / Z)
Taxonomic identifieri410358 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanomicrobiaMethanomicrobialesMethanocorpusculaceaeMethanocorpusculum
Proteomesi
  • UP000000365 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000430311 – 340Anthranilate phosphoribosyltransferaseAdd BLAST340

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi410358.Mlab_1397.

Structurei

3D structure databases

ProteinModelPortaliA2STA7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni84 – 85Phosphoribosylpyrophosphate bindingUniRule annotation2
Regioni91 – 94Phosphoribosylpyrophosphate bindingUniRule annotation4
Regioni109 – 117Phosphoribosylpyrophosphate bindingUniRule annotation9

Sequence similaritiesi

Belongs to the anthranilate phosphoribosyltransferase family.UniRule annotation

Phylogenomic databases

eggNOGiarCOG02012. Archaea.
COG0547. LUCA.
HOGENOMiHOG000230451.
KOiK00766.
OMAiWLVHGSD.

Family and domain databases

Gene3Di3.40.1030.10. 1 hit.
HAMAPiMF_00211. TrpD. 1 hit.
InterProiIPR005940. Anthranilate_Pribosyl_Tfrase.
IPR000312. Glycosyl_Trfase_fam3.
IPR017459. Glycosyl_Trfase_fam3_N_dom.
[Graphical view]
PfamiPF02885. Glycos_trans_3N. 1 hit.
PF00591. Glycos_transf_3. 1 hit.
[Graphical view]
SUPFAMiSSF47648. SSF47648. 1 hit.
SSF52418. SSF52418. 1 hit.
TIGRFAMsiTIGR01245. trpD. 1 hit.

Sequencei

Sequence statusi: Complete.

A2STA7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIAECIKKVA SHSDLSVYEA KGAMQDIMSG NATDGQIGAF LTALVMKGET
60 70 80 90 100
SSEIAAFASV MRENAVQITP KRNGMLVDTC GTGGDGKNTF NISTAAAFTA
110 120 130 140 150
AGAGVTVVKH GNRGATSKCG SADVLEALGI KIDISPERVC EIIDENGIGF
160 170 180 190 200
MFAQSHHPAM KYAGKVRKEI GIRSFFNLIG PLSNPAGADA QLLGVYDSPL
210 220 230 240 250
TEKIAEVLNI LGTKRAMVVH GDGYDEITTT GITQVSEVND GQVRSYSLDP
260 270 280 290 300
SSFGFQKADA ASLFGGDSQY NAHIIRSVLS GDEGPRRDIV ILNAAAAIYL
310 320 330 340
GERAGSIADG IKYAEKSIDS GLALEKLENL ILLSGGKNDS
Length:340
Mass (Da):35,571
Last modified:March 6, 2007 - v1
Checksum:iF379E7C718F72724
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000559 Genomic DNA. Translation: ABN07563.1.
RefSeqiWP_011833766.1. NC_008942.1.

Genome annotation databases

EnsemblBacteriaiABN07563; ABN07563; Mlab_1397.
GeneIDi4796162.
KEGGimla:Mlab_1397.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000559 Genomic DNA. Translation: ABN07563.1.
RefSeqiWP_011833766.1. NC_008942.1.

3D structure databases

ProteinModelPortaliA2STA7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi410358.Mlab_1397.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABN07563; ABN07563; Mlab_1397.
GeneIDi4796162.
KEGGimla:Mlab_1397.

Phylogenomic databases

eggNOGiarCOG02012. Archaea.
COG0547. LUCA.
HOGENOMiHOG000230451.
KOiK00766.
OMAiWLVHGSD.

Enzyme and pathway databases

UniPathwayiUPA00035; UER00041.

Family and domain databases

Gene3Di3.40.1030.10. 1 hit.
HAMAPiMF_00211. TrpD. 1 hit.
InterProiIPR005940. Anthranilate_Pribosyl_Tfrase.
IPR000312. Glycosyl_Trfase_fam3.
IPR017459. Glycosyl_Trfase_fam3_N_dom.
[Graphical view]
PfamiPF02885. Glycos_trans_3N. 1 hit.
PF00591. Glycos_transf_3. 1 hit.
[Graphical view]
SUPFAMiSSF47648. SSF47648. 1 hit.
SSF52418. SSF52418. 1 hit.
TIGRFAMsiTIGR01245. trpD. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiTRPD_METLZ
AccessioniPrimary (citable) accession number: A2STA7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: March 6, 2007
Last modified: November 2, 2016
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.